Impact of the Covid-19 Pandemic Outbreak on Panic Buying Behavior in the FMCG Sector

There is no doubt that a very challenging market climate has been created by the crisis triggered by the global coronavirus pandemic. Many firms have faced partial and even extended stoppages, with employees facing financial uncertainties and concerns for months. Consumer behavior has been compelled involuntarily to alter their habit of consumption in a large scale. Distress over the delivery of the commodities has led many individuals to panic purchasing of vital materials in bulk quantities. The view of a long-term recession and financial instability will have a notable effect on customer expectations, outlook and actions. The current research attempts to analyze and quantify customer preferences, emotions and consumer behavior during the coronavirus crisis. The report also reflects on the transition in eating patterns after the outbreak of COVID-19. It will also examine and present the variations in eating habits and behavior across different genders and ages

A THERAPEUTIC APPROACH OF SUDHA VARGA DRAVYA W.S.R. TO GASTROINTESTINAL DISORDER

The human Gastro intestinal tract is responsible for transporting and digesting food stuffs, absorbing nutrients and expelling waste. Any interruption or change in physiology of GIT results in various disease like Hyperacidity, Peptic ulcer, duodenal ulcer, Irritable Bowel Syndrome, Gastro-Esophageal Reflux Disorder etc. In Ayurveda all these diseases comes under Annavaha Srotas Vikara. There are many treatment modalities available in Ayurveda but Sudha vargiya Dravyas describe in Rasa-shastra literature plays an important role in the treatment of GIT disorders. Bhasmas of Sudha vargiya Dravyas have attained importance in prevention and cure of conditions such as AmlaPitta (hyperacidity), Grahani (Irritable Bowel Syndrome), Annadrava shula (Gastric ulcer), Parinaam shula (Duodenal ulcer), Atisara (Diarrhoea) etc. Bhasmas are considered as nano medicine in Ayurveda which is therapeutically very potent in small dose, quick acting and without specific taste. All the drugs in Sudha Varga have calcium in compound form, as salt. Calcium has very essential role in physiology related to bone structure as well as regulation of Gastro intestinal secretions. As these having Sheet virya in all the Sudha vargiya Dravyas the acid neutralizing capacity is present due to higher pH value.

A REVIEW ON REFERENCES OF HERBOMINERAL PREPARATIONS IN BRUHATRAYEE

Ayurveda science has been explained in the form of Hetu, Linga and Aushadha, where Aushadha has been given the much importance as success of treatment depends upon the usage of medicine considering the dose, time as well as the forms of medicine. Various sources are available to be used in the form of medicines as Herbs, Metals/Minerals or Animal products. Processed Metals/ Minerals such as Copper, Lead, Mercury were used in Ancient times but as the time goes, there was a drop in the usage of Herbomineral preparations in practice considering the claims put on its safety. Bruhatrayee being the most ancient and authentic texts of Ayurveda provides ample of references regarding usage of Herbomineral preparations for treatment of various conditions

Formulation and Evaluation of Antimicrobial Potential of Glycerosomes Containing Allium sativum, Zingiber officinale Extracts

The aim of the present investigation is to evaluate the antimicrobial potential of A. sativum and Z. officinalis extracts mediated glycerosomes formulation by thin film of lipid hydration method.  The water content present in the A. sativum and Z. officinale was 42.3 and 27.2 % respectively. The yield of A. sativum and Z. officinale extract using ethanol as solvent through the Soxhlation process was found to be 4.7 ± 1.05 and 12.7 ± 1.108 % respectively. The crude drug of A. sativum and Z. officinale showed foreign organic was found to be 0.2 and 0.21 % and volatile oil was found to be 1.8 and 2.4 % only.  The ash study revealed that total, acid-insoluble, water-soluble, and sulfated ash values were for the crude drugs of A. sativum and Z. officinale. The ethanol extracts showed maximum extractive yield. The phytochemicals detected in A. sativum bulb ethanol extract are Alkaloids, Carbohydrates, Cardiac glycosides, Phenols, Sterols, Triterpenoids, Saponins, Flavonoids, and Fixed oils and in Z. officinale rhizome ethanol extract are Alkaloids, Carbohydrates, Cardiac glycosides, Anthraquinone glycosides, Proteins and Amino acids, Triterpenoids, Saponins, Flavonoid, and Fixed oils. The prepared glycerosome was spherical with a slightly irregular shape.  The negative potential of glycerosomes demonstrates the greater stability of the vesicular dispersion.  The ASEE glycerosome formulations (F1 and F2) exhibited better antibacterial activity and greater antifungal activity against the gram-negative bacteria in comparison with the ZOEE glycerosome formulations (F3 and F4).   The present research work strongly concluded that the A. sativum and Z. officinale and their glycerosome formulations are good candidate drugs and formulations for the safe and effective treatment of microbial infection

