696 research outputs found
A Wavelet Analysis of Pliopleistocene Climate Indicators: A New View of Periodicity Evolution
Wavelet analysis offers an alternative to Fourier based time-series analysis, and is particularly useful when the amplitudes and periods of dominant cycles are time dependent. We analyse climatic records derived from oxygen isotopic ratios of marine sediment cores with modified Morlet wavelets. We use a normalization of the Morlet wavelets which allows direct correspondence with Fourier analysis. This provides a direct view of the oscillations at various frequencies, and illustrates the nature of the time-dependence of the dominant cycles
Risk and charitable organizations: the case of Atlantic Canada
Using panel data from 2003-2010 on charitable organizations in Canada we explore the implications that exposure to risk, in various guises, has on organizations' ability to meet their mandate. We run a random effects panel estimation focusing our attention on the case of Atlantic Canada in an effort to explore the idiosyncrasies that make it an interesting case study, and a microcosm of sorts for producing risk metrics in general. A comparative analysis is provided with the Canadian charitable sector as a whole to contrast the results and afford a context for discussion. Results suggest that diversification in revenue streams may in fact increase risk for charitable firms; and comprehensive modeling techniques, which categorize the entire Canadian market quite well, lead to increased noise in estimating exposure to risk for Atlantic Canada firms. The latter seem somewhat more sensitive to exogenous economic changes, when compared to the entire marketplace
The value of 99mTc-MAA SPECT/CT for lung shunt estimation in 90Y radioembolization: a phantom and patient study
Abstract
Background
A major toxicity concern in radioembolization therapy of hepatic malignancies is radiation-induced pneumonitis and sclerosis due to hepatopulmonary shunting of 90Y microspheres. Currently, 99mTc macroaggregated albumin (99mTc-MAA) imaging is used to estimate the lung shunt fraction (LSF) prior to treatment. The aim of this study was to evaluate the accuracy/precision of LSF estimated from 99mTc planar and SPECT/CT phantom imaging, and within this context, to compare the corresponding LSF and lung-absorbed dose values from 99mTc-MAA patient studies. Additionally, LSFs from pre- and post-therapy imaging were compared.
Results
A liver/lung torso phantom filled with 99mTc to achieve three lung shunt values was scanned by planar and SPECT/CT imaging with repeat acquisitions to assess accuracy and precision. To facilitate processing of patient data, a workflow that relies on SPECT and CT-based auto-contouring to define liver and lung volumes for the LSF calculation was implemented. Planar imaging-based LSF estimates for 40 patients, obtained from their medical records, were retrospectively compared with SPECT/CT imaging-based calculations with attenuation and scatter correction. Additionally, in a subset of 20 patients, the pre-therapy estimates were compared with 90Y PET/CT-based measurements.
In the phantom study, improved accuracy in LSF estimation was achieved using SPECT/CT with attenuation and scatter correction (within 13% of the true value) compared with planar imaging (up to 44% overestimation). The results in patients showed a similar trend with planar imaging significantly overestimating LSF compared to SPECT/CT. There was no correlation between lung shunt estimates and the delay between 99mTc-MAA administration and scanning, but off-target extra hepatic uptake tended to be more likely in patients with a longer delay. The mean lung absorbed dose predictions for the 28 patients who underwent therapy was 9.3 Gy (range 1.3–29.4) for planar imaging and 3.2 Gy (range 0.4–13.4) for SPECT/CT. For the patients with post-therapy imaging, the mean LSF from 90Y PET/CT was 1.0%, (range 0.3–2.8). This value was not significantly different from the mean LSF estimate from 99mTc-MAA SPECT/CT (mean 1.0%, range 0.4–1.6; p = 0.968), but was significantly lower than the mean LSF estimate based on planar imaging (mean 4.1%, range 1.2–15.0; p = 0.0002).
