Soil Improvement Using Deep Dynamic Compaction

The use of a conventional shallow foundation system in the construction of a baseball stadium on the Delaware River waterfront was only possible by improvement of existing soils using deep dynamic compaction (DDC). Subsurface conditions at the site consisted of 5 ft to 15 ft of miscellaneous fill materials overlying up to 10 ft of soft river sediments over dense sand. Numerous obstructions and old foundations were found in the fill making pile driving difficult and extremely expensive. Several foundation designs and ground improvement alternatives were evaluated for building support. A deep dynamic compaction soil improvement plan was designed to allow for the use of a conventional shallow foundation and slab-on-grade system. Prior to construction, a full-scale plate load test was performed at a dynamically compacted area to verify soil behavior under maximum column loads. The load test was monitored using precise survey methods to determine settlements as well as using piezometers to monitor pore water pressure changes due to the DDC impacts. Soil borings were also drilled to verify soil improvement. Analysis of the load test and boring results showed that the soil improvement using DDC was effective and would allow the use of a shallow foundation system to support the stadium’s loads. The use of deep dynamic compaction proved to be an economical alternative resulting in significant savings in construction cost and a shorter construction schedule

Performance of Foundations and Retaining Structures

The design, construction, and performance of several building foundations and temporary earth retaining structures located in the downtown area of White Plains, New York are presented in this paper. High rise structures were supported on shallow mat or spread foundations bearing on erratic saturated alluvial silt and sand deposits. Additionally, the construction of two and three level underground parking structures required the use of cantilevered and braced excavation support systems to retain the adjacent streets and utilities. Several assumptions were required to design and predict the performance of the building foundations and retaining structures. The accuracy of these assumptions was verified through the use of precise field measurements during and after construction. The results of these field measurements and comparison with predicted values are presented and discussed

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival

Abstract Pancreatic ductal adenocarcinoma (PDAC) has reactive stroma that promotes tumor signaling, fibrosis, inflammation, and hypoxia, which activates HIF-1α to increase tumor cell metastasis and therapeutic resistance. Carbonic anhydrase IX (CA9) stabilizes intracellular pH following induction by HIF-1α. Redox effector factor-1 (APE1/Ref-1) is a multifunctional protein with redox signaling activity that converts certain oxidized transcription factors to a reduced state, enabling them to upregulate tumor-promoting genes. Our studies evaluate PDAC hypoxia responses and APE1/Ref-1 redox signaling contributions to HIF-1α-mediated CA9 transcription. Our previous studies implicated this pathway in PDAC cell survival under hypoxia. We expand those studies, comparing drug responses using patient-derived PDAC cells displaying differential hypoxic responses in 3D spheroid tumor-stroma models to characterize second generation APE1/Ref-1 redox signaling and CA9 inhibitors. Our data demonstrates that HIF-1α-mediated CA9 induction differs between patient-derived PDAC cells and that APE1/Ref-1 redox inhibition attenuates this induction by decreasing hypoxia-induced HIF-1 DNA binding. Dual-targeting of APE1/Ref-1 and CA9 in 3D spheroids demonstrated that this combination effectively kills PDAC tumor cells displaying drastically different levels of CA9. New APE1/Ref-1 and CA9 inhibitors were significantly more potent alone and in combination, highlighting the potential of combination therapy targeting the APE1-Ref-1 signaling axis with significant clinical potential

Challenging assumptions of the enlargement literature : the impact of the EU on human and minority rights in Macedonia

This article argues that from the very start of the transition process in Macedonia, a fusion of concerns about security and democratisation locked local nationalist elites and international organisations intoa political dynamic that prioritised security over democratisation. This dynamic resulted in little progress in the implementation of human and minority rights until 2009, despite heavy EU involvement in Macedonia after the internal warfare of 2001. The effects of this informally institutionalised relationship have been overlooked by scholarship on EU enlargement towards Eastern Europe, which has made generalisations based on assumptions relevant to the democratisation of countries in Eastern Europe, but not the Western Balkans

Iron line profiles in Suzaku spectra of bare Seyfert galaxies

We methodically model the broad-band Suzaku spectra of a small sample of six 'bare' Seyfert galaxies: Ark 120, Fairall 9, MCG-02-14-009, Mrk 335, NGC 7469 and SWIFT J2127.4+5654. The analysis of bare Seyferts allows a consistent and physical modelling of AGN due to a weak amount of any intrinsic warm absorption, removing the degeneracy between the spectral curvature due to warm absorption and the red-wing of the Fe K region. Through effective modelling of the broad-band spectrum and investigating the presence of narrow neutral or ionized emission lines and reflection from distant material, we obtain an accurate and detailed description of the Fe K line region using models such as laor, kerrdisk and kerrconv. Results suggest that ionized emission lines at 6.7 keV and 6.97 keV (particularly Fe XXVI) are relatively common and the inclusion of these lines can greatly affect the parameters obtained with relativistic models i.e. spin, emissivity, inner radius of emission and inclination. Moderately broad components are found in all objects, but typically the emission originates from tens of Rg, rather than within <6Rg of the black hole. Results obtained with kerrdisk line profiles suggest an average emissivity of q~2.3 at intermediate spin values with all objects ruling out the presence of a maximally spinning black hole at the 90% confidence level. We also present new spin constraints for Mrk 335 and NGC 7469 with intermediate values of a=0.70(+0.12,-0.01) and a=0.69(+0.09,-0.09) respectively.Comment: 19 pages, 7 figures, 9 tables, MNRAS accepte

