Positive and Negative Effects of Social Media on Adolescent Well-Being.

Social media use is rapidly growing among adolescents, studies cite that the rates of “constant use” doubled from 2015 to 2018 (Anderson & Jiang, 2018; Lenhart, 2015). Social media use can have a serious negative impact on areas of well-being including feelings of depression, anxiety, fear of missing out, body image, bullying and sleep. Mojtabai, Olfson and Han (2016) cite the problematic use of mobile phones and social media applications as one of the trends aligning with the increase in major depressive episodes. Conversely, use of social media can promote positive feelings of well-being including creating a sense of community, providing access to needed health information, helping create new relationships and maintain existing ones and offering a platform for self-expression and creation of self-identity. The purpose of this study was to compare the positive and negative impacts of the top four social media platforms used by adolescents on 14 areas of well-being. SPSS was used for data analysis to compare well-being scores for Facebook, Instagram, Snapchat and YouTube. Analysis was also completed to see if there was a relationship between time spent online and perceived well-being. Consistent with research, the majority of adolescents cite that their smartphone is the primary way they access social media. YouTube was identified as having the most positive impact on adolescent well-being while Instagram was perceived as having the most negative. Time spent online indicated a weak, positive correlation to well-being with only YouTube

The Experience of Dispositional Optimism among female African Americans, Hispanics/Latinas, and Caucasians In Generation Z: An Existential Phenomenological Investigation

Mental health is becoming an increasingly important topic within Generation Z. 39% of college students in the United States reported experiencing symptoms of depression and anxiety (Burwell, 2018). Conversely, researchers have shown an inverse relationship between high levels of optimism and depression, as well as optimism and suicide ideation (Chang, Martos, Sallay, Change, Wright, Najarian, & Lee, 2016). Additionally, Optimism has been negatively correlated with negative psychological outcomes (Chang, et al., 2016). The purpose of this study will be to examine dispositional optimism within female Generation Z university students. Researchers will use a qualitative interviewing process to capture the full essence of an individual’s experience with optimism by asking the singular question “what does optimism mean to you?” Further probing questions will be asked to gather the most complete and detailed experience from the individual. The interviews will then be analyzed using a phenomenological analysis technique. From this, a thematic structure on the lived experience of Optimism will be created. Discussions of Optimism and future directions of optimism research will take place

An Examination of Sex-Differences in Quadriceps Fatigability During High- and Low-Intensity Contractions

The purpose of the current study was to compare sex-differences in quadriceps fatigability following both high- and low-intensity repeated, isometric contractions. Twenty-four (12 males, 12 females) participants completed two experimental visits consisting of repeated, isometric contractions of the knee extensors at 30% (LT) and 70% (HT) of maximal voluntary force (MVIC) until failure. Prior to, and immediately following the fatiguing contractions, strength, voluntary activation (VA), and peak twitch torque (PTT) were assessed while measuring surface electromyographic amplitude of the vastus lateralis (VLAMP) and vastus medialis (VMAMP ). Fatiguing bouts were assessed via mean torque (TQMEAN), total repetitions completed, torque coefficient of variation (TQcv ), EMG amplitude (VLAMP; VMAMP) and integrated EMG (iEMG) signal, and torque impulse (TQ1MP). Repeated measures Analysis of Variance analyses indicated females completed nearly double the repetitions of males during LT contractions (p = 0.001 ). Greater central fatigue was experienced during the LT contractions than HT (p = 0.050), despite having lower EMG amplitude throughout the fatiguing bout (p \u3c 0.001). A sex difference may be present during LT repeated isometric contractions, but further investigation is needed

Refinement and validation of multi-source blood detection for operational use.

The operational deployment of any technique in forensic casework must undergo thorough investigation of its capabilities and limitations. At Sheffield Hallam University for the past 14 years, the Francese Group have focused on developing the utilisation of Matrix Assisted Laser Desorption Ionisation Mass Spectrometry (MALDI MS) for forensic applications. Not only has this technique shown potential in several different areas (MALDI MS analysis of latent fingermarks, condom lubricants and drug detection in fingermarks and hair as some examples), also being deployed in casework, but in more recent years, the detection of blood also. The end users, namely police and forensic providers have shaped the programme of work on blood detection by letting priorities and needs drive the research. The validation studies conducted in this thesis offer evidence of robustness and versatility as well as further insights as to what circumstances MALDI MS would be most suited/needed for the investigation of blood at a sceneof a violent crime. Currently, crime scene investigators (CSI) and crime labs employ commercially available presumptive tests for the detection of blood when recovered from crime scenes. However, these tests are not specific and occasionally yield false positives. Furthermore, confirmatory testing is not routinely performed. The risk of a false positive result could potentially result in a wrongful conviction or dismissal in court and brings into question the validity of these tests when their findings are heavily relied on in judicial proceedings. The utilisation of MALDI MS Profiling (MSP) and MS Imaging (MSI) for the rapid and informative detection of blood in this thesis has shed light on the multiplex nature of this alternative approach. A great deal of the work presented has shown the capability to not only distinguish between human and animal blood, but to determine blood provenance down to the species level (Chapter 2). In terms of animal blood detection, even more intelligence has been gained within this strand of the project, highlighting that a distinction can be made between intravenous animal blood and traces of animal blood from packaged meat (Chapter 4). If animal blood was detected at a crime scene, being able to offer insight on the manner in how the blood was shed could offer considerable assistance in reconstructing the dynamics of the crime. The compatibility and robustness testing performed in this project, which has been demonstrated across several strands of the project (Chapters 2,3 and 5) has additionally shown that MALDI MS can be used in conjunction with several blood enhancement techniques (BET), deposition surfaces, in the co-presence of other biofluids, and in tandem with DNA typing post MALDI MSI analysis. This body of knowledge significantly contributes to further advance implementation of MALDI based approaches for the forensic analysis of blood in stains and fingermarks in an operational environment and to the further promotion of MALDI as a Category A technique in the Home Office Fingermark Visualisation Manual after its recent promotion to Category B

