Compensation of a Cavitary Bone Defect in Conditions of Implantation of Mesh Structures from Titanium Nickelide

The purpose of our research was to study reparative osteogenesis for implanting mesh structures of titanium nickelide (TN) into a cavitary bone defect. Methods: The authors modeled cavitary defects of femoral metaphysis experimentally in Wistar rats divided into an experimental and a control group. The study duration was 60 days in total. Scanning electron microscope JSM-840 (JEOL, Japan) equipped with energy dispersive X-ray analyzer (INCA 200, Oxford Instruments) was used. Results: Under implantation, the defect was filled with cancellous bone the volumetric density of which exceeded control values more than 1.5-fold (P< 0.001). The implant had biocompatibility, osteoconductive and osteoinductive properties, and it stopped inflammatory processes. The membrane protective barrier, which prevented connective tissue sprouting, was formed on the surface of the implant in the defect periosteal zone. The osteointegrative junction was formed and persisted up to the end of the experiment. Reparative osteogenesis was performed by direct intramembranous and apposition type. Conclusion: The implant of three-dimensional mesh titanium-nickelide structures has marked osteoplastic properties, and it can be successfully used in orthopedic surgery

x509-free access to WLCG resources

Access to WLCG resources is authenticated using an x509 and PKI infrastructure. Even though HEP users have always been exposed to certificates directly, the development of modern Web Applications by the LHC experiments calls for simplified authentication processes keeping the underlying software unmodified. In this work we will show a solution with the goal of providing access to WLCG resources using the user's home organisations credentials, without the need for user-acquired x509 certificates. In particular, we focus on identity providers within eduGAIN, which interconnects research and education organisations worldwide, and enables the trustworthy exchange of identity-related information. eduGAIN has been integrated at CERN in the SSO infrastructure so that users can authenticate without the need of a CERN account. This solution achieves x509-free access to Grid resources with the help of two services: STS and an online CA. The STS (Security Token Service) allows credential translation from the SAML2 format used by Identity Federations to the VOMS-enabled x509 used by most of the Grid. The IOTA CA (Identifier-Only Trust Assurance Certification Authority) is responsible for the automatic issuing of short-lived x509 certificates. The IOTA CA deployed at CERN has been accepted by EUGridPMA as the CERN LCG IOTA CA, included in the IGTF trust anchor distribution and installed by the sites in WLCG. We will also describe the first pilot projects which are integrating the solution.Peer reviewe

Experience of Reconstruction of Yakut Women’s Clothing of the 17th-18th Centuries (based on the Materials of At-Daban (At-Byran) VI Burial)

The experience of carrying out a hypothetical reconstruction of women's clothing "tangalai" XVII-XVIII centuries is considered. It is reported that this sample of clothing was found during archaeological research in 2016 in the area of At-Byran, Khangalassky district of the Republic of Sakha (Yakutia). Earlier it was revealed that the tangalai was part of the bride’s costume, which means an indispensable element of the wedding ceremony. As a result of studies of the Yakut burials of the XVII-XVIII centuries, it was established that the tangalai was included in the complex of accompanying material during the funeral rite of a married woman. An analysis of ethnographic literature, the results of field scientific research, available visual sources was made, fragments of clothing stored in museums extracted from funerary monuments were studied. As the study showed, the tangalai from the At-Daban VI burial has similar features with samples of similar shoulder-clothes found and studied earlier: general principles of decor, color scheme, and peculiarities of the location of sewn jewelry. Distinctive features: a lowered waist line and narrow bibs were revealed. Based on a detailed study of the original source, masters of decorative and applied art carried out a hypothetical reconstruction of the tangalaya. Attention was paid to leather processing, seams, design features. Unsaved pieces of clothing were recreated using existing analogues

A Mathematical Model of the Immune and Neuroendocrine Systems Mutual Regulation under the Technogenic Chemical Factors Impact

The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted. Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known. This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example