Conclusions
The improved accuracy demonstrated by the phantom study, agreement with 90Y PET/CT in patient studies, and the practicality of using auto-contouring for liver/lung definition suggests that 99mTc-MAA SPECT/CT with scatter and attenuation corrections should be used for lung shunt estimation prior to radioembolization.https://deepblue.lib.umich.edu/bitstream/2027.42/144504/1/13550_2018_Article_402.pd
The COMPLETE Survey of Star-Forming Regions: Phase I Data
We present an overview of data available for the Ophiuchus and Perseus
molecular clouds from ``Phase I'' of the COMPLETE Survey of Star-Forming
Regions. This survey provides a range of data complementary to the Spitzer
Legacy Program ``From Molecular Cores to Planet Forming Disks.'' Phase I
includes: Extinction maps derived from 2MASS near-infrared data using the NICER
algorithm; extinction and temperature maps derived from IRAS 60 and 100um
emission; HI maps of atomic gas; 12CO and 13CO maps of molecular gas; and
submillimetre continuum images of emission from dust in dense cores. Not
unexpectedly, the morphology of the regions appears quite different depending
on the column-density tracer which is used, with IRAS tracing mainly warmer
dust and CO being biased by chemical, excitation and optical depth effects.
Histograms of column-density distribution are presented, showing that
extinction as derived from 2MASS/NICER gives the closest match to a log-normal
distribution as is predicted by numerical simulations. All the data presented
in this paper, and links to more detailed publications on their implications
are publically available at the COMPLETE website.Comment: Accepted by AJ. Full resolution version available from:
http://www.cfa.harvard.edu/COMPLETE/papers/complete_phase1.pd
DoDo Learning: DOmain-DemOgraphic Transfer in Language Models for Detecting Abuse Targeted at Public Figures
Public figures receive a disproportionate amount of abuse on social media,
impacting their active participation in public life. Automated systems can
identify abuse at scale but labelling training data is expensive, complex and
potentially harmful. So, it is desirable that systems are efficient and
generalisable, handling both shared and specific aspects of online abuse. We
explore the dynamics of cross-group text classification in order to understand
how well classifiers trained on one domain or demographic can transfer to
others, with a view to building more generalisable abuse classifiers. We
fine-tune language models to classify tweets targeted at public figures across
DOmains (sport and politics) and DemOgraphics (women and men) using our novel
DODO dataset, containing 28,000 labelled entries, split equally across four
domain-demographic pairs. We find that (i) small amounts of diverse data are
hugely beneficial to generalisation and model adaptation; (ii) models transfer
more easily across demographics but models trained on cross-domain data are
more generalisable; (iii) some groups contribute more to generalisability than
others; and (iv) dataset similarity is a signal of transferability.Comment: 15 pages, 7 figures, 4 table
Characterization of Single-Mode Vertical Cavity Surface-Emitting Lasers
A high-quality single-mode beam is desirable for the efficient use of lasers as light sources for optical data communications and interconnects, however there is little data which characterizes operating ranges and near-field beam qualities of Vertical Cavity Surface Emitting Lasers (VCSELs), which has resulted in a lack of analysis of these devices. Measures of beam quality include beam-quality factor (M2 ), Side-Mode-Suppression-Ratio (SMSR) and RMS linewidth. M2 is a measurement of how closely the beam is to an ideal Gaussian. SMSR is the difference, in dB, between the amplitude of the primary peak and the amplitude of the next highest peak of the output spectrum, with single-mode operation defined by a SMSR \u3e 30 dB. RMS linewidth is a second moment calculation involving the power spectral density, where smaller RMS linewidth indicates higher beam quality. Utilizing a novel vertical M2 setup in which on-wafer VCSEL M2 can be measured, a study was conducted on the relation between M2 , SMSR and RMS linewidth, for various oxide-confined VCSELs of varying aperture sizes and Photonic Crystal (PhC) VCSELs of varying aperture sizes and photonic crystal configurations. First, the operating range of the VCSEL was determined utilizing a Semiconductor Parameter Analyzer to obtain the LIV characteristics. Along with this measurement, spectral data was collected using an Optical Spectrum Analyzer at several key operating points, which allowed the RMS linewidths and SMSRs of the devices to be calculated at these points. The novel beam-profiler setup was used to measure the device’s M2 . Initial results show a strong correlation between the measures of beam quality, with increasing SMSR, corresponding to M2 values closer to 1, and single-mode operation characterized by a M2 of less than 1.5. A strong correlation between RMS linewidth and M2 was also seen, with increasing RMS linewidths corresponding to an increase in M2