Learning on the job: A Webinar Series for Early Career Librarians for Early Career Librarians

The Early Career Librarians Initiative (ECLI) aims to impart valuable professional information to Library Information Science (LIS) students and early career librarians. ECLI noticed a lack of content specific to the challenges and concerns often encountered by early career librarians. In an effort to address this gap, ECLI partnered with Region 3 of the Network of the National Library of Medicine (NNLM) and hosted a three-part webinar series on job searching, setting professional goals, and navigating promotion and tenure. ECLI members will share their experiences about this process, what skills they learned, and how these experiences impacted their professional growt

C-C bond-forming reactions of ground-state aryl halides under reductive activation

Under basic conditions aryl halides can undergo SRN1 reactions, BHAS reactions and benzyne formations. Appropriate complex substrates afford an opportunity to study inherent selectivities. SRN1 reactions are usually favoured under photoactivated conditions, but this paper reports their success using ground-state and transition metal-free conditions. In benzene, the enolate salt 12, derived by deprotonation of diketopiperazine 11, behaves as an electron donor, and assists the initiation of the reactions, but in DMSO, it is not required. The outcomes are compared and contrasted with a recent photochemical study on similar substrates. A particular difference is the prevalence of hydride shuttle reactions under relatively mild thermal conditions

Estimating the size of dog populations in Tanzania to inform rabies control

Estimates of dog population sizes are a prerequisite for delivering effective canine rabies control. However, dog population sizes are generally unknown in most rabies-endemic areas. Several approaches have been used to estimate dog populations but without rigorous evaluation. We compare post-vaccination transects, household surveys, and school-based surveys to determine which most precisely estimates dog population sizes. These methods were implemented across 28 districts in southeast Tanzania, in conjunction with mass dog vaccinations, covering a range of settings, livelihoods, and religious backgrounds. Transects were the most precise method, revealing highly variable patterns of dog ownership, with human/dog ratios ranging from 12.4:1 to 181.3:1 across districts. Both household and school-based surveys generated imprecise and, sometimes, inaccurate estimates, due to small sample sizes in relation to the heterogeneity in patterns of dog ownership. Transect data were subsequently used to develop a predictive model for estimating dog populations in districts lacking transect data. We predicted a dog population of 2,316,000 (95% CI 1,573,000–3,122,000) in Tanzania and an average human/dog ratio of 20.7:1. Our modelling approach has the potential to be applied to predicting dog population sizes in other areas where mass dog vaccinations are planned, given census and livelihood data. Furthermore, we recommend post-vaccination transects as a rapid and effective method to refine dog population estimates across large geographic areas and to guide dog vaccination programmes in settings with mostly free roaming dog populations

No Differences in Strength Improvements Following Low- or High-Volume Resistance Training

Resistance training is a widely used modality for improving muscular strength and reducing risks of injury, which is vital to counteracting physical declines associated with aging and poor health. Despite this, the minimal effective training dose for improving muscular strength has yet to be fully elucidated. PURPOSE: The purpose of this study was to examine the role of training volume (number of sets per session) on muscular strength changes following 8 weeks of progressive resistance training. METHODS: Fourteen and 12 trained males (Mean±SD; Age: 23±3y) and females (Age: 20±1y) participated in 8 weeks of supervised 3x/week progressive resistance training. Experimental sessions consisted of 3-5 repetition maximum testing both pre- and post-intervention, in accordance with the protocol outlined by the NSCA, in the following exercises: leg press (LP), bench press (BP), horizontal row (ROW), barbell Romanian deadlift (RDL), dumbbell overhead press (OHP), and lat pulldown (LAT). Following baseline strength testing, each participant was randomly allocated to either a low volume (LV; n=12 (5F)) or high volume (HV; n=14 (7F)) training group, completing 2 or 4 sets per exercise per training visit, respectively. Across all 8 weeks, participants completed each lift twice weekly, and loads were adjusted based on exercise performance using the autoregulated progressive resistance exercise protocol. Each group completed the same repetitions in their first sets, but completed the last set of every exercise until volitional failure. Percent change for each exercise was calculated as the difference between baseline strength (kgs) and post-training strength (kgs), expressed as a percentage of baseline strength. To examine the effect of group and exercise on the change in strength, a 2 (Group) × 6 (Exercise) analysis of covariance (ANCOVA) was performed, covarying for pre-test strength. In the event of a significant F test, the Bonferroni-corrected dependent-samples t-test was used. Values are presented as estimated marginal means ± standard error. RESULTS: There was no significant Group × Exercise interaction effect on percent strength change (p=0.754), nor a main effect of Group (p=0.397). However, there was a significant effect of Exercise (p\u3c0.001). Post-hoc analyses indicated, when collapsing across training groups, improvements in strength were greater in LP when compared to BP (40.6±6.8%; p\u3c0.001), RDL (26.9±6.1%; p\u3c0.001), OHP (37.4±7.9%; p\u3c0.001), and LAT (22.7±6.8%; p=0.015). Additionally, greater strength improvements were seen in ROW when compared to BP (29.7±4.5%, p\u3c0.001), RDL (16.0±4.6%, p\u3c0.001), and OHP (26.5±4.8%, p\u3c0.001). Finally, LAT experienced greater strength increases than both BP (17.8±4.5%, p\u3c0.01) and OHP (14.6±4.7%, p=0.036). There were no additional significant differences between exercises (p=0.054-0.999). CONCLUSION: Our findings suggest that a resistance training volume of as few as 2 sets per exercise twice weekly is adequate to induce muscular strength adaptations in previously trained young adults. Further examination is needed to determine if upper and lower body exercises require differing volumes to elicit similar adaptations

Identification of germline transcriptional regulatory elements in Aedes aegypti

The mosquito Aedes aegypti is the principal vector for the yellow fever and dengue viruses, and is also responsible for recent outbreaks of the alphavirus chikungunya. Vector control strategies utilizing engineered gene drive systems are being developed as a means of replacing wild, pathogen transmitting mosquitoes with individuals refractory to disease transmission, or bringing about population suppression. Several of these systems, including Medea, UD^MEL, and site-specific nucleases, which can be used to drive genes into populations or bring about population suppression, utilize transcriptional regulatory elements that drive germline-specific expression. Here we report the identification of multiple regulatory elements able to drive gene expression specifically in the female germline, or in the male and female germline, in the mosquito Aedes aegypti. These elements can also be used as tools with which to probe the roles of specific genes in germline function and in the early embryo, through overexpression or RNA interference

Comparing methods of assessing dog rabies vaccination coverage in rural and urban communities in Tanzania

Rabies can be eliminated by achieving comprehensive coverage of 70% of domestic dogs during annual mass vaccination campaigns. Estimates of vaccination coverage are, therefore, required to evaluate and manage mass dog vaccination programs; however, there is no specific guidance for the most accurate and efficient methods for estimating coverage in different settings. Here, we compare post-vaccination transects, school-based surveys, and household surveys across 28 districts in southeast Tanzania and Pemba island covering rural, urban, coastal and inland settings, and a range of different livelihoods and religious backgrounds. These approaches were explored in detail in a single district in northwest Tanzania (Serengeti), where their performance was compared with a complete dog population census that also recorded dog vaccination status. Post-vaccination transects involved counting marked (vaccinated) and unmarked (unvaccinated) dogs immediately after campaigns in 2,155 villages (24,721 dogs counted). School-based surveys were administered to 8,587 primary school pupils each representing a unique household, in 119 randomly selected schools approximately 2 months after campaigns. Household surveys were conducted in 160 randomly selected villages (4,488 households) in July/August 2011. Costs to implement these coverage assessments were $12.01,$66.12, and $155.70 per village for post-vaccination transects, school-based, and household surveys, respectively. Simulations were performed to assess the effect of sampling on the precision of coverage estimation. The sampling effort required to obtain reasonably precise estimates of coverage from household surveys is generally very high and probably prohibitively expensive for routine monitoring across large areas, particularly in communities with high human to dog ratios. School-based surveys partially overcame sampling constraints, however, were also costly to obtain reasonably precise estimates of coverage. Post-vaccination transects provided precise and timely estimates of community-level coverage that could be used to troubleshoot the performance of campaigns across large areas. However, transects typically overestimated coverage by around 10%, which therefore needs consideration when evaluating the impacts of campaigns. We discuss the advantages and disadvantages of these different methods and make recommendations for how vaccination campaigns can be better monitored and managed at different stages of rabies control and elimination programs