Continuous k-to-1 functions between complete graphs of even order

A function between graphs is k-to-1 if each point in the co-domain has precisely k pre-images in the domain. Given two graphs, G and H, and an integer k ≥ 1, and considering G and H as subsets of R 3, there may or may not be a k-to-1 continuous function (i.e. a k-to-1 map in the usual topological sense) from G onto H. In this paper we review and complete the determination of whether there are finitely discontinuous, or just infinitely discontinuous k-to-1 functions between two intervals, each of which is one of the following: ]0, 1[, [0, 1[and [0, 1]. We also show that for k even and 1 ≤ r < 2s, (r, s) 6= (1, 1) and (r, s) 6= (3, 2), there is a k-to-1 map from K2r onto K2s if and only if k ≥ 2s.peer-reviewe

Productivity of Boran cattle maintained by chemoprophylaxis under trypanosomiasis risk

Evaluates the productivity of grade Boran cattle maintained by chemoprophylaxis under severe trypanosomiasis risk at Mkwaja ranch, Tanzania; uses data based on more than 20,000 calving records over the 10-year period from 1973 to 1982; discusses environmental influences on performance traits and links between tsetse population dynamics & cattle; includes comparison of Boran genotypes and its effect on pre-weaning growth characters

Journey of an Arctic ice island

In August 2010, a 253 km2 ice island calved from the floating glacial tongue of Petermann Glacier in Northwest Greenland. Petermann Ice Island (PII)-B, a large fragment of this original ice island, is the most intensively observed ice island in recent decades. We chronicle PII-B’s deterioration over four years while it drifted more than 2,400 km south along Canada’s eastern Arctic coast, investigate the ice island’s interactions with surrounding ocean waters, and report on its substantial seafloor scour. Three-dimensional sidewall scans of PII-B taken while it was grounded 130 km southeast of Clyde River, Nunavut, show that prolonged wave erosion at the waterline during sea ice-free conditions created a large underwater protrusion. The resulting buoyancy forces caused a 100 m × 1 km calving event, which was recorded by two GPS units. A field team observed surface waters to be warmer and fresher on the side of PII-B where the calving occurred, which perhaps led to the accelerated growth of the protrusion. PII-B produced up to 3.8 gigatonnes (3.8 × 1012 kg) of ice fragments, known hazards to the shipping and resource extraction industries, monitored over 22 months. Ice island seafloor scour, such as a 850 m long, 3 m deep trench at PII-B’s grounding location, also puts subseafloor installations (e.g., pipelines) at risk. This long-term and interdisciplinary assessment of PII-B is the first such study in the eastern Canadian Arctic and captures the multiple implications and risks that ice islands impose on the natural environment and offshore industries

A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty

__Background:__ The likelihood of restenosis is a major limitation of coronary angioplasty. We studied whether hirudin, a highly selective inhibitor of thrombin with irreversible effects, would prevent restenosis after angioplasty. We compared two regimens of recombinant hirudin with heparin. __Methods:__ We randomly assigned 1141 patients with unstable angina who were scheduled for angioplasty to receive one of three treatments: (1) a bolus dose of 10,000 IU of heparin followed by an intravenous infusion of heparin for 24 hours and subcutaneous placebo twice daily for three days (382 patients), (2) a bolus dose of 40 mg of hirudin followed by an intravenous infusion of hirudin for 24 hours and subcutaneous placebo twice daily for three days (381 patients), or (3) the same hirudin regimen except that 40 mg of hirudin was given subcutaneously instead of placebo twice daily for three days (378 patients). The primary end point was event-free survival at seven months. Other end points were early cardiac events (within 96 hours), bleeding and other complications of the study treatment, and angiographic measurements of coronary diameter at six months of follow-up. __Results:__ At seven months, event-free survival was 67.3 percent in the group receiving heparin, 63.5 percent in the group receiving intravenous hirudin, and 68.0 percent in the group receiving both intravenous and subcutaneous hirudin (P=0.61). However, the administration of hirudin was associated with a significant reduction in early cardiac events, which occurred in 11.0, 7.9, and 5.6 percent of patients in the respective groups (combined relative risk with hirudin, 0.61; 95 percent confidence interval, 0.41 to 0.90; P=0.023). The mean minimal luminal diameters in the respective groups on follow-up angiography at six months were 1.54, 1.47, and 1.56 mm. __Conclusions:__ Although significantly fewer early cardiac events occurred with hirudin than with heparin, hirudin had no apparent benefit with longer-term follow-up

