Effect of ascorbic acid on lipoprotein lipase activity

Baboons kept on hypovitaminotic C diets, but without clinical signs of scurvy, had significantly higher heart muscle lipoprotein lipase activity than baboons on vitamin C 34 mg/kg body mass/day. When the serum vitamin C levels were above 0,35 mg/100 ml the heart muscle lipoprotein lipase was repressed. Serum vitamin C levels below 0,35 mg/100 ml stimulated lipoprotein lipase to between 2 and 3 times the repressed value. Heart muscle lipoprotein lipase from baboons receiving dietary vitamin C was inhibited by 0,34 mM vitamin C in vitro, whereas heart muscle lipoprotein lipase from baboons on scorbutogenic diets were stimulated by addition of vitamin C in vitro.S. Afr. Med. J., 48, 511 (1974)

Die verhouding tussen openbaring, dogmavorming en doksa-uiting in die himniese stof van die Nuwe Testament

The relation between revelation, the formation of dogma and the expression of doxa in the hymnal matter of the New Testament This article proceeds from the central theoretical argument that in the liturgical song an integral relation exists between revelation, the formation of confession (dogma) and the expression of glory (doxa). The purpose of the article is to analyse the mentioned relationship as it becomes manifest in the hymnal matter of the New Testament and to determine its significance in the hymnal action of the community of worshippers. It is kept in mind that the New Testament, unlike the Old Testament, does not contain a book of songs and that the number of complete songs is limited. The article thus also focuses on song fragments. The conclusion arrived at is that the song material of the New Testament indicates that the revelation stands in a causal relation to dogma formation and doxa expression that occur in the liturgical song. Dogma formation and doxa expression respond to the revelation and actualize the revelation, while these two vital elements of the hymnal content (dogma formation and doxa expression) stand in a convergent and symbiotic relation to each other. The result of this investigation appears to be important for the meaningful use of New Testament songs in contemporary liturgy

Relaxations of the satisfiability problem using semidefinite programming

We derive a semidefinite relaxation of the satisfiability (SAT) problem and discuss its strength. We give both the primal and dual formulation of the relaxation. The primal formulation is an eigenvalue optimization problem, while the dual formulation is a semidefinite feasibility problem. It is shown that using the relaxation, the notorious pigeon hole and mutilated chessboard problems are solved in polynomial time. As a byproduct we find a new `sandwich' theorem that is similar to Lov'asz' famous $vartheta$-function. Furthermore, using the semidefinite relaxation 2SAT problems are solved. By adding an objective function to the dual formulation, a specific class of polynomially solvable 3SAT instances can be identified. We conclude with discussing how the relaxation can be used to solve more general SAT problems and some empirical observations

Effect of ascorbic acid on serum cholesterol levels and on die-away curves of 14C-4-cholesterol in baboons

Fourteen young male baboons (Papio ursinus) were divided into two groups. All the animals received the same dietary regimen during a 2%-month adaptation period. During the next 3 months one group received 250 mg and the other 20 mg vitamin C daily. For the last 2% months of the experiment no vitamin C was given to the first group, and that of the second group was increased to 350 mg daily. Simultaneously with the switchover, 14C-4-cholesterol was administered. A classical twopool system for the kinetic behaviour of cholesterol in the body was confirmed. Vitamin C treatment did not alter the serum cholesterol levels significantly, but the production rate was repressed. It was also shown that vitamin C was depleted from the body in a typical two-pool fashion.S. Afr. Med. J., 48, 1182 (1974)

Seasonal variation in serum ascorbic acid and serum lipid composition of free-living baboons (Papio ursinus)

Two surveys were conducted in the Kruger National Park in which 205 baboons were captured. The first survey was done during late summer and the second during late winter. Serum ascorbic acid, serum cholesterol and serum phospholipids were determined. Baboons of both sexes and various ages were captured. This work was undertaken to establish serum ascorbic acid, serum cholesterol and serum phospholipid values for baboons under free-living conditions. A seasonal variation was found, and the serum ascorbic acid serum cholesterol and serum phospholipid values were significantly higher during winter than during summer.S. Afr. Med. J., 48, 1700 (1974

The role of 18F-FDG-PET/CT in the management of patients with high-risk breast cancer: case series and guideline comparison

