First Record of the Poorly Known Skink Sphenomorphus oligolepis (Boulenger, 1914) (Reptilia: Squamata: Scincidae) from Seram Island, Maluku Province, Indonesia

Based on four specimens discovered in the collection of The Natural History Museum, London, United Kingdom, we present a new distribution record for the skink Sphenomorphus oligolepis for Seram Island, Maluku Province, Indonesia. This find constitutes the westernmost record for the species and extends its range by over 800 km. The species was heretofore only known from apparently isolated mainland New Guinean populations

MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling.

NK cells express variable receptors that engage polymorphic MHC class I molecules and regulate their function. Maternal NK cells accumulate at the maternal-fetal interface and can interact with MHC class I molecules from both parents. The relative contribution of the two sets of parental MHC molecules to uterine NK cell function is unknown. Here we show that, in mice, maternal and not paternal MHC educates uterine NK cells to mature and acquire functional competence. The presence of an additional MHC allele that binds more inhibitory than activating NK cell receptors results in suppressed NK cell function, compromised uterine arterial remodelling and reduced fetal growth. Notably, reduced fetal growth occurs irrespectively of the parental origin of the inhibitory MHC. This provides biological evidence for the impact of MHC-dependent NK inhibition as a risk factor for human pregnancy-related complications associated with impaired arterial remodelling.This work was supported by the Wellcome Trust, the Medical Research Council, the Centre for Trophoblast Research and the British Heart Foundation.This is the final version of the article. It first appeared from Nature Publishing Group at http://dx.doi.org/10.1038/ncomms4359

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus.

The placenta mediates the exchange of factors such as gases and nutrients between mother and fetus and has specific demands for supply of blood from the maternal circulation. The maternal uterine vasculature needs to adapt to this temporary demand and the success of this arterial remodeling process has implications for fetal growth. Cells of the maternal immune system, especially natural killer (NK) cells, play a critical role in this process. Here we describe a method to assess the degree of remodeling of maternal spiral arteries during mouse pregnancy. Hematoxylin and eosin-stained tissue sections are scanned and the size of the vessels analysed. As a complementary validation method, we also present a qualitative assessment for the success of the remodeling process by immunohistochemical detection of smooth muscle actin (SMA), which normally disappears from within the arterial vascular media at mid-gestation. Together, these methods enable determination of an important parameter of the pregnancy phenotype. These results can be combined with other endpoints of mouse pregnancy to provide insight into the mechanisms underlying pregnancy-related complications.This work was funded by The Wellcome Trust [094073/Z/10/Z], The Centre for Trophoblast Research and The British Heart Foundation.This is the author accepted manuscript. The final version is available from JOVE via http://dx.doi.org/10.3791/5353

First captive breeding of a night skink (Scincidae: Eremiascincus) from Timor-Leste, Lesser Sunda Islands, with remarks on the reproductive biology of the genus

We report two instances of captive breeding in a species of Timorese night skink (genus Eremiascincus Greer, 1979) in October and December 2012. Four and three neonates, respectively, with total lengths of ca 40 mm each, were discovered during routine maintenance of a terrarium, in which three adult animals (1 male, 2 females) were kept. The absence of eggshells in the terrarium and the unlikelihood of post-eclosion oophagy by the adults suggest that the reproductive mode of the species is viviparous. We also provide a summary of available information pertaining to the reproductive biology of other members of the genus Eremiascincus

An inconspicuous, conspicuous new species of Asian pipesnake, genus Cylindrophis (Reptilia: Squamata: Cylindrophiidae), from the south coast of Jawa Tengah, Java, Indonesia, and an overview of the tangled taxonomic history of C. ruffus (Laurenti, 1768)

We describe a new species of Cylindrophis currently known only from Grabag, Purworejo Regency, Jawa Tengah Province (Central Java), Java, Indonesia. Cylindrophis subocularis sp. nov. can be distinguished from all congeners by the presence of a single, eponymous subocular scale between the 3rd and 4th or 4th and 5th supralabial, preventing contact between the 4th or 5th supralabial and the orbit, and by having the prefrontal in narrow contact with or separated from the orbit. We preface our description with a detailed account of the tangled taxonomic history of the similar and putatively wide-ranging species C. ruffus, which leads us to (1) remove the name Scytale scheuchzeri from the synonymy of C. ruffus, (2) list the taxon C. rufa var. javanica as species inquirenda, and (3) synonymize C. mirzae with C. ruffus. We provide additional evidence to confirm that the type locality of C. ruffus is Java. Cylindrophis subocularis sp. nov. is the second species of Asian pipesnake from Java

Parâmetros de resfriamento de frutas e hortaliças de diferentes dimensões em um sitema com água fria

