236 research outputs found
POSSIBLE PROTECTIVE ROLE OF SODIUM SALICYLATE NANOEMULSION AND GINGER ON CISPLATIN‑INDUCED HEPATOTOXICITY IN RATS (BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY)
Objective: To describe the preparation and characterization of nanoemulsion of sodium salicylate loaded butane tetracarboxylic acid (Bt-Sc-NPs). It also investigates the possible protective effects of Bt-Sc-NPs and\or medicinal plant ginger to evaluate the changes of liver functions, oxidative stress and histopathological investigations against cisplatin-induced hepatotoxicity.
Methods: Serum was used to determine alanine aminotransferase (ALT), aspartate aminotransferase (AST), δ-glutamyl transferase (δGT), serum human laminin (LN) and tissue inhibitors of metalloproteinase1 (TIMP1). Liver tissue samples collected from the rats were used for the measurement of malondialdehyde (MDA), nitric oxide (NO) and paraoxonase 1 (PON1).
Results: The beneficial effects of Bt-Sc-NPs with its anti-inflammatory effect and the medicinal ginger with its antioxidant effect were observed. Injection of rats with cisplatin significantly increased serum ALT, AST, ɤGT, TIMP1 and LN. It also increased cisplatin-induced oxidative stress by a significant elevation in liver MDA, NO content; however, a significant decrease of PON1 content. While protection with Bt-Sc-NPs or ginger significantly improved these parameters. In addition, combination of both Bt-Sc-NPs and ginger significantly induced a decrease in serum ALT, AST, ɤGT, TIMP1 and LN. It also reduced cisplatin-induced oxidative stress by the significant reduction in liver MDA, NO content and elevation of PON1 content much more than protection with Bt-Sc-NPs or ginger alone.
Conclusion: Bt-Sc-NPs were synthesized using nanoemulsion with the help of homogenization and ultra-sonication waves. Combination with both of Bt-Sc-NPs and ginger showed a hepatoprotective role in ameliorating cisplatin‑induced hepatotoxicity due to their anti-inflammatory and antioxidant effects
The ratio of proton's electric to magnetic form factors measured by polarization transfer
The ratio of the proton's elastic electromagnetic form factors was obtained
by measuring the transverse and longitudinal polarizations of recoiling protons
from the elastic scattering of polarized electrons with unpolarized protons.
The ratio of the electric to magnetic form factor is proportional to the ratio
of the transverse to longitudinal recoil polarizations. The ratio was measured
over a range of four-momentum transfer squared between 0.5 and 3.5 GeV-squared.
Simultaneous measurement of transverse and longitudinal polarizations in a
polarimeter provides good control of the systematic uncertainty. The results
for the ratio of the proton's electric to magnetic form factors show a
systematic decrease with increasing four momentum squared, indicating for the
first time a marked difference in the spatial distribution of charge and
magnetization currents in the proton.Comment: 5 pages, 2 figures, version of paper after corrections due to
referees comments and shortened by removing one figure for Physical Review
Letter
Virtual Compton Scattering and the Generalized Polarizabilities of the Proton at Q^2=0.92 and 1.76 GeV^2
Virtual Compton Scattering (VCS) on the proton has been studied at Jefferson
Lab using the exclusive photon electroproduction reaction (e p --> e p gamma).
This paper gives a detailed account of the analysis which has led to the
determination of the structure functions P_LL-P_TT/epsilon and P_LT, and the
electric and magnetic generalized polarizabilities (GPs) alpha_E(Q^2) and
beta_M(Q^2) at values of the four-momentum transfer squared Q^2= 0.92 and 1.76
GeV^2. These data, together with the results of VCS experiments at lower
momenta, help building a coherent picture of the electric and magnetic GPs of
the proton over the full measured Q^2-range, and point to their non-trivial
behavior.Comment: version 2: modified according to PRC Editor's and Referee's
recommendations. Archival paper for the E93-050 experiment at JLab Hall A. 28
pages, 23 figures, 5 cross-section tables. To be submitted to Phys.Rev.
