The relationship between teacher candidates' lifelong learning tendencies and their digital competencies

Digital competencies and lifelong learning tendencies are among the features that every teacher candidate should have. Therefore, carrying out research on both lifelong learning trends and digital competencies can contribute to the development and updating of teacher education programs. In this context, the aim of this research is to analyses the relationship between lifelong learning tendencies and digital competencies of teacher candidates. In this research, scanning model from descriptive research models and explanatory model from relational research methods were used. The sample of this research consists of 287 teacher candidates selected by simple random sampling method from among teacher candidates studying at this state university. In this study, two scales were used to determine the relationship between the lifelong learning tendencies of teacher candidates and their digital competencies. The first of these scales is the “Lifelong Learning Tendency Scale”. The second scale used in the research is the "Digital Competency Scale". There is a significant and moderate relationship between the lifelong learning tendencies scale in general and the competencies of using basic internet tools and the competencies of acquiring and using information in digital environment. Since there is a moderately significant relationship between lifelong learning tendencies and digital competence, these two concepts should be reflected in teacher education programs in a way that supports each other, without considering each other separately

Successful treatment of refractory gastrointestinal bleeding by systemic (oral) ankaferd blood stopper in a patient with Glanzmann thrombasthenia

Background: Glanzmann Thrombasthenia (GT) is a genetic platelet dysfunction and a life threatening disease. Ankaferd Blood Stopper (ABS) is a topical hemostatic agent of herbal origin which has been recently made available for clinical use. Its hemostatic effect is independent from blood clotting factors and occurs as a result of the aggregation of focal red blood cells by an encapsulated protein web. Case Report: In this paper, a patient with GT is presented in whom 3 months of gastrointestinal bleeding refractory to all medical therapies was controlled within a short time of using oral ABS. Conclusion: The difference between this patient and other cases presented in the medical literature is the oral use of ABS. Thus, this patient may contribute to the medical community in showing the safety and efficacy of systemic (oral) ABS in patients with disorders of coagulation. However, there is a need for more patient experiences. © Trakya University Faculty of Medicine

THE PERCEPTION OF DEVOTED TEACHING: TEACHER PERSPECTIVES

The purpose of this research is to examine the devoted teachers' devoted teacher perceptions. For this purpose, according to the perceptions of teachers in a sense the answer was sought for the question "who is devoted teachers". The research is expected to contribute to the literature in this respect. In this research, screening method was used. In research it was tried to be revealed as the teachers' perceptions of devoted teaching. The universe of the research was composed of teachers working in secondary school and high school. The sample consisted of 355 teachers working in secondary and high school. The research data were collected during the 2016-2017 academic year spring semester. A devoted teacher scale developed by the researchers was used in the research. The scale consists of 37 items with one factor. According to the findings of the research, teachers' devoted teaching perceptions are "always" at the level of 4.29. Teachers' perceptions of devoted teaching do not make a meaningful difference in terms of gender, educational status, branch, school, and graduated faculty. However, teachers 'perceptions of devoted teachers vary according to seniority, and according to seniority variable, devoted teachers' perceptions differ significantly. According to the results of the research, teachers perceive themselves as devoted at the "always" level.    Article visualizations

Application of the Support Vector Machine to Predict Subclinical Mastitis in Dairy Cattle

This study presented a potentially useful alternative approach to ascertain the presence of subclinical and clinical mastitis in dairy cows using support vector machine (SVM) techniques. The proposed method detected mastitis in a cross-sectional representative sample of Holstein dairy cattle milked using an automatic milking system. The study used such suspected indicators of mastitis as lactation rank, milk yield, electrical conductivity, average milking duration, and control season as input data. The output variable was somatic cell counts obtained from milk samples collected monthly throughout the 15 months of the control period. Cattle were judged to be healthy or infected based on those somatic cell counts. This study undertook a detailed scrutiny of the SVM methodology, constructing and examining a model which showed 89% sensitivity, 92% specificity, and 50% error in mastitis detection

