Association of polycystic ovary syndrome and a non-dipping blood pressure pattern in young women

OBJECTIVE: The association between polycystic ovarian syndrome and increased cardiovascular disease risk is still a controversial issue. In light of data documenting some common pathways or common end-points, the present study was undertaken to determine whether there is a relationship between sleep blood pressure pattern disturbances and polycystic ovarian syndrome in young women. METHOD: The daytime and nighttime ambulatory blood pressures (BPs) were determined for each subject, according to the actual waking and sleeping times recorded in their individual diaries, in this cross-sectional study. RESULTS: The study group comprised 168 women (mean age: 25.7±5.5) diagnosed with polycystic ovarian syndrome, while the control group included 52 age- and BMI-matched healthy subjects (mean age: 26.1±5.4). When nocturnal BP declines very little or not at all, with the BP falling less than 10% during sleep compared with waking values, this pattern is classified as a non-dipping BP pattern. However, the non-dipping pattern of BP changes was significantly more common in polycystic ovarian syndrome patients compared to the control group (p<0.01). The prevalence of a non-dipping BP pattern was 43.4% (73 patients) in polycystic ovarian syndrome patients and 3.9% (2 patients) in the control group. CONCLUSION: Our cross-sectional study revealed that a non-dipping BP pattern is highly prevalent in polycystic ovarian syndrome patients, even if they are young and non-obese

Coming from behind to win - A Qualitative research about psychological conditions of adolescents who have undergone open-heart surgery for single ventricle between the ages 0-5

Early recognition of congenital cardiac pathologies and their treatment by means of palliative or corrective surgery at birth or infancy has vital importance. Successful repair of congenital cardiac defects by surgical methods has gained importance especially during the last twenty years. As the scope of the surveillance increased so did the interest in the outcomes of these treatments when the patients had reached puberty and adulthood. The purpose of our research was to study the psychological framework of the adolescents who had experienced these surgeries by listening both the children and the parents talk about their feelings and experiences. Our data was accumulated through interviews with 17 adolescents and their families, using qualitative methods. The main theme at the end of the analysis was "to be strong and resistive". We reached the conclusion that this condition was not a pathological build up but an attitude of coping, as it did not cause loss of functionality. The defensive psychological mechanisms used by these adolescents consisted of repression, compensation and reaction formation. We believe that this information is important to understand the real meaning of the manners displayed when these adolescents and their families pursue their daily lives, communicate and make relationships with their environment and especially professionals in the health services

Elm1 kinase activates the spindle position checkpoint kinase Kin4

Elm1 phosphorylates a conserved residue within the Kin4 kinase domain to coordinate spindle position with cell cycle progression

Synthesis, structures, electrochemical studies and antioxidant activities of cis-dioxomolybdenum(VI) complexes of the new bisthiocarbohydrazones

Potentially pentadentate ONSNO donor new Schiff bases were prepared by the condensation of thiocarbodihydrazide with 3,5-dibromosalicylaldehyde (H3L1), 3-bromo-5-chlorosalicy-laldehyde (H3L2) and 3,5-dichlorosalicylaldehyde (H3L3). The reactions between his (acetylacetonato) dioxomolybdenum(VI) and Schiff bases in the presence of donor solvents yielded neutral cis-dioxomolybdenum(VI) complexes with the general formula [MoO2HL(D)] (HL = tridentate ONS donor Schiff base ligand; HL1, HL2, HL3) and D = methanol, ethanol, dimethyl sulfoxide, dimethylformamide, pyridine). All the compounds were characterized by elemental analysis, UV, IR, H-1 NMR spectroscopies. The thermal properties of the complexes were also investigated by thermogravimetry technique and the thermal behavior depending on the second ligand molecule was discussed. The synthesized compounds were screened for their antioxidant capacity by using the cupric reducing antioxidant capacity (CUPRAC) method. In addition, electrochemical behaviors of the complexes were studied using cyclic voltammetry and square wave voltammetry. Half wave potentials (E-1/2) are significantly influenced with the central metal ions, but slightly influenced with the nature of substituents on thiocarbohydrazone ligands. In situ spectroelectrochemical studies were employed to determine the spectra of electrogenerated species of the complexes and to assign the redox processes. The fluorescence properties of the bisthiocarbohydrazone ligands and their dioxomolybdenum(VI) complexes in DMSO solutions were investigated. (C) 2015 Published by Elsevier B.V