The cooling of fruits and vegetables in hydrocooling system can be a suitable technique. This work aimed to define cooling time for fruits and vegetables of different sizes, presenting practical indexes that could be used to estimate cooling time for produce with similar characteristics. Fruits (orange melon-Cucumis melo, mango-Mangifera indica, guava-Psidium guajava, orange-Citrus sinensis Osbeck, plum-Prunus domestica, lime-Citrus limon, and acerola-Prunus cerasus) and vegetables (cucumber-Cucumis sativus, carrot-Daucus carota, and green bean-Phaseolus vulgaris), were cooled in a hydrocooling system at 1°C. The volume of fruits and vegetables ranged between 8.18 cm³ and 1,150.35 cm³, and between 13.06 cm³ and 438.4 cm³, respectively. Cooling time varied proportionally to produce volume (from 8.5 to 124 min for fruits, and from 1.5 to 55 min, for vegetables). The relationship between volume and time needed to cool fruits (from 1.03 min cm-3 to 0.107 min cm-3) and vegetables (from 0.06 min cm-3 to 0.12 min cm-3) is an index that could be used to estimate cooling time for fruits and vegetables with similar dimensions as those presented in this work.O resfriamento com água gelada pode ser uma técnica adequada para frutas e hortaliças frescas. Este trabalho teve como objetivo obter o tempo de resfriamento de frutas e hortaliças de dimensões diferentes, e apresentar índices práticos que possam ser usados para estimar o tempo de resfriamento de produtos com características semelhantes. Frutas (melão-Cucumis melo, manga-Mangifera indica, goiaba-Psidium guajava, laranja-Citrus sinensis Osbeck, ameixa-Prunus domestica, limão-Citrus limon e acerola-Malpighia glabra) e hortaliças (pepino-Cucumis sativus, cenoura-Daucus carota e vagem-Phaseolus vulgaris), foram resfriadas num sistema por imersão em água à 1°C. O volume das frutas oscilou de 1150,35 cm³ a 8,18 cm³ e das hortaliças entre 438,4 cm³ a 13,06 cm³. O tempo de resfriamento variou proporcionalmente com o volume dos frutos, de 8,5 min até 124 min (frutas) e de 1,5 min até 55 min (hortaliças). Foi calculado o índice relacionando volume e tempo de resfriamento das frutas (1,03 min cm-3 a 0,107 min cm-3) e hortaliças (0,06 min cm-3 a 0,12 min cm-3), que pode ser usado para a estimativa do tempo de resfriamento de frutas e hortaliças com dimensões semelhantes.655658Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

Parâmetros de resfriamento de frutas e hortaliças de diferentes dimensões em um sitema com água fria

The cooling of fruits and vegetables in hydrocooling system can be a suitable technique. This work aimed to define cooling time for fruits and vegetables of different sizes, presenting practical indexes that could be used to estimate cooling time for produce with similar characteristics. Fruits (orange melon-Cucumis melo, mango-Mangifera indica, guava-Psidium guajava, orange-Citrus sinensis Osbeck, plum-Prunus domestica, lime-Citrus limon, and acerola-Prunus cerasus) and vegetables (cucumber-Cucumis sativus, carrot-Daucus carota, and green bean-Phaseolus vulgaris), were cooled in a hydrocooling system at 1°C. The volume of fruits and vegetables ranged between 8.18 cm³ and 1,150.35 cm³, and between 13.06 cm³ and 438.4 cm³, respectively. Cooling time varied proportionally to produce volume (from 8.5 to 124 min for fruits, and from 1.5 to 55 min, for vegetables). The relationship between volume and time needed to cool fruits (from 1.03 min cm-3 to 0.107 min cm-3) and vegetables (from 0.06 min cm-3 to 0.12 min cm-3) is an index that could be used to estimate cooling time for fruits and vegetables with similar dimensions as those presented in this work.O resfriamento com água gelada pode ser uma técnica adequada para frutas e hortaliças frescas. Este trabalho teve como objetivo obter o tempo de resfriamento de frutas e hortaliças de dimensões diferentes, e apresentar índices práticos que possam ser usados para estimar o tempo de resfriamento de produtos com características semelhantes. Frutas (melão-Cucumis melo, manga-Mangifera indica, goiaba-Psidium guajava, laranja-Citrus sinensis Osbeck, ameixa-Prunus domestica, limão-Citrus limon e acerola-Malpighia glabra) e hortaliças (pepino-Cucumis sativus, cenoura-Daucus carota e vagem-Phaseolus vulgaris), foram resfriadas num sistema por imersão em água à 1°C. O volume das frutas oscilou de 1150,35 cm³ a 8,18 cm³ e das hortaliças entre 438,4 cm³ a 13,06 cm³. O tempo de resfriamento variou proporcionalmente com o volume dos frutos, de 8,5 min até 124 min (frutas) e de 1,5 min até 55 min (hortaliças). Foi calculado o índice relacionando volume e tempo de resfriamento das frutas (1,03 min cm-3 a 0,107 min cm-3) e hortaliças (0,06 min cm-3 a 0,12 min cm-3), que pode ser usado para a estimativa do tempo de resfriamento de frutas e hortaliças com dimensões semelhantes

Composition, Development, and Function of Uterine Innate Lymphoid Cells.

