Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group

The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and presentation to T and B cells. This Report summarizes the key points of that discussion, and subsequent discussions with the Chairs of the other Enterprise Working Groups, the Enterprise Science Committee, the Enterprise Council and the broader scientific community during open sessions at scientific conferences

Readers and Reading in the First World War

This essay consists of three individually authored and interlinked sections. In ‘A Digital Humanities Approach’, Francesca Benatti looks at datasets and databases (including the UK Reading Experience Database) and shows how a systematic, macro-analytical use of digital humanities tools and resources might yield answers to some key questions about reading in the First World War. In ‘Reading behind the Wire in the First World War’ Edmund G. C. King scrutinizes the reading practices and preferences of Allied prisoners of war in Mainz, showing that reading circumscribed by the contingencies of a prison camp created an unique literary community, whose legacy can be traced through their literary output after the war. In ‘Book-hunger in Salonika’, Shafquat Towheed examines the record of a single reader in a specific and fairly static frontline, and argues that in the case of the Salonika campaign, reading communities emerged in close proximity to existing centres of print culture. The focus of this essay moves from the general to the particular, from the scoping of large datasets, to the analyses of identified readers within a specific geographical and temporal space. The authors engage with the wider issues and problems of recovering, interpreting, visualizing, narrating, and representing readers in the First World War

Voicing researched activists with responsive action research

Purpose: What it is like to experience being the subject of the research process when you are an actor within a new social movement organization? And what lessons can be learned for researchers engaging with members of New Social Movements? Debates on engagement and the relationship between the researcher and the researched so far have taken the perspective solely of the researcher. Based on insights gained by full participation in a horizontal worker cooperative, we aim at contributing to the facilitation of more fruitful, mutually engaging research relations between organizational theory scholars and members of New Social Movement organizations by voicing the researched in this debate. Design/methodology/approach: After providing some accounts from the researched point of view, the paper focuses on crafting an appropriate research process based on Participatory Action Research (PAR) ethos and experience. Findings: Since our research findings suggest that PAR combines elements that both trouble and inspire research participants, namely workload/availability and relevancy/contribution in practice, we introduce and provide a case study of Responsive Action Research (RAR) that emphasizes adaptation and responsiveness in the research process instead of shared governance. Originality/value: The originality of this article lies in voicing the research participants with the aim to aid both scholars and social movements adopt appropriate research designs for the mutual benefit of both theory/action and researchers/researched (even when researchers are already active in the field)

King's Framework and Theory in Japan, Sweden, and the United States

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71420/1/j.1547-5069.1995.tb00835.x.pd

Stellar Nucleosynthesis in the Hyades Open Cluster

We report a comprehensive light element (Li, C, N, O, Na, Mg, and Al) abundance analysis of three solar-type main sequence (MS) dwarfs and three red giant branch (RGB) clump stars in the Hyades open cluster using high-resolution and high signal-to-noise spectroscopy. For each group (MS or RGB), the CNO abundances are found to be in excellent star-to-star agreement. Our results confirm that the giants have undergone the first dredge-up and that material processed by the CN cycle has been mixed to the surface layers. The observed abundances are compared to predictions of a standard stellar model based on the Clemson-American University of Beirut (CAUB) stellar evolution code. The model reproduces the observed evolution of the N and O abundances, as well as the previously derived 12C/13C ratio, but it fails to predict by a factor of 1.5 the observed level of 12C depletion. Li abundances are derived to determine if non-canonical extra mixing has occurred in the Hyades giants. The Li abundance of the giant gamma Tau is in good accord with the predicted level of surface Li dilution, but a ~0.35 dex spread in the giant Li abundances is found and cannot be explained by the stellar model. Possible sources of the spread are discussed; however, it is apparent that the differential mechanism responsible for the Li dispersion must be unrelated to the uniformly low 12C abundances of the giants. Na, Mg, and Al abundances are derived as an additional test of our stellar model. All three elements are found to be overabundant by 0.2-0.5 dex in the giants relative to the dwarfs. Such large enhancements of these elements are not predicted by the stellar model, and non-LTE effects significantly larger (and, in some cases, of opposite sign) than those implied by extant literature calculations are the most likely cause.Comment: 40 pages, 6 figures, 6 tables; accepted by Ap

Assessing the UK policies for broadband adoption

Broadband technology has been introduced to the business community and the public as a rapid way of exploiting the Internet. The benefits of its use (fast reliable connections, and always on) have been widely realised and broadband diffusion is one of the items at the top of the agenda for technology related polices of governments worldwide. In this paper an examination of the impact of the UK government’s polices upon broadband adoption is undertaken. Based on institutional theory a consideration of the manipulation of supply push and demand pull forces in the diffusion of broadband is offered. Using primary and secondary data sources, an analysis of the specific institutional actions related to IT diffusion as pursued by the UK government in the case of broadband is provided. Bringing the time dimension into consideration it is revealed that the UK government has shifted its attention from supply push-only strategies to more interventional ones where the demand pull forces are also mobilised. It is believed that this research will assist in the extraction of the “success factors” in government intervention that support the diffusion of technology with a view to render favourable results if applied to other national settings

North Carolina's federalists in an evolving public sphere, 1790-1810

Frustrated by electoral defeat at the hands of Jefferson and his allies in 1800, North Carolina’s Federalists devised a plan in 1802 to send the Minerva, a Raleigh newspaper edited by William Boylan, to leading Federalists across the state. These Federalist leaders, including Duncan Cameron, William R. Davie, and Alfred Moore, all prominent politicians and lawyers, believed that the public mind had been corrupted by the newspaper propaganda of the Jeffersonian Republicans. The dissemination of the Minerva, however, could restore the public to a deferential position as well as increase their knowledge about the true state of political affairs. Though the newspapers found their way to each judicial district in North Carolina, they failed to transform the public sphere. The editor of the Minerva, William Boylan, increased the rancor of his partisan invective throughout 1802 and 1803, even though Federalist electoral success still remained elusive. Boylan also pursued the position of state printer, a job which he and his uncle had held for a number of years, but which had been given to Joseph Gales, an Englishman and Republican editor of the Raleigh Register. When Boylan failed to obtain the position of state printer in 1804, he became increasingly bitter toward Gales. When Gales accused Boylan of burning down the press of the Raleigh Register, Boylan responded by beating Gales savagely on the streets of Raleigh in 1804. Boylan, humbled in court by a fine in 1805, retreated from his former partisanship as his Federalist comrades abandoned him because of his attack on Gales. The Federalists, therefore, failed in their attempt to control the public sphere because they could not imitate Jeffersonian propaganda without betraying their conceptions of disinterestedness, virtue, and reason