Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum

The Hedgehog signaling pathway is essential for embryogenesis and for tissue homeostasis in the adult. However, it may induce malignancies in a number of tissues when constitutively activated, and it may also have a role in other forms of normal and maladaptive growth. Cyclopamine, a naturally occurring steroidal alkaloid, specifically inhibits the Hedgehog pathway by binding directly to Smoothened, an important Hedgehog response element. To use cyclopamine as a tool to explore and/or inhibit the Hedgehog pathway in vivo, a substantial quantity is required, and as a practical matter cyclopamine has been effectively unavailable for usage in animals larger than mice

Epoxidation of Alkenes by Peracids:From Textbook Mechanisms to a Quantum Mechanically Derived Curly-Arrow Depiction

Using the intrinsic bond orbital (IBO) analysis based on accurate quantum mechanical calculations of the reaction path for the epoxidation of propene using peroxyacetic acid, we find that the four commonly used curly arrows for representing this reaction mechanism are insufficient and that seven curly arrows are required as a result of changes to sigma and pi bonding interactions, which are usually neglected in all textbook curly arrow representations. The IBO method provides a convenient quantitative method for deriving curly arrows in a rational manner rather than the normal ad hoc representations used ubiquitously in teaching organic chemistry

Explicitly solvable cases of one-dimensional quantum chaos

We identify a set of quantum graphs with unique and precisely defined spectral properties called {\it regular quantum graphs}. Although chaotic in their classical limit with positive topological entropy, regular quantum graphs are explicitly solvable. The proof is constructive: we present exact periodic orbit expansions for individual energy levels, thus obtaining an analytical solution for the spectrum of regular quantum graphs that is complete, explicit and exact

Deconstructing holographic liquids

We argue that there exist simple effective field theories describing the long-distance dynamics of holographic liquids. The degrees of freedom responsible for the transport of charge and energy-momentum are Goldstone modes. These modes are coupled to a strongly coupled infrared sector through emergent gauge and gravitational fields. The IR degrees of freedom are described holographically by the near-horizon part of the metric, while the Goldstone bosons are described by a field-theoretical Lagrangian. In the cases where the holographic dual involves a black hole, this picture allows for a direct connection between the holographic prescription where currents live on the boundary, and the membrane paradigm where currents live on the horizon. The zero-temperature sound mode in the D3-D7 system is also re-analyzed and re-interpreted within this formalism.Comment: 21 pages, 2 figure

Spectra of regular quantum graphs

We consider a class of simple quasi one-dimensional classically non-integrable systems which capture the essence of the periodic orbit structure of general hyperbolic nonintegrable dynamical systems. Their behavior is simple enough to allow a detailed investigation of both classical and quantum regimes. