Assessment of Gas-Surface Interaction Models for Computation of Rarefied Hypersonic Flow

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76727/1/AIAA-36375-113.pd

Aerosolized Delivery of Antifungal Agents

Pulmonary infections caused by Aspergillus species are associated with significant morbidity and mortality in immunocompromised patients. Although the treatment of pulmonary fungal infections requires the use of systemic agents, aerosolized delivery is an attractive option in prevention because the drug can concentrate locally at the site of infection with minimal systemic exposure. Current clinical evidence for the use of aerosolized delivery in preventing fungal infections is limited to amphotericin B products, although itraconazole, voriconazole, and caspofungin are under investigation. Based on conflicting results from clinical trials that evaluated various amphotericin B formulations, the routine use of aerosolized delivery cannot be recommended. Further research with well-designed clinical trials is necessary to elucidate the therapeutic role and risks associated with aerosolized delivery of antifungal agents. This article provides an overview of aerosolized delivery systems, the intrapulmonary pharmacokinetic properties of aerosolized antifungal agents, and key findings from clinical studies

Eunotiaceae (Bacillariophyceae) em igarapés da Amazônia Central, Manaus e Presidente Figueiredo, Brasil

Estudos florísticos e taxonômicos envolvendo diatomáceas são escassos para a região amazônica. As publicações existentes incluem registros de diatomáceas da Amazônia brasileira, do Equador, da Colômbia e do Peru e comumente mostram que Eunotia e Actinella (Eunotiaceae) são gêneros bem representados nessa região. A maioria dos igarapés amazônicos costuma apresentar potencial hidrogeniônico (pH) ácido, característica aquática que promove o desenvolvimento de uma comunidade típica de diatomáceas, dominada por espécimes de Eunotiaceae. O objetivo deste trabalho foi providenciar um levantamento florístico das espécies de Eunotiaceae presentes em igarapés da Amazônia Central brasileira e registrar os morfotipos de algumas espécies. Amostras fitoplanctônicas e perifíticas foram coletadas em cinco igarapés na rodovia BR-174, em Manaus e Presidente Figueiredo, em setembro e outubro de 1996 e fevereiro e março de 1997. Lâminas permanentes foram preparadas de acordo com a técnica de oxidação lenta para o estudo qualitativo. Vinte e três espécies pertencentes ao gênero Eunotia e seis ao gênero Actinella foram determinadas. Chaves dicotômicas de identificação, descrição detalhada, comentários relevantes e ilustrações foram providenciadas para cada táxon determinado. Morfotipos foram documentados para Eunotia zygodon. Espécies raramente citadas na literatura foram registradas, tais como, Eunotia falcifera e Eunotia rostellata.Floristic and taxonomical studies about diatoms to Amazonian region are commonly well represented by Eunotia and Actinella (Eunotiaceae). The available works include diatom assemblage from Brazilian, Ecuadorian, Colombian and Peruvian Amazonia. The local streams often present acid pH which provides environmental conditions to develop a very particular diatom community dominated by specimens of Eunotiaceae. Thus, the aim of this paper is to give a floristic survey of Eunotiaceae from central Amazonian rivers and to register the typical morphologic frustule variations of some species. Planktonic and periphytic samples were collected from five rivers located at the BR-174 highway, near Manaus and Presidente Figueiredo districts, during 1996 and 1997. Slides were prepared in accordance with the technique of slow oxidation for the qualitative determination. Twenty-three species of Eunotia and six of Actinella were identified. Dicotomic keys, taxonomic comments and photographic illustrations were added. Morphotypes of Eunotia zygodon were registered. Species scarcelly mentioned on diatom literature were registered, such as, Eunotia falcifera and Eunotia rostellata

Influence of moulding process on strength of glass frit bonded structures

The glass frit layer in wafer-bonded MEMS is subjected to mechanical and thermo mechanical stresses during production steps such as moulding. In this work the influence of the moulding process on the strength and failure of glass frit bonded devices is characterized by numerical and experimental investigations. A finite element model was developed to predict critical stress distributions in the glass frit layer. Reference and preloaded glass frit bonded micro packages were tensile tested to verify whether the stress distributions induced by the moulding process have an influence on the strength. It was shown that the strength decreases after a preload and is strongly influenced by the layout of the micro package