DISTURB SLEEP IS A PATHOLOGICAL CONDITION THAT DISRUPTED THE HEALTH-AN AYURVEDIC APPROACH WITH CONTEMPORARY VIEW

Sleep is thought to have powerful restoratives properties. Sleep deprivation in human is widely believe to impact in health system, and is a well known risk factor for development of many diseases. All most all individual suffer from disturb sleep at least one occasion in his life time. Ayurveda describe sleep (Nidra) as a basic need like food and copulation. It is inevitable of all living being like death. Anidra (Disturb sleep) include any kind of abnormal sleep in respect of amount and quality in classical text of Ayurveda. Anidra has been described under the heading of causative factor, premonitory symptom, clinical feature, complication and bad prognostic sign of many diseases and as a disease itself in classical texts. Contemporary science also regarded disturb sleep is one of the pathological condition that distorted homeostasis. All major physiological systems affected by it. Disturb sleep alter the neurological, behavioral, metabolic as well as immune response. The circadian clock controls most hormone secretion and sleep has a major impact on it. Disturb sleep hampered the metabolism of many hormone and there secretions also. Sound sleep is a major criterion for maintenance of normal health. This review is try to illustrate how disturb sleep affect the health and its acute as well as chronic consequences

A STUDY ON ANIDRA WITH SPECIAL REFERENCE TO EFFECT OF BOERHAVIA DIFFUSA (SWETA PUNARNAVA) ON CERTAIN BIO CHEMICAL ALTERATION INDUCED BY SLEEP DEPRIVATION IN RAT

Anidra (disturb sleep) remain a significant health problem in the all age group especially in the elder people till date. Free radical reactions have been implicated in the pathology of many diseases. Sleep deprivation has recently been reported to causes oxidative stress and produces free radicals. B.diffusa has potent anti oxidant activity. The present study was conducted to assess the effect of Boerhavia diffusa (Sweta punarnava) decoction on certain bio chemical alteration induced by sleep deprivation in albino rat. The biochemical study revealed that the enzymatic and non enzymatic anti oxidant in B.biffusa exhibit preventive role to maintains the cell survival, cellular interaction and also maintain the cell membrane architecture. Oxidative stress plays an important role in the patho-physiology of sleep deprivation, and it indicate that the enhancement of oxidative biomarker (Total Glutathione concentration, M.D.A in terms of lipid per oxidation) indicate that chronic sleep deprivation would actually contribute to oxidative stress, but the present study concluded that scientific evaluation of this plant on disturbed sleep is unclear and it has definite role to check oxidative stress

A CLINICAL STUDY ON GUDUCHI SATTAVA (STARCH OBTAIN FROM STEM OF TINOSPORA CORDIFOLIA) IN MADHUMEHA W.S.R. TO DIABETES MELLITUS TYPE II

Madhumeha (Type 2 Diabetes Mellitus) is a global burden. At present, it occupies significant position among non-communicable diseases. It is a major cause of mortality and morbidity in middle age group people. Alterations in metabolism have been main culprit in the pathology of Type 2 Diabetes Mellitus. There are several challenges in diabetes management, including a rising prevalence in urban and rural areas, lack of disease awareness among the public, limited health care facilities, high cost of treatment, suboptimal glycemic control and rising prevalence of diabetic complications. India has to take drastic and urgent steps to develop an integrated national system for early detection and prevention and better management of Diabetes Mellitus. The present clinical study conducted to evaluate the effectiveness of Guduchi sattava in reliving the symptoms of hyperglycemia. Fifty newly diagnosed Madhumeha patients of either sex in the age group of 30-70 years are included in this study. Guduchi sattava (1g daily) are given orally for 90 days with plan water with and without diet restriction and exercise. Type 1Diabetes Mellitus, Diabetes Mellitus with pregnancy, Gestational diabetes etc are excluded here. All patients are evaluated based on clinical features, and laboratory parameters like-blood glucose level, lipid profile and HbA1C. The present study concluded that Guduchi sattava has definite hypoglycemic effect and more effective on fasting glucose level then postprandial glucose along with diet and exercise

EVALUATION OF EFFICACY OF AROHANAKRAMA SNEHAPANA AND VIRECHANA IN THE MANAGEMENT OF ADHOGAAMLAPITTA

Amlapitta is one of the leading problems of new era due to irregular and improper diet, dietetics and stressful life style. It is a very common disorder of Annavahasrotasa caused by Vidagdha Pitta with features like, Abipaka (indigestion), Klama (fatigue), Utklesha (nausea), Tikta-Amlodgara (sour or bitter eructation), Gourava (heaviness), Hritkanthadaha (heart burn), Aruchi (anorexia) etc., Amlapitta include acid peptic disorders (APD)- gastroesophageal reflux disease (GERD), Peptic ulcer diseases (PUD), dyspepsia and functional disorder of GI tract, In the present study, aimed to compare the efficacy of Jeerakadya Ghrita Arohanakrama Snehapana (increasing order) followed by Virechana with Trivrit Churnaadi yoga and Patolashunti Ghrita Arohanakrama Snehapana followed by Virechana with Trivritchurnadi yoga in the management of Adhoga Amlapitta. Material and methods: A minimum of 30 patients suffering from Adhoga Amlapitta were selected in 2 groups, 15 patients in each group. Group A- 15 patients were given Jeerakadya Ghrita Arohanakramasnehapana and Virechana. Group B-15 patients were given Patolashunti Ghrita Arohanakramasnehapana and Virechana. Follow up for 14 days (Patients will be assessed clinically on day 0, 7th day & 14th day). Total study duration is 35days. Virechana is highly significant on all the parameters, except Bhrama at both the phases. Statistical analysis of Group A and Group B are showing same result, but there will be reduction percentage in sign and symptoms like Agnimagda, Trishna, Hrillasa, Bhrama, Vividhavarnayoukta Malapravritti Group A is given better result

