Failure of vaccination to prevent outbreaks of foot-and-mouth disease

Outbreaks of foot-and-mouth disease persist in dairy cattle herds in Saudi Arabia despite revaccination at intervals of 4-6 months. Vaccine trials provide data on antibody responses following vaccination. Using this information we developed a mathematical model of the decay of protective antibodies with which we estimated the fraction of susceptible animals at a given time after vaccination. The model describes the data well, suggesting over 95% take with an antibody half-life of 43 days. Farm records provided data on the time course of five outbreaks. We applied a 'SLIR' epidemiological model to these data, fitting a single parameter representing disease transmission rate. The analysis provides estimates of the basic reproduction number R(0), which may exceed 70 in some cases. We conclude that the critical intervaccination interval which would provide herd immunity against FMDV is unrealistically short, especially for heterologous challenge. We suggest that it may not be possible to prevent foot-and-mouth disease outbreaks on these farms using currently available vaccines

Relativistic eikonal description of A(p,pN) reactions

The authors present a relativistic and cross-section factorized framework for computing quasielastic A(p,pN) observables at intermediate and high energies. The model is based on the eikonal approximation and can accomodate both optical potentials and the Glauber method for dealing with the initial- and final-state interactions (IFSI). At lower nucleon energies, the optical-potential philosophy is preferred, whereas at higher energies the Glauber method is more natural. This versatility in dealing with the IFSI allows one to describe A(p,pN) reactions in a wide energy range. Most results presented here use optical potentials as this approach is argued to be the optimum choice for the kinematics of the experiments considered in the present paper. The properties of the IFSI factor, a function wherein the entire effect of the IFSI is contained, are studied in detail. The predictions of the presented framework are compared with two kinematically different experiments. First, differential cross sections for quasielastic proton scattering at 1 GeV off 12C, 16O, and 40Ca target nuclei are computed and compared to data from PNPI. Second, the formalism is applied to the analysis of a 4He(p,2p) experiment at 250 MeV. The optical-potential calculations are found to be in good agreement with the data from both experiments, showing the reliability of the adopted model in a wide energy range.Comment: 34 pages, 14 figures, accepted for publication in Phys. Rev.

Estimating the Integrated Bispectrum from Weak Lensing Maps

We use a recently introduced statistic called {\em Integrated Bispectrum} (IB) to probe the gravity-induced non-Gaussianity at the level of the bispectrum from weak lensing convergence or $\kappa$ maps. We generalize the concept of the IB to spherical coordinates. This result is next connected to the response function approach. Finally, we use the Euclid Flagship simulations to compute the IB as a function of redshift and wave number. We also outline how the IB can be computed using a variety of analytical approaches including the ones based on Effective Field Theory (EFT), {\em Halo models} and models based on the {\em Separate Universe approach} in projection or two-dimension (2D). Comparing these results against simulations we find that the existing theoretical models tend to over-predict the numerical value of the IB. We emphasize the role of the finite volume effect in the numerical estimation of the IB. We introduced the concept of squeezed and collapsed tripsectrum for 2D $\kappa$ maps. We derive the IB for many parameterized theories of modified gravity including the Horndeskii and beyond-Horndeskii theories specifically for the non-degenerate scenarios that are also known as the Gleyzes-Langlois-Piazza-Venizzi or GPLV theories. In addition, the cosmological models with clustering quintessence and models involving massive neutrinos are also derived.Comment: 49 pages, 8 figures, To appear in JCA

On the unique possibility to increase significantly the contrast of dark resonances on D1 line of 87^{87}Rb

We propose and study, theoretically and experimentally, a new scheme of excitation of a coherent population trapping resonance for D1 line of alakli atoms with nuclear spin $I=3/2$ by bichromatic linearly polarized light ({\em lin}$||${\em lin} field) at the conditions of spectral resolution of the excited state. The unique properties of this scheme result in a high contrast of dark resonance for D1 line of $^{87}$Rb.Comment: 9 pages, 7 figures. This material has been partially presented on ICONO-2005, 14 May 2005, St. Petersburg, Russia. v2 references added; text is changed a bi

