ОБРАЗ МИРА И ДЕВАЛЬВАЦИЯ НРАВСТВЕННЫХ ЦЕННОСТЕЙ В СОВРЕМЕННОМ ОБЩЕСТВЕ: АСПЕКТЫ ПРОБЛЕМЫ

The article analyzes the dangers of scientific and technological progress for society, it is argued that the relativization of moral values in modern society has its source in relation to man as an object, which leads to primitivization and disintegration of the individual. The attitude to another culture as an object for colonization also contributes to the moral degradation of society. The article draws a distinction between a moral and a civilized person, criticizes the theoretical foundations of the concepts of posthumanism, transhumanism, radical constructivism and constructive alternativeism from the standpoint of the concept of moral values as a manifestation of the substantiality of the individual and mass consciousness in general. The moral sphere is considered in the article as a manifestation of the substantiality of human consciousness, the image of the world based on the relationship to the Other as a subject. The article discusses the process of formation of the moral sphere of society as the basis of the image of the world, a manifestation of the substantiality of human consciousness, its irreducibility to schemes and attitudes imposed within the framework of private interests. As examples of the attitude to moral values as a criterion of the substantiality of human consciousness, the legend of the Grand Inquisitor in the novel by F. Dostoevsky "The Brothers Karamazov", the understanding of humanitarian values in the novel by Yu. Dombrovsky "Faculty of unnecessary things", as well as the concept of the categorical imperative by I. Kant are given.The article analyzes the dangers of scientific and technological progress for society, it is argued that the relativization of moral values in modern society has its source in relation to man as an object, which leads to primitivization and disintegration of the individual. The attitude to another culture as an object for colonization also contributes to the moral degradation of society. The article draws a distinction between a moral and a civilized person, criticizes the theoretical foundations of the concepts of posthumanism, transhumanism, radical constructivism and constructive alternativeism from the standpoint of the concept of moral values as a manifestation of the substantiality of the individual and mass consciousness in general. The moral sphere is considered in the article as a manifestation of the substantiality of human consciousness, the image of the world based on the relationship to the Other as a subject. The article discusses the process of formation of the moral sphere of society as the basis of the image of the world, a manifestation of the substantiality of human consciousness, its irreducibility to schemes and attitudes imposed within the framework of private interests. As examples of the attitude to moral values as a criterion of the substantiality of human consciousness, the legend of the Grand Inquisitor in the novel by F. Dostoevsky "The Brothers Karamazov", the understanding of humanitarian values in the novel by Yu. Dombrovsky "Faculty of unnecessary things", as well as the concept of the categorical imperative by I. Kant are given

On the electronic properties of GaSb irradiated with reactor neutrons and its charge neutrality level

The electronic properties and the limiting position of the Fermi level in p-GaSb crystals irradiated with full-spectrum reactor neutrons at up to a fluence of 8.6 × 1018 cm−2 are studied. It is shown that the irradiation of GaSb with reactor neutrons results in an increase in the concentration of free holes to p lim = (5−6) × 1018 cm−3 and in pinning of the Fermi level at the limiting position F lim close to E V + 0.02 eV at 300 K. The effect of the annealing of radiation defects in the temperature range 100–550°C is explored

Molecular-genetic aspects of the endometrium state on the day of the tentative implantation window in women with recurrent miscarriage in the programs of assisted reproductive technologies

Golovatyuk K. P., Nosenko O. M., Makshayeva E. T., Trofimov D. Yu., Donnikov A. E., Kolin V. V. Molecular-genetic aspects of the endometrium state on the day of the tentative implantation window in women with recurrent miscarriage in the programs of assisted reproductive technologies. Journal of Education, Health and Sport. 2017;7(9):621-626. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1068361 http://ojs.ukw.edu.pl/index.php/johs/article/view/5076 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.08.2017. Revised: 20.09.2017. Accepted: 29.09.2017. MOLECULAR-GENETIC ASPECTS OF THE ENDOMETRIUM STATE ON THE DAY OF THE tentative IMPLANTATION WINDOW IN WOMEN WITH recurrent miscarriage IN THE PROGRAMS OF ASSISTED REPRODUCTIVE TECHNOLOGIES 1K. P. Golovatyuk, 2O. M. Nosenko, 1E. T. Makshayeva, 3D. Yu. Trofimov, 4A. E. Donnikov, 3V. V. Kolin 1Limited Liability Company Medical Center for Reproductive Health "Gameta", Odessa, Ukraine; 2Odessa National Medical University, Ukraine; 3Limited Liability Company "NPF DNA-Technology", Moscow, Russia; 4FGBU Scientific Center for Obstetrics, Gynecology and Perinatology. named after acad. V.I. Kulakov Ministry of Health care and Social Development of Russia, Moscow, Russia; e-mail: [email protected] Abstract More than 50% of pregnant women after the programs of assisted reproductive technologies (ART) face the problem of recurrent miscarriage (RMC), especially in the first trimester. Significant role in the development of RMC has infectious factor and chronic inflammation in the endometrium. The aim: to reveal the peculiarities of immune response mRNA genes of the inflammatory component expression in the period of the tentative implantation window (TIW) in women with RMC in ART programs. Material and methods. The main group consisted of 240 patients with RMC in ART programs; the control group included 100 conditionally healthy fertile women. On the ground of PCR reverse transcription, the mRNA of the IL-1β, IL-2, IL-10, Foxp3, TLR9, IL-2Rα cytokine genes was examined in endometrial samples obtained with the help of biopsy on the TIW day. Results. Analysis of the transcriptional profile of the immune response genes in the endometrium on TIW day revealed that the relative level of mRNA expression of the IL-1β, IL-2, Foxp3, TLR9, IL-2Rα genes did not differ significantly in the main and control groups. Statistically significant decrease in mRNA expression of IL-10 gene was observed in women with RPL. Conclusions. A feature of mRNA expression of the inflammatory component of the immune response in TIW period in women with RMC in ART programs is a decrease in the expression level of the IL-10 gene mRNA, which may be one of the reasons for the unfavorable outcomes of the onset pregnancy. Key words: recurrent miscarriage, assisted reproductive technologies, immune response, reverse transcription-polymerase chain reaction, tentative implantation window

