Impact of anesthetic management and use of tranexamic acid on outcomes in tonsillectomy.

Recurrent tonsillitis is one of the most common pathologies in otorhinolaryngology. The proportion of tonsillectomies varies from 10% to 20% of all surgical interventions in the otorhinolaryngological departments. Important factors for tonsillectomy are the duration of operation, the amount of blood loss, postoperative complications, the general condition of the patient in the postoperative period, the severity of pain, the time of the hospital stay. The type of anesthesia and postoperative medical hemostatic support can have a significant impact on these factors. Our study aimed to optimize the approach to carry out tonsillectomy by preoperative application of the tranexamic acid 10% solution (TXA) and choosing between general and local anesthesia. Clinical studies were made among 212 patients with recurrent tonsillitis who went through a bilateral tonsillectomy. The patients were divided into three groups. The first group included 54 patients undergoing tonsillectomy using general anesthesia with the administration of TXA at the rate of 10 mg/kg of body weight. The second group consisted of 97 patients undergoing tonsillectomy using local anesthesia. A third control group included 61 patient undergoing tonsillectomy using general anesthesia. The first and control (third) groups of patients were compared to assess the efficacy of using TXA. Factors such as the duration of the surgery, the amount of blood loss, intraoperative events, the number of incidents of primary and secondary bleeding, and laboratory data were considered. The second and control (third) groups were compared to evaluate the impact of anesthetic management. We considered the factors such as duration of surgery, the amount of blood loss, intraoperative events, number of incidents of primary and secondary bleeding, assessment of pain syndrome, necessity of analgesics administration, length of hospital stay, and recovery period. We conclude that tonsillectomy using local anesthesia requires less time to perform, has less blood loss, fewer intraoperative events, and less incidents of primary and secondary bleeding. The average level of pain is higher in patients using general anesthesia. The use of TXA significantly reduces the amount of blood loss, intraoperative complications, and lower the emergence of postoperative bleeding and its intensity

Zoning of territory on the basis of modeling of efficiency of forest resources use in Russian regions’ economy

The purpose of this work is development of the model of evaluation of efficiency of the use of resources in economy of regions of sparsely forested area, which allows offering a typology of zones in the region and performing zoning of territory depending on the efficiency of activities of structures which use forest resources. The offered model is peculiar for calculation of deviations of current income of state and entrepreneur from optimal income from the point of view of the most profitable use of lands. On the basis of the offered model, the typology for regions of sparsely forested area is developed, which includes four types of territories: high-profitable territories – characterized by minimal deviations of profitability of entrepreneur and state, due to which they are considered to be territories with well-balanced use of forest resources in economy; profitable territories with emphasis on state’s interest, where the deviation of profitability of entrepreneur is maximal, and profitability of state is minimal; profitable territories with emphasis on interest of entrepreneurs, where deviation of entrepreneur’s profitability is minimal, and of state’s profitability is maximal; low-income territories, unattractive for forest use, where deviation of profitability of entrepreneur and state is maximal. This typology conforms to the task of formation of differentiated instrumentarium of well-balanced use of forest resources in territories’ economy.peer-reviewe

Double-kink fishbone instability caused by circulating energetic ions

The destabilization of double kink modes by the circulating energetic ions in tokamaks with the plasma current having an off-axis maximum is studied. It is shown that the high-frequency fishbone instability [Energetic Particle Mode (EPM)] and the low-frequency (diamagnetic) fishbones are possible for such an equilibrium, their poloidal and toroidal mode numbers being not necessarily equal to unity. A new kind of the EPM instability, ''doublet fishbones,'' is predicted. This instability is characterized by two frequencies; it can occur in a plasma with a non-monotonic radial profile of the energetic ions when the particle orbit width is less than the width of the region where the mode is localized. It is found that the diamagnetic fishbone branch exists even when the orbit width exceeds the mode width; in this case, however, the instability growth rate is relatively small

Evaluation of pharmacological correction of L-NAME-induced endothelial dysfunction, platelet aggregation and venous tone with diosmin detralex 1000 mg

Chronic venous diseases are one of the urgent problems of modern medicine. Recent studies have shown high significance of endothelial dysfunction (ED) and oxidative stress in their pathogenesis. For the correction of the occurring changes, drugs of the flavonoid group, particularly diosmin and hesperidin, are currently use

