21 research outputs found
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The effects of a dialogue-based intervention to promote psychosocial well-being after stroke: a randomized controlled trial
Objective:
To evaluate the effect of a dialogue-based intervention targeting psychosocial well-being at 12âmonths post-stroke.
Design:
Multicenter, prospective, randomized, assessor-blinded, controlled trial with two parallel groups.
Setting:
Community.
Subjects:
Three-hundred and twenty-two adults (â©Ÿ18âyears) with stroke within the last four weeks were randomly allocated into intervention group (nâ=â166) or control group (nâ=â156).
Interventions:
The intervention group received a dialogue-based intervention to promote psychosocial well-being, comprising eight individual 1â1Âœâhour sessions delivered during the first six months post-stroke.
Main measures:
The primary outcome measure was the General Health Questionnaire-28 (GHQ-28). Secondary outcome measures included the Stroke and Aphasia Quality of Life Scale-39g, the Sense of Coherence scale, and the Yale Brown single-item questionnaire.
Results:
The mean (SD) age of the participants was 66.8 (12.1) years in the intervention group and 65.7 (13.3) years in the control group. At 12âmonths post-stroke, the mean (SE) GHQ-28 score was 20.6 (0.84) in the intervention group and 19.9 (0.85) in the control group. There were no between-group differences in psychosocial well-being at 12âmonths post-stroke (mean difference: â0.74, 95% confidence interval (CI): â3.08, 1.60). The secondary outcomes showed no statistically significant between-group difference in health-related quality of life, sense of coherence, or depression at 12âmonths.
Conclusion:
The results of this trial did not demonstrate lower levels of emotional distress and anxiety or higher levels of health-related quality of life in the intervention group (dialogue-based intervention) as compared to the control group (usual care) at 12âmonths post-stroke
âTrapped in an Empty Waiting RoomââThe Existential Human Core of Loneliness in Old Age: A Meta-Synthesis
Loneliness in old age has a negative influence on quality of life, health and survival. To understand the phenomenon of loneliness in old age, the voices of lonely older adults should be heard. Therefore, the purpose of this meta-synthesis was to synthesize scientific studies of older adultsâ experiences of loneliness. Eleven qualitative articles that met the inclusion criteria were analyzed and synthesized according to Noblit and Hareâs meta-ethnographic approach. The analysis revealed the overriding meaning of the existential human core of loneliness in old age expressed through the metaphor "trapped in an empty waiting room". Four interwoven themes were found: 1) the negative emotions of loneliness, 2) the loss of meaningful interpersonal relationships, 3) the influence of loneliness on self-perception and 4) the older adultsâ endeavors to deal with loneliness. The joint contribution of family members, health care providers, and volunteers is necessary to break the vicious circle of loneliness
Measuring, in solution, multiple-fluorophore labeling by combining Fluorescence Correlation Spectroscopy and photobleaching
Determining the number of fluorescent entities that are coupled to a given
molecule (DNA, protein, etc.) is a key point of numerous biological studies,
especially those based on a single molecule approach. Reliable methods are
important, in this context, not only to characterize the labeling process, but
also to quantify interactions, for instance within molecular complexes. We
combined Fluorescence Correlation Spectroscopy (FCS) and photobleaching
experiments to measure the effective number of molecules and the molecular
brightness as a function of the total fluorescence count rate on solutions of
cDNA (containing a few percent of C bases labeled with Alexa Fluor 647). Here,
photobleaching is used as a control parameter to vary the experimental outputs
(brightness and number of molecules). Assuming a Poissonian distribution of the
number of fluorescent labels per cDNA, the FCS-photobleaching data could be
easily fit to yield the mean number of fluorescent labels per cDNA strand (@
2). This number could not be determined solely on the basis of the cDNA
brightness, because of both the statistical distribution of the number of
fluorescent labels and their unknown brightness when incorporated in cDNA. The
statistical distribution of the number of fluorophores labeling cDNA was
confirmed by analyzing the photon count distribution (with the cumulant
method), which showed clearly that the brightness of cDNA strands varies from
one molecule to the other.Comment: 38 pages (avec les figures
Correlation between clinical performance and degree of conversion of resin cements: a literature review
Bleach correction ImageJ plugin for compensating the photobleaching of time-lapse sequences
Balloon valvuloplasty in the treatment of congenital aortic valve stenosis - a retrospective multicenter survey of more than 1000 patients
In this retrospective multicenter study, balloon valvuloplasty of the aortic valve has effectively postponed the need for surgery in infants, children and adolescents up to 18 years of age