Noncontact no-moving parts surface height measurement sensor using liquid crystal-based axial scanning confocal optical microscopy

An analog liquid crystal lens-based axial scanning confocal microscope is demonstrated as a 48 &mgr;m continuous range optical height measurement sensor used to characterize a 2.3 &mgr;m height Indium Phosphide twin square optical waveguide chip

Robust, Resilient and Reliable Architecture for V2X Communication

The new developments in mobile edge computing (MEC) and vehicle-to-everything (V2X) communications has positioned 5G and beyond in a strong position to answer the market need towards future emerging intelligent transportation systems and smart city applications. The major attractive features of V2X communication is the inherent ability to adapt to any type of network, device, or data, and to ensure robustness, resilience and reliability of the network, which is challenging to realize. In this work, we propose to drive these further these features by proposing a novel robust, resilient and reliable architecture for V2X communication based on harnessing MEC and blockchain technology. A three stage computing service is proposed. Firstly, a hierarchcial computing architecture is deployed spanning over the vehicular network that constitutes cloud computing (CC), edge computing (EC), fog computing (FC) nodes. The resources and data bases can migrate from the high capacity cloud services (furthest away from the individual node of the network) to the edge (medium) and low level fog node, according to computing service requirements. Secondly, the resource allocation filters the data according to its significance, and rank the nodes according to their usability, and selects the network technology according to their physical channel characteristics. Thirdly, we propose a blockchain-based transaction service that ensures reliability. We discussed two use cases for experimental analysis, plug- in electric vehicles in smart grid scenarios, and massive IoT data services for autonomous cars. The results show that car connectivity prediction is accurate 98% of the times, where 92% more data blocks are added using micro-blockchain solution compared to the public blockchain, where it is able to reduce the time to sign and compute the proof-of-work (PoW), and deliver a low-overhead Proof-of-Stake (PoS) consensus mechanism. This approach can be considered a strong candidate architecture for future V2X, and with more general application for everything- to-everything (X2X) communications

Use of 450-808 nm diode lasers for efficient energy absorption during powder bed fusion of Ti6Al4V

The additive manufacturing process selective laser melting (SLM) uses a powder bed fusion approach to fully melt layers of powdered metal and create 3D components. Current SLM systems are equipped with either single or multiple (up to four) high-power galvo-scanning infrared fibre laser sources operating at a fixed wavelength of 1064 nm. At this wavelength, a limited laser energy absorption takes place for most metals (e.g. alloys of aluminium have less than 10% absorption and titanium 50-60% absorption). The lower absorption of 1064-nm laser sources requires higher laser powers to compensate for the loss of energy due to reflectivity and fully melt the feedstock material. This makes the use of 1064-nm lasers within current powder bed fusion SLM systems energy inefficient. Further to this, there is limited potential for scale-up of these laser sources within an SLM system architecture due to physical space requirements and high economic cost, placing further limitations on current state-of-the-art SLM productivity. This research investigates the use of low power, highly scalable fibre coupled diode laser sources and the influence of shorter laser wavelengths (450–808 nm) on material absorption and processing efficiency using a diode area melting (DAM) approach. It was found that when processing Ti6Al4V, absorption was 11% higher using 450-nm lasers when compared to using 808-nm lasers and 14% higher than 1064-nm lasers. The maximum powder bed temperature for irradiation at 450 nm and 808 nm was 1920 0C and 1760 0C respectively when using only 3.5 W of laser power. Due to the speed at which the DAM process scans the powder bed, the melt pool cooling rate was much slower (750–1400 0C/s) than traditional SLM (105–106 0C/s). This encouraged the development of β phases within the formed Ti6Al4V component. The low power, low cost, highly compact short wavelength diode laser is viable energy source for future powder bed fusion additive manufacturing systems, with potential for productivity scale-up using a DAM methodology

Development of RAPD based markers for wheat rust resistance gene cluster (Lr37-Sr38-Yr17) derived from Triticum ventricosum L.

Rust diseases are the major cause of low yield of wheat in Pakistan. Wheat breeders all over the world as well as in Pakistan are deriving rust resistance genes from alien species like Triticum ventricosumand introducing them in common wheat (Triticum aestivum). One such example is the introgression of rust resistance gene cluster Lr37-Sr38-Yr17 derived from T. ventricosum chromosome 2NS into thecommon wheat. A basic prerequisite to introduce alien rust resistance gene (like those present on 2NS segment) in locally adapted varieties is availability of a suitable marker system which can be used tokeep track of presence of newly added gene in the old background. In this present study, one hundred and fifty Randomly Amplified Polymorphic DNA (RAPD) primers were used to detect polymorphismbetween two near isogenic lines NILs (Anza and Anza+2NS) of wheat and to develop RAPD based molecular markers for rust resistance gene cluster derived from T. ventricosum. Polymerase chainreactions were carried out using standard protocols. All the amplification products were in the range of 250 to 1000 bp. Thirteen molecular markers (RAPDs) out of a total of 150 (approximately 8.6%) were developed for rust resistance gene cluster Lr37-Sr38-Yr17 and recommendations have been made to utilize these markers in Pakistani wheat breeding programs aimed at establishing rust resistantgermplasm

