Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1-7. In man, six functional forms are expressed (TRPC1, TRPC3-7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion.Peer reviewe

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1–7. In man, six functional forms are expressed (TRPC1, TRPC3–7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion

Quality assurance of measurements in steam-condensate systems

Syftet med diplomarbetet är att göra en granskning av ång-kondensatsystem i sin helhet och göra en djupare analys av flödesmätningar i lågtrycksånga och möjliga kalibreringsmetoder, som inte förlitar sig på radioaktiva spårämnen. Ång-kondensatsystem är viktiga eftersom de spelar en stor roll i dagens och framtidens energiproduktion, -distribution och -konsumtion. Digitaliseringstrenden ställer krav på kvaliteten hos de mätdata som samlas in från allt mer invecklade processer, är den inte på en pålitlig nivå, kan ingen kontrollerad processoptimering utföras. Våt ånga orsakar de största utmaningarna för flödesmätning på grund av dess två-faskaraktär och ofta bristfällig kännedom av ångans kvalitet. Här granskas de vanligaste korrigerings-faktorerna för att kompensera för felvisningen av två-fasångflöden. Ur ett energitekniskt perspektiv granskas i diplomarbetet även vikten av tillvaratagandet på värme-energin i kondensatet och i expansionsångan. De inaktiva flödeskalibreringsmetoderna som testats och evaluerats är baserade på transit-tidmetoden med pulser försorsakade av temperatur- och syrekoncentration-ändringar genom att injicera tryckluft och kallvatten i ånglinjen respektive matarvattenlinjen. Temperaturpulsmetoden, vilken byggde på termoelement fästa på rörets utsida vid två detektionspunkter, gav en positiv indikation av att fungera som en flödesmätningsmetod. De facto, att detektionsutrustningen gick att installera på rörets utsida visade sig vara metodens främsta egenskap, då anslutningar inte finns tillgängliga i de flesta ånglinjer, vilket avsevärt försvårar tillämpningen av kemiska spårämnen. Temperaturpulsmetoden applicerades i såväl ånglinjen som matarvattenlinjen. Det systematiska felet i flödesmätningen i ånglinjen var 1.5%, men en stor standard-avvikelse, orsakad av ångans stora naturliga temperaturfluktuationer, resulterade i en total osäkerhet på 4.4%. Som referens till de utförda flödesmätningarna och strypflänsmätaren användes en massbalanskalkyl mellan ångmätarna och den tillförda energin till ångproduktionen. Luftpulsmetoden baserad på ändringar i syrekoncentrationen fungerade inte med den detektionsutrustning som användes. Detektionen av temperaturdifferens är inte lika precis som för radioaktivitet, det betyder att mätsträckan bör vara längre än vid användning av radioaktiva spårämnen. Den längre sträckan ökar dock osäkerheten eftersom det finns risk för rörsvängar, som komplicerar mätningen av rörvolymen.The aim of this master’s thesis work is to explain the whole picture of the steam-condensate system and measurements that it includes with a deeper insight to the flow measurements as well as inactive calibration methods for flow pressure steam. Steam-condensate systems are important as they play an essential role in production, distribution as well as consumption of energy, both today and in the future. The widening digitalization sets high quality requirements on the measurement data that is collected from increasingly complicated processes, without reliable data, no controlled process optimizing can be done. Wet steam causes the biggest challenges for the flow measurements because of its two-phase character and often inadequate knowledge of the steams quality. This work describes the most usual correcting factors for compensating the meters’ error. From an energy technological point of view, the importance of utilization of the heat energy in the return condensate and expansion steam is also reviewed. The inactive flow calibration methods developed and evaluated are based on the transit-time method and the pulses were induced using temperature and oxygen concentration differences by injecting compressed air and cold water to the steam and feed water pipes respectively. The result shows that the equipment for detecting the oxygen didn’t work for this purpose, but the temperature pulse method based on thermocouple temperature measurements on the pipe surface gave strong indications of being a desirable technique. One of the biggest benefits is that the detections can be made on the outside of the pipe, since most of the steam pipes are out of connections, which complicates the use of chemical tracers. The temperature pulse method had a total systematic uncertainty of 1.5%, but the turbulent steam temperature resulted in a large standard deviation, thus the total uncertainty was 4.4%. As a reference to the flow calibration methods and the orifice plate meters, the oil and electricity consumptions in the steam production were used. As the detection of the temperature difference is not as precise as of the activity, the measuring distance needs to be longer than with radioactive tracers. The longer distance, though, increases uncertainty as there might be pipe curvature that makes the volume measuring complicated

