Numerical simulation of transom-stern waves

The flow field generated by a transom-stern hullform is a complex, broad-banded, three-dimensional phenomenon marked by a large breaking wave. This unsteady multiphase turbulent flow feature is difficult to study experimentally and simulate numerically. The results of a set of numerical simulations, which use the Numerical Flow Analysis (NFA) code, of the flow around the Model 5673 transom stern at speeds covering both wet- and dry-transom operating conditions are shown in the accompanying fluid dynamics video. The numerical predictions for wet-transom and dry-transom conditions are presented to demonstrate the current state of the art in the simulation of ship generated breaking waves. The interested reader is referred to Drazen et al. (2010) for a detailed and comprehensive comparison with experiments conducted at the Naval Surface Warfare Center Carderock Division (NSWCCD).Comment: Fluid Dynamics Video for 2010 APS Division of Fluid Dynamics Gallery of Fluid Motion include

A Comparative Study in the Use of Brachial Photoplethysmography and the QRS Complex as Timing References in Determination of Pulse Transit Time

For more than a century, there has been interest in pulse wave velocity and pulse transit time as a possible metric for blood pressure and other cardiovascular parameters. The most common approach in noninvash:e measurement of these metries has been to measure the time delay between the QRS complex on the electrocardiograph and the detection of the finger photoplethysmograph. This paper introduces a new technique for measuring the brachial photoplethysmograph and argues that this forms a better timing reference than the QRS complex

A Comparative Study in the Use of Brachial Photoplethysmography and the QRS Complex as Timing References in Determination of Pulse Transit Time

For more than a century, there has been interest in pulse wave velocity and pulse transit time as a possible metric for blood pressure and other cardiovascular parameters. The most common approach in noninvash:e measurement of these metries has been to measure the time delay between the QRS complex on the electrocardiograph and the detection of the finger photoplethysmograph. This paper introduces a new technique for measuring the brachial photoplethysmograph and argues that this forms a better timing reference than the QRS complex

Older adults’ experiences with using wearable devices:Qualitative systematic review and meta-synthesis

Background: Older adults may use wearable devices for various reasons, ranging from monitoring clinically relevant health metrics or detecting falls to monitoring physical activity. Little is known about how this population engages with wearable devices, and no qualitative synthesis exists to describe their shared experiences with long-term use. Objective: This study aims to synthesize qualitative studies of user experience after a multi-day trial with a wearable device to understand user experience and the factors that contribute to the acceptance and use of wearable devices. Methods: We conducted a systematic search in CINAHL, APA PsycINFO, PubMed, and Embase (2015-2020; English) with fixed search terms relating to older adults and wearable devices. A meta-synthesis methodology was used. We extracted themes from primary studies, identified key concepts, and applied reciprocal and refutational translation techniques; findings were synthesized into third-order interpretations, and finally, a “line-of-argument” was developed. Our overall goal was theory development, higher-level abstraction, and generalizability for making this group of qualitative findings more accessible. Results: In total, we reviewed 20 papers; 2 evaluated fall detection devices, 1 tested an ankle-worn step counter, and the remaining 17 tested activity trackers. The duration of wearing ranged from 3 days to 24 months. The views of 349 participants (age: range 51-94 years) were synthesized. Four key concepts were identified and outlined: motivation for device use, user characteristics (openness to engage and functional ability), integration into daily life, and device features. Motivation for device use is intrinsic and extrinsic, encompassing many aspects of the user experience, and appears to be as, if not more, important than the actual device features. To overcome usability barriers, an older adult must be motivated by the useful purpose of the device. A device that serves its intended purpose adds value to the user’s life. The user’s needs and the support structure around the device—aspects that are often overlooked—seem to play a crucial role in long-term adoption. Our “line-of-argument” model describes how motivation, ease of use, and device purpose determine whether a device is perceived to add value to the user’s life, which subsequently predicts whether the device will be integrated into the user’s life. Conclusions: The added value of a wearable device is the resulting balance of motivators (or lack thereof), device features (and their accuracy), ease of use, device purpose, and user experience. The added value contributes to the successful integration of the device into the daily life of the user. Useful device features alone do not lead to continued use. A support structure should be placed around the user to foster motivation, encourage peer engagement, and adapt to the user’s preferences

Adult Safeguarding and People Living with Dementia in Nursing Homes

While there has been an increased focus on ageing in place in the Irish context, for some people, including people living with dementia (PLWD), nursing home care may be required to adequately meet their care needs as their dementia progresses and care needs increase. Nursing homes are the homes of many PLWD who, despite their frailty and health problems (including dementia), should be supported to enjoy a good quality of life, maintain, and develop relationships, and contribute to society (ADI, 2013).University College DublinIrish Dementia Working Group/AS

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition

Synthesis and biological evaluation of a series of novel indole derivatives as anticancer agents is described. A bisindolylmaleimide template has been derived as a versatile pharmacophore with which to pursue chemical diversification. Starting from maleimide, the introduction of an oxygen to the headgroup (hydroxymaleimide) was initially investigated and the bioactivity assessed by screening of kinase inhibitory activity, identifying substituent derived selectivity. Extension of the hydroxymaleimide template to incorporate substitution of the indole nitrogens was next completed and assessed again by kinase inhibition identifying unique selectivity patterns with respect to GSK-3 and CDK kinases. Subsequently, the anticancer activity of bisindolylmaleimides were assessed using the NCI-60 cell screen, disclosing the discovery of growth inhibitory profiles towards a number of cell lines, such as SNB-75 CNS cancer, A498 and UO-31 renal, MDA MB435 melanoma and a panel of leukemia cell lines. The potential for selective kinase inhibition by modulation of this template is evident and will inform future selective clinical candidates

Antibody Engineering Using Phage Display with a Coiled-Coil Heterodimeric Fv Antibody Fragment

A Fab-like antibody binding unit, ccFv, in which a pair of heterodimeric coiled-coil domains was fused to VH and VL for Fv stabilization, was constructed for an anti-VEGF antibody. The anti-VEGF ccFv showed the same binding affinity as scFv but significantly improved stability and phage display level. Furthermore, phage display libraries in the ccFv format were constructed for humanization and affinity maturation of the anti-VEGF antibody. A panel of VH frameworks and VH-CDR3 variants, with a significant improvement in affinity and expressibility in both E. coli and yeast systems, was isolated from the ccFv phage libraries. These results demonstrate the potential application of the ccFv antibody format in antibody engineering