Clinical effects of Streptococcus salivarius K12 in hospitalized COVID-19 patients: results of a preliminary study

Anatomical and physiological considerations indicate that the oral cavity is a primary source of the lung microbiota community, and recent studies have shown that the microbiota in the lungs contributes to immunological homeostasis, potentially altering the organ’s susceptibility to viral infection, including SARS-CoV-2. It has been proposed that, in the case of viral infection, lung Gram-negative bacteria could promote the cytokine cascade with a better performance than a microbiota mainly constituted by Gram-positive bacteria. Recent observations also suggest that Prevotella-rich oral microbiotas would dominate the oral cavity of SARS-CoV-2-infected patients. In comparison, Streptococcus-rich microbiotas would dominate the oral cavity of healthy people. To verify if the modulation of the oral microbiota could have an impact on the current coronavirus disease, we administered for 14 days a well-recognized and oral-colonizing probiotic (S. salivarius K12) to hospitalized COVID-19 patients. The preliminary results of our randomized and controlled trial seem to prove the potential role of this oral strain in improving the course of the main markers of pathology, as well as its ability to apparently reduce the death rate from COVID-19. Although in a preliminary and only circumstantial way, our results seem to confirm the hypothesis of a direct involvement of the oral microbiota in the construction of a lung microbiota whose taxonomic structure could modulate the inflammatory processes generated at the pulmonary and systemic level by a viral infection

Oral Co-Supplementation of Curcumin, Quercetin, and Vitamin D3 as an Adjuvant Therapy for Mild to Moderate Symptoms of COVID-19-Results From a Pilot Open-Label, Randomized Controlled Trial

Background: Curcumin, quercetin, and vitamin D3 (cholecalciferol) are common natural ingredients of human nutrition and reportedly exhibit promising anti-inflammatory, immunomodulatory, broad-spectrum antiviral, and antioxidant activities. Objective: The present study aimed to investigate the possible therapeutic benefits of a single oral formulation containing supplements curcumin, quercetin, and cholecalciferol (combinedly referred to here as CQC) as an adjuvant therapy for early-stage of symptomatic coronavirus disease 2019 (COVID-19) in a pilot open-label, randomized controlled trial conducted at Mayo Hospital, King Edward Medical University, Lahore, Pakistan. Methods: Reverse transcriptase polymerase chain reaction (RT-PCR) confirmed, mild to moderate symptomatic COVID-19 outpatients were randomized to receive either the standard of care (SOC) (n = 25) (control arm) or a daily oral co-supplementation of 168 mg curcumin, 260 mg quercetin, and 9 µg (360 IU) of cholecalciferol, as two oral soft capsules b.i.d. as an add-on to the SOC (n = 25) (CQC arm) for 14 days. The SOC includes paracetamol with or without antibiotic (azithromycin). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR test, acute symptoms, and biochemistry including C-reactive protein (CRP), D-dimer, lactate dehydrogenase, ferritin, and complete blood count were evaluated at baseline and follow-up day seven. Results: Patients who received the CQC adjuvant therapy showed expedited negativization of the SARS-CoV-2 RT-PCR test, i.e., 15 (60.0%) vs. five (20.0%) of the control arm, p = 0.009. COVID-19- associated acute symptoms were rapidly resolved in the CQC arm, i.e., 15 (60.0%) vs. 10 (40.0%) of the control arm, p = 0.154. Patients in the CQC arm experienced a greater fall in serum CRP levels, i.e., from (median (IQR) 34.0 (21.0, 45.0) to 11.0 (5.0, 16.0) mg/dl as compared to the control arm, i.e., from 36.0 (28.0, 47.0) to 22.0 (15.0, 25.0) mg/dl, p = 0.006. The adjuvant therapy of co-supplementation of CQC was safe and well-tolerated by all 25 patients and no treatment-emergent effects, complications, side effects, or serious adverse events were reported. Conclusion: The co-supplementation of CQC may possibly have a therapeutic role in the early stage of COVID-19 infection including speedy negativization of the SARS-CoV-2 RT-PCR test, resolution of acute symptoms, and modulation of the hyperinflammatory response. In combination with routine care, the adjuvant co-supplementation of CQC may possibly help in the speedy recovery from early-stage mild to moderate symptoms of COVID-19. Further research is warranted. Clinical Trial Registration: Clinicaltrials.gov, identifier NCT0513067

Iron Deficiency Anaemia In Reproductive Age Women Attending Obstetrics And Gynecology Outpatient Of University Health Centre In Al-Ahsa, Saudi Arabia

