362 research outputs found
Civicâled banishment in South Africa: punishment, authority, and spatialised precarity
Civic-led banishment, a fundamentally spatial punishment, is an understudied phenomenon in South Africa and beyond. We define it as âa punitive spatial practice, enacted by non-state actors in response to alleged criminality or deviance, which attempts varying degrees of socio-spatial expulsion over timeâ. This definition lays the framework for a socio-spatial analysis of punishment, and yields insights into the exercise of socio-spatial control in public and private space. We emphasise the specific challenges associated with banishment, together with the relationship between space, punishment, public authority, and sovereignty. We demonstrate how ânegotiationsâ around banishment trade off two forms of intersecting precarity: those faced by residents in informal settlements and the potential precarity of public authorities. Finally, we argue that an exploration of all forms of punishment through the lens of socio-spatial expulsion enables us to tap into conversations around penal abolitionism
Effect of major school playground reconstruction on physical activity and sedentary behaviour: Camden active spaces.
BACKGROUND: The physical school environment is a promising setting to increase children's physical activity although robust evidence is sparse. We examined the effects of major playground reconstruction on physical activity and sedentary time in primary schools using a quasi-experimental design (comparison group pre-test/post-test design). METHODS: Five experimental and two control schools from deprived areas of inner city London were recruited at baseline. Main outcome was physical activity and sedentary time measured from objective monitoring (Actigraph accelerometer) at one year follow up. Pupils' impressions of the new playground were qualitatively assessed post construction. RESULTS: A total of 347 pupils (mean age = 8 years, 55% boys; 36% Caucasian) were recruited into the study at baseline; 303 provided valid baseline Actigraph data. Of those, 231 (76%) completed follow-up (n = 169 intervention; n = 62 control) and 77.4% of the sample recorded at least 4 days of Actigraph wear. In mixed models adjusted for age, sex, ethnicity, ratio activity or sedentary/wear time at baseline, wear time at follow up, and school, no differences were observed in total moderate - vigorous activity (B = -1.4, 95% CI, -7.1, 4.2 min/d), light activity (B = 4.1, 95% CI, -17.9, 26.1), or sedentary time (B = -3.8, 95% CI, -29.2, 21.6 min/d) between groups. There were significant age interactions for sedentary (p = 0.002) and light intensity physical activity (p = 0.008). We observed significant reductions in total sedentary (-28.0, 95% CI, -1.9, -54.1 min/d, p = 0.037) and increases in total light intensity activity (24.6, 95% CI, 0.3, 48.9 min/d, p = 0.047) for children aged under 9 yrs. old in the intervention. CONCLUSION: Major playground reconstruction had limited effects on physical activity, but reduced sedentary time was observed in younger children. Qualitative data suggested that the children enjoyed the new playgrounds and experienced a perceived positive change in well-being and social interactions
The end of the beginning? Taking forward local democratic renewal in the post-referendum North East.
This article draws upon the authorâs commissioned research on the nature of regional governance following the 2004 Referendum in the North East on elected regional assemblies. The article aimed to both capture these views and to assess how the âNo vote in the referendum has impacted on subsequent developments in sub-national governance. The article provides both an empirical overview of recent developments and engages with the wider conceptual debates on democratic renewal. The arguments covered in this output are aimed at both academic and practitioner audiences, and have been also disseminated at regional and national conferences
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Temperature and territoriality in the Duke of Burgundy butterfly, Hamearis lucina
Abstract: The Duke of Burgundy butterfly (Hamearis lucina) has undergone severe declines over the last four decades. However, in recent years the UK population appears to have begun expanding again. This is likely to be due to beneficial management, although a warming regional climate may also have contributed to the resurgence of this spring-flying species. In this study, we investigated the effect of air temperature on the flight behaviour of adult male Duke of Burgundy butterflies. We also looked at the ability of adult males to behaviourally thermoregulate their body temperature and assessed their tendency to remain within small established territories. Increasing air temperature lead to a marked increase in the number and duration of flights associated with territorial behaviour but had no significant effect on other flights. This suggests that high temperatures are particularly important for sustaining energetically-demanding flights involved in territory defence and mate interception, which could impact the reproductive potential of Duke of Burgundy populations. We also found that butterflies had only a limited ability to regulate their body temperature behaviourally and may, therefore, be especially dependent on suitable environmental conditions to maintain the right temperatures for these flights. During observations, most males also remained confined to a few square meters within their territories, which could further restrict butterfly ability to thermoregulate by limiting relocation to other habitat types. However, we did find more males to leave the confines of their territories than expected from reports in previous studies. Our findings highlight the key role that warm, sheltered locations on reserves have in supporting the Duke of Burgundy. If this traditionally poor disperser is to take advantage of a warmer climate and extend its range North, a close network of such areas, appropriately managed, may be critical
Consistent oviposition preferences of the Duke of Burgundy butterfly over 14 years on a chalk grassland reserve in Bedfordshire, UK
