Design and structural dynamic characteristics of an irregular staircase under earthquake loading

Reinforced concrete staircases are structurally designed as cantilevered, slab type or beam-slab type. Within this study an irregular cantilevered staircase is studied and its structural dynamic characteristics are explored. An eigen-value modal analysis is performed to determine the mode shapes, their corresponding modal participation factors and natural periods of vibration. The highest modes of interest are identified. Following on that, a scaled record of a previous historical earthquake was applied within a direct integration time-history analysis in order to assess the performance of that irregular stair case under earthquake loading. That load was applied within two perpendicular load cases representing the different possible directions of earthquake vibrations in which the effect of the structure irregularity was assessed per direction. The structure was found to have large drifts creating a need to change the structural system

Recent Advances In Stimuli-Responsive Drug release and targeting concepts using mesoporous silica nanoparticles

Being a developed and promising approach, nanotechnology has attracted a lot of attention in biomedical and pharmaceutical therapy applications. Among nanostructured materials, mesoporous silica nanoparticles (MSNs) are effectively used as nanocarriers for drug delivery systems. MSNs can be tailored-designed by different synthetic techniques. Their morphological characteristics dictate the type of application of such materials. Recently, polymer-based materials have been employed to functionalize the MSNs surface. These modified nanocarriers are loaded with the drug and can unload their “cargo” upon exposure to either endogenous or exogenous types of stimuli. In this study, different targeting concepts, including passive, active, vascular, nuclear, and multistage targeting, are discussed

Interaction Effects of Different Soil Moisture levels, Arbuscular Mycorrhizal Fungi and Three Phosphate Levels on: II-Mineral ions, Protein and Amino Acids contents of Garden Cress (Lepidium sativum L.) plant

The contents of mineral ions, protein and amino acids in seeds of (Lepidium sativum L.) were determined in response to water stress (85, 55 and25% depletion of the available soil water), Arbuscular mycorrhizal fungi and three phosphate levels (control (without mycorrhiza and phosphorus), zero phosphorus + mycorrhiza (P0), 25% recommended phosphorus + mycorrhiza (P1), 50% recommended phosphorus + mycorrhiza (P2) and 100% recommended phosphorus + mycorrhiza (P3)). Treatments were arranged in a randomized complete blocks design with five replicates. The results revealed significant decrease in protein and mineral ions contents of L. sativum seeds with increasing water stress level. These changes were accompanied with an increment in proline and amino acids contents of L. sativum seeds. AMF inoculation clearly increased protein and mineral ions contents compared with non-AMF plants. Moreover, the composition of amino acids was changed by AMF inoculation, where their contents were mostly decreased specially after phosphate addition. It seems that the AMF symbiosis enhanced drought tolerance mechanisms of L. sativum plants

An Approximate Model of Load Frequency Control Systems with Time Delay

In this paper we present an approximate model for load frequency control system with time delay. The load frequency control is one of the conventional power system control problems. In order to secure the stability of the grid the frequency must remain within its limited range which is achieved through the load frequency control. The load frequency control signals experience time delay that could destabilize the power systems. The presence of the time delay complicates the analysis of the load frequency control system. In this paper we present a stability method based on the Direct Frequency Response approximation for the time delay. This approximation transforms the transcendental time delay equation into linear equation. This results in a simple stability criterion for the load frequency control system with time delay. A one-area load frequency control system is chosen as a case study. The effectiveness of the proposed approximation has been tested through simulation and comparison with the published research work. By tracking the eigenvalues or using Routh's criterion the maximum delay margin can be estimated. The proposed stability criterion has been compared with the most recent methods and showed it is merit. The range of the PI controller parameters for a given time delay can be determined which is very important in practice

Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate

New selective and sensitive spectrophotometric and spectrofluorometric methods have been developed and validated for the determination of amantadine hydrochloride (AMD) in capsules and plasma. The methods were based on the condensation of AMD with 1,2-naphthoquinone-4-sulphonate (NQS) in an alkaline medium to form an orange-colored product. The spectrophotometric method involved the measurement of the colored product at 460  nm. The spectrofluorometric method involved the reduction of the product with potassium borohydride, and the subsequent measurement of the formed fluorescent reduced AMD-NQS product at 382  nm after excitation at 293  nm. The variables that affected the reaction were carefully studied and optimized. Under the optimum conditions, linear relationships with good correlation coefficients (0.9972–0.9974) and low LOD (1.39 and 0.013 μg mL−1) were obtained in the ranges of 5–80 and 0.05–10  μg mL−1 for the spectrophotometric and spectrofluorometric methods, respectively. The precisions of the methods were satisfactory; RSD ≤2.04%. Both methods were successfully applied to the determination of AMD in capsules. As its higher sensitivity, the spectrofluorometric method was applied to the determination of AMD in plasma; the recovery was 96.3–101.2 ± 0.57–4.2%. The results obtained by the proposed methods were comparable with those obtained by the official metho