The measurement and comparison of dosimetry parameters of Orion (4 MV) lineer accelerators after magnetron changes

OBJECTIVE

Anomalous left coronary artery from pulmonary artery (ALCAPA) in asymptomatic 11-year-old case

Origin of the left coronary artery from the pulmonary trunk [Anomalous origin of the Left Coronary Artery from the Pulmonary Artery (ALCAPA)] is a rare congenital heart defect. ALCAPA is one of the common causes of myocardial ischemia or infarction in infants and children. In this report, we present an eleven-years-old patient presenting with murmur and accompanied by echocardiographic findings of dilated cardiomyopathy and angiocardiographic investigation that revealed left coronary artery originating from the pulmonary artery. (Turk Arch Ped 2012; 47: 298-301

Relationships between Left Heart Chamber Dilatation on Echocardiography and Left-to-Right Ventricle Shunting Quantified by Cardiac Catheterization in Children with Ventricular Septal Defects

Left atrium and/or left ventricle dilatation on echocardiography is considered to be an indication for closure of ventricular septal defects (VSD). No study has addressed the accuracy of using dilated left heart chambers when defining significant left-to-right shunting quantified by cardiac catheterization in isolated small or moderate VSDs. In this study, the relation between dilated left heart chambers, measured by echocardiography, and left-to-right ventricle shunting, quantified by cardiac catheterization, was evaluated in patients with isolated VSD. The medical records of all patients with isolated VSD who had undergone catheterization from 1996 to 2010 were examined retrospectively. Normative data for left heart chambers adjusted for body weight (BW) and body surface area (BSA) were used. The pulmonary-to-systemic flow ratio (Qp:Qs) was calculated by an oximetry technique. A total of 115 patients (mean age 7.3 +/- A 5 years) fulfilled the inclusion criteria. There was a statistically significant difference in terms of Qp:Qs between the patient groups with normal and dilated left heart chambers, when adjusted for BW and BSA (p = 0.001 and p = 0.002, respectively). But the relationships between Qp:Qs and left heart chamber sizes on echocardiography were not strong enough to be useful for making surgical decisions, as left heart chamber dilatation was not significantly associated with Qp:Qs a parts per thousand yen 2 (p = 0.349 when adjusted for BW, p = 0.107 when adjusted for BSA). Left heart chamber dilatation was significantly associated with Qp:Qs a parts per thousand yen 1.5 only when it was adjusted for BSA (for BW p = 0.022, for BSA p = 0.006). As a result, left heart chamber dilatation measured by echocardiography does not show significant left-to-right ventricle shunting, as quantified by catheterization. We still advocate that catheter angiography should be undertaken when left heart chambers are dilated in echocardiography in order to make decisions about closing small- to moderate-sized VSD

The safe limits of mechanical factors in the apnea testing for the diagnosis of brain death

Apneic oxygenation is an apnea testing method in the diagnosis of brain death. In this method, oxygen (O-2) is delivered into the trachea via an O-2 catheter (O2C). However, barotrauma may develop during O-2 insufflation into the trachea. Oxygen catheter diameters, O-2 catheter tip position in the trachea, and O-2 flow rate have been proposed as causes of barotrauma. This study was designed to highlight the airway pressure changes during apneic oxygenation in a model consisting of an anesthesia bag, which was connected to a pressure transducer and to an endotracheal tube (ETT). The pressure of the system was monitored while delivering O-2 continuously to the system through O2C of different diameters, which were placed in the ETT. Tested variables were ETT/O2C ratio, O2C tip position in ETT (proximal 1/3 of the ETT, mid point of the ETT, and distal 1/3 of the ETT) and O-2 flow rate (6, 8, and 10 L min(-1)). The increase in the airway pressure significantly correlated with O2C tip position in ETT (p = 0.017). ETT/O2C ratio smaller than 1.75 caused significantly high airway pressures (p < 0.05). The pressure was significantly higher at the flow rate of 10 L min(-1) O-2 compared with the flow rate of 6 L min(-1) O-2 (p < 0.01). Thus, ETT/O2C ratio, O2C tip position in ETT and O-2 flow rate are the important factors that determine the airway pressure in the trachea during O-2 insufflation. In conclusion, overlooked mechanical factors dangerously increase airway pressure during apnea testing