The reaction dynamics of the 16O(e,e'p) cross section at high missing energies
We measured the cross section and response functions (R_L, R_T, and R_LT) for
the 16O(e,e'p) reaction in quasielastic kinematics for missing energies 25 <=
E_miss <= 120 MeV at various missing momenta P_miss <= 340 MeV/c. For 25 <
E_miss < 50 MeV and P_miss \approx 60 MeV/c, the reaction is dominated by
single-nucleon knockout from the 1s1/2-state. At larger P_miss, the
single-particle aspects are increasingly masked by more complicated processes.
For E_miss > 60 MeV and P_miss > 200 MeV/c, the cross section is relatively
constant. Calculations which include contributions from pion exchange currents,
isobar currents and short-range correlations account for the shape and the
transversity but only for half of the magnitude of the measured cross section.Comment: 6 pages, 4 figures, submitted to Phys Rev Lett, formatting error
fixe
Backward electroproduction of pi0 mesons on protons in the region of nucleon resonances at four momentum transfer squared Q**2 = 1.0 GeV**2
Exclusive electroproduction of pi0 mesons on protons in the backward
hemisphere has been studied at Q**2 = 1.0 GeV**2 by detecting protons in the
forward direction in coincidence with scattered electrons from the 4 GeV
electron beam in Jefferson Lab's Hall A. The data span the range of the total
(gamma* p) center-of-mass energy W from the pion production threshold to W =
2.0 GeV. The differential cross sections sigma_T+epsilon*sigma_L, sigma_TL, and
sigma_TT were separated from the azimuthal distribution and are presented
together with the MAID and SAID parametrizations.Comment: 17 pages, 11 figures, information can be found at
http://hallaweb.jlab.org/experiment/E93-050/vcs.html updated content about
SAID analysis updated MAID results following new reference nucl-th/0310041
updated figure
Large Momentum Transfer Measurements of the Deuteron Elastic Structure Function A(Q^2) at Jefferson Laboratory
The deuteron elastic structure function A(Q^2) has been extracted in the Q^2
range 0.7 to 6.0 (GeV/c)^2 from cross section measurements of elastic
electron-deuteron scattering in coincidence using the Hall A Facility of
Jefferson Laboratory. The data are compared to theoretical models based on the
impulse approximation with inclusion of meson-exchange currents, and to
predictions of quark dimensional scaling and perturbative quantum
chromodynamicsComment: Submitted to Physical Review Letter
Precision Determination of the Neutron Spin Structure Function g1n
We report on a precision measurement of the neutron spin structure function
using deep inelastic scattering of polarized electrons by polarized
^3He. For the kinematic range 0.014<x<0.7 and 1 (GeV/c)^2< Q^2< 17 (GeV/c)^2,
we obtain at an average . We find relatively large negative
values for at low . The results call into question the usual Regge
theory method for extrapolating to x=0 to find the full neutron integral
, needed for testing quark-parton model and QCD sum rules.Comment: 5 pages, 3 figures To be published in Phys. Rev. Let
Display of probability densities for data from a continuous distribution
Based on cumulative distribution functions, Fourier series expansion and
Kolmogorov tests, we present a simple method to display probability densities
for data drawn from a continuous distribution. It is often more efficient than
using histograms.Comment: 5 pages, 4 figures, presented at Computer Simulation Studies XXIV,
Athens, GA, 201
Virtual Compton Scattering and Neutral Pion Electroproduction in the Resonance Region up to the Deep Inelastic Region at Backward Angles
We have made the first measurements of the virtual Compton scattering (VCS)
process via the H exclusive reaction in the nucleon resonance
region, at backward angles. Results are presented for the -dependence at
fixed GeV, and for the -dependence at fixed near 1.5 GeV.
The VCS data show resonant structures in the first and second resonance
regions. The observed -dependence is smooth. The measured ratio of
H to H cross sections emphasizes the different
sensitivity of these two reactions to the various nucleon resonances. Finally,
when compared to Real Compton Scattering (RCS) at high energy and large angles,
our VCS data at the highest (1.8-1.9 GeV) show a striking -
independence, which may suggest a transition to a perturbative scattering
mechanism at the quark level.Comment: 20 pages, 8 figures. To appear in Phys.Rev.
The effects of ZrO2 nanoparticles on physical and mechanical properties of high strength self compacting concrete
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