Perceptions of nurses on the medication errors in primary health care clinics in Greater Tzaneen Municipality of Limpopo Province, South Africa

Thesis (M. Pharmacy (Pharmacology)) -- University of Limpopo, 2019Background Previous studies have shown that medication errors are the most frequent cause of preventable morbidity in health care facilities. Although medication errors are inevitable, the determination of medication errors and their predisposing factors may pave a way of establishing mechanisms of reducing these errors to a minimum. In researching the relationship between possible contributing factors and medication errors, the safety of patients can be greatly enhanced and costs of healthcare reduced. Determining error types is the first step in preventing errors. The goal of the study was to fill the information gap that is there regarding medication errors in Primary Health Care. The objective was to determine the perceptions of nurses on the types of medication errors, the predisposing factors and the prevalence of medication errors at these PHC clinics. Methods A mixed method approach was used in this study, combining a quantitative descriptive research method together with a qualitative approach. The study was carried- out at PHC clinics in the Greater Tzaneen Municipality which has a total number of 40 clinics. The Greater Tzaneen Municipality health care professionals in these facilities were the subjects and questionnaires and field notes were used to collect the relevant data. All the health care professionals that participated in the study were from the nursing profession. The sample volume consisted of 63 health care professionals from nine randomly selected PHC facilities. Results The study identified different types of medication errors as per PHC staff perceptions. Some of the identified errors were as follows: no medication (49%), changing of medication (40%), wrong dose and incorrect documentation both at (27%) and dispensing omission (24%).It was found in the study that the more the experience and the higher the level of education the less likely was the chances of error commitment by the participants. v Predisposing factors in these institutions were found to be of personal and systematic nature. Some of these were identified as follows :Heavy workload(78%),lack of equipment(70%),insufficient training(63%) and poor medication supply system (52%).In terms of the frequency of occurrence of the medication errors, the findings for some of the most frequent errors were: No medication(22%),incorrect documentation(13%),changing of medication(8%),wrong duration of treatment(8%) and wrong time (8%).The findings for some of the moderate frequent medication errors were: Changing of medication(19%),frequency of medication(19%),no medication(14%),wrong duration of treatment(13%) and wrong medication (11%).Some of the least frequent errors were identified as :Changing of medication(32%),incorrect medication(24%),wrong dose (22%) and dispensing omission(21%). Conclusion Generally, medication errors and unsafe acts at PHC should be worrisome. Medication errors and their related predisposing factors or latent conditions, if not addressed may impair the attainment of primary health care goals of providing effective, efficient and accessible health care to communities if proper care is not taken to reduce medication errors to a minimum. Key words Medication error; Patient safety; Primary health car

Historia Magistra Vitae: Os Letrados Do Império E A História Nacional

O objetivo deste trabalho é discutir as relações que se estabeleceram entre a escrita da história nacional e a escrita biográfica no Brasil do século XIX. Ao buscar rastrear as possíveis referências dos letrados oitocentistas redefine-se, aqui, o problema da apropriação que estes homens de letras fizeram da tradição, uma vez que nomes como Cícero e Plutarco apareciam como parâmetro da produção letrada quando da constituição de um saber histórico sobre a pátria. Mira-se, portanto, neste trabalho, a possibilidade de articular os dois elementos – história e biografia –, que, juntos, conformam-se às demandas dos letrados oitocentistas na escrita da história nacional9294