A 24 HR global campaign to assess precision timing of the millisecond pulsar J1713+0747

The radiomillisecond pulsar J1713+0747 is regarded as one of the highest-precision clocks in the sky and is regularly timed for the purpose of detecting gravitational waves. The International Pulsar Timing Array Collaboration undertook a 24 hr global observation of PSR J1713+0747 in an effort to better quantify sources of timing noise in this pulsar, particularly on intermediate (1.24 hr) timescales. We observed the pulsar continuously over 24 hr with the Arecibo, Effelsberg, GMRT, Green Bank, LOFAR, Lovell, Nancay, Parkes, and WSRT radio telescopes. The combined pulse times-of-arrival presented here provide an estimate of what sources of timing noise, excluding DM variations, would be present as compared to an idealized N√ improvement in timing precision, where N is the number of pulses analyzed. In the case of this particular pulsar, we find that intrinsic pulse phase jitter dominates arrival time precision when the signal-to-noise ratio of single pulses exceeds unity, as measured using the eight telescopes that observed at L band/1.4 GHz.We present first results of specific phenomena probed on the unusually long timescale (for a single continuous observing session) of tens of hours, in particular interstellar scintillation, and discuss the degree to which scintillation and profile evolution affect precision timing. This paper presents the data set as a basis for future, deeper studies

Phase 2 study of dovitinib in patients with relapsed or refractory multiple myeloma with or without t(4;14) translocation

Objectives: Approximately 15% of patients with multiple myeloma (MM) exhibit a t(4;14) translocation, which often results in constitutive activation of the receptor tyrosine kinase (RTK) fibroblast growth factor receptor 3 (FGFR3). This study evaluated the efficacy and safety of dovitinib, an RTK inhibitor with in vitro inhibitory activity against FGFR, in patients with r

Our friend in the north: the origins, evolution and appeal of the cult of St Duthac of Tain in later Middle Ages

St Duthac of Tain was one of the most popular Scottish saints of the later middle ages. From the late fourteenth century until the reformation devotion to Duthac outstripped that of Andrew, Columba, Margaret and Mungo, and Duthac's shrine in Easter Ross became a regular haunt of James IV (1488-1513) and James V (1513-42). Hitherto historians have tacitly accepted the view of David McRoberts that Duthac was one of several local saints whose emergence and popularity in the fifteenth century was part of a wider self-consciously nationalist trend in Scottish religious practice. This study looks beyond the paradigm of nationalism to trace and explain the popularity of St Duthac from the shadowy origins of the cult to its heyday in the early sixteenth century

Full genome of Phialocephala scopiformis DAOMC 229536, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin

We present the full genome of Phialocephala scopiformis DAOMC 229536 (Helotiales, Ascomycota), a foliar endophyte of white spruce from eastern Quebec. DAOMC 229536 produces the anti-insectan compound rugulosin, which inhibits a devastating forestry pest, the spruce budworm. This genome will enable fungal genotyping and host-endophyte evolutionary genomics in inoculated trees

Widespread use of migratory megafauna for aquatic wild meat in the tropics and subtropics

Wild animals are captured or taken opportunistically, and the meat, body parts, and/or eggs are consumed for local subsistence or used for traditional purposes to some extent across most of the world, particularly in the tropics and subtropics. The consumption of aquatic animals is widespread, in some places has been sustained for millennia, and can be an important source of nutrition, income, and cultural identity to communities. Yet, economic opportunities to exploit wildlife at higher levels have led to unsustainable exploitation of some species. In the literature, there has been limited focus on the exploitation of aquatic non-fish animals for food and other purposes. Understanding the scope and potential threat of aquatic wild meat exploitation is an important first step toward appropriate inclusion on the international policy and conservation management agenda. Here, we conduct a review of the literature, and present an overview of the contemporary use of aquatic megafauna (cetaceans, sirenians, chelonians, and crocodylians) in the global tropics and subtropics, for species listed on the Appendices of the Convention on the Conservation of Migratory Species of Wild Animals (CMS). We find that consumption of aquatic megafauna is widespread in coastal regions, although to varying degrees, and that some species are likely to be at risk from overexploitation, particularly riverine megafauna. Finally, we provide recommendations for CMS in the context of the mandate of the Aquatic Wild Meat Working Group