Comparing Competing Theories on the Causes of Mandate Perceptions

The discussion of presidential mandates is as certain as a presidential election itself. Journalists inevitably discuss whether the president-elect has a popular mandate. Because they see elections as too complex to allow the public to send a unitary signal, political scientists are more skeptical of mandates. Mandates, however, have received new attention by scholars asking whether perceptions of mandate arise and lead representatives to act as if voters sent a policy directive. Two explanations have emerged to account for why elected officials might react to such perceptions. One focuses on the President’s strategic decision to declare a mandate, the second on how members of Congress read signals of changing preferences in the electorate from their own election results. We test these competing views to see which more accurately explains how members of Congress act in support of a perceived mandate. The results indicate that members respond more to messages about changing preferences than to the president’s mandate declaration

ChemBank: a small-molecule screening and cheminformatics resource database

ChemBank (http://chembank.broad.harvard.edu/) is a public, web-based informatics environment developed through a collaboration between the Chemical Biology Program and Platform at the Broad Institute of Harvard and MIT. This knowledge environment includes freely available data derived from small molecules and small-molecule screens and resources for studying these data. ChemBank is unique among small-molecule databases in its dedication to the storage of raw screening data, its rigorous definition of screening experiments in terms of statistical hypothesis testing, and its metadata-based organization of screening experiments into projects involving collections of related assays. ChemBank stores an increasingly varied set of measurements derived from cells and other biological assay systems treated with small molecules. Analysis tools are available and are continuously being developed that allow the relationships between small molecules, cell measurements, and cell states to be studied. Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of biomedically relevant assays that have been performed at the Broad Institute by collaborators from the worldwide research community. The goal of ChemBank is to provide life scientists unfettered access to biomedically relevant data and tools heretofore available primarily in the private sector

The Iowa Homemaker vol.3, no.12

Table of Contents A Greeting to Iowa Homemakers by Dr. Louise Stanley, page 3 A New Book on “Meal Planning and Table Service” by Florence E. Busse, page 4 A Bill of Rights for the Child by Lulu R. Lancaster, page 4 Shrubs as a Garden Background by Juanita Beard, page 5 ‘Tis Egg Time Again by Beth Bailey McLean, page 6 The New Domestic System by Claude L. Benner, page 7 A Time Budget for the Homemaker by Ruth M. Lindquist, page 8 Figures That Do Not Lie by Mae L. Kelley, page 9 The Cooking of Meats by P. Mabel Nelson, page 10 The Psychology of Clothing by Eveleth Pedersen, page 11 Iowa State Women in Rural Schools by W. H. Lancelot, page 12 A Yarn about Yarns by Irene Christian, page 13 Tea Room Accounting by George M. Fuller, page 14 Who’s There and Where by Dryden Quist, page 15 Editorial, page 16 Homemaker as Citizen, page 17 The Eternal Question, page 18 Mrs. Purchaser Chooses Upholstery by Lucile Barta, page 1

Comet 240P/NEAT Is Stirring

Comets are primitive objects that formed in the protoplanetary disk, and have been largely preserved over the history of the solar system. However, they are not pristine, and surfaces of cometary nuclei do evolve. In order to understand the extent of their primitive nature, we must define the mechanisms that affect their surfaces and comae. We examine the lightcurve of comet 240P/NEAT over three consecutive orbits, and investigate three events of significant brightening (Δm ~ −2 mag). Unlike typical cometary outbursts, each of the three events are long-lived, with enhanced activity for at least 3–6 months. The third event, observed by the Zwicky Transient Facility, occurred in at least two stages. The anomalous behavior appears to have started after the comet was perturbed by Jupiter in 2007, reducing its perihelion distance from 2.53 to 2.12 au. We suggest that the brightening events are temporary transitions to a higher baseline activity level, brought on by the increased insolation, which has warmed previously insulated sub-surface layers. The new activity is isolated to one or two locations on the nucleus, indicating that the surface or immediate sub-surface is heterogeneous. Further study of this phenomenon may provide insight into cometary outbursts, the structure of the near-surface nucleus, and cometary nucleus mantling