27 research outputs found

    Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink

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    A multi-center study has been set up to accurately characterize the optical properties of diffusive liquid phantoms based on Intralipid and India ink at near-infrared (NIR) wavelengths. Nine research laboratories from six countries adopting different measurement techniques, instrumental set-ups, and data analysis methods determined at their best the optical properties and relative uncertainties of diffusive dilutions prepared with common samples of the two compounds. By exploiting a suitable statistical model, comprehensive reference values at three NIR wavelengths for the intrinsic absorption coefficient of India ink and the intrinsic reduced scattering coefficient of Intralipid-20% were determined with an uncertainty of about 2% or better, depending on the wavelength considered, and 1%, respectively. Even if in this study we focused on particular batches of India ink and Intralipid, the reference values determined here represent a solid and useful starting point for preparing diffusive liquid phantoms with accurately defined optical properties. Furthermore, due to the ready availability, low cost, long-term stability and batch-to-batch reproducibility of these compounds, they provide a unique fundamental tool for the calibration and performance assessment of diffuse optical spectroscopy instrumentation intended to be used in laboratory or clinical environment. Finally, the collaborative work presented here demonstrates that the accuracy level attained in this work for optical properties of diffusive phantoms is reliable

    Hidden Markov Random Field Models for TCA Image Analysis

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    Tooth Cementum Annulation (TCA) is an age estimation method carried out on thin cross sections of the root of mammalian teeth. Age is computed by adding the tooth eruption age to the count of annual incremental lines which are called tooth rings and appear in the cementum band. The number of rings is computed from an intensity (gray scale) image of the cementum band, by estimating the average ring width and then dividing the area of the cementum band by this estimate. The ring width is estimated by modelling the image by a hidden Markov random field, where intensities are assumed to be pixelwise conditionally independent and normally distributed, given a Markov random field of hidden binary labels, representing the“true scene”. To incorporate image macro-features (the long-range dependence among intensities and the quasi-periodicity in the placement of tooth rings), the label random field is defined by an energy function that depends on a parametric Gabor filter, convolved with the true scene. The filter parameter represents the unknown of main interest, i.e. the average width of the rings. The model is estimated through an EM algorithm, relying on the mean field approximation of the hidden label distribution and allows to predict the locations of the rings in the image

    Long-term skin temperature measurements -A practical diagnostic tool in complex regional pain syndrome

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    Abstract Despite the development of the IASP criteria, diagnosing complex regional pain syndrome (CRPS) remains a challenge because all symptoms vary interindividually, including the vascular abnormalities. Previous studies showed that skin temperature asymmetries between the affected and contralateral extremity around 2°C are useful for diagnosing CRPS. However, they were either assessed only at one single point in time or during specific investigations including controlled thermoregulatory modulation of sympathetic activity which limits their practicability. The present study evaluated long-term skin temperature changes under everyday circumstances in 22 patients with CRPS, 18 patients with limb pain of other origin and 23 healthy controls. The asymmetries in skin temperature and oscillation number (Q Oscill ), the percentage of assessed time with a-synchron temperature changes on both body sides and the determination coefficient of the individual regression (r 2 id ) were compared between the groups. Patients with CRPS differed significantly from healthy controls in nearly all parameters. Minor differences between both patient groups were found regarding the percentage of assessed time with side difference >2°C (DT2). However, both patient groups differed significantly in parameters characterizing the skin temperature dynamics. A sum score (2ÃQ Oscill + r 2 id + DT2) allowed diagnosing CRPS with a specificity of 67% vs. patients with other painful diseases and 79% vs. healthy controls (sensitivity: 73%, respectively, 94%) and reflected the severity of the dysfunction in CRPS better than the mean skin temperature side differences alone. The applied skin temperature analysis can be easily applied in the clinical settings and serves as a further facet in the difficult diagnosis of CRPS.
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