Examining digital competence of teachers within the context of lifelong learning based on of the twenty-first century skillsÖğretmenlerin yirmi birinci yüzyıl becerileri ışığında ve yaşam boyu öğrenme bağlamında dijital yeterliliklerinin incelenmesi

Undoubtedly, the twenty-first century has witnessed rapid changes and developments in the information world. As science and technology develop, sharing information and knowledge has been accelerated. Digital tools are of paramount importance and play an important role in the production and sharing of this information. The world has become a global village by means of digital tools. Digital skills are also an important sub-dimension of lifelong learning. Within this context, our teachers to educate the people of our age are required to acquire and use these skills throughout their lives in order to catch our era in which the information production and sharing are accelerated. The aim of this study is to assess digital competence of teachers within the context of lifelong learning and in the light of the twenty-first century skills. Scope of this study includes teachers in service at high school and junior high school in Diyarbakır, during the spring semester of 2014-2015 academic years. The sample of the study consisted of 286 teachers randomly selected from the population. One of the descriptive research models, survey model has been used in this study. As data collection tool, a scale developed by researchers was used. Developed scale consists of 30 items and three-dimensional. SPSS software was used for analysing the data. In data analysis, digital qualifications of teachers was both examined overall and compared in terms of gender, level of education, branch, school type, institutions, seniority and whether to take computer lessons or courses variables. According to the results obtained, it was observed that teachers have digital qualifications at ‘Adequate level ( =3,5)’, male teachers are more qualified than female teachers and having studied computing either in university or another institution significantly increases digital qualifications.  The results obtained were compared with similar studies in literature and the following suggestions were developed: 1- Teachers, especially senior teachers, should participate in in-service training in line with the teacher’s profile required by the 21st century. 2- Universities should renew their programs according to the needs of the era and should teach especially prospective teachers "learning to learn."  3- In this field, more detailed, more versatile studies on larger samples should be carried out and the findings should be presented to the attention of policy-makers in particular. ÖzetYirmi birinci yüzyıl hiç kuşkusuz bilgi dünyasında hızlı değişme ve gelişmelere sahne olmaktadır. Bilim ve teknolojinin gelişmesi ile bilgi üretimi ve bilginin paylaşımı hızlanmıştır. Bu bilgi üretimi ve paylaşımında dijital araçlar önemli bir yer tutmaktadır. Dijital araçlar vasıtasıyla dünya küresel bir köy halini almıştır. Yirmi birinci yüzyıl becerileri arasında dijital beceriler önemli bir yer tutmaktadır. Dijital beceriler aynı zamanda hayat boyu öğrenmenin de önemli bir alt boyutudur. Bu bağlamda bilgi üretiminin ve paylaşımın hızlandığı çağımızı yakalamak için çağımızın insanını yetiştirecek öğretmenlerimizin bu becerileri edinmeleri ve hayat boyunca kullanmaları gerekmektedir. Bu çalışmanın amacı öğretmenlerin yirmi birinci yüzyıl becerileri ışığında ve hayat boyu öğrenme bağlamında dijital yeterliliklerinin incelenmesidir. Çalışmada betimsel araştırma modellerinden tarama modeli kullanılmıştır. Araştırmanın evrenini 2015-2015 eğitim öğretim yılı bahar döneminde Diyarbakır ili merkez ilçelerinde görev yapan ortaokul ve lise öğretmenleri oluşturmaktadır. Araştırmanın örneklemini ise bu evrenden rastgele seçilen 286 öğretmen oluşturmaktadır. Araştırmada ölçme aracı olarak araştırmacılara tarafından geliştirilen 30 maddeden oluşan bir ölçek kullanılmıştır. Verilerin çözümlenmesinde SPSS Statistic 22 programı kullanılmıştır. Verilerin analizinde öğretmenlerin dijital yeterlilikleri hem genel olarak hem de cinsiyet , eğitim durumu, branş, okul türü, mezuniyet, bilgisayar dersi/kursu alma ve kıdem değişkenlerine göre incelenmiştir. Elde edilen sonuçlara göre öğretmenlerin ölçek ortalamasından 3,5 ortalama elde ederek dijital yeterliliklerinin yeterli düzeyde oldukları, cinsiyet bakımından erkek öğretmenlerin kadın öğretmenlere göre daha yeterli oldukları, lisans dersi olarak veya kurs ile bilgisayar dersi almanın dijital yeterlilikleri önemli ölçüde arttırdığı tespit edilmiştir.Elde edilen sonuçlar alan yazındaki benzer çalışmalarla karşılaştırılmış ve tespit edilen eksikliklerle ilgili öğretmenler, üniversitelere ve milli eğitim bakanlığına yönelik aşağıdaki öneriler geliştirilmiştir.1-Öğretmenler, özellikle kıdemli olanalar 21. Yüzyılın ihtiyacı olan öğretmen profili doğrultusunda hizmet içi eğitime tabi tutulmalı ve çağın gereklerine göre donatılmalıdırlar. Milli eğitim bakanlığı bu konuda üniversitelerin ilgili bölümlerinde ve öğretim üyelerinden profesyonel destek almalıdır. 2-Üniversiteler programlarını çağın ihtiyaçlarına göre yenilemeli ve özellikle öğretmen adaylarını “öğrenmeyi öğrenme” alışkanlığı kazandırmalıdır. 3-Bu alanda daha ayrıntılı, çok yönlü ve geniş katılımlı çalışmalar yapılmalı ve özellikle politika yapıcıların dikkatine sunulmalıdır

