The local dayside reconnection rate for oblique interplanetary magnetic fields

We present an analysis of local properties of magnetic reconnection at the dayside magnetopause for various interplanetary magnetic field (IMF) orientations in global magnetospheric simulations. This has heretofore not been practical because it is difficult to locate where reconnection occurs for oblique IMF, but new techniques make this possible. The approach is to identify magnetic separators, the curves separating four regions of differing magnetic topology, which map the reconnection X-line. The electric field parallel to the X-line is the local reconnection rate. We compare results to a simple model of local two-dimensional asymmetric reconnection. To do so, we find the plasma parameters that locally drive reconnection in the magnetosheath and magnetosphere in planes perpendicular to the X-line at a large number of points along the X-line. The global magnetohydrodynamic simulations are from the three-dimensional Block-Adaptive, Tree Solarwind Roe-type Upwind Scheme (BATS-R-US) code with a uniform resistivity, although the techniques described here are extensible to any global magnetospheric simulation model. We find that the predicted local reconnection rates scale well with the measured values for all simulations, being nearly exact for due southward IMF. However, the absolute predictions differ by an undetermined constant of proportionality, whose magnitude increases as the IMF clock angle changes from southward to northward. We also show similar scaling agreement in a simulation with oblique southward IMF and a dipole tilt. The present results will be an important component of a full understanding of the local and global properties of dayside reconnection.Comment: 12 pages, 7 figures, 1 table, Submitted to Journal Geophysical Research Space Physics February 12, 2016; Revised April 28, 201

Molecular Peptide Grafting as a Tool to Create Novel Protein Therapeutics

The study of peptides (synthetic or corresponding to discrete regions of proteins) has facilitated the understanding of protein structure-activity relationships. Short peptides can also be used as powerful therapeutic agents. However, the functional activity of many short peptides is usually substantially lower than that of their parental proteins. This is (as a rule) due to their diminished structural organization, stability, and solubility often leading to an enhanced propensity for aggregation. Several approaches have emerged to overcome these limitations, which are aimed at imposing structural constraints into the backbone and/or sidechains of the therapeutic peptides (such as molecular stapling, peptide backbone circularization and molecular grafting), therefore enforcing their biologically active conformation and thus improving their solubility, stability, and functional activity. This review provides a short summary of approaches aimed at enhancing the biological activity of short functional peptides with a particular focus on the peptide grafting approach, whereby a functional peptide is inserted into a scaffold molecule. Intra-backbone insertions of short therapeutic peptides into scaffold proteins have been shown to enhance their activity and render them a more stable and biologically active conformation

Tracing magnetic separators and their dependence on IMF clock angle in global magnetospheric simulations

A new, efficient, and highly accurate method for tracing magnetic separators in global magnetospheric simulations with arbitrary clock angle is presented. The technique is to begin at a magnetic null and iteratively march along the separator by finding where four magnetic topologies meet on a spherical surface. The technique is verified using exact solutions for separators resulting from an analytic magnetic field model that superposes dipolar and uniform magnetic fields. Global resistive magnetohydrodynamic simulations are performed using the three-dimensional BATS-R-US code with a uniform resistivity, in eight distinct simulations with interplanetary magnetic field (IMF) clock angles ranging from 0 (parallel) to 180 degrees (anti-parallel). Magnetic nulls and separators are found in the simulations, and it is shown that separators traced here are accurate for any clock angle, unlike the last closed field line on the Sun-Earth line that fails for southward IMF. Trends in magnetic null locations and the structure of magnetic separators as a function of clock angle are presented and compared with those from the analytic field model. There are many qualitative similarities between the two models, but quantitative differences are also noted. Dependence on solar wind density is briefly investigated.Comment: 10 pages, 10 figures, Presented at 2012 AGU Fall Meeting and 2013 Geospace Environment Modeling (GEM) Worksho