The effects of rhododendron on salamander communities in the Nantahala Mountains

Rhododendron or great laurel is a common evergreen shrub found throughout eastern North America. Although native, rhododendron has been increasing in the Southern Appalachian Mountains landscape due to fire suppression, logging, and loss of the American chestnut. It now has the potential to affect a larger variety of ecosystems and species that it did historically. Salamanders of the family Plethodontidae are highly diverse in the Southern Appalachian Mountains. They are known to be sensitive to their environment and are often considered to be potential indicators of ecosystem changes. Rhododendron has known effects on plants, soil nutrients, and leaf litter macroinvertebrates. The expansion of rhododendron may play an important role in determining terrestrial and aquatic salamander community structure and population dynamics. This study aimed to see how rhododendron affects salamander communities in sites in the Nantahala Mountains of western North Carolina. Initially, four sites were chosen in the upper Nantahala River watershed to conduct a mark-recapture study. Sites were divided into two plots; one within a rhododendron thicket and one in the larger forest matrix, both alongside small streams. After collecting data in 2009, concerns from highly variable population estimates and differences in detection between rhododendron and non-rhododendron plots with the mark-recapture study led to methods being changed in 2010 to removal sampling to ameliorate these concerns. Population estimates from removal sampling varied greatly amongst sites and were not significantly different between rhododendron and non-rhododendron plots. Overall, red-legged and ocoee salamanders were the most abundant species across all sites. Rhododendron does not appear to have a net effect on salamander population sizes. Rhododendron does appear to reduce people’s ability to find salamanders and may have negative influences in studies that do not account for differences in detection between plots in and outside of rhododendron thickets

Judicialização da saúde: escolhas trágicas necessárias a uma correta categorização dos direitos para a oferta de soluções abrangentes

The judicialization of the right to health is a complex and growing phenomenon, in which citizens seek to guarantee access to treatments and medicines not available by the public health system through legal actions. Given this scenario, new mechanisms have emerged to assist and organize this judicialization process, such as the recognition of general repercussion by the Federal Supreme Court, which establishes a judgment necessary to establish a thesis to assist other judicial bodies in the analysis of complex demands. , mainly involving the right to health, involving procedures with new interinstitutional communication channels to produce a socially fair decision; the objectification of the processes initially proposed to satisfy subjective interests; the structuring of a system of precedents, stabilizing social expectations, with the binding of the Courts and first-degree judges. This dissertation investigates such mechanisms based on existing research, with a special focus on decisions of general repercussion handed down by the Federal Supreme Court (STF). The research examines the STF's performance in emblematic cases related to the right to health and how these decisions impact new judicialization mechanisms. The methodological approach includes a systematic review of the literature on health judicialization, analyzing studies that discuss the characteristics and effects of the new mechanisms created. The results reveal that the judicialization of the right to health has led to an overload of the judicial system and generated financial impacts for the State. Furthermore, an increase in the use of new mechanisms has been identified, such as the creation of technical chambers, admission of amicus curiae and the holding of public hearings, to facilitate the judicialization process. The analysis of decisions of general repercussion within the scope of the STF demonstrates a tendency towards recognition and protection of fundamental rights related to health, with the prevalence of the principle of human dignity and the right to life as foundations for decisions. However, there is also concern about the budgetary impact of legal demands on public health, which has led the STF to establish stricter criteria for granting high-cost medicines and treatments. Given these results, the dissertation proposes reflections on the balance between access to justice and the financial sustainability of the health system. It also suggests the need to improve dialogue mechanisms between the Executive, Legislative and Judiciary branches to seek more effective solutions to guarantee the right to health without overloading the judicial system. Furthermore, it highlights the importance of a holistic and multidisciplinary approach to tackling the problem, considering legal, political, economic and social aspects involved in the judicialization of the right to health.A judicialização do direito à saúde é um fenômeno complexo e crescente, no qual os cidadãos buscam garantir o acesso a tratamentos e medicamentos não disponibilizados pelo sistema público de saúde por meio de ações judiciais. Diante desse cenário, têm surgido novos mecanismos para auxiliar e organizar esse processo de judicialização, a exemplo do reconhecimento de repercussão geral pelo Supremo Tribunal Federal, que estabelece um julgamento necessário a fixação de uma tese para auxiliar as demais instâncias judiciais na análise de demandas complexas, envolvendo, principalmente o direito à saúde, envolvendo procedimentos com novos canais de comunicação interinstitucionais para a produção de uma decisão socialmente justa; a objetivação dos processos inicialmente propostos para a satisfação de interesses subjetivos; a estruturação de um sistema de precedentes, estabilizador das expectativas sociais, com a vinculação dos Tribunais e dos juízes de primeiro grau. Esta dissertação investiga tais mecanismos a partir de pesquisas existentes, com foco especial nas decisões de repercussão geral proferidas pelo Supremo Tribunal Federal (STF). A pesquisa examina a atuação do STF em casos emblemáticos relacionados ao direito à saúde e como essas decisões impactam os novos mecanismos de judicialização. A abordagem metodológica inclui uma revisão sistemática da literatura sobre judicialização da saúde, analisando estudos que discutem as características e os efeitos dos novos mecanismos criados. Os resultados revelam que a judicialização do direito à saúde tem levado a uma sobrecarga do sistema judiciário e gerado impactos financeiros para o Estado. Além disso, identifica-se um aumento na utilização de novos mecanismos, como a criação de câmaras técnicas, admissão de amicus curiae e a realização de audiências públicas, para facilitar o processo de judicialização. A análise das decisões de repercussão geral no âmbito do STF demonstra uma tendência de reconhecimento e proteção dos direitos fundamentais relacionados à saúde, com a prevalência do princípio da dignidade da pessoa humana e o direito à vida como fundamentos para as decisões. Contudo, verifica-se também uma preocupação com o impacto orçamentário das demandas judiciais sobre a saúde pública, o que tem levado o STF a estabelecer critérios mais rigorosos para a concessão de medicamentos e tratamentos de alto custo. Diante desses resultados, a dissertação propõe reflexões sobre o equilíbrio entre o acesso à justiça e a sustentabilidade financeira do sistema de saúde. Também sugere a necessidade de aprimorar os mecanismos de diálogo entre os Poderes Executivo, Legislativo e Judiciário para buscar soluções mais efetivas para a garantia do direito à saúde sem sobrecarregar o sistema judiciário. Ademais, destaca a importância de uma abordagem holística e multidisciplinar para o enfrentamento do problema, considerando aspectos jurídicos, políticos, econômicos e sociais envolvidos na judicialização do direito à saúde.São Cristóvã

