34,847 research outputs found
Immunoreactivity for a calmodulin-dependent protein kinase is selectively increased in macaque striate cortex after monocular deprivation
Immunocytochemical methods were used to localize type II Ca2+/calmodulin-dependent protein kinase in the macaque primary visual cortex. Neurons that stain for the kinase include both pyramidal and nonpyramidal cells and they appear to form a subset of cortical neurons. They are densely packed in layers II and IVB, somewhat more sparse in layers III, IVCĆ, and VI, and nearly absent in layer V. In normal animals the distribution of kinase-positive cells within each layer is relatively uniform. However, in animals in which one eye is removed 7-14 days before sacrifice or sutured shut for 9 or 11 weeks, the cells in layer IVCĆ are divided into alternating lightly and darkly stained bands. Comparison of immunocytochemically stained sections with adjacent sections stained for the mitochondrial enzyme, cytochrome oxidase, reveals that the kinase staining increases in ocular dominance columns originally driven by the removed or closed eye. These findings suggest that either the concentration of type II Ca2+/calmodulin-dependent protein kinase or its accessibility to the antibody probe increases dramatically and selectively in neurons of macaque primary visual cortex that have been deprived of their normal visual input. This may indicate that changing levels of activity in cortical neurons can alter their regulatory machinery
Making the small oblique parameters large
We compute the oblique parameters, including the three new parameters ,
and introduced recently by the Montreal group, for the case of one
scalar multiplet of arbitrary weak isospin and weak hypercharge . We
show that, when the masses of the heaviest and lightest components of the
multiplet remain constant, but increases, the oblique parameter and
the three new oblique parameters increase like , while only
increases like . For large multiplets with masses not much higher than , the oblique parameters and may become much larger than
and .Comment: 9 pages, standard LATEX, 3 figures available from the authors, report
CMU-HEP93-17 and DOE-ER/40682-4
Coplanar Circumbinary Debris Disks
We present resolved Herschel images of circumbinary debris disks in the alpha
CrB (HD139006) and beta Tri (HD13161) systems. We find that both disks are
consistent with being aligned with the binary orbital planes. Though secular
perturbations from the binary can align the disk, in both cases the alignment
time at the distances at which the disk is resolved is greater than the stellar
age, so we conclude that the coplanarity was primordial. Neither disk can be
modelled as a narrow ring, requiring extended radial distributions. To satisfy
both the Herschel and mid-IR images of the alpha CrB disk, we construct a model
that extends from 1-300AU, whose radial profile is broadly consistent with a
picture where planetesimal collisions are excited by secular perturbations from
the binary. However, this model is also consistent with stirring by other
mechanisms, such as the formation of Pluto-sized objects. The beta Tri disk
model extends from 50-400AU. A model with depleted (rather than empty) inner
regions also reproduces the observations and is consistent with binary and
other stirring mechanisms. As part of the modelling process, we find that the
Herschel PACS beam varies by as much as 10% at 70um and a few % at 100um. The
70um variation can therefore hinder image interpretation, particularly for
poorly resolved objects. The number of systems in which circumbinary debris
disk orientations have been compared with the binary plane is now four. More
systems are needed, but a picture in which disks around very close binaries
(alpha CrB, beta Tri, and HD 98800, with periods of a few weeks to a year) are
aligned, and disks around wider binaries (99 Her, with a 50 yr period) are
misaligned, may be emerging. This picture is qualitatively consistent with the
expectation that the protoplanetary disks from which the debris emerged are
more likely to be aligned if their binaries have shorter periods.Comment: accepted to MNRA
Star - Planet - Debris Disk Alignment in the HD 82943 system: Is planetary system coplanarity actually the norm?