Symmetry, singularities and integrability in complex dynamics III: approximate symmetries and invariants

The different natures of approximate symmetries and their corresponding first integrals/invariants are delineated in the contexts of both Lie symmetries of ordinary differential equations and Noether symmetries of the Action Integral. Particular note is taken of the effect of taking higher orders of the perturbation parameter. Approximate symmetries of approximate first integrals/invariants and the problems of calculating them using the Lie method are considered

Parametric Mass Modeling for Mars Entry, Descent and Landing System Analysis Study

This paper provides an overview of the parametric mass models used for the Entry, Descent, and Landing Systems Analysis study conducted by NASA in FY2009-2010. The study examined eight unique exploration class architectures that included elements such as a rigid mid-L/D aeroshell, a lifting hypersonic inflatable decelerator, a drag supersonic inflatable decelerator, a lifting supersonic inflatable decelerator implemented with a skirt, and subsonic/supersonic retro-propulsion. Parametric models used in this study relate the component mass to vehicle dimensions and mission key environmental parameters such as maximum deceleration and total heat load. The use of a parametric mass model allows the simultaneous optimization of trajectory and mass sizing parameters

Type And Material of Fixed Prosthodontic Appliances in Patients Living in the Region of Metković

The aim of this study was to evaluate the type and the aesthetic material in relation to age, gender, level of education, employment, socio-economic status and frequency of visits to the dentist. The examination was performed on 212 patients who had a fixed prosthodontic appliance for more than a year (55% males and 45% females, age 18-80 yrs.). The following conclusions were made: 1. The older patients and retired patients had significantly more bridges than crowns (p0.05). Patients who visit their dentist regularly have significantly more crowns than bridges than patients who visit their dentist irregularly or when in pain (p0.05). 2. Almost all fixed prosthodontic appliances older than 10 years were made of porcelain (98%), while acrylic veneer crowns were more frequent in appliances older than 10 or 15 years (p0.05). Patients older than 60 years had more acrylic material compared to younger patients. While patients younger than 39 years had almost exclusively ceramic appliances (p<0.01). Less educated patients had more acrylic veneer appliances. Employed patients had significantly more ceramic appliances than retired patients

The local dayside reconnection rate for oblique interplanetary magnetic fields

We present an analysis of local properties of magnetic reconnection at the dayside magnetopause for various interplanetary magnetic field (IMF) orientations in global magnetospheric simulations. This has heretofore not been practical because it is difficult to locate where reconnection occurs for oblique IMF, but new techniques make this possible. The approach is to identify magnetic separators, the curves separating four regions of differing magnetic topology, which map the reconnection X-line. The electric field parallel to the X-line is the local reconnection rate. We compare results to a simple model of local two-dimensional asymmetric reconnection. To do so, we find the plasma parameters that locally drive reconnection in the magnetosheath and magnetosphere in planes perpendicular to the X-line at a large number of points along the X-line. The global magnetohydrodynamic simulations are from the three-dimensional Block-Adaptive, Tree Solarwind Roe-type Upwind Scheme (BATS-R-US) code with a uniform resistivity, although the techniques described here are extensible to any global magnetospheric simulation model. We find that the predicted local reconnection rates scale well with the measured values for all simulations, being nearly exact for due southward IMF. However, the absolute predictions differ by an undetermined constant of proportionality, whose magnitude increases as the IMF clock angle changes from southward to northward. We also show similar scaling agreement in a simulation with oblique southward IMF and a dipole tilt. The present results will be an important component of a full understanding of the local and global properties of dayside reconnection

Gravitational multi-NUT solitons, Komar masses and charges

Generalising expressions given by Komar, we give precise definitions of gravitational mass and solitonic NUT charge and we apply these to the description of a class of Minkowski-signature multi-Taub-NUT solutions without rod singularities. A Wick rotation then yields the corresponding class of Euclidean-signature gravitational multi-instantons.Comment: Some references adde