The Relationship Between Level of Empathy and Stress Contagion

Although potential benefits associated with social support are well documented, it is also the case that social networks expose an individual to the stressful life events of others. Studies have shown that the stressful life events of others are positively related to negative affect. It has been theorized by several researchers that relationships between, for example, stressful life events of others and negative affect are evidence of a stress contagion process that may occur through empathy. The current study addressed this idea by testing whether the positive relationship that exists between network stress and depressive symptoms varied dependent upon (ie. was moderated by) an individual’s level of empathy. A sample of 160 Native American individuals, ages fifty and older, who completed the “Coping in Later Life” survey was utilized. A series of hierarchical multiple regression analyses revealed that when network stress is measured by number of life events that occurred to others, empathy does moderate the relationship between network stress and depressive symptoms. This significant interaction occurs both when using a global level of empathy and when the Personal Distress dimension of the measure is removed. Personal Distress alone does not moderate the relationship between overall network stress and depressive symptoms. These data fill several gaps in the social network, stress, and empathy research literature. It also advances the understanding of the stress contagion process

Tell Me More About Alex: Helping Instructors Uncover and Mitigate Their Implicit Biases

All instructors bring a set of unconscious or implicit biases to the classroom. These biases can negatively impact the way they interact with students, thus affecting important student outcomes (for example, grades, sense of belonging). Facilitators leading programming on inclusive teaching may struggle to identify strategies they should include in sessions to help unearth and address these biases in others. We have created an activity that can be tailored to fit a variety of teaching contexts and audiences and that helps unveil implicit biases while potentially mitigating some challenges associated with participant responses to such conversations

Enhancing Employability Through a Multi-disciplinary Approach to Graduate Attributes: Embedding Engagement and Developing Self Efficacy in Pre-honours Undergraduates

There is increasing emphasis on the importance of making Graduate Attributes (GAs) explicit to students as part of their degree programme and the role of students themselves in proactively developing GAs (HEA 2015). However, it can be challenging to engage students in non-core activities in large pre-honours classes, and the success of employability activities are also subject to efficacy beliefs and personal qualities (Yorke & Knight, 2007). A further issue is how we embed employability whilst accounting for the specific needs of the subject discipline and linkages with university careers services (O’Leary 2016). The aim of the present project was to work in partnership with careers professionals and students in reflecting on how curricular and extra-curricular activities can develop graduate attributes throughout the degree programme (Daniels & Brooker, 2014). To this end we extended our work with psychology undergraduates (Swingler et al., 2016), by developing and evaluating short-self-reflection in class exercises for pre-honours psychology, earth sciences, and business school undergraduates, which asked students to reflect on their curricular and extra-curricular activities and how the practical skills gained from these activities are linked to graduate attributes. Class activities were followed by discipline specific careers workshops and alumni events, focused on gaining confidence in communicating graduate attributes in an interview context, and the benefits of engaging with alumni on professional networking sites. Our presentation will focus on: 1) students’ levels of self-efficacy in specific GAs across subject disciplines; 2) the relationship of student self efficacy in GAs to self efficacy in H.E.; 3) Student feedback on the in class reflection activities, careers and alumni events, and their intentions to further develop their GAs. The findings will inform participants about the benefits and challenges of embedding GAs and employability in the pre-honours curriculum and include perspectives from students and staff

The SEGUE Stellar Parameter Pipeline. V. Estimation of Alpha-Element Abundance Ratios From Low-Resolution SDSS/SEGUE Stellar Spectra

We present a method for the determination of [alpha/Fe] ratios from low-resolution (R = 2000) SDSS/SEGUE stellar spectra. By means of a star-by-star comparison with degraded spectra from the ELODIE spectral library and with a set of moderately high-resolution (R = 15,000) and medium-resolution (R = 6000) spectra of SDSS/SEGUE stars, we demonstrate that we are able to measure [alpha/Fe] from SDSS/SEGUE spectra (with S/N > 20/1) to a precision of better than 0.1 dex, for stars with atmospheric parameters in the range Teff = [4500, 7000] K, log g = [1.5, 5.0], and [Fe/H] = [-1.4, +0.3], over the range [alpha/Fe] = [-0.1, +0.6]. For stars with [Fe/H] < -1.4, our method requires spectra with slightly higher signal-to-noise to achieve this precision (S/N > 25/1). Over the full temperature range considered, the lowest metallicity star for which a confident estimate of [alpha/Fe] can be obtained from our approach is [Fe/H] ~ -2.5; preliminary tests indicate that a metallicity limit as low as [Fe/H] ~ -3.0 may apply to cooler stars. As a further validation of this approach, weighted averages of [alpha/Fe] obtained for SEGUE spectra of likely member stars of Galactic globular clusters (M15, M13, and M71) and open clusters (NGC 2420, M67, and NGC 6791) exhibit good agreement with the values of [alpha/Fe] from previous studies. The results of the comparison with NGC 6791 imply that the metallicity range for the method may extend to ~ +0.5.Comment: 47 pages, 11 figures, 5 tables, to appear in A