О КРИТЕРИЯХ ОПРЕДЕЛЕНИЯ КАТЕГОРИЙ ПРИГОРОДНЫХ ПОЕЗДОВ

The authors study Russian and foreign approaches of the classification of passenger regional and commuter trains. They substantiate certain adjustments to the existing categories and criteria of estimation of the length of commuter routes.Анализ зарубежных и отечественных подходов к классификации пассажирских поездов в пригородном и региональном сообщении. Обоснование поправок к существующим категориям и критериям оценки дальности пригородных маршрутов

Малодеятельные линии: состояние и варианты оптимизации

[For the English abstract and full text of the article please see the attached PDF-File (English version follows Russian version)].ABSTRACT The methodology and methods of the conducted research are based on the system analysis and scientific generalization of domestic and foreign experience in operation and maintenance of low-density railway lines. At the same time, not only the current state in this sphere of transportation is evaluated, but also suggestions are made with regard to optimizing processes using technical re-equipment strategies, changing technologies, stimulating demand through organization of new types of service, and use of forms of public-private partnership. Keywords: management strategy, low-density railway lines, cost-effective operation, freight and passenger transportation, optimization, methodology, differentiation of destination.Текст аннотации на англ. языке и полный текст статьи на англ. языке находится в прилагаемом файле ПДФ (англ. версия следует после русской версии).Методология и методы проведённого исследования основываются на системном анализе и научном обобщении отечественного и зарубежного опыта эксплуатации и содержания малодеятельных железнодорожных линий. При этом оценивается не только текущее состояние в этой сфере перевозок, но и даются предложения по оптимизации процессов с использованием стратегий технического перевооружения, изменения технологий, стимулирования спроса за счёт организации новых видов сервиса, применения форм государственно-частного партнёрства

Prospective Observational Study of Pazopanib in Patients with Advanced Renal Cell Carcinoma (PRINCIPAL Study)

Background: Real-world data are essential to accurately assessing efficacy and toxicity of approved agents in everyday practice. PRINCIPAL, a prospective, observational study, was designed to confirm the real-world safety and efficacy of pazopanib in patients with advanced renal cell carcinoma (RCC). Subjects, Materials, and Methods: Patients with clear cell advanced/metastatic RCC and a clinical decision to initiate pazopanib treatment within 30 days of enrollment were eligible. Primary objectives included progression-free survival (PFS), overall survival (OS), objective response rate (ORR), relative dose intensity (RDI) and its effect on treatment outcomes, change in health-related quality of life (HRQoL), and safety. We also compared characteristics and outcomes of clinical-trial-eligible (CTE) patients, defined using COMPARZ trial eligibility criteria, with those of non-clinical-trial-eligible (NCTE) patients. Secondary study objectives were to evaluate clinical efficacy, safety, and RDI in patient subgroups. Results: Six hundred fifty-seven patients were enrolled and received ≥1 dose of pazopanib. Median PFS and OS were 10.3 months (95% confidence interval [CI], 9.2–12.0) and 29.9 months (95% CI, 24.7 to not reached), respectively, and the ORR was 30.3%. HRQoL showed no or little deterioration over time. Treatment-related serious adverse events (AEs) and AEs of special interest occurred in 64 (9.7%), and 399 (60.7%) patients, respectively. More patients were classified NCTE than CTE (85.2% vs. 14.8%). Efficacy of pazopanib was similar between the two groups. Conclusion: PRINCIPAL confirms the efficacy and safety of pazopanib in patients with advanced/metastatic RCC in a real-world clinical setting. Implications for Practice: PRINCIPAL is the largest (n = 657) prospective, observational study of pazopanib in patients with advanced/metastatic renal cell carcinoma, to the authors’ knowledge. Consistent with clinical trial results that often contain specific patient types, the PRINCIPAL study demonstrated that the effectiveness and safety of pazopanib is similarly safe and effective in patients with advanced kidney cancer in a real-world clinical setting. The PRINCIPAL study showed that patients with advanced kidney cancer who are treated with first-line pazopanib generally do not show disease progression for approximately 10 months and generally survive for nearly 30 months

Image of the World and Devaluation of Moral Values: Aspects of the Problem

The article analyzes the dangers of scientific and technological progress for society, it is argued that the relativization of moral values in modern society has its source in relation to man as an object, which leads to primitivization and disintegration of the individual. The attitude to another culture as an object for colonization also contributes to the moral degradation of society. The article draws a distinction between a moral and a civilized person, criticizes the theoretical foundations of the concepts of posthumanism, transhumanism, radical constructivism and constructive alternativeism from the standpoint of the concept of moral values as a manifestation of the substantiality of the individual and mass consciousness in general. The moral sphere is considered in the article as a manifestation of the substantiality of human consciousness, the image of the world based on the relationship to the Other as a subject. The article discusses the process of formation of the moral sphere of society as the basis of the image of the world, a manifestation of the substantiality of human consciousness, its irreducibility to schemes and attitudes imposed within the framework of private interests. As examples of the attitude to moral values as a criterion of the substantiality of human consciousness, the legend of the Grand Inquisitor in the novel by F. Dostoevsky "The Brothers Karamazov", the understanding of humanitarian values in the novel by Yu. Dombrovsky "Faculty of unnecessary things", as well as the concept of the categorical imperative by I. Kant are given