An Inquiry into the Implementation of ICT among Pre-Service English Teachers

In recent years, the trend toward globalization and the needs of an information-oriented society have become a focus of attention for science educators. However, many teachers are still struggling to adopt and implement computers into their classrooms. Some researchers contend that beginning teachers are not adequately prepared to integrate computers into their teaching. Furthermore, among teachers, differences exist in instructional decision-making and behaviors when implementing new innovations into their teaching practice. This  study examines the implementation of  ICT (Information and Communication Technology) into English language instruction. Through studying aspects of learning among pre-service teachers, the study seeks to review the studies done on the impact on their new understanding of teaching and decision-making.  The results of this study can provide pre-service teachers with a direction that enables them to make the best use of technology such as ICT in learning to teach English and other core subject areas is necessary

Optimization and prediction of different building forms for thermal energy performance in the hot climate of Cairo using genetic algorithm and machine learning

The climate change crisis has resulted in the need to use sustainable methods in architectural design, including building form and orientation decisions that can save a significant amount of energy consumed by a building. Several previous studies have optimized building form and envelope for energy performance, but the isolated effect of varieties of possible architectural forms for a specific climate has not been fully investigated. This paper proposes four novel office building form generation methods (the polygon that varies between pentagon and decagon; the pixels that are complex cubic forms; the letters including H, L, U, T; cross and complex cubic forms; and the round family including circular and oval forms) and evaluates their annual thermal energy use intensity (EUI) for Cairo (hot climate). Results demonstrated the applicability of the proposed methods in enhancing the energy performance of the new forms in comparison to the base case. The results of the optimizations are compared together, and the four families are discussed in reference to their different architectural aspects and performance. Scatterplots are developed for the round family (highest performance) to test the impact of each dynamic parameter on EUI. The round family optimization process takes a noticeably high calculation time in comparison to other families. Therefore, an Artificial Neural Network (ANN) prediction model is developed for the round family after simulating 1726 iterations. Training of 1200 configurations is used to predict annual EUI for the remaining 526 iterations. The ANN predicted values are compared against the trained to determine the time saved and accuracy

Determinants of Increasing Trend of Self-Medication in a Pakistani Community

Purpose: To determine the major reasons, sources, diseases and drugs responsible for increasing trend of self-medication.Method: A community-based cross-sectional survey was carried out in the district of Faisalabad in Pakistan. Respondents (1488) were classified on the basis of age, sex, education, lifestyle and their economical level. A questionnaire was distributed among the sample population to collect data.Results: Majority of respondents involved in self-medication were aged between 15 and 20 years. Family members (N = 717, 48 %) were considered the major source of information for self-medicated drugs. Lack of time (N = 504, 37 %) while economic issues (N = 485, 33 %) were the major reasons for self-medication. Medical stores were the source of drug purchase by 1087 (73 %) respondents. Headache (N = 772, 52 %) and fever (N = 600, 40 %) were the main indications for self-medication while 694 respondents reported that they engage in single-dose self-medication. Paracetamol (N = 689, 46 %), other analgesics (N = 488, 33 %),  non-steroidal anti-inflammatory (N = 680, 46 %) were reported to be used frequently for self-medication.Conclusion: Self-medication is prevalent in the Pakistani community due to easy access to over the counter (OTC) and prescription-only medicines  (POM). This may lead to untoward effects in consumers of the products. Special interventions by relevant regulatory agencies regarding the sale of the drugs are therefore required.Keywords: Self-medication, OTC drugs, Pharmacist

Design and Implementation of Lab Scale Automated Solar Powered Irrigation and Fertigation System

In Brunei, natural oil and gas contributes to about 99% in the generation of electricity and about 88% to the country revenue. Since Brunei is heavily dependent on a non-renewable energy, potential exhaustion of oil and gas reserves pose a challenge to the country, especially with continuous increase of energy consumption in order to meet the population demand. Additionally, Brunei has ambition to improve its agriculture sector. Implementations of PV systems in local agricultural sectors can also help improving the country revenue by increasing yield and reducing costs from electricity consumption. In this paper, we present design and practical implementation of fully automated solar powered irrigation and fertigation system. Ultrasonic sensors and moisture sensors are used to detect the state of the tank and the soil. The whole system is controlled with a microcontroller and a wireless monitoring system with mobile application is designed. The operation of the system was tested and the performance was acceptable