Investigation of the Respiration Rate During Storage of Fruit Vegetables Under the Influence of Abiotic Factors

The aim of the work was to establish the influence of most important abiotic planting factors (temperature, precipitation quantity) on the respiratory rate of fruit vegetables at storage and also a possibility of correction of respiratory metabolism by post-harvest thermal processing by antioxidant compositions. Fruits of cucumbers of the hybrids Masha and Afina, bush pumpkins Kavili and Tamino, sweet pepper of the hybrids Nikita and Hercules, tomato of the varieties Novachok and Rio Grande Original were used for the studies. It was established, that the respiratory rate of pumpkin fruit vegetables is importantly influenced by the variety specificity. The respiratory level of pumpkin vegetables directly correlates with the sum of active temperatures of the period of fruits formation and reversibly – with precipitation and hydrothermal coefficient.The influence of the variety specificity for nightshade vegetables is leveled, and among meteorological planting conditions the important intense influence on the respiratory rate is realized by the sum of active temperatures of the period of fruits formation and ripening. Precipitation and hydrothermal coefficient have the important influence only on pepper fruits.It was established, that the use of post-harvest thermal processing by antioxidant compositions results in inhibition of respiratory processes in fruit vegetables at storage

Influence of the drug Detralex on calcium ion-dependent smooth muscle contractility, function of an endothelium and aggregation of thrombocytes in the conditions of experimental modeling of endothelial dysfunction

A venotonic effect was investigated after week administration of drug inside on model of the endoteliumdependent smooth muscle response to increased calcium ion isolated portal vein of rats. In model of endothelial dysfunction rising of sensitivity to the contractile response to Сa2+ the isolated segment of a portal vein after use of the drug Detralex of 500 mg/kg per day, and also elongation of AT and decrease of coefficient of endothelial dysfunction on a background the course reception of the investigated preparatio

Morphology of the rat’s brain in four vessels model of ischemic stroke after administration of carbamylated darbepoetin

The aim was the study of the cerebroprotective effect of carbamylated darbepoetin in a four-vessel model of rat brain ischemia-reperfusion. A massive preconditioning cerebroprotective effect of carbamylated darbepoetin in the fourth group of animals and massive ischemic changes of the hippocampal and cortical neurons in the third group were revealed. These were manifested by karyopyknosis, karyorrhexis, and violation of stratification of CA1-CA3 layers of the hippocampu

Potentiating interaction of ethoxydol and rosuvastatin in an experimental model of Langendorf-isolated rat heart total ischemia-reperfusion

The study of cardioprotective activity showed that in vitro ethoxydol at a dose of 3.8 × 10-4 g/l can significantly improve the morphofunctional state of cardiomyocytes, which is manifested in an increase in the proportion of postischemic cardiac resumption, reduction of ischemic contracture, and recovery of contractility during the reperfusion perio

Exotic hybrid mesons in hard electroproduction

We estimate the sizeable cross section for deep exclusive electroproduction of an exotic $J^{PC}=1^{-+}$ hybrid meson in the Bjorken regime. The production amplitude scales like the one for usual meson electroproduction, i.e. as $1/Q^2$. This is due to the non-vanishing leading twist distribution amplitude for the hybrid meson, which may be normalized thanks to its relation to the energy momentum tensor and to the QCD sum rules technique. The hard amplitude is considered up to next-to-leading order in $\alpha_{S}$ and we explore the consequences of fixing the renormalization scale ambiguity through the BLM procedure. We study the particular case where the hybrid meson decays through a $\pi\eta$ meson pair. We discuss the $\pi\eta$ generalized distribution amplitude and then calculate the production amplitude for this process. We propose a forward-backward asymmetry in the production of $\pi$ and $\eta$ mesons as a signal for the hybrid meson production. We briefly comment on hybrid electroproduction at very high energy, in the diffractive limit where a QCD Odderon exchange mechanism should dominate. The conclusion of our study is that hard electroproduction is a promissing way to study exotic hybrid mesons, in particular at JLAB, HERA (HERMES) or CERN (Compass)