CATEGORY OF MODALITY IN ENGLISH AND TATAR PROVERBS: COMPARATIVE ASPECT

Purposes: The article discusses one of the most significant and contradictory categories in linguistics, the category of modality, using the proverbs of two different structural languages like English and Tatar. Methodology: The basic methods of scientific research are the statistics method, method of comparative and quantities analyses of the data, method of description. Implications/Applications A systematic study of the complex of multilevel means of expressing the category of modality will help to study the mechanism of action of this category as a functional-semantic subsystem of the language, to determine its essence, volume and boundaries in such different structural languages as English and Tatar. Results: The results of the study allow us to conclude that the representation of the category of modality is similar in languages ​​of different structures, which may become the basis for assuming the similarity of semantic processes in both languages. Novelty: The problem of determining modality is still debatable, and research on how to express it in different languages is relevant. The authors give a classification of the selected proverbs; determine the criteria for comparison, on the basis of which determine the general and various ways of expressing modality in folklore texts

Hands-on management : theoretical and methodological approaches and Russian practice of state and municipal management

The work considers basic scientific and theoretical, and applied aspects of state and municipal management in Russia, and “hands-on” management as a separate method of management impact used by all levels of state and local authorities. The authors analyze reasons, legal basis, legitimacy, forms and methods of applying “hands-on procedures” in the management process, and estimate the level of their impact on social and economic life of the contemporary Russian society. The article defines the notion hands-on management and predicts possible consequences of expanding the practice of “hands-on procedures” both in the medium and long-term perspective.peer-reviewe

Additional files for paper "Plasma metabolome signature in patients with early-stage Parkinson disease".

<div>Patients.pdf - Clinical characteristics of patients.          </div><div>Mass list.zip - Mass lists.</div>Mass spectra.zip - Mass spectra in mzXL format. <div>Mass spectra.tif - Mass spectra (screenshots) of the metabolites listed in the Table 2.<br><div><br></div></div

Clinical and genetic characteristics of late-onset Huntington's disease

Background: The frequency of late-onset Huntington's disease (&gt;59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P &lt;.001). Overall motor and cognitive performance (P &lt;.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P &lt;.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P &lt;.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P &lt;.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients