100m疾走の後半における走スピード, ピッチおよびストライドの変化

本研究では, 成人男子7名を被験者にして, 100m疾走中の後半における走スピード, ピッチ数およびストライド長の変化を明らかにした。本研究で得られた結果は, 次のように要約できる。1) 100m疾走後半の50mから100mまで, 走スピードは減少し続けた。2) 100m疾走後半の50mから100mまで, ピッチ数は減少し続けた。3) 100m疾走後半の50mから90mまでストライド長はほぼ一定を保ったが, 90mから100mまでの区間ではストライド長は急激に増加した。The purpose of this study was to measure running speed, stride length and step frequecny in the latter half of 100m sprint running. The subjects used in this study were four collegiate jumpers, 2 graduate students and an assistant of Chukyo University. All were healthy males. Each run was filmed at 50 frames/sec with Photosonics and Bolex 16mm cameras. Stride length and step frequency was measured from film analysis. Resultes obtanied from this study were summarized as follows. 1. Running speed and step frquency were gradually decreased in the latter half 50m of 100m sprint running. 2. Stride length was almost constant from 50m to 90m. After that, however, it was significantly decreased

Non-Covalent Loading of Anti-Cancer Doxorubicin by Modularizable Peptide Self-Assemblies for a Nanoscale Drug Carrier

We prepared nanoscale, modularizable, self-assembled peptide nanoarchitectures with diameters less of than 20 nm by combining β-sheet-forming peptides tethering a cell-penetrating peptide or a nuclear localization signal sequence. We also found that doxorubicin (Dox), an anti-cancer drug, was non-covalently accommodated by the assemblies at a ratio of one Dox molecule per ten peptides. The Dox-loaded peptide assemblies facilitated cellular uptake and subsequent nuclear localization in HeLa cells, and induced cell death even at low Dox concentrations. This peptide nanocarrier motif is a promising platform for a biocompatible drug delivery system by altering the targeting head groups of the carrier peptides

Total Synthesis of (+)-Vibsanin A

The first total synthesis of (+)-vibsanin A, an 11-membered vibsane diterpenoid, was achieved, unambiguously establishing its relative and absolute stereochemistry. Highlights of the synthesis include the stereoselective formation of an all-carbon quaternary stereocenter by a zinc-mediated Barbier-type allylation in an aqueous medium, and the efficient construction of an 11-membered ring skeleton by a combination of an intramolecular Nozaki–Hiyama–Kishi (NHK) reaction and a Mitsunobu reaction

Anaplastic carcinoma of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration: a case report and review of the literature

Abstract Background Anaplastic carcinoma of the pancreas is a rare pancreatic neoplasm with a poor prognosis. It is classified as a variant of ductal adenocarcinoma, but the clinical features and treatment of it remain unknown because of its rarity and aggressiveness. Endoscopic ultrasonography and endoscopic ultrasound-guided fine-needle aspiration are useful techniques for the diagnosis of pancreatic tumors with high sensitivity and specificity. Case presentation A 72-year-old Japanese woman presented with a diagnosis of acute pancreatitis, and a cystic lesion with slightly high density area was observed by computed tomography in her pancreatic head. In addition, endoscopic ultrasound revealed a heterogeneous lesion. Endoscopic ultrasound-guided fine-needle aspiration showed pleomorphic atypical cells. We diagnosed anaplastic carcinoma of the pancreas. We resected the lesion, and she has shown no sign of recurrence for > 6 months. There are few reports of anaplastic carcinoma of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration and treated by surgery. Our analysis indicates that anaplastic carcinoma of the pancreas is more likely than typical ductal carcinomas to have cystic lesions with the tumor. Conclusions We report a case of anaplastic carcinoma of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration and subsequently resected with a clear margin. We speculate that anaplastic carcinoma of the pancreas is more likely to have cystic changes than pancreatic ductal adenocarcinoma. When we diagnose pancreas tumor as having cystic changes, anaplastic carcinoma of the pancreas should be considered one of the differential diagnoses