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)

Background: Amyotrophic lateral sclerosis (ALS), a common late-onset neurodegenerative disease, is associated with fronto-temporal dementia (FTD) in 3-10% of patients. A mutation in CHMP2B was recently identified in a Danish pedigree with autosomal dominant FTD. Subsequently, two unrelated patients with familial ALS, one of whom also showed features of FTD, were shown to carry missense mutations in CHMP2B. The initial aim of this study was to determine whether mutations in CHMP2B contribute more broadly to ALS pathogenesis. Methodology/Principal Findings: Sequencing of CHMP2B in 433 ALS cases from the North of England identified 4 cases carrying 3 missense mutations, including one novel mutation, p. Thr104Asn, none of which were present in 500 neurologically normal controls. Analysis of clinical and neuropathological data of these 4 cases showed a phenotype consistent with the lower motor neuron predominant (progressive muscular atrophy (PMA)) variant of ALS. Only one had a recognised family history of ALS and none had clinically apparent dementia. Microarray analysis of motor neurons from CHMP2B cases, compared to controls, showed a distinct gene expression signature with significant differential expression predicting disassembly of cell structure; increased calcium concentration in the ER lumen; decrease in the availability of ATP; down-regulation of the classical and p38 MAPK signalling pathways, reduction in autophagy initiation and a global repression of translation. Transfection of mutant CHMP2B into HEK-293 and COS-7 cells resulted in the formation of large cytoplasmic vacuoles, aberrant lysosomal localisation demonstrated by CD63 staining and impairment of autophagy indicated by increased levels of LC3-II protein. These changes were absent in control cells transfected with wild-type CHMP2B. Conclusions/Significance: We conclude that in a population drawn from North of England pathogenic CHMP2B mutations are found in approximately 1% of cases of ALS and 10% of those with lower motor neuron predominant ALS. We provide a body of evidence indicating the likely pathogenicity of the reported gene alterations. However, absolute confirmation of pathogenicity requires further evidence, including documentation of familial transmission in ALS pedigrees which might be most fruitfully explored in cases with a LMN predominant phenotype

The management of sexual dysfunction resulting from radiotherapy and androgen deprivation therapy to treat prostate cancer: a comparison of uro-oncology practice according to disease stage

Objectives To establish current uro‐oncology practice in the management of sexual dysfunction (SD) following radiotherapy (RT) and/or androgen deprivation therapy (ADT) to treat prostate cancer. To identify differences in approach to the management of SD according to disease stage. Subjects and methods A 14‐question mixed methods survey was designed to assess the current UK practice. Closed‐ and open‐ended questions were used to quantify results while allowing participants to expand on answers. The survey was distributed to members of the British Uro‐Oncology Group at the 2019 annual meeting. Results Surveys were completed by 63 uro‐oncologists attending the annual meeting of the British Uro‐Oncology Group (response rate 66%). The major issue highlighted was a difference in approach to managing SD according to disease stage. More than half of the participants (56%) said ‘advanced stage of disease’ was a barrier to discussing SD. Clinicians were less likely to discuss SD, take baseline assessments, refer to a specialist clinic or offer rehabilitation when dealing with patients with advanced disease. Only a minority said that the management of SD was primarily their responsibility (11%). Nearly all clinicians (92%) had access to SD clinics; however, the majority of clinicians did not routinely refer patients. Conclusions This study shows that men with advanced prostate cancer need better support in managing SD. Patients receiving long‐term ADT are less likely to be offered any kind of help or intervention. Specific guidance on managing SD in this cohort may result in improvements in sexual function, emotional well‐being, quality of life, mental health and confidence

Identifying High Metallicity M Giants at Intragroup Distances with SDSS

Tidal stripping and three-body interactions with the central supermassive black hole may eject stars from the Milky Way. These stars would comprise a set of `intragroup' stars that trace the past history of interactions in our galactic neighborhood. Using the Sloan Digital Sky Survey DR7, we identify candidate solar metallicity red giant intragroup stars using color cuts that are designed to exclude nearby M and L dwarfs. We present 677 intragroup candidates that are selected between 300 kpc and 2 Mpc, and are either the reddest intragroup candidates (M7-M10) or are L dwarfs at larger distances than previously detected.Comment: 8 pages, 6 figures, 1 table (for full version, see http://astro.phy.vanderbilt.edu/~palladl2), Accepted for publication in A