Preparation and experimental efficiency mark of new direct anticoagulant

Compounds with anticoagulant activity have been extracted from plant (Vaccinium myrtillus). The action of effectors realize at intrinsic way of blood coagulation. In this work we study influences of new plantderived direct anticoagulant in vitro and in vivo (in laser-induced model of thrombosis) at hemostasis and hemodynamics and compare its effects with heparin

Извлечение ионов фтора из водных сред при использовании минералов

В рамках данного исследования рассматриваются различные образцы минеральных пород (бентонит, диатомит, пирит и другие) на определение их удельной поверхности и удельного объёма пор и возможности извлечения ими из воды ионов фтора. Определены наиболее эффективные образцы минералов.In this work, various samples of mineral rocks (bentonite, diatomite, pyrite and more) were studied to determine their specific surface area, specific pore volume and the possibility of extracting fluoride ions from water. The most effective samples of minerals were determined

Повышение эффективности нефтяных скважин в условиях коррозионной агрессивности скважинной продукции

Объектом исследования является ингибиторы коррозии и насосно-компрессорные трубы. Цель работы – провести глубокий анализ ингибиторов коррозии технологии подачи их в скважину и глубокий анализ насосно-компрессорные труб. Определить оптимальную дозировку реагента и оптимальный тип насосно-компрессорных труб для данных условий. В процессе исследования изучались негативные влияния коррозии на работу глубинно-насосного оборудование, рассматривались наиболее популярные технологии подачи ингибитора в скважину, а также проведён углубленный анализ ингибитор… Область применения: разработаны рекомендации для достижения наилучших показателей МРП и СНО.Object of a research is inhibitors of corrosion and pump and compressor pipes. The work purpose – to carry out the deep analysis of inhibitors of corrosion of technology of giving them to the well and the deep analysis pump and compressor pipes. To define an optimum dosage of reagent and optimum type of pump and compressor pipes for these conditions. In the course of the research negative impacts of corrosion on work deep and pump the equipment were studied, the most popular technologies of supply of inhibitor to the well were considered and also the profound analysis inhibitor is carried out … Scope: recommendations for achievement of the best indicators of MRP and SNO are developed

Die offene Mundhaltung - Ursache oder Wirkung der vergrößerten Rachenmandel ?

EINLEITUNG: Klärung des kausalen Zusammenhangs von Adenoiden und Mundatmung. METHODEN: Es erfolgten eine HNO-ärztliche Untersuchung und eine kieferorthopädische Untersuchung vor und nach Adenotomie, die anamnestische und klinische Befunde beinhalteten. ERGEBNISSE: 50 Kinder im Alter von 2,5 - 6,5 Jahren wurden untersucht. Offene Mundhaltung wurde unabhängig von der Rachenmandelgröße beobachtet. SCHLUSSFOLGERUNG: Trotz Beseitigung der Adenoide ist bei der Mehrzahl noch eine offene Mundhaltung vorhanden. Diese Kinder müssen interdisziplinär betreut werden

Root canal pre-treatment and adhesive system affect bond strength durability of fiber posts ex vivo

Objectives: To investigate the effect of different pre-treatments on the long-term bond strength of fiberglass posts luted either with dual-curing self-etch adhesives and core build-up composites or with a self-adhesive resin (SAR) cement. Materials and methods: In total, 180 human root-filled teeth received post-space preparations and three different dentin pre-treatments (PTs): PT1, ethanol (99%); PT2, ethanol-tertiary-butanol-water-solution (AH Plus Cleaner, Dentsply Sirona; York, USA); and PT3, distilled water (control). Five luting systems were used: FU, Futurabond U (Voco; Cuxhaven, Germany); CL, Clearfil DC Bond (Kuraray Noritake; Okayama, Japan); GR, Gradia Core SE Bond (GC Europe NV; Leuven, Belgium); LU, LuxaBond Universal (DMG; Hamburg, Germany); and RX, RelyX Unicem 2 (3M; Minnesota, USA). Roots were cut into six slices (1 mm thick). From each root canal region, three slices were submitted to immediate and three to post-storage push-out testing. The latter were subjected to thermocycling (5–55°C, 6.000 cycles) and stored for six months in saline solution (0.9%, 37°C). Data were analysed using repeated measures ANOVA and chi-square tests (MV±SD). Results: Bond strength was significantly affected by material (p<0.0005), pre-treatment (p=0.016), and storage (p<0.0005; repeated-measures ANOVA). LU (18.8±8.1MPa) revealed significantly higher bond strength than RX (16.08±6.4MPa), GR (15.1±4.6MPa), CL (13.95±5.2MPa), and FU (13.7±6.3MPa). PT1 (16.5±6.9MPa) revealed significantly higher bond strength than PT3 (14.5±5.7MPa). Conclusions: A universal adhesive in self-etch mode combined with a core build-up material revealed higher bond strength than a SAR cement, both interacted positively with Ethanol pre-treatment. Clinical relevance statement: Ethanol (99%) rinsing can be recommended as part of post and core pre-treatment for the investigated luting systems