Análisis de viabilidad técnica y económica de la compactación dinámica para la mejora de suelos en Sapallanga, 2022

El propósito de este estudio fue evaluar el efecto de la compactación dinámica y las inclusiones duras en la mejora técnica y económica del suelo. Estas técnicas han mejorado significativamente las propiedades geotécnicas de los suelos en su estado natural, como la capacidad portante, la reducción de los niveles de hundimiento y la evitación de fenómenos de licuefacción. La compactación dinámica (D.C.) es una técnica desarrollada en Europa y utilizada con buenos resultados en América del Sur. Propiedades Mecánica de Suelos. Detallaremos un caso práctico del C.D. Cómo se lleva a cabo el proceso de mejoramiento de suelos en el Perú. Las propiedades antes y después del análisis mediante ensayos de campo y laboratorio, avalados por la especificación técnica vigente (N.T.E. 050), estos suelos son finos y colapsables, con una capacidad portante inicial de 0,80 Kg/cm2, con esta tecnología evaluamos cómo mejoro el valor anterior y redujo significativamente la sedimentación. A partir de las inclusiones rígidas se estableció un modelo teórico para evaluar las propiedades del suelo en situaciones reales. En base a los resultados obtenidos en ambos casos, se procedió a evaluar y comparar técnicamente, teniendo en cuenta tiempo y costo, para obtener conclusiones y recomendaciones para la aprobación de los objetivos de este trabajo

ANALISIS COMPARATIVO ENTRE XEN SERVER Y VMWARE SERVER PARA LOS SERVIDORES VISUALES DE LA EMPRESA DE GENERACIÓN HUALLAGA S.A.

El principal objetivo del presente trabajo de investigación es realizar un estudio comparativo de las plataformas Xen Server y VMware Server para su posterior implementación en la institución. El análisis comparativo se realizó de la siguiente manera: Estudio de las plataformas de virtualización, diseño y realización de pruebas de rendimiento, Análisis de los resultados obtenidos, Comparar las plataformas en base a los resultados Este trabajo de suficiencia profesional estudiara las cualidades de dos plataformas de virtualización es de enfoque cualitativo, reúne las características de una investigación exploratoria, el diseño que se adoptó para esta investigación será la explicativa. En base a las pruebas realizadas se estudiaran los resultados obtenidos y se contrastarán las conclusiones.Trabajo de suficiencia profesiona

Katalog Induk Daerah Daerah Istimewa Yogyakarta No. 54 Tahun 2024

Katalog Induk Daerah DIY No. 54 Tahun 2024 memuat koleksi bahan pustaka yang dimiliki 29 anggota jaringan perpustakaan di DIY. Jumlah entri yang tercantum dalam KID adalah 16.841 entri, terbagi dalam tiga jilid, yaitu Jilid I memuat 6.039 entri; Jilid II memuat 5.393 entri dan Jilid III memuat 5.409 entri