The Web Can Be Suitable for Learning

The authors discuss the advantages and difficulties of Web-based online distance learning. Web-based ODL can and does work for most learners when designed with high levels of interactivity and when cost and access issues can be adequately addressed. However, Web-based ODL requires a fundamental paradigm shift in how we define concepts like education and the classroom

The Web Can Be Suitable for Learning

The authors discuss the advantages and difficulties of Web-based online distance learning. Web-based ODL can and does work for most learners when designed with high levels of interactivity and when cost and access issues can be adequately addressed. However, Web-based ODL requires a fundamental paradigm shift in how we define concepts like education and the classroom

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers : implications for autoimmunity in rheumatoid arthritis

Introduction: Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic. To investigate this mechanism, we examined human lung tissue from 40 subjects with defined smoking status, with or without chronic obstructive pulmonary disease (COPD), and control tissues from other organs for citrullinated proteins and the deiminating enzymes peptidylarginine deiminase type-2 (PAD2) and -4 (PAD4). Methods: Lung tissue samples, dissected from lobectomy specimens from 10 never smokers, 10 smokers without airflow limitation, 13 COPD smokers and eight COPD ex-smokers, and control tissue samples (spleen, skeletal muscle, liver, ovary, lymph node, kidney and heart), were analysed for citrullinated proteins, PAD2 and PAD4 by immunoblotting. Citrulline and homocitrulline residues in enolase and vimentin were analysed by partial purification by gel electrophoresis followed by mass spectrometry in 12 of the lung samples and one from each control tissues. Band intensities were scored semi-quantitatively and analysed by two-tailed Mann-Whitney T-test. Results: Within the lung tissue samples, citrullinated proteins, PAD2 and PAD4 were found in all samples, with an increase in citrullination in COPD (P = 0.039), but minimal difference between smokers and non-smokers (P = 0.77). Citrullination was also detected at lower levels in the tissues from other organs, principally in lymph node, kidney and skeletal muscle. Mass spectrometry of the lung samples showed that vimentin was citrullinated at positions 71, 304, 346, 410 and 450 in non-smokers and smokers both with and without COPD. A homocitrulline at position 104 was found in four out of six COPD samples and one out of six non-COPD. Citrulline-450 was also found in three of the control tissues. There were no citrulline or homocitrulline residues demonstrated in a-enolase. Conclusions: We have shown evidence of citrullination of vimentin, a major autoantigen in RA, in both non-smokers and smokers. The increase in citrullinated proteins in COPD suggests that citrullination in the lungs of smokers is mainly due to inflammation. The ubiquity of citrullination of vimentin in the lungs and other tissues suggests that the relationship between smoking and autoimmunity in RA may be more complex than previously thought

Tropical Pacific observing system

This paper reviews the design of the Tropical Pacific Observing System (TPOS) and its governance and takes a forward look at prospective change. The initial findings of the TPOS 2020 Project embrace new strategic approaches and technologies in a user-driven design and the variable focus of the Framework for Ocean Observing. User requirements arise from climate prediction and research, climate change and the climate record, and coupled modeling and data assimilation more generally. Requirements include focus on the upper ocean and air-sea interactions, sampling of diurnal variations, finer spatial scales and emerging demands related to biogeochemistry and ecosystems. One aim is to sample a diversity of climatic regimes in addition to the equatorial zone. The status and outlook for meeting the requirements of the design are discussed. This is accomplished through integrated and complementary capabilities of networks, including satellites, moorings, profiling floats and autonomous vehicles. Emerging technologies and methods are also discussed. The outlook highlights a few new foci of the design: biogeochemistry and ecosystems, low-latitude western boundary currents and the eastern Pacific. Low latitude western boundary currents are conduits of tropical-subtropical interactions, supplying waters of mid to high latitude origin to the western equatorial Pacific and into the Indonesian Throughflow. They are an essential part of the recharge/discharge of equatorial warm water volume at interannual timescales and play crucial roles in climate variability on regional and global scales. The tropical eastern Pacific, where extreme El Niño events develop, requires tailored approaches owing to the complex of processes at work there involving coastal upwelling, and equatorial cold tongue dynamics, the oxygen minimum zone and the seasonal double Intertropical Convergence Zone. A pilot program building on existing networks is envisaged, complemented by a process study of the East Pacific ITCZ/warm pool/cold tongue/stratus coupled system. The sustainability of TPOS depends on effective and strong collaborative partnerships and governance arrangements. Revisiting regional mechanisms and engaging new partners in the context of a planned and systematic design will ensure a multi-purpose, multi-faceted integrated approach that is sustainable and responsive to changing needs

The Low-Velocity, Rapidly Fading Type Ia Supernova 2002es

SN 2002es is a peculiar subluminous Type Ia supernova (SN Ia) with a combination of observed characteristics never before seen in a SN Ia. At maximum light, SN 2002es shares spectroscopic properties with the underluminous SN 1991bg subclass of SNe Ia, but with substantially lower expansion velocities (~6000 km/s) more typical of the SN 2002cx subclass. Photometrically, SN 2002es differs from both SN 1991bg-like and SN 2002cx-like supernovae. Although at maximum light it is subluminous (M_B=-17.78 mag), SN 2002es has a relatively broad light curve (Dm15(B)=1.28 +/- 0.04 mag), making it a significant outlier in the light-curve width vs. luminosity relationship. We estimate a 56Ni mass of 0.17 +/- 0.05 M_sun synthesized in the explosion, relatively low for a SN Ia. One month after maximum light, we find an unexpected plummet in the bolometric luminosity. The late-time decay of the light curves is inconsistent with our estimated 56Ni mass, indicating that either the light curve was not completely powered by 56Ni decay or the ejecta became optically thin to gamma-rays within a month after maximum light. The host galaxy is classified as an S0 galaxy with little to no star formation, indicating the progenitor of SN 2002es is likely from an old stellar population. We also present a less extensive dataset for SN 1999bh, an object which shares similar observed properties. Both objects were found as part of the Lick Observatory Supernova Search, allowing us to estimate that these objects should account for ~2.5% of SNe Ia within a fixed volume. We find that current theoretical models are unable to explain the observed of characteristics of SN 2002es.Comment: 19 pages, 15 figures, Submitted to Ap

Faint 6.7um Galaxies and their Contributions to the Stellar Mass Density in the Universe

We discuss the nature of faint 6.7um galaxies detected with the mid-infrared camera ISOCAM on board the Infrared Space Observatory (ISO). The 23 hour integration on the Hawaii Deep Field SSA13 has provided a sample of 65 sources down to 6uJy at 6.7um. For 57 sources, optical or near-infrared counterparts were found with a statistical method. All four Chandra sources, three SCUBA sources, and one VLA/FIRST source in this field were detected at 6.7um with high significance. Using their optical to mid-infrared colors, we divided the 6.7um sample into three categories: low redshift galaxies with past histories of rapid star formation, high redshift ancestors of these, and other star forming galaxies. Rapidly star forming systems at high redshifts dominate the faintest end. Spectroscopically calibrated photometric redshifts were derived from fits to a limited set of template SEDs. They show a high redshift tail in their distribution with faint (1. The 6.7um galaxies tend to have brighter K magnitudes and redder I-K colors than the blue dwarf population at intermediate redshifts. Stellar masses of the 6.7um galaxies were estimated from their rest-frame near-infrared luminosities. Massive galaxies (M_star~10e11M_sun) were found in the redshift range of z=0.2-3. Epoch dependent stellar mass functions indicate a decline of massive galaxies' comoving space densities with redshift. Even with such a decrease, the contributions of the 6.7um galaxies to the stellar mass density in the universe are found to be comparable to those expected from UV bright galaxies detected in deep optical surveys.Comment: 31 pages, 15 figures, AJ (accepted), a version with color figures at http://www.ioa.s.u-tokyo.ac.jp/~ysato/pub/3/p3c-ysato.ps.g

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder

<p>Abstract</p> <p>Background</p> <p>Attention deficit hyperactivity disorder (ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/<it>SLC6A3</it>) has been considered a good candidate for ADHD. Most association studies with ADHD have investigated the 40-base-pair variable number of tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1. Only few studies have reported association between promoter polymorphisms of the gene and ADHD.</p> <p>Methods</p> <p>To investigate the association between the polymorphisms -67A/T (rs2975226) and -839C/T (rs2652511) in promoter region of DAT1 in ADHD, two samples of ADHD patients from the UK (n = 197) and Taiwan (n = 212) were genotyped, and analysed using within-family transmission disequilibrium test (TDT).</p> <p>Results</p> <p>A significant association was found between the T allele of promoter polymorphism -67A/T and ADHD in the Taiwanese population (<it>P </it>= 0.001). There was also evidence of preferential transmission of the T allele of -67A/T polymorphism in combined samples from the UK and Taiwan (<it>P </it>= 0.003). No association was detected between the -839C/T polymorphism and ADHD in either of the two populations.</p> <p>Conclusion</p> <p>The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.</p

Tropical Pacific Observing System

This paper reviews the design of the Tropical Pacific Observing System (TPOS) and its governance and takes a forward look at prospective change. The initial findings of the TPOS 2020 Project embrace new strategic approaches and technologies in a user-driven design and the variable focus of the Framework for Ocean Observing. User requirements arise from climate prediction and research, climate change and the climate record, and coupled modeling and data assimilation more generally. Requirements include focus on the upper ocean and air-sea interactions, sampling of diurnal variations, finer spatial scales and emerging demands related to biogeochemistry and ecosystems. One aim is to sample a diversity of climatic regimes in addition to the equatorial zone. The status and outlook for meeting the requirements of the design are discussed. This is accomplished through integrated and complementary capabilities of networks, including satellites, moorings, profiling floats and autonomous vehicles. Emerging technologies and methods are also discussed. The outlook highlights a few new foci of the design: biogeochemistry and ecosystems, low-latitude western boundary currents and the eastern Pacific. Low latitude western boundary currents are conduits of tropical-subtropical interactions, supplying waters of mid to high latitude origin to the western equatorial Pacific and into the Indonesian Throughflow. They are an essential part of the recharge/discharge of equatorial warm water volume at interannual timescales and play crucial roles in climate variability on regional and global scales. The tropical eastern Pacific, where extreme El Niño events develop, requires tailored approaches owing to the complex of processes at work there involving coastal upwelling, and equatorial cold tongue dynamics, the oxygen minimum zone and the seasonal double Intertropical Convergence Zone. A pilot program building on existing networks is envisaged, complemented by a process study of the East Pacific ITCZ/warm pool/cold tongue/stratus coupled system. The sustainability of TPOS depends on effective and strong collaborative partnerships and governance arrangements. Revisiting regional mechanisms and engaging new partners in the context of a planned and systematic design will ensure a multi-purpose, multi-faceted integrated approach that is sustainable and responsive to changing needs