Background: Iron deficiency is the most common nutritional disorder in the world. The aim of this questionnaire based survey study was to determine the prevalence of iron deficiency anemia in reproductive age women, and their relation to variables such as age, marital status, education with those attending obstetrics and gynecology outpatient of King Faisal University Health Centre in Al-Ahsa in eastern region of Kingdom of Saudi Arabia.Materials and Methods: This study was conducted for the period of 6 month staring from September 2012 to February 2013. The questionnaire had three sections on personal information: their educational indicators, gynecological clinical history, and hematological indices.Results: The average age was 25.97±7.17 years. According to the  gynecological clinical history of the respondents, 15 (48.4%) respondents were pregnant while 16 (51.6%) were not pregnant. There was significant effect of pregnancy status on Hb level. Majority of the anemic respondents 15/17 were married. Moreover 14/17 anemic women were experiencing severe menstrual bleeding, 11/17 respondents were pregnant. 54.8% of respondents were hemoglobin deficient while 77.4% were found to have low Hct. In 87.1 % of the respondents, transferrin saturation was found to be abnormal.Conclusion: In this study iron deficiency anemia is quite prevalent in the university community especially among pregnant women. The fetus’s and newborn infant’s iron status depends on the iron status of the pregnant woman and therefore, iron deficiency in the mother-to-be means that growing fetus probably will be iron deficient as well. Thus iron deficiency anemia during pregnancy in well-educated set up needs more attention by the concerned authorities.Keywords: Iron deficiency Anemia (IDA), Hemoglobin, Female, Reproductive Age

Quercetin as a possible complementary agent for early-stage COVID-19: concluding results of a randomized clinical trial

Background: Quercetin, a natural polyphenol with demonstrated broad-spectrum antiviral, anti-inflammatory, and antioxidant properties, has been proposed as an adjuvant for early-stage coronavirus disease 2019 (COVID-19) infection. Objective: To explore the possible therapeutic effect of quercetin in outpatients with early-stage mild to moderate symptoms of COVID-19. Methods: This was an open-label randomized controlled clinical trial conducted at the department of medicine, King Edward Medical University, Lahore, PK. Patients were randomized to receive either standard of care (SC) plus an oral quercetin supplement (500 mg Quercetin Phytosome®, 1st week, TDS: 2nd week, BDS) (n = 50, quercetin group) or SC alone (n = 50, control group). Results: After one week of treatment, patients in the quercetin group showed a speedy recovery from COVID-19 as compared to the control group, i.e., 34 patients (vs. 12 in the control group) tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (p = 0.0004), and 26 patients (vs. 12 in the control group) had their COVID-19-associated acute symptoms resolved (p = 0.0051). Patients in the quercetin group also showed a significant fall in the serum lactate dehydrogenase (LDH) mean values i.e., from 406.56 ± 183.92 to 257.74 ± 110.73 U/L, p = 0.0001. Quercetin was well-tolerated by all the 50 patients, and no side effects were reported. Conclusion: Our results, suggest the possible therapeutic role of quercetin in early-stage COVID-19, including speedy clearance of SARS-CoV-2, early resolution of the acute symptoms and modulation of the host’s hyperinflammatory response. Clinical Trial Registration: clinicaltrials.gov, identifier NCT04861298

Multi-dimensional potential assessment of grid-connected mega-scale floating PV power plants across heterogeneous climatic zones

Floating Photovoltaic (FPV) systems are gradually becoming more desirable due to a multitude of reasons, encompassing proximity to urban water reservoirs (facilitating city access) and their technical advantages. Climate change potentially presents risks of drought and FPV can potentially benefit by providing clean energy as well as saving water from evaporation. However, detailed studies are required to comprehensively evaluate the potential of FPV considering not only the technical parameters but evaluating the climatic effects as well. This paper presents an integrated multi-dimensional framework for the analysis of 2.5 MW grid-connected FPV systems over different climatic zones. In the first layer, a techno-economic and performance evaluation is carried out by fine-tuning different inputs of systems to make it ideal for proposed analyses under actual FPV conditions. Similarly, in the second layer environmental along with forest absorbing carbon analyses are performed. While socio analysis observed in the third fold is based on various SDGs and their indicators. Results reveal that the Dam with cold in winter and hot in summer climate conditions observed a most feasible site with a Levelized cost of energy (LCOE) of $0.047/kWh and a Net present value (NPV) of million$1.7705, respectively. In contrast, a Dam with mild cold climate conditions proves the least feasible site with LCOE of $0.057/kWh and NPV of million$1.0256, respectively. Similarly, the former Dam saved 20.50% higher CO2 emissions as compared to the latter, as well as required hectares of forest absorbing carbon. A comparative analysis observes a capacity factor of 22% and a performance ratio (PR) of 5%–10% higher as compared to solar photovoltaic (SPV) for dams with extreme weather