Gestión educativa y calidad de la educación superior tecnológica en instituciones estatales de Lima Metropolitana

The research determines the relationship between educational management and quality of education of the state institutes of Higher Technological Education of metropolitan Lima. We worked with two samples: 346 students and 211 teachers. The instrument was the questionnaire adapted from the Matrix of Standards for the Accreditation of Study Programs (SINEACE). The study is descriptive level and used two research designs: correlational and comparative descriptive. To estimate parameters and analyze the hypotheses presented, the Rho Spearman correlation coefficient was applied and to perform the comparisons of the samples, the Mann-Whitney U test. The results show that there is a significant relationship between educational management and quality of education. Likewise, there are significant differences between the dimensions of educational management and the dimensions of the quality of education, obtaining lower average scores for teachers, compared to students.La investigación determina la relación entre gestión educativa y calidad de la educación de los institutos estatales de Educación Superior Tecnológica de Lima Metropolitana. Se trabajó con dos muestras: 346 estudiantes y 211 docentes. El instrumento fue el cuestionario adaptado a partir de la Matriz de Estándares para la Acreditación de Programas de Estudios (SINEACE). El estudio es de nivel descriptivo y utilizó dos diseños de investigación: correlacional y descriptivo comparativo. Para estimar parámetros y analizar las hipótesis planteadasse aplicó el coeficiente de correlación de Rho Spearman y para realizar las comparaciones de las muestras la prueba U de Mann-Whitney. Los resultados evidencian que existe una relación significativa entre gestión educativa y calidad de la educación. Asimismo, existen diferencias significativas entre las dimensiones de gestión educativa y las dimensiones de la calidad de la educación obteniendo puntajes promedios más bajos los docentes, en comparación con los estudiantes

Treatment of Clostridium difficile infection: a national survey of clinician recommendations and the use of faecal microbiota transplantation

Adherence to Clostridium difficile infection treatment guidelines is associated with lower recurrence rates and mortality as well as cost savings. Our survey of Irish clinicians indicates that patients are managed using a variety of approaches. FMT is potentially underutilised despite its recommendation in national and European guidelines

IBD genetic risk profile in healthy first-degree relatives of Crohn's disease patients

BACKGROUND: Family history provides important information on risk of developing inflammatory bowel disease [IBD], and genetic profiling of first-degree relatives [FDR] of Crohn's disease [CD]- affected individuals might provide additional information. We aimed to delineate the genetic contribution to the increased IBD susceptibility observed in FDR. METHODS: N = 976 Caucasian, healthy, non-related FDR; n = 4997 independent CD; and n = 5000 healthy controls [HC]; were studied. Genotyping for 158 IBD-associated single nucleotide polymorphisms [SNPs] was performed using the Illumina Immunochip. Risk allele frequency [RAF] differences between FDR and HC cohorts were correlated with those between CD and HC cohorts. CD and IBD genetic risk scores [GRS] were calculated and compared between HC, FDR, and CD cohorts. RESULTS: IBD-associated SNP RAF differences in FDR and HC cohorts were strongly correlated with those in CD and HC cohorts, correlation coefficient 0.63 (95% confidence interval [CI] 0.53 - 0.72), p = 9.90 x 10(-19). There was a significant increase in CD-GRS [mean] comparing HC, FDR, and CD cohorts: 0.0244, 0.0250, and 0.0257 respectively [p < 1.00 x 10(-7) for each comparison]. There was no significant difference in the IBD-GRS between HC and FDR cohorts [p = 0.81]; however, IBD-GRS was significantly higher in CD compared with FDR and HC cohorts [p < 1.00 x 10(-10) for each comparison]. CONCLUSION: FDR of CD-affected individuals are enriched with IBD risk alleles compared with HC. Cumulative CD-specific genetic risk is increased in FDR compared with HC. Prospective studies are required to determine if genotyping would facilitate better risk stratification of FDR

Nanitas SOS, propuesta de implementación de servicios de contratación de nanas, cuyo propósito es contribuir con la independencia económica de mujeres otorgando un puesto de trabajo digno y formal.

