Discourses of conflict and collaboration and institutional context in the implementation of forest conservation policies in Soria, Spain

This article examines the emergence of conflict and collaboration in the implementation of forest conservation policies in Soria, Spain. We draw insights from discursive institutionalism and use a comparative case study approach to analyse and compare a situation of social conflict over the Natural Park declaration in the Sierra de Urbión, and a civil society led collaborative process to develop management plans for the “Sierra de Cabrejas” in Soria. The implementation of the EU Habitats Directive generated different outcomes in these two cases, which unfolded in the context of the same nature conservation legislation and national and provincial administrative structures but differed in terms of types of forests involved, property rights arrangements and forest use histories. We critically examine the influence of the institutional context and dominant discourses on the emergence of outcomes: conflict emerged where local institutions and discourses were threatened by the EU directive, while collaboration was possible where local institutions and counter-discourses were weak. We find that the institutional context plays an important part in determining local discourses in the implementation of forest conservation policies. Yet local counter-discourses have limited influence in the implementation and policy processes in the face of contestation by the discourses of regional civil servants conservation activists

A perspective on SIDS pathogenesis. The hypotheses: plausibility and evidence

Several theories of the underlying mechanisms of Sudden Infant Death Syndrome (SIDS) have been proposed. These theories have born relatively narrow beach-head research programs attracting generous research funding sustained for many years at expense to the public purse. This perspective endeavors to critically examine the evidence and bases of these theories and determine their plausibility; and questions whether or not a safe and reasoned hypothesis lies at their foundation. The Opinion sets specific criteria by asking the following questions: 1. Does the hypothesis take into account the key pathological findings in SIDS? 2. Is the hypothesis congruent with the key epidemiological risk factors? 3. Does it link 1 and 2? Falling short of any one of these answers, by inference, would imply insufficient grounds for a sustainable hypothesis. Some of the hypotheses overlap, for instance, notional respiratory failure may encompass apnea, prone sleep position, and asphyxia which may be seen to be linked to co-sleeping. For the purposes of this paper, each element will be assessed on the above criteria

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary.

S

Fatal asphyxial episodes in the very young: Classification and diagnostic issues

Infants and young children are exposed to a relatively limited range of circumstances that may result in accidental or inflicted asphyxial deaths. These usually involve situations that interfere with oxygen uptake by the blood, or that decrease the amount of circulating oxygen. Typically infants and toddlers asphyxiate in sleeping accidents where they smother when their external airways are covered, hang when clothing is caught on projections inside cots, or wedge when they slip between mattresses and walls. Overlaying may cause asphyxiation due to a combination of airway occlusion and mechanical asphyxia, as may inflicted asphyxia with a pillow. The diagnosis of asphyxiation in infancy is difficult as there are usually no positive findings at autopsy and so differentiating asphyxiation from sudden infant death syndrome (SIDS) based purely on the pathological features will usually not be possible. Similarly, the autopsy findings in inflicted and accidental suffocation will often be identical. Classifications of asphyxia are sometimes confusing as particular types of asphyxiating events may involve several processes and so it may not be possible to precisely compartmentalize a specific incident. For this reason asphyxial events have been classified as being due to: insufficient oxygen availability in the surrounding environment, critical reduction of oxygen transfer from the atmosphere to the blood, impairment of oxygen transport in the circulating blood, or compromise of cellular oxygen uptake. The range of possible findings at the death scene and autopsy are reviewed, and the likelihood of finding markers/indicators of asphyxia is discussed. The conclusion that asphyxiation has occurred often has to be made by integrating aspects of the history, scene, and autopsy, while recognizing that none of these are necessarily pathognomonic, and also by excluding other possibilities. However, even after full investigation a diagnosis of asphyxia may not be possible and a number of issues concerning possible lethal terminal mechanisms may remain unresolved.Roger W. Byard and Lisbeth L. Jense

Medical treatment of primary sclerosing cholangitis: A role for novel bile acids and other (post-)transcriptional modulators?

Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disease of the liver and bile ducts that is associated with inflammatory bowel disease, generally leads to end-stage liver disease, and is complicated by malignancies of the biliary tree and the large intestine. The pathogenesis of PSC remains enigmatic, making the development of targeted therapeutic strategies difficult. Immunosuppressive and antifibrotic therapeutic agents were ineffective or accompanied by major side effects. Ursodeoxycholic acid (UDCA) has consistently been shown to improve serum liver tests and might lower the risk of colon carcinoma and cholangiocarcinoma by yet unknown mechanisms. Whether "high dose" UDCA improves the long-term prognosis in PSC as suggested by small pilot trials remains to be demonstrated. The present overview discusses potential therapeutic options aside of targeted immunological therapies and UDCA. The C23 bile acid norUDCA has been shown to markedly improve biochemical and histological features in a mouse model of sclerosing cholangitis without any toxic effects. Studies in humans are eagerly being awaited. Nuclear receptors like the farnesoid-X receptor (FXR), pregnane-X receptor (PXR), vitamin D receptor (VDR), and peroxisome-proliferator-activator receptors (PPARs) have been shown to induce expression of diverse carriers and biotransformation enzymes of the intestinal and hepatic detoxification machinery and/or to modulate fibrogenesis. Pros and cons of respective receptor agonists for the future treatment of PSC are discussed in detail. In our view, the novel bile acid norUDCA and agonists of PPARs, VDR, and PXR appear particularly attractive for further studies in PSC

Broadband dielectric and Mössbauer studies of BaTiO3–NiFe2O4 composite multiferroics

A broadband dielectric investigation and Mossbauer studies were performed on 0.7BaTiO(3)-0.3NiFe(2)O(4) composite ceramics prepared from chemically obtained barium titanate and nickel ferrite powders. Dielectric spectroscopy revealed a Debye-type relaxation at frequencies between 10 GHz and 1 THz. The relaxation time slows down on cooling according to the Arrhenius law which can be attributed to the transformation of the system from the paraelectric to the ferroelectric phase through an intermediate relaxor state. The temperature dependence of the center shift of the Mossbauer spectrum was analyzed by applying Debye and Einstein models. Its deviation from these models can be attributed to the anharmonicity. It is also possible that the center shift is affected by the Fe atoms incorporated in BaTiO3 lattice or at the interfaces between BaTiO3 and NiFe2O4