PROSPECTS FOR CREATION OF ULTRA-SUPERCRITICAL STEAM PARAMETERS POWER UNITS IN RUSSIA AND IN THE WORLD

The article discusses the prospects for the development of power units for ultra-supercritical steam parameters, analyzes their advantages and limitations, and examines the current state of the development in Russia.В статье рассматриваются перспективы разработок энергоблоков на ультрасверхкритические параметры пара, анализируются их преимущества и ограничения, рассматривается текущее состояние разработок в России

Spatiotemporal 3D image registration for mesoscale studies of brain development

Comparison of brain samples representing different developmental stages often necessitates registering the samples to common coordinates. Although the available software tools are successful in registering 3D images of adult brains, registration of perinatal brains remains challenging due to rapid growth-dependent morphological changes and variations in developmental pace between animals. To address these challenges, we introduce CORGI (Customizable Object Registration for Groups of Images), an algorithm for the registration of perinatal brains. First, we optimized image preprocessing to increase the algorithm's sensitivity to mismatches in registered images. Second, we developed an attention-gated simulated annealing procedure capable of focusing on the differences between perinatal brains. Third, we applied classical multidimensional scaling (CMDS) to align ("synchronize") brain samples in time, accounting for individual development paces. We tested CORGI on 28 samples of whole-mounted perinatal mouse brains (P0-P9) and compared its accuracy with other registration algorithms. Our algorithm offers a runtime of several minutes per brain on a laptop and automates such brain registration tasks as mapping brain data to atlases, comparing experimental groups, and monitoring brain development dynamics

Scientific Data Lake for High Luminosity LHC project and other data-intensive particle and astro-particle physics experiments

Indexación ScopusThe next phase of LHC Operations-High Luminosity LHC (HL-LHC), which is aimed at ten-fold increase in the luminosity of proton-proton collisions at the energy of 14 TeV, is expected to start operation in 2027-2028 and will deliver an unprecedented scientific data volume of multi-exabyte scale. This amount of data has to be stored and the corresponding storage system should ensure fast and reliable data delivery for processing by scientific groups distributed all over the world. The present LHC computing and data processing model will not be able to provide the required infrastructure growth even taking into account the expected hardware technology evolution. To address this challenge the new state-of-The-Art computing infrastructure technologies are now being developed and are presented here. The possibilities of application of the HL-LHC distributed data handling technique for other particle and astro-particle physics experiments dealing with large-scale data volumes like DUNE, LSST, Belle-II, JUNO, SKAO etc. are also discussed. © Published under licence by IOP Publishing Ltd.https://iopscience-iop-org.recursosbiblioteca.unab.cl/article/10.1088/1742-6596/1690/1/01216

Numerical Modeling and Validation of the CFD Model of Bubble Column Hydrodynamics for CO2 Mineralization

The CFD-model of a bubble column (water-air) was validated using published experimental data obtained on a cylindrical installation. The results of the validation showed the satisfactory applicability of the model for engineering calculations

New criteria of morphological assessment of the prognosis of the prostate cancer

New criteria of morphological assessment of the prognosis of the patients with a prostate cancer recommended for application of WHO in 2016 are presented. Prospects of the offered criteria on material of the oncology clinic of Udmurtia are shown.В работе представлены новые критерии морфологической оценки прогноза пациентов с раком предстательной железы, рекомендованных к применению ВОЗ в 2016 году. Показана перспективность предложенных критериев на материале онкологического диспансера в Удмуртии

Alcohol increases circulatory disease mortality in Russia: acute and chronic effects or misattribution of cause?

Background There is a consensus that the large fluctuations in mortality seen in Russia in the past two decades can be attributed to trends in alcohol consumption. However, the precise mechanisms linking alcohol to mortality from circulatory disease remain unclear. It has recently been argued that a substantial number of such deaths currently ascribed to cardiovascular disorders are misclassified cases of acute alcohol poisoning