Medical Image Data and Datasets in the Era of Machine Learning-Whitepaper from the 2016 C-MIMI Meeting Dataset Session.

At the first annual Conference on Machine Intelligence in Medical Imaging (C-MIMI), held in September 2016, a conference session on medical image data and datasets for machine learning identified multiple issues. The common theme from attendees was that everyone participating in medical image evaluation with machine learning is data starved. There is an urgent need to find better ways to collect, annotate, and reuse medical imaging data. Unique domain issues with medical image datasets require further study, development, and dissemination of best practices and standards, and a coordinated effort among medical imaging domain experts, medical imaging informaticists, government and industry data scientists, and interested commercial, academic, and government entities. High-level attributes of reusable medical image datasets suitable to train, test, validate, verify, and regulate ML products should be better described. NIH and other government agencies should promote and, where applicable, enforce, access to medical image datasets. We should improve communication among medical imaging domain experts, medical imaging informaticists, academic clinical and basic science researchers, government and industry data scientists, and interested commercial entities

Application of the trajectory error matrix for assessing the temporal transferability of OBIA for slum detection

High temporal and spatial-resolution imageries are a valuable data source for slum monitoring. However, the transferability of OBIA methods across space and time remains problematic, due to the complexity of the term “slum”. Hence, transparency is important when analysing the transferability of OBIA methods for slum mapping. Our research developed a framework for measuring the temporal transferability of OBIA methods employing the trajectory error matrix (TEM). We found relatively low trajectory accuracies indicating low temporal transferability of OBIA methods for slum monitoring using point-based assessment methods. However, the analysis of change needs to be combined with an analysis of the certainty of this change by considering the context of the change to deal with common problems such as variations of the viewing angles and uncertainties in producing reference data on slums

Association between possession of ExoU and antibiotic resistance in pseudomonas aeruginosa

© 2018 Subedi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Virulent strains of Pseudomonas aeruginosa are often associated with an acquired cytotoxic protein, exoenzyme U (ExoU) that rapidly destroys the cell membranes of host cells by its phospholipase activity. Strains possessing the exoU gene are predominant in eye infections and are more resistant to antibiotics. Thus, it is essential to understand treatment options for these strains. Here, we have investigated the resistance profiles and genes associated with resistance for fluoroquinolone and beta-lactams. A total of 22 strains of P. aeruginosa from anterior eye infections, microbial keratitis (MK), and the lungs of cystic fibrosis (CF) patients were used. Based on whole genome sequencing, the prevalence of the exoU gene was 61.5% in MK isolates whereas none of the CF isolates possessed this gene. Overall, higher antibiotic resistance was observed in the isolates possessing exoU. Of the exoU strains, all except one were resistant to fluoroquinolones, 100% were resistant to beta-lactams. 75% had mutations in quinolone resistance determining regions (T81I gyrA and/or S87L parC) which correlated with fluoroquinolone resistance. In addition, exoU strains had mutations at K76Q, A110T, and V126E in ampC, Q155I and V356I in ampR and E114A, G283E, and M288R in mexR genes that are associated with higher beta-lactamase and efflux pump activities. In contrast, such mutations were not observed in the strains lacking exoU. The expression of the ampC gene increased by up to nine-fold in all eight exoU strains and the ampR was upregulated in seven exoU strains compared to PAO1. The expression of mexR gene was 1.4 to 3.6 fold lower in 75% of exoU strains. This study highlights the association between virulence traits and antibiotic resistance in pathogenic P. aeruginosa

Causal Effects of the Timing of Life-course Events Age at Retirement and Subsequent Health

In this article, we combine the extensive literature on the analysis of life-course trajectories as sequences with the literature on causal inference and propose a new matching approach to investigate the causal effect of the timing of life-course events on subsequent outcomes. Our matching approach takes into account pre-event confounders that are both time-independent and time-dependent as well as life-course trajectories. After matching, treated and control individuals can be compared using standard statistical tests or regression models. We apply our approach to the study of the consequences of the age at retirement on subsequent health outcomes, using a unique data set from Swedish administrative registers. Once selectivity in the timing of retirement is taken into account, effects on hospitalization are small, while early retirement has negative effects on survival. Our approach also allows for heterogeneous treatment effects. We show that the effects of early retirement differ according to preretirement income, with higher income individuals tending to benefit from early retirement, while the opposite is true for individuals with lower income

Educational needs of patients, families, and healthcare professionals to support the patient journey in haemophilia gene therapy in the UK

With the first gene therapies for haemophilia approved by the European Commission, the US Food and Drug Administration, and the Medicines and Healthcare products Regulatory Agency, it is important to consider the remaining unmet needs and challenges that may arise throughout patients’ treatment journeys. We discuss existing unmet needs and important considerations prior to, during, and following haemophilia gene therapy treatment in the UK, and propose potential next steps. Key areas for attention are education, psychological support, and guidance on implementation. Strategies are urgently required to fulfil these needs. An immediate priority for information providers should be comprehensive education for people with haemophilia (PWH) and healthcare professionals (HCPs). Greater access to resources and training in psychological services will be required throughout the treatment pathway. More specific guidance is required to define the implementation model, criteria for accreditation, and responsibilities of care centres. Furthermore, PWH may revisit discussions with HCPs multiple times pre-infusion, thus the patient journey is unlikely to be linear. Consideration of these challenges, and of potential strategies to address them, will be integral to optimising the future success of this promising therapy

Childlessness and Intergenerational Transfers in Later Life

First Online: 13 January 2017Childlessness in later life has been attracting increased attention from researchers and policy makers. Yet a number of misconceptions about childlessness among the elderly remain, such as the claim that elderly childless people are mainly on the receiving end of intergenerational exchanges, or that they are a homogeneous group. Contrary to these assumptions, we find that elderly childless people give as well as receive, and that parental status is a continuum, ranging from full childlessness across several intermediary conditions to full current natural parenthood. In a study of the elderly population across 11 European countries, we show that non-parents make significant contributions to their social networks of family and friends through financial and time transfers, and that the latter in particular differ little from those of natural parents. The same applies to their participation in charitable and voluntary work. Different parental statuses are significantly associated with the various dimensions of giving and receiving. Social parents (i.e., people who have no natural children, but who have adopted, foster, or stepchildren) are shown to be much more similar to natural parents than to non-parents. Family recomposition thus does not seem to inhibit intergenerational exchanges, as long as social parents have sufficient contact with their non-natural social children. On the other hand, parents who have lost contact with their children – natural or otherwise – are likely to require more formal care in later life