A COMPREHENSIVE STUDY OF KUSTHA (SAUSSUREA LAPPA (C.B. CLARKE) IN BRIHATTRAYI AND LAGHUTTRAYI

Brihattrayi (Greater triad) and Laghuttrayi (Lesser triad) are excellent, highly esteemed and extensively used sources of Ayurvedic knowledge. Brihattrayi comprises Charaka samhita, Sushruta samhita and Astanga Hridaya and Laghuttrayi comprises Madhava nidana, Sharangdhar samhita and Bhava prakasha. Ayurveda delineates the uses of Kustha (Saussurea lappa (C.B. Clarke) for the management of different diseased conditions. Most of the Samhita Grantha have mentioned it in the treatment of Kustha, Shvitra (skin disease), Vata vyadhi (epilepsy), Arsha (piles), Mutrakricha (difficulty in micturition), Jvara (fever) and Vrana prasadana (wound healing). This article reviews the various references of Kustha in Brihattrayi and Laghuttrayi, regarding its different formulations and its prime therapeutic indications

A study on clinical profile of patients presenting with adverse drug reaction: a hospital based prospective observational study

Background: The aim of the study was to study the clinical profile of patients presenting with adverse drug reaction.Methods: The study was conducted in the Department of Medicine, IGMC Shimla from 01 July 2015 to 30 June 2016. A total of 129 patients were included in this study. A detailed history was taken followed by examination of patients. The routine investigations were done and special investigations as per need. For analysis patients detail, suspected drugs and the adverse drug reactions caused by them were used.Results: Bleeding from various sites was the most common event (39.5%), followed by symptomatic hypoglycemia 22.5% of events and symptomatic hyponatremia in 16.3% events. Amongst various drug classes anticoagulants were the most commonly involved drug class followed by oral hypoglycaemic agents, diuretics and antiplatelets. Type A was predominant ADR constituting (97.7%) of total ADRs and only (2.3%) of ADRs were of type B. After causality assessment, majority 86 (66.6%) were probable related and large number 127 (98.3%) of ADRs were serious which recovered after hospitalization.Conclusions: Our study revealed that ADRs are frequent and are easily recognized in clinical practice and are mostly preventable. Most ADRs are due to the use of drugs with high toxicity for example, warfarin often results in bleeding. It also shows that careful drug monitoring in hospitals  may lead to reduction of many such ADRs, suggesting that some type A, ADRs may be due to inadequate monitoring of therapies and doses. This study will aid the development of interventions to reduce the impact of ADRs in hospital in-patients

In vitro Prebiotic Effects of Bamboo Shoots and Potato Peel Extracts on the Proliferation of Lactic Acid Bacteria Under Simulated GIT Conditions

The present study explored the possible prebiotic application of potato peel and bamboo shoot extracts for the proliferation of lactic acid bacteria (LAB) from diverse niches and their tolerance ability to simulated gastrointestinal tract (GIT) conditions was also examined. Initially, the complete 16S rDNA sequencing of selected isolates revealed them as Lactobacillus paracasei (6), Staphylococcus simulans (2), and Streptococcus thermophilus (1). Higher cell densities and rapid pH change were obtained from cultured media supplemented with BS (2%) and PP (2%) as a carbon source. Their higher tolerance and the lowest reducing sugar abilities were obtained for BS at pH 2.5 and 9.0, while at pH 3.5 and 8.0 for PP. The isolates were screened for additional functional and technological properties to harvest the most appropriate starter. The selected isolates harbored promising functional properties such as amylase presence, cell surface hydrophobicity, autoaggregation, proteolytic and lipolytic activity, antifungal action, as well as exopolysaccharide production. On the basis of these attributes, microencapsulated strain K3 was found resistant to gastrointestinal conditions after 2 h, resulting in significantly (p ≤ 0.05) improved survival compared to non-capsulated strain. The current approach presents an interesting economical strategy to modulate LAB through supplementation of plant-derived carbon sources as well as to enhance their survival under GIT

Tension capnothorax during laparoscopic transhiatal oesophagectomy – A case report

Minimally invasive transhiatal oesophagectomy (THE) is a common operative procedure for carcinoma of the oesophagus. This technique has many advantages over other surgical approaches to oesophagectomy. Common complications associated with THE are pulmonary in nature and can lead to increased morbidity and mortality. We present a case where a tension capnothorax developed during laparoscopic THE

The Effect of Cooling Temperature on Microstructure and Mechanical Properties of Al 6061-T6 Aluminum Alloy during Submerged Friction Stir Welding

Submerged friction stir welding (SFSW) is a new modification of friction stir welding. In this paper, 6 mm thick 6061Al-T6 alloy plates were welded using the friction stir technique under normal air and submerged water conditions at 108 mm/min welding speeds and a rotational rate of 900 rpm. The cooling water temperature in SFSW varied at 0 °C, 35 °C, and 80 °C to clarify the effect of water temperature. The characteristic hourglass-shaped stir zone was observed in the macrostructure of all the samples. All the samples exhibited defect-free joints. The results revealed that the finer grain size of 2.43 μm was at 0 °C. The macrostructure of SFSW joints separated into the shoulder-driven zone and pin-driven zone due to the low-temperature difference between the environment and water media and the high heat absorption capacity of the water, which caused a more substantial cooling rate during water-submerged welded joints. The microhardness distribution of all the joints showed typical “W” shape characteristics. The microhardness for all submerged samples was higher than in normal air conditions due to the higher thermal cycling effect in submerged conditions. Improved dynamic recrystallization in the joint welded at 80 °C resulted in the highest tensile strength (~249 MPa) and microhardness (~95 HV)