Possible role of GADD45γ methylation in diffuse large B-cell Lymphoma: Does it affect the progression and tissue involvement?

Objective: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma among adults and is characterized by heterogeneous clinical, immunophenotypic, and genetic features. Different mechanisms deregulating cell cycle and apoptosis play a role in the pathogenesis of DLBCL. Growth arrest DNA damage-inducible 45 (GADD45γ) is an important gene family involved in these mechanisms. The aims of this study are to determine the frequency of GADD45γ methylation, to evaluate the correlation between GADD45γ methylation and protein expression, and to investigate the relation between methylation status and clinicopathologic parameters in DLBCL tissues and reactive lymphoid node tissues from patients with reactive lymphoid hyperplasia. Materials and Methods: Thirty-six tissue samples of DLBCL and 40 nonmalignant reactive lymphoid node tissues were analyzed in this study. Methylation-sensitive high-resolution melting analysis was used for the determination of GADD45γ methylation status. The GADD45γ protein expression was determined by immunohistochemistry. Results: GADD45γ methylation was frequent (50.0%) in DLBCL. It was also significantly higher in advanced-stage tumors compared with early-stage (p=0.041). In contrast, unmethylated GADD45γ was associated with nodal involvement as the primary anatomical site (p=0.040). Conclusion: The results of this study show that, in contrast to solid tumors, the frequency of GADD45γ methylation is higher and this epigenetic alteration of GADD45γ may be associated with progression in DLBCL. In addition, nodal involvement is more likely to be present in patients with unmethylated GADD45γ. © 2015 Turkish Society of Hematology. All rights reserved

Relationship of Lysosomal Storage Diseases (LSD) with Autophagy

Lysosomes are organelles that degrade damaged components or structures that have completed their functions and have roles in the last step of the autophagy pathway. Damage of the autophagy-lysosome pathway can cause vital problems for the cell. Lysosomal storage diseases (LSD) are one of the most common human genetic disorder caused by gene mutations. Up to now, more than 70 LSD were identified. LSD is mainly caused by functional disorders of enzymes in lysosomes or proteins associated with lysosomes. These disorders lead to the accumulation of undigested macromolecules in cells LSD can cause many systemic damages mainly in the nervous system, skeletal system, and reticuloendothelial system especially at early stages of the disease. Modulation and reactivation of autophagy is accepted as a new therapeutic approach for LSD. In this review, the general mechanisms of the relationship between lysosomal storage diseases and autophagy were evaluated together with the treatment approaches

Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency

MakaleWOS:000922080700001PubMed ID: 36089538Background: IgG subclass deficiency is a laboratory diagnosis and becomes important with recurrent infections. This study aimed to examine the demographic, clinical, and laboratory results of pediatric cases with IgG subclass deficiency and to improve the understanding of the clinical significance of IgG subclass deficiency. Methods: In this study, the clinical and laboratory features of 111 pediatric patients, with at least one whose serum IgG subclasses was measured as lower than 2 standard deviation of healthy aged-matched control values, were evaluated. The clinical and laboratory features of the cases with isolated IgG subclass deficiency (Group 1) and those with low serum levels of any of IgG, IgA, and IgM in addition to the IgG subclass deficiency (Group 2) were compared. Results: A total of 55 (49.54%) and 56 (50.45 %) patients were included in Groups 1 and 2, respectively. Among our studied cases, 20 (18. 1%) had a history of hospitalization in the neonatal period, 61 (54.95 %) had at least one hospitalization due to infection, and 55 (49.54%) had a history of recurrent infection. The frequencies of these three conditions were statistically significantly higher in Group 2 (p < 0.05). The frequencies of infections in the last year in Groups 1 and 2 were 4.4 +/- 1.2 and 5.4 +/- 1.9, respectively (p < 0.05). As a result of recurrent infections, 43.24% (n = 48) of our patients received antibiotic prophylaxis, and 21.62% (n = 24) had immunoglobulin replacement therapy. Furthermore, the numbers of pa-tients who needed these treatments were higher in Group 2 (p < 0.05).Conclusion: In cases with IgG subclass deficiencies, concomitant main-group immunoglobulin deficiencies may increase the number and severity of infections, leading to hospitalizations, antibiotic prophylaxis, and immunoglobulin therapy. More attention should be paid to cases of immunoglobulin main-group deficiencies in the follow-up of these cases.Copyright (c) 2022, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/)

SELECTION OF SEEDLING ROOTSTOCK FOR APRICOT

The aim of this study is to select promising wild apricot rootstocks among wild apricot populations propagated by seeds naturally found in Malatya, Erzincan, Nev?ehir, Sivas and Elaz?g provinces. In the first stage, land scans were carried out between 2007 and 2009 and 756 genotypes were determined which could be suitable for the characteristics of the rootstock by considering the phenotypic characteristics. On land surveys,&nbsp; the wild apricot trees that are healthy, productive, bitter seeds, thornless, dwarth growth habit and smooth trunk structure was selected. Among the marked wild apricot types were selected 240 types in 2008, 262 types in 2009 and 254 types in 2010. Seeds taken from these determined wild apricot trees were planted for 2 years in Erzincan and Malatya locations and germination experiments were carried out. In the study, Hasanbey and Hac?halilo?lu apricot varieties were used as control plants. Seed germination percentage, seedling diameter, height, diameter and high homogeneity were determined. At the end of three years of germination experiments were evaluated according to weighting ranking score and finally 8 types that has hight score selected for Malatya location and 18 types for Erzincan location. In the second step, these 26 types after selected in germination tests, was grafted by cv. Hac?halilo?lu in Malatya and by cv. Hasanbey in Erzincan. After grafting success, shoot diameter, homogenity, shoot length and homogenity were evaluated. Then, the data was selected according to weighting ranking score and finally 7 types (58/6, 58/7, 24/111, 24/7, 24/25, 24/33 and 44/8) that has hight score selected for Malatya and Erzincan locations, and transferred to the third stage. In third stage, collection orchards will be established and rootstocks-scion, yield, phenological observations, pomological analysis, tree growth and habit will be evaluated.&nbsp