El presente trabajo identifica el problema actual que sufren hoy en día los padres de familia en el cuidado de sus menores hijos. Por otro lado, la solución a este problema busca que los padres puedan tener acceso de manera segura y sencilla para obtener apoyo en esta área. A su vez, se busca fomentar mayor trabajo para las mujeres en igualdad de condiciones, generándoles la oportunidad de conseguir un trabajo digno. La solución planteada es crear la empresa Nanitas SOS quien ofrecerá un servicio en línea de colocación de personal para el cuidado de niños, en el cual, el usuario podrá filtrar según sus necesidades específicas y acceder al perfil de las nanas y su documentación principal; tales como exámenes psicológicos, antecedentes y recomendaciones. Todo ello acompañado de un reporte de seguimiento del estatus del servicio cada seis meses. Nanitas SOS es una solución en la cual, un padre de familia desde la comodidad de su hogar puede realizar entrevistas con diversas alternativas de nanas ya evaluadas a detalle, este servicio brinda una suscripción anual, la misma que incluye beneficios adicionales. Nanitas SOS es una empresa que está dirigida a los niveles socioeconómicos A y B de Lima Moderna, de los cuales, más del 95% cuentan con acceso a internet. (Asociación Peruana de Investigación de Mercados [APEIM], 2020) lo cual nos permite tener un mercado exponencial. Por otro lado, Nanitas SOS es un modelo socialmente sostenible ya que se encuentra alineada con las ODS 5, 8 y 11, no solo buscando generar rentabilidad financiera sino poder brindar oportunidades a mujeres que desean acceder a un trabajo que les incluya todos sus beneficios sociales. A nivel económico es sostenible y viable, ya que proyecta el crecimiento exponencial de sus ventas. Se proyecta un VAN de S/. 4,428,195 y un TIR de 70.47% para los próximos 10 años.The present business plan identifies an issue that mostly all parents go through: housekeeping and supervision of their children. The solution we introduce in this paper aims directly at the issue of finding help in a secure and simple manner, as well as providing employment opportunities. We introduce this solution by Nanitas SOS, a new concept of hiring babysitters through an application, in which the user will be able to filter their needs according to a certain profile, recommendations, and other details such as psychological examinations and background checks. All of this will be possible from the comfort of user's houses, or anywhere with an internet connection and a smartphone. The service includes an annual subscription accompanied by additional benefits such as a babysitter replacement and different lessons. Nanitas SOS is a company with a considerable expansion potential, due to its business model, which is directed to socioeconomic levels determined as "A" and "B", in which 95% of users have an internet connection. (Asociación Peruana de Investigación de Mercados [APEIM], 2020). Also, we view our company as a socially sustainable one. As well as making profits, we focus on aiding women in finding decent jobs, which include all benefits provided by law. We work according to SDGs 5, 8 and 11. Finally, Nanitas SOS is economically sustainable and feasible, given that it projects an increasement in sales. For the next decade, we estimate an NPV of S/4,428,195 and an IRR of 70.47%

The role of diet in the aetiopathogenesis of inflammatory bowel disease

Crohn’s disease and ulcerative colitis, collectively known as IBD, are chronic inflammatory disorders of the gastrointestinal tract. Although the aetiopathogenesis of IBD is largely unknown, it is widely thought that diet has a crucial role in the development and progression of IBD. Indeed, epidemiological and genetic association studies have identified a number of promising dietary and genetic risk factors for IBD. These preliminary studies have led to major interest in investigating the complex interaction between diet, host genetics, the gut microbiota and immune function in the pathogenesis of IBD. In this Review, we discuss the recent epidemiological, gene–environment interaction, microbiome and animal studies that have explored the relationship between diet and the risk of IBD. In addition, we highlight the limitations of these prior studies, in part by explaining their contradictory findings, and review future directions

Gene expression profiling in sinonasal adenocarcinoma

<p>Abstract</p> <p>Background</p> <p>Sinonasal adenocarcinomas are uncommon tumors which develop in the ethmoid sinus after exposure to wood dust. Although the etiology of these tumors is well defined, very little is known about their molecular basis and no diagnostic tool exists for their early detection in high-risk workers.</p> <p>Methods</p> <p>To identify genes involved in this disease, we performed gene expression profiling using cancer-dedicated microarrays, on nine matched samples of sinonasal adenocarcinomas and non-tumor sinusal tissue. Microarray results were validated by quantitative RT-PCR and immunohistochemistry on two additional sets of tumors.</p> <p>Results</p> <p>Among the genes with significant differential expression we selected <it>LGALS4, ACS5, CLU, SRI and CCT5 </it>for further exploration. The overexpression of <it>LGALS4, ACS5, SRI</it>, <it>CCT5 </it>and the downregulation of <it>CLU </it>were confirmed by quantitative RT-PCR. Immunohistochemistry was performed for LGALS4 (Galectin 4), ACS5 (Acyl-CoA synthetase) and CLU (Clusterin) proteins: LGALS4 was highly up-regulated, particularly in the most differentiated tumors, while CLU was lost in all tumors. The expression of ACS5, was more heterogeneous and no correlation was observed with the tumor type.</p> <p>Conclusion</p> <p>Within our microarray study in sinonasal adenocarcinoma we identified two proteins, LGALS4 and CLU, that were significantly differentially expressed in tumors compared to normal tissue. A further evaluation on a new set of tissues, including precancerous stages and low grade tumors, is necessary to evaluate the possibility of using them as diagnostic markers.</p