Autism spectrum disorder classification based on interpersonal neural synchrony: Can classification be improved by dyadic neural biomarkers using unsupervised graph representation learning?

Research in machine learning for autism spectrum disorder (ASD) classification bears the promise to improve clinical diagnoses. However, recent studies in clinical imaging have shown the limited generalization of biomarkers across and beyond benchmark datasets. Despite increasing model complexity and sample size in neuroimaging, the classification performance of ASD remains far away from clinical application. This raises the question of how we can overcome these barriers to develop early biomarkers for ASD. One approach might be to rethink how we operationalize the theoretical basis of this disease in machine learning models. Here we introduced unsupervised graph representations that explicitly map the neural mechanisms of a core aspect of ASD, deficits in dyadic social interaction, as assessed by dual brain recordings, termed hyperscanning, and evaluated their predictive performance. The proposed method differs from existing approaches in that it is more suitable to capture social interaction deficits on a neural level and is applicable to young children and infants. First results from functional near-infrared spectroscopy data indicate potential predictive capacities of a task-agnostic, interpretable graph representation. This first effort to leverage interaction-related deficits on neural level to classify ASD may stimulate new approaches and methods to enhance existing models to achieve developmental ASD biomarkers in the future.Comment: Accepted in Medical Image Computing and Computer Assisted Intervention - MICCAI 2022: The 5th International Workshop on Machine Learning in Clinical Neuroimagin

A mother-child intervention program in adolescent mothers and their children to improve maternal sensitivity, child responsiveness and child development (the TeeMo study): study protocol for a randomized controlled trial

Background: Children of adolescent mothers present a high-risk group for child neglect and maltreatment. Previous findings suggest that early interventions can reduce maltreatment by improving the quality of mother-child interaction, particularly maternal sensitivity. The aim of the current study is to evaluate the effects of a mother-child intervention program using home visits and video-feedback regarding mother-child interaction (STEEP-b) plus psychiatric treatment of the mother in cases where mental illness is present compared with TAU (treatment as usual, that is, standardized support by the child welfare system) on enhancing maternal sensitivity and child responsiveness in adolescent, high-risk mothers. The second aim of the current project is to investigate behavioral and neural differences between adolescent and adult mothers at baseline and postintervention. Methods/Design: This is a randomized controlled trial (RCT) with 120 high-risk adolescent mothers (25 years) will additionally be recruited to investigate behavioral and neural differences between the adolescent and adult group. Blind assessments will take place at T1 (pre-intervention), at the end of the 9-month intervention (T2, postintervention) and 6 months postintervention (T3, follow-up). Moderators of treatment outcomes and sociodemographic data will be assessed at T1. The primary outcome hypothesis is that STEEP-b added to treatment as usual will improve maternal sensitivity and child responsiveness compared with treatment as usual alone in high-risk adolescent mothers. The primary hypothesis will be evaluated at the end of the 9-month follow-up assessment based on the intention-to-treat principle. The trial is funded by the German Ministry for Research and Education (BMBF). Data collection started in October 2012. Discussion: This is a randomized controlled trial that evaluates the effects of an early intervention program (STEEP-b) on the quality of mother-child interaction and child development in adolescent, high-risk mothers. Trial registration DRKS00004409 (27 September 2012