Characterization of Single-Mode Vertical Cavity Surface-Emitting Lasers
A high-quality single-mode beam is desirable for the efficient use of lasers as light sources for optical data communications and interconnects, however there is little data which characterizes operating ranges and near-field beam qualities of Vertical Cavity Surface Emitting Lasers (VCSELs), which has resulted in a lack of analysis of these devices. Measures of beam quality include beam-quality factor (M2 ), Side-Mode-Suppression-Ratio (SMSR) and RMS linewidth. M2 is a measurement of how closely the beam is to an ideal Gaussian. SMSR is the difference, in dB, between the amplitude of the primary peak and the amplitude of the next highest peak of the output spectrum, with single-mode operation defined by a SMSR \u3e 30 dB. RMS linewidth is a second moment calculation involving the power spectral density, where smaller RMS linewidth indicates higher beam quality. Utilizing a novel vertical M2 setup in which on-wafer VCSEL M2 can be measured, a study was conducted on the relation between M2 , SMSR and RMS linewidth, for various oxide-confined VCSELs of varying aperture sizes and Photonic Crystal (PhC) VCSELs of varying aperture sizes and photonic crystal configurations. First, the operating range of the VCSEL was determined utilizing a Semiconductor Parameter Analyzer to obtain the LIV characteristics. Along with this measurement, spectral data was collected using an Optical Spectrum Analyzer at several key operating points, which allowed the RMS linewidths and SMSRs of the devices to be calculated at these points. The novel beam-profiler setup was used to measure the device’s M2 . Initial results show a strong correlation between the measures of beam quality, with increasing SMSR, corresponding to M2 values closer to 1, and single-mode operation characterized by a M2 of less than 1.5. A strong correlation between RMS linewidth and M2 was also seen, with increasing RMS linewidths corresponding to an increase in M2
The enigmatic core L1451-mm: a first hydrostatic core? or a hidden VeLLO?
We present the detection of a dust continuum source at 3-mm (CARMA) and
1.3-mm (SMA), and 12CO(2-1) emission (SMA) towards the L1451-mm dense core.
These detections suggest a compact object and an outflow where no point source
at mid-infrared wavelengths is detected using Spitzer. An upper limit for the
dense core bolometric luminosity of 0.05 Lsun is obtained. By modeling the
broadband SED and the continuum interferometric visibilities simultaneously, we
confirm that a central source of heating is needed to explain the observations.
This modeling also shows that the data can be well fitted by a dense core with
a YSO and disk, or by a dense core with a central First Hydrostatic Core
(FHSC). Unfortunately, we are not able to decide between these two models,
which produce similar fits. We also detect 12CO(2-1) emission with red- and
blue-shifted emission suggesting the presence of a slow and poorly collimated
outflow, in opposition to what is usually found towards young stellar objects
but in agreement with prediction from simulations of a FHSC. This presents the
best candidate, so far, for a FHSC, an object that has been identified in
simulations of collapsing dense cores. Whatever the true nature of the central
object in L1451-mm, this core presents an excellent laboratory to study the
earliest phases of low-mass star formation.Comment: 15 pages, 9 figures, emulateapj. Accepted by Ap
Continuum reverberation mapping of Mrk 876 over three years with remote robotic observatories
Funding: Research at UC Irvine is supported by NSF grant AST-1907290. HL acknowledges a Daphne Jackson Fellowship sponsored by the Science and Technology Facilities Council (STFC), UK. ERC acknowledges support by the NRF of South Africa. TT acknowledges support from NSF through grant NSF-AST-1907208.Continuum reverberation mapping probes the sizescale of the optical continuum-emitting region in active galactic nuclei (AGN). Through 3 years of multiwavelength photometric monitoring in the optical with robotic observatories, we perform continuum reverberation mapping on Mrk~876. All wavebands show large amplitude variability and are well correlated. Slow variations in the light curves broaden the cross-correlation function (CCF) significantly, requiring detrending in order to robustly recover interband lags. We measure consistent interband lags using three techniques (CCF, JAVELIN, PyROA), with a lag of around 13~days from u to z. These lags are longer than the expected radius of 12~days for the self-gravitating radius of the disk. The lags increase with wavelength roughly following λ4/3, as would be expected from thin disk theory, but the lag normalization is approximately a factor of 3 longer than expected, as has also been observed in other AGN. The lag in the i band shows an excess which we attribute to variable Hα broad-line emission. A flux-flux analysis shows a variable spectrum that follows fν ∝ λ-1/3 as expected for a disk, and an excess in the i band that also points to strong variable Hα emission in that band.Publisher PDFPeer reviewe
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