Innate lymphoid cells (ILCs), including NK cells, contribute to barrier immunity and tissue homeostasis. In addition to the role of uterine NK cells in placentation and fetal growth, other uterine ILCs (uILCs) are likely to play roles in uterine physiology and pathology. In this article, we report on the composition of uILCs in the endometrium during the luteal phase and in the decidua during early pregnancy. Whereas nonkiller uILC1s and uILC2s are barely detectable in mouse and not detected in humans, a sizeable population of uILC3s is found in human endometrium and decidua, which are mostly NCR(+) and partially overlap with previously described IL-22-producing uterine NK cells. Development of mouse uILC3 is Nfil3 independent, suggesting unique features of uILCs. Indeed, although the cytokine production profile of mouse uILCs recapitulates that described in other tissues, IL-5, IL-17, and IL-22 are constitutively produced by uILC2s and uILC3s. This study lays the foundation to understand how ILCs function in the specialized uterine mucosa, both in tissue homeostasis and barrier immunity and during pregnancy.Work supported by grants from the Wellcome Trust, the Medical Research Council, the British Heart Foundation and the Leukaemia & Lymphoma Research to FC. EB is the recipient of a Centre for Trophoblast Research Graduate Studentship. SB is the recipient of a Marie Curie FP7 Fellowship.This is the final version of the article. It first appeared from the American Association of Immunologists via http://dx.doi.org/10.4049/​jimmunol.150068

Improved clinical data imputation via classical and quantum determinantal point processes

Imputing data is a critical issue for machine learning practitioners, including in the life sciences domain, where missing clinical data is a typical situation and the reliability of the imputation is of great importance. Currently, there is no canonical approach for imputation of clinical data and widely used algorithms introduce variance in the downstream classification. Here we propose novel imputation methods based on determinantal point processes that enhance popular techniques such as the Multivariate Imputation by Chained Equations (MICE) and MissForest. Their advantages are two-fold: improving the quality of the imputed data demonstrated by increased accuracy of the downstream classification; and providing deterministic and reliable imputations that remove the variance from the classification results. We experimentally demonstrate the advantages of our methods by performing extensive imputations on synthetic and real clinical data. We also develop quantum circuits for implementing determinantal point processes, since such quantum algorithms provide a computational advantage with respect to classical ones. We demonstrate competitive results with up to ten qubits for small-scale imputation tasks on a state-of-the-art IBM quantum processor. Our classical and quantum methods improve the effectiveness and robustness of clinical data prediction modeling by providing better and more reliable data imputations. These improvements can add significant value in settings where where high precision is critical, such as in pharmaceutical drug trials where our approach can provide higher confidence in the predictions made

Mecanismo de negociação por aprendizado por reforço no sequenciamento de decolagem de aeroportos

Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Instituto de Ciências Exatas, Departamento de Ciência da Computação, 2019.Aprendizado por Reforço busca ensinar um agente como se comportar a partir da experimentação do ambiente e aquisição de recompensas envolvidas no processo. Para isso, o agente mapeia os estados encontrados no ambiente, as ações possíveis em cada um destes estados e as recompensas da execução destas ações nestes estados. Em um ambiente de negociação, as configurações possíveis entre as partes podem ser descritas como estados do ambiente, com as ofertas realizadas entre os oponentes constituindo ações e os acordos encontrados gerando recompensas às partes. Este trabalho busca ensinar uma aeronave em espera pela utilização da pista de decolagem a negociar sua posição com as demais. O trabalho apresenta melhorias em relação aos modelos existentes para o problema de sequenciamento de decolagens e apresenta resultados positivos nos estudos de caso realizados.Reinforcement Learning aims to teach an agent how to behave using only the rewards received by exploring an environment. To achieve this, the enviroment is modeled in states, the available actions in each of these states and the associated rewards gained by executing these action. In a negotiation environment, the configurations between the stakeholders may be described as states of the enviroment, with offers done by each participant beign described as actions and the outcome of the negotiation, as rewards. This paper presents a model to teach aircrafts to negotiate their position in the queue for airport runway use. This papes presents improvements over the existing methods for aircraft departure scheduling and postive results in the case studies carried out