Recent results suggest that the two planets in the HD 82943 system are
inclined to the sky plane by 20 +/- 4deg. Here, we show that the debris disk in
this system is inclined by 27 +/- 4deg, thus adding strength to the derived
planet inclinations and suggesting that the planets and debris disk are
consistent with being aligned at a level similar to the Solar System. Further,
the stellar equator is inferred to be inclined by 28 +/- 4deg, suggesting that
the entire star - planet - disk system is aligned, the first time such
alignment has been tested for radial velocity discovered planets on ~AU wide
orbits. We show that the planet-disk alignment is primordial, and not the
result of planetary secular perturbations to the disk inclination. In addition,
we note three other systems with planets at >10AU discovered by direct imaging
that already have good evidence of alignment, and suggest that empirical
evidence of system-wide star - planet - disk alignment is therefore emerging,
with the exception of systems that host hot Jupiters. While this alignment
needs to be tested in a larger number of systems, and is perhaps unsurprising,
it is a reminder that the system should be considered as a whole when
considering the orientation of planetary orbits.Comment: Accepted to MNRA
Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus
Autophosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) at threonine-286 produces Ca2+-independent kinase activity and has been proposed to be involved in induction of long-term potentiation by tetanic stimulation in the hippocampus. We have used an immunocytochemical method to visualize and quantify the pattern of autophosphorylation of CaMKII in hippocampal slices after tetanization of the Schaffer collateral pathway. Thirty minutes after tetanic stimulation, autophosphorylated CaM kinase II (P-CaMKII) is significantly increased in area CA1 both in apical dendrites and in pyramidal cell somas. In apical dendrites, this increase is accompanied by an equally significant increase in staining for nonphosphorylated CaM kinase II. Thus, the increase in P-CaMKII appears to be secondary to an increase in the total amount of CaMKII. In neuronal somas, however, the increase in P-CaMKII is not accompanied by an increase in the total amount of CaMKII. We suggest that tetanic stimulation of the Schaffer collateral pathway may induce new synthesis of CaMKII molecules in the apical dendrites, which contain mRNA encoding its alpha-subunit. In neuronal somas, however, tetanic stimulation appears to result in long-lasting increases in P-CaMKII independent of an increase in the total amount of CaMKII. Our findings are consistent with a role for autophosphorylation of CaMKII in the induction and/or maintenance of long-term potentiation, but they indicate that the effects of tetanus on the kinase and its activity are not confined to synapses and may involve induction of new synthesis of kinase in dendrites as well as increases in the level of autophosphorylated kinase
Evaluation of materials and design modifications for aircraft brakes
A test program is described which was carried out to evaluate several proposed design modifications and several high-temperature friction materials for use in aircraft disk brakes. The evaluation program was carried out on a specially built test apparatus utilizing a disk brake and wheel half from a small het aircraft. The apparatus enabled control of brake pressure, velocity, and braking time. Tests were run under both constant and variable velocity conditions and covered a kinetic energy range similar to that encountered in aircraft brake service. The results of the design evaluation program showed that some improvement in brake performance can be realized by making design changes in the components of the brake containing friction material. The materials evaluation showed that two friction materials show potential for use in aircraft disk brakes. One of the materials is a nickel-based sintered composite, while the other is a molybdenum-based material. Both materials show much lower wear rates than conventional copper-based materials and are better able to withstand the high temperatures encountered during braking. Additional materials improvement is necessary since both materials show a significant negative slope of the friction-velocity curve at low velocities
Dephasing dynamics of Rydberg atom spin waves
A theory of Rydberg atom interactions is used to derive analytical forms for
the spin wave pair correlation function in laser-excited cold-atom vapors. This
function controls the quantum statistics of light emission from dense,
inhomogeneous clouds of cold atoms of various spatial dimensionalities. The
results yield distinctive scaling behaviors on the microsecond timescale,
including generalized exponential decay. A detailed comparison is presented
with a recent experiment on a cigar-shaped atomic ensemble [Y. Dudin and A.
Kuzmich, Science 336, 887 (2012)], in which Rb atoms are excited to a set of
Rydberg levels.Comment: 4 pages, Supplemental Material in Appendix, 4 figure
Opening of an interface flaw in a layered elastic half-plane under compressive loading
A static analysis is given of the problem of an elastic layer perfectly bonded, except for a frictionless interface crack, to a dissimilar elastic half-plane. The free surface of the layer is loaded by a finite pressure distribution directly over the crack. The problem is formulated using the two dimensional linear elasticity equations. Using Fourier transforms, the governing equations are converted to a pair of coupled singular integral equations. The integral equations are reduced to a set of simultaneous algebraic equations by expanding the unknown functions in a series of Jacobi polynomials and then evaluating the singular Cauchy-type integrals. The resulting equations are found to be ill-conditioned and, consequently, are solved in the least-squares sense. Results from the analysis show that, under a normal pressure distribution on the free surface of the layer and depending on the combination of geometric and material parameters, the ends of the crack can open. The resulting stresses at the crack-tips are singular, implying that crack growth is possible. The extent of the opening and the crack-top stress intensity factors depend on the width of the pressure distribution zone, the layer thickness, and the relative material properties of the layer and half-plane
Baseline design of the filters for the LAD detector on board LOFT
The Large Observatory for X-ray Timing (LOFT) was one of the M3 missions
selected for the phase A study in the ESA's Cosmic Vision program. LOFT is
designed to perform high-time-resolution X-ray observations of black holes and
neutron stars. The main instrument on the LOFT payload is the Large Area
Detector (LAD), a collimated experiment with a nominal effective area of ~10 m
2 @ 8 keV, and a spectral resolution of ~240 eV in the energy band 2-30 keV.
These performances are achieved covering a large collecting area with more than
2000 large-area Silicon Drift Detectors (SDDs) each one coupled to a collimator
based on lead-glass micro-channel plates. In order to reduce the thermal load
onto the detectors, which are open to Sky, and to protect them from out of band
radiation, optical-thermal filter will be mounted in front of the SDDs.
Different options have been considered for the LAD filters for best compromise
between high quantum efficiency and high mechanical robustness. We present the
baseline design of the optical-thermal filters, show the nominal performances,
and present preliminary test results performed during the phase A study.Comment: Proc. SPIE 9144, Space Telescopes and Instrumentation 2014:
Ultraviolet to Gamma Ray, 91446
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