Finding Evidence for Massive Neutrinos using 3D Weak Lensing

In this paper we investigate the potential of 3D cosmic shear to constrain massive neutrino parameters. We find that if the total mass is substantial (near the upper limits from LSS, but setting aside the Ly alpha limit for now), then 3D cosmic shear + Planck is very sensitive to neutrino mass and one may expect that a next generation photometric redshift survey could constrain the number of neutrinos N_nu and the sum of their masses m_nu to an accuracy of dN_nu ~ 0.08 and dm_nu ~ 0.03 eV respectively. If in fact the masses are close to zero, then the errors weaken to dN_nu ~ 0.10 and dm_nu~0.07 eV. In either case there is a factor 4 improvement over Planck alone. We use a Bayesian evidence method to predict joint expected evidence for N_nu and m_nu. We find that 3D cosmic shear combined with a Planck prior could provide `substantial' evidence for massive neutrinos and be able to distinguish `decisively' between many competing massive neutrino models. This technique should `decisively' distinguish between models in which there are no massive neutrinos and models in which there are massive neutrinos with |N_nu-3| > 0.35 and m_nu > 0.25 eV. We introduce the notion of marginalised and conditional evidence when considering evidence for individual parameter values within a multi-parameter model.Comment: 9 pages, 2 Figures, 2 Tables, submitted to Physical Review

Nucleon-nucleon bremsstrahlung: An example of the impossibility of measuring off-shell amplitudes

For nearly fifty years theoretical and experimental efforts in nucleon-nucleon bremsstrahlung (NN$\gamma$) have been devoted to measuring off-shell amplitudes and distinguishing among various NN potentials on the basis of their off-shell behavior. New experiments are underway, designed specifically to attain kinematics further off shell than in the past, and thus to be more sensitive to the off-shell behavior. This letter shows that, contrary to these expectations, and due to the invariance of the S-matrix under transformations of the fields, the off-shell NN amplitude is as a matter of principle an unmeasurable quantity in NN$\gamma$.Comment: 9 pages, Latex, using RevTeX; Minor wording changes, title changed, version to be published in Phys. Rev. Letter

A magneto-optic trap using a reversible, solid-state alkali-metal source

We demonstrate a novel way to form and deplete a vapor-cell magneto-optic trap (MOT) using a reversible, solid-state alkali-metal source (AMS) via an applied polarized voltage. Using ~100 mW of electrical power, a trapped-atom number of 5x10^6 has been achieved starting from near zero and the timescales of the MOT formation and depletion of ~1 s. This fast, reversible, and low power alkali-atom source is desirable in both tabletop and portable cold-atom systems. The core technology of this device should translate readily to other alkali and alkaline-earth elements that could find a wide range of uses in cold-atom systems and instruments.Comment: 7 page

Dynamic characterization of an alkali-ion battery as a source for laser-cooled atoms

We investigate a solid-state, reversible, alkali-ion battery (AIB) capable of regulating the density of alkali atoms in a vacuum system used for the production of laser-cooled atoms. The cold-atom sample can be used with in-vacuum chronoamperometry as a diagnostic for the voltage-controlled electrochemical reaction that sources or sinks alkali atoms into the vapor. In a combined reaction-diffusion-limited regime, we show that the number of laser-cooled atoms in a magneto-optical trap can be increased both by initially loading the AIB from the vapor for longer, and by using higher voltages across the AIB when atoms are subsequently sourced back into the vapor. The time constants associated with the change in atom number in response to a change in AIB voltage are in the range of 0.5 s - 40 s. The AIB alkali reservoir is demonstrated to survive oxidization during atmospheric exposure, simplifying reservoir loading prior to vacuum implementation as a replacement for traditional resistively-heated dispensers. The AIB capabilities may provide an improved atom number stability in next-generation atomic clocks and sensors, while also facilitating fast loading and increased interrogation times.Comment: 7 pages, 5 figure

VIS: the visible imager for Euclid

Euclid-VIS is a large format visible imager for the ESA Euclid space mission in their Cosmic Vision program, scheduled for launch in 2019. Together with the near infrared imaging within the NISP instrument it forms the basis of the weak lensing measurements of Euclid. VIS will image in a single r+i+z band from 550-900 nm over a field of view of ~0.5 deg2. By combining 4 exposures with a total of 2240 sec, VIS will reach to V=24.5 (10{\sigma}) for sources with extent ~0.3 arcsec. The image sampling is 0.1 arcsec. VIS will provide deep imaging with a tightly controlled and stable point spread function (PSF) over a wide survey area of 15000 deg2 to measure the cosmic shear from nearly 1.5 billion galaxies to high levels of accuracy, from which the cosmological parameters will be measured. In addition, VIS will also provide a legacy imaging dataset with an unprecedented combination of spatial resolution, depth and area covering most of the extra-Galactic sky. Here we will present the results of the study carried out by the Euclid Consortium during the Euclid Definition phase.Comment: 10 pages, 6 figure