A CRITICAL STUDY ON KARYA- KARAN VADA IN RELATION TO GRAM NEGATIVE MICRO-ORGANISM IN UTI

The doctrine of cause & effect (Karya-Karana Vada) is well versed and common in ancient Indian Philosophy Sankhya Darsana which is clinically adopted in Ayurveda. Karya-Karana Sidhanta is applicable for both Swastha and Vikara avastha. Therefore the study was conducted to evaluate the critical doctrine of Cause and Effect in the light of its clinical entity, and the efficacy of Padma (Nelumbium speciousum Willd), Priyangu (Callicarpa macrophylla Vahi) and Agnimantha (Premna intergrifolia Linn) on gram negative organisms to establish the stipulated doctrine i.e. Karya-Karana Vada. This was a in-vitro study conducted on the microorganisms causing UTI commonly E. coli sp. and Klebsiella sp. The Bacteria Escherichi colli species and Klebsiella species were collected separately from the stock culture of Pathology Laboratory. Crude and Sterile Plant extract of above plant are used for the study. The crude and the sterile extract of the selected plants named Padma, Priyangu and Agnimantha are effective to inhibit the zone of colonisation of E.coli & Klebsiella in varying degree. These studies were performed in triplicate. This study concluded that micro organism enter into the bladder and kidney through urethra or any others means, they multiply in urine and change urine pH, causes Urinary Tract Infection. The responsible above said two gram negative micro-organism may or may not produce UTI, it depends upon the potentiality causative factors as justified in the doctrine of Cause and Effect (Karya-Karana Vada), and above mention three herbs shows significant anti microbial activities

STUDIES ON RUKSHA GUNA OF VATA DOSHA AND VALIDATION OF ITS ASSESSMENT CRITERIA

Guna (attribute) is one of the causes for the efficacy of any substance and is inseparable concomitance with substance. Ruksha guna is one of the Vata gunas perform the action of Dosha soshana karma (absorption). In broad perspective Soshana karma may be taken as the exchange of various materials in between the cell and respective environment. No study in context to the assessment of Ruksha guna has yet been carried out in modern perspective in the field of Ayurveda. The present study, was planned to evaluate the etymological and syntactical derivation of the Guna of Vata dosha, the biophysical and molecular basis of the Ruksha guna. and to validate the assessment criteria of Ruksha guna. For the assessment of Ruksha guna, observed the relative changes in the skin pH and skin moister with the level of vascular osmolality. These parameters are indicators of skin hydration in both healthy (with Dhatu samya lakshana) and Twaka rukahata condition (as patient with Rakta kshaya lakahana). Comparing the relation of skin pH and skin hydration along with vascular osmolality in both group to reveal the relation between osmolality and Rukstwa (roughness) the study was conducted. The study concluded that Ruksha guna of Vata dosha is critical requirement to make cell alive or to sustain the cellular homeostasis by its absorption and transport mechanism. Rakta kshaya may be correlated with decrease in the amount of circulatory hemoglobin in plasma. Rukshatwa therefore correlate with plasma osmolality and assessed by skin pH and hydration

Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

Background The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include hematological malignancies in Bangladesh. Methods This was a multi-center hospital-based retrospective descriptive study of over 5000 confirmed hematological cancer cases in between January 2008 to December 2012. Morphological typing was carried out using the “French American British” classification system. Results A total of 5013 patients aged between 2 to 90 years had been diagnosed with malignant hematological disorders. A 69.2% were males (n = 3468) and 30.8% females (n = 1545), with a male to female ratio of 2.2:1. The overall median age at diagnosis was 42 years. Acute myeloid leukemia was most frequent (28.3%) with a median age of 35 years, followed by chronic myeloid leukemia with 18.2% (median age 40 years), non-Hodgkin lymphoma (16.9%; median age 48 years), acute lymphoblastic leukemia (14.1%; median age 27 years), multiple myeloma (10.5%; median age 55 years), myelodysplastic syndromes (4.5%; median age 57 years) and Hodgkin’s lymphoma (3.9%; median age 36 years). The least common was chronic lymphocytic leukemia (3.7%; median age 60 years). Below the age of 20 years, acute lymphoblastic leukemia was predominant (37.3%), followed by acute myeloid leukemia (34%). Chronic lymphocytic leukemia and multiple myeloma had mostly occurred among older patients, aged 50-over. Conclusions For the first time, our study presents the pattern and distribution of diagnosed hematological cancers in Bangladesh. It shows differences in population distributions as compared to other settings with possibly a lower presence of non-Hodgkin lymphoma. There might be under-reporting of affected women. Further studies are necessary on the epidemiology, genetics and potential environmental risk factors within this rapidly aging country

Thalassemias in South Asia:clinical lessons learnt from Bangladesh

Abstract Thalassemias are emerging as a global public health concern. Due to remarkable success in the reduction of childhood mortality by controlling infectious diseases in developing countries, thalassemias are likely to be a major public health concern in the coming decades in South Asia. Despite the fact that Bangladesh lies in the world’s thalassemia belt, the information on different aspects (epidemiology, clinical course, mortality, complications and treatment outcomes) of thalassemias is lacking. In this comprehensive review, the aim is to to depict the epidemiological aspects of thalassemias, mutation profile and current treatment and management practices in the country by sharing the experience of dealing with 1178 cases over 2009–2014 time periods in a specialized thalassemia treatment centre. We have also discussed the preventative strategies of thalassemias from the context of Bangladesh which could be effective for other developing countries