Raised cortisol excretion rate in urine and contamination by topical steroids

No abstract available

Nonequilibrium statistical mechanics of shear flow: invariant quantities and current relations

In modeling nonequilibrium systems one usually starts with a definition of the microscopic dynamics, e.g., in terms of transition rates, and then derives the resulting macroscopic behavior. We address the inverse question for a class of steady state systems, namely complex fluids under continuous shear flow: how does an externally imposed shear current affect the microscopic dynamics of the fluid? The answer can be formulated in the form of invariant quantities, exact relations for the transition rates in the nonequilibrium steady state, as discussed in a recent letter [A. Baule and R. M. L. Evans, Phys. Rev. Lett. 101, 240601 (2008)]. Here, we present a more pedagogical account of the invariant quantities and the theory underlying them, known as the nonequilibrium counterpart to detailed balance (NCDB). Furthermore, we investigate the relationship between the transition rates and the shear current in the steady state. We show that a fluctuation relation of the Gallavotti-Cohen type holds for systems satisfying NCDB.Comment: 24 pages, 11 figure

Georgia Library Association - Technical Services Interest Group

Published in Georgia Library Quarterl

Structure of the stationary state of the asymmetric target process

We introduce a novel migration process, the target process. This process is dual to the zero-range process (ZRP) in the sense that, while for the ZRP the rate of transfer of a particle only depends on the occupation of the departure site, it only depends on the occupation of the arrival site for the target process. More precisely, duality associates to a given ZRP a unique target process, and vice-versa. If the dynamics is symmetric, i.e., in the absence of a bias, both processes have the same stationary-state product measure. In this work we focus our interest on the situation where the latter measure exhibits a continuous condensation transition at some finite critical density $\rho_c$, irrespective of the dimensionality. The novelty comes from the case of asymmetric dynamics, where the target process has a nontrivial fluctuating stationary state, whose characteristics depend on the dimensionality. In one dimension, the system remains homogeneous at any finite density. An alternating scenario however prevails in the high-density regime: typical configurations consist of long alternating sequences of highly occupied and less occupied sites. The local density of the latter is equal to $\rho_c$ and their occupation distribution is critical. In dimension two and above, the asymmetric target process exhibits a phase transition at a threshold density $\rho_0$ much larger than $\rho_c$. The system is homogeneous at any density below $\rho_0$, whereas for higher densities it exhibits an extended condensate elongated along the direction of the mean current, on top of a critical background with density $\rho_c$.Comment: 30 pages, 16 figure

Lithology and Internal Structure of the San Andreas Fault at Depth Based on Characterization of Phase 3 Whole-rock Core in the San Andreas Fault Observatory at Depth (SAFOD) Borehole

We characterize the lithology and structure of the spot core obtained in 2007 during Phase 3 drilling of the San Andreas Fault Observatory at Depth (SAFOD) in order to determine the composition, structure, and deformation processes of the fault zone at 3 km depth where creep and microseismicity occur. A total of approximately 41 m of spot core was taken from three separate sections of the borehole; the core samples consist of fractured arkosic sandstones and shale west of the SAF zone (Pacific Plate) and sheared fine-grained sedimentary rocks, ultrafine black fault-related rocks, and phyllosilicate-rich fault gouge within the fault zone (North American Plate). The fault zone at SAFOD consists of a broad zone of variably damaged rock containing localized zones of highly concentrated shear that often juxtapose distinct protoliths. Two zones of serpentinite-bearing clay gouge, each meters-thick, occur at the two locations of aseismic creep identified in the borehole on the basis of casing deformation. The gouge primarily is comprised of Mg-rich clays, serpentinite (lizardite ± chrysotile) with notable increases in magnetite, and Ni-Cr-oxides/hydroxides relative to the surrounding host rock. The rocks surrounding the two creeping gouge zones display a range of deformation including fractured protolith, block-in-matrix, and foliated cataclasite structure. The blocks and clasts predominately consist of sandstone and siltstone embedded in a clay-rich matrix that displays a penetrative scaly fabric. Mineral alteration, veins and fracture-surface coatings are present throughout the core, and reflect a long history of syn-deformation, fluid-rock reaction that contributes to the low-strength and creep in the meters-thick gouge zones

Anxious/depressed symptoms are related to microstructural maturation of white matter in typically developing youths