Funder: Christ's College, University of Cambridge (GB)Funder: Isaac Newton Trust; doi: http://dx.doi.org/10.13039/501100004815Funder: Museums Association and EsmĂ©e Fairbairn Collections Fund (GB)Abstract: The Duke of Burgundy butterfly (Hamearis lucina) is known to have specific habitat requirements for its larval foodplants. However, no studies have yet investigated whether these preferences vary over time or in relation to climate, and there is a paucity of data on whether management on reserves can replicate preferred conditions. Here, we build upon existing research to confirm which characteristics Duke of Burgundy prefer for their larval foodplants, whether preferences remain consistent across years, and whether conservation management on reserves can replicate these conditions. Fieldwork was carried out at Totternhoe Quarry Reserve, a chalk grassland site in Bedfordshire, UK. Confirming previous research, we found that large Primula plants in dense patches were chosen for oviposition, but that once chosen there was no preference to lay eggs on a plantâs largest leaf. Chosen foodplants were also more sheltered and in closer proximity to scrub than their controls. However, at a finer scale, we found little evidence for any preference based on differences in microclimate, or vegetation height immediately surrounding the plants. This suggests features that alter microclimatic conditions at a larger scale are relatively more important for determining the suitability of oviposition sites. Nearly all preferences remained consistent over time and did not vary between years. Management of scrub on the reserve was able to reproduce some preferred habitat features (high plant density), but not others (large plant size). Implications for insect conservation: The consistency of findings across years, despite inter-annual variation in temperature, rainfall and number of adults, indicates that the Duke of Burgundy is conservative in its foodplant choice, highlighting its need for specific habitat management. Targeted management for foodplants could form part of a tractable set of tools to support Duke of Burgundy numbers on reserves, but a careful balance is needed to avoid scrub clearance leaving plants in sub-optimal conditions
The Equilibria of LipidâK+ Ions in Monolayer at the Air/Water Interface
The effect of K+ ion interaction with monolayers of phosphatidylcholine (lecithin, PC) or cholesterol (Ch) was investigated at the air/water interface. We present surface tension measurements of lipid monolayers obtained using a Langmuir method as a function of K+ ion concentration. Measurements were carried out at 22°C using a Teflon trough and a Nima 9000 tensiometer. Interactions between lecithin and K+ ions or Ch and K+ ions result in significant deviations from the additivity rule. An equilibrium theory to describe the behavior of monolayer components at the air/water interface was developed in order to obtain the stability constants and area occupied by one molecule of lipidâK+ ion complex (LK+). The stability constants for lecithinâK+ ion (PCK+) complex, \documentclass[12pt]{minimal}
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Exaggerated Texture and Grain Growth in a Supperplastic SiAlON
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65254/1/j.1151-2916.1992.tb05497.x.pd
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy
GGGGCC repeat expansions of C9ORF72 represent the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We and others have proposed that RNA transcribed from the repeat sequence is toxic via sequestration of RNA-binding factors. Both GGGGCC-repeat (sense) and CCCCGG-repeat (antisense) molecules are detectable by fluorescence in situ hybridisation as RNA foci, but their relative expression pattern within the CNS and contribution to disease has not been determined. Blinded examination of CNS biosamples from ALS patients with a repeat expansion of C9ORF72 showed that antisense foci are present at a significantly higher frequency in cerebellar Purkinje neurons and motor neurons, whereas sense foci are present at a significantly higher frequency in cerebellar granule neurons. Consistent with this, inclusions containing sense or antisense derived dipeptide repeat proteins were present at significantly higher frequency in cerebellar granule neurons or motor neurons, respectively. Immunohistochemistry and UV-crosslinking studies showed that sense and antisense RNA molecules share similar interactions with SRSF2, hnRNP K, hnRNP A1, ALYREF, and hnRNP H/F. Together these data suggest that, although sense and antisense RNA molecules might be expected to be equally toxic via their shared protein binding partners, distinct patterns of expression in various CNS neuronal populations could lead to relative differences in their contribution to the pathogenesis of neuronal injury. Moreover in motor neurons, which are the primary target of pathology in ALS, the presence of antisense foci (Ï2, p 2, p = 0.75) correlated with mislocalisation of TDP-43, which is the hallmark of ALS neurodegeneration. This has implications for translational approaches to C9ORF72 disease, and furthermore interacting RNA-processing factors and transcriptional activators responsible for antisense versus sense transcription might represent novel therapeutic targets
Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells
Hematopoietic stem cell (HSC) aging has become a concern in chemotherapy of older patients. Humoral and paracrine signals from the bone marrow (BM) hematopoietic microenvironment (HM) control HSC activity during regenerative hematopoiesis. Connexin-43 (Cx43), a connexin constituent of gap junctions (GJs) is expressed in HSCs, down-regulated during differentiation, and postulated to be a self-renewal gene. Our studies, however, reveal that hematopoietic-specific Cx43 deficiency does not result in significant long-term competitive repopulation deficiency. Instead, hematopoietic Cx43 (H-Cx43) deficiency delays hematopoietic recovery after myeloablation with 5-fluorouracil (5-FU). 5-FU-treated H-Cx43-deficient HSC and progenitors (HSC/P) cells display decreased survival and fail to enter the cell cycle to proliferate. Cell cycle quiescence is associated with down-regulation of cyclin D1, up-regulation of the cyclin-dependent kinase inhibitors, p21cip1. and p16INK4a, and Forkhead transcriptional factor 1 (Foxo1), and activation of p38 mitogen-activated protein kinase (MAPK), indicating that H-Cx43-deficient HSCs are prone to senescence. The mechanism of increased senescence in H-Cx43-deficient HSC/P cells depends on their inability to transfer reactive oxygen species (ROS) to the HM, leading to accumulation of ROS within HSCs. In vivo antioxidant administration prevents the defective hematopoietic regeneration, as well as exogenous expression of Cx43 in HSC/P cells. Furthermore, ROS transfer from HSC/P cells to BM stromal cells is also rescued by reexpression of Cx43 in HSC/P. Finally, the deficiency of Cx43 in the HM phenocopies the hematopoietic defect in vivo. These results indicate that Cx43 exerts a protective role and regulates the HSC/P ROS content through ROS transfer to the HM, resulting in HSC protection during stress hematopoietic regeneration
Global Assessment Report on Disaster Risk Reduction 2019
The Global Assessment Report on Disaster Risk Reduction (GAR) is the flagship report of the United Nations on worldwide efforts to reduce disaster risk
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