Objectives: In grade III-IV breast cancer, dissemination of disease needs to be assessed. Until now this was done by conventional imaging (liver ultrasonography, chest X-ray and bone scintigraphy), but evidence favoring the use of FDG-PET/CT is accumulating. Methods: Patients with high-risk breast cancer, who had received conventional imaging and FDG-PET/CT, were included. Patients were staged and assigned a treatment after 1) conventional imaging and 2) FDG-PET/CT, both by a multidisciplinary oncology team. Equivocal FDG-PET/CT findings were histologically confirmed. Results: 16 patients were included (mean age 59 years). TNM-stage changed in 5 patients (31%) after FDG-PET/CT. In 3 patients (19%) unknown distant metastases were detected by FDG-PET/CT. An adjustment of treatment took place in 4 patients (25%). Conclusions: Our case series emphasizes the role of FDG-PET/CT in the staging of high-risk breast carcinoma, especially in the assessment of distant metastases. We suggest replacing conventional imaging with FDG-PET/CT

FPTAS for optimizing polynomials over the mixed-integer points of polytopes in fixed dimension

We show the existence of a fully polynomial-time approximation scheme (FPTAS) for the problem of maximizing a non-negative polynomial over mixed-integer sets in convex polytopes, when the number of variables is fixed. Moreover, using a weaker notion of approximation, we show the existence of a fully polynomial-time approximation scheme for the problem of maximizing or minimizing an arbitrary polynomial over mixed-integer sets in convex polytopes, when the number of variables is fixed.Comment: 16 pages, 4 figures; to appear in Mathematical Programmin

In search of hair damage using metabolomics?

YesHair fibres are extraordinary materials, not least because they are exquisitely formed by each of the 5 million or so hair follicles on our bodies and have functions that cross from physiology to psychology, but also because they have well known resistance to degradation as seen in hair surviving from archaeological and historical samples [1]. Hair fibres on the head grow at around 1cm each month, together totalling approximately 12km of growth per person per year. Each fibre is incredibly strong for its small diameter; with one fibre typically holding 100g and together a well-formed ponytail [allegedly] has the collective strength to support the weight of a small elephant! Hair – and from here I mean scalp hair – is under constant scrutiny by each of us; whether it be style, split ends, the first few grey hairs or the collection of hairs in the shower that should be firmly attached - leading to the fear that is hair loss

Osteoporosis care during the COVID-19 pandemic in the Netherlands: a national survey

This is a survey study concerning osteoporosis care during the COVID-19 pandemic in the Netherlands. Respondents reported that osteoporosis care stagnated and lower quality of care was provided. This leads to the conclusion that standardization of osteoporosis care delivery in situations of crisis is needed.Purpose: During the initial phase of the COVID-19 pandemic, there was no guidance of professional societies or guidelines on the organization of osteoporosis care in case of such a crisis, and treatment relied on local ad hoc strategies. Experiences from the current pandemic need to be taken into account for the near future, and therefore, a national multidisciplinary survey was carried out in the Netherlands.Methods: A survey of 17 questions concerning the continuation of bone mineral density measurements by Dual Energy X-ray absorptiometry (DXA), outpatient clinic visits, and prescription of medication was sent to physicians, nurses, nurse practitioners, and physician assistants working in the field of osteoporosis.Results: 77 respondents finished the questionnaire, of whom 39 (50.6%) reported a decline in DXA-scanning and 36 (46.8%) no scanning at all during the pandemic. There was an increase in remote consultations for both new and control patient visits (n = 48, 62.3%; n = 62, 81.7% respectively). Lower quality of care regarding fracture prevention was reported by more than half of the respondents (n = 44, 57.1%). Treatment with intravenous bisphosphonates and denosumab was delayed according to 35 (45.4%) and 6 (6.3%) of the respondents, respectively.Conclusion: During the COVID-19 pandemic, osteoporosis care almost completely arrested, especially because of the discontinuation of DXA-scanning and closing of outpatient clinics. More than half of the respondents reported a substantial lower quality of osteoporosis care during the COVID pandemic. To prevent an increase in fracture rates and a decrease in patient motivation, adherence and satisfaction, standardization of osteoporosis care delivery in situations of crisis is needed.Diabetes mellitus: pathophysiological changes and therap