AbstractThere are multiple recent reports of an association between anxious/depressed (A/D) symptomatology and the rate of cerebral cortical thickness maturation in typically developing youths. We investigated the degree to which anxious/depressed symptoms are tied to age-related microstructural changes in cerebral fiber pathways. The participants were part of the NIH MRI Study of Normal Brain Development. Child Behavior Checklist A/D scores and diffusion imaging were available for 175 youths (84 males, 91 females; 241 magnetic resonance imagings) at up to three visits. The participants ranged from 5.7 to 18.4 years of age at the time of the scan. Alignment of fractional anisotropy data was implemented using FSL/Tract-Based Spatial Statistics, and linear mixed model regression was carried out using SPSS. Child Behavior Checklist A/D was associated with the rate of microstructural development in several white matter pathways, including the bilateral anterior thalamic radiation, bilateral inferior longitudinal fasciculus, left superior longitudinal fasciculus, and right cingulum. Across these pathways, greater age-related fractional anisotropy increases were observed at lower levels of A/D. The results suggest that subclinical A/D symptoms are associated with the rate of microstructural development within several white matter pathways that have been implicated in affect regulation, as well as mood and anxiety psychopathology.</jats:p

Macrolide antibiotics for non-cystic fibrosis bronchiectasis

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the impact of macrolide antibiotics in the treatment of adults and children with non-cystic fibrosis bronchiectasis

Migration of northern Yellowstone elk: implications of spatial structuring

Migration can enhance survival and recruitment of mammals by increasing access to higher-quality forage or reducing predation risk, or both. We used telemetry locations collected from 140 adult female elk during 2000– 2003 and 2007–2008 to identify factors influencing the migration of northern Yellowstone elk. Elk wintered in 2 semidistinct herd segments and migrated 10–140 km to at least 12 summer areas in Yellowstone National Park (YNP) and nearby areas of Montana. Spring migrations were delayed after winters with increased snow pack, with earlier migration in years with earlier vegetation green-up. Elk wintering at lower elevations outside YNP migrated an average of 13 days earlier than elk at higher elevations. The timing of autumn migrations varied annually, but elk left their summer ranges at about the same time regardless of elevation, wolf numbers, or distance to their wintering areas. Elk monitored for multiple years typically returned to the same summer (96% fidelity, n 5 52) and winter (61% fidelity, n 5 41) ranges. Elk that wintered at lower elevations in or near the northwestern portion of the park tended to summer in the western part of YNP (56%), and elk that wintered at higher elevations spent summer primarily in the eastern and northern parts of the park (82%). Elk did not grossly modify their migration timing, routes, or use areas after wolf restoration. Elk mortality was low during summer and migration (8 of 225 elk-summers). However, spatial segregation and differential mortality and recruitment between herd segments on the northern winter range apparently contributed to a higher proportion of the elk population wintering outside the northwestern portion of YNP and summering in the western portion of the park. This change could shift wolf spatial dynamics more outside YNP and increase the risk of transmission of brucellosis from elk to cattle north of the park

Migration of northern Yellowstone elk: implications of spatial structuring

Migration can enhance survival and recruitment of mammals by increasing access to higher-quality forage or reducing predation risk, or both. We used telemetry locations collected from 140 adult female elk during 2000– 2003 and 2007–2008 to identify factors influencing the migration of northern Yellowstone elk. Elk wintered in 2 semidistinct herd segments and migrated 10–140 km to at least 12 summer areas in Yellowstone National Park (YNP) and nearby areas of Montana. Spring migrations were delayed after winters with increased snow pack, with earlier migration in years with earlier vegetation green-up. Elk wintering at lower elevations outside YNP migrated an average of 13 days earlier than elk at higher elevations. The timing of autumn migrations varied annually, but elk left their summer ranges at about the same time regardless of elevation, wolf numbers, or distance to their wintering areas. Elk monitored for multiple years typically returned to the same summer (96% fidelity, n 5 52) and winter (61% fidelity, n 5 41) ranges. Elk that wintered at lower elevations in or near the northwestern portion of the park tended to summer in the western part of YNP (56%), and elk that wintered at higher elevations spent summer primarily in the eastern and northern parts of the park (82%). Elk did not grossly modify their migration timing, routes, or use areas after wolf restoration. Elk mortality was low during summer and migration (8 of 225 elk-summers). However, spatial segregation and differential mortality and recruitment between herd segments on the northern winter range apparently contributed to a higher proportion of the elk population wintering outside the northwestern portion of YNP and summering in the western portion of the park. This change could shift wolf spatial dynamics more outside YNP and increase the risk of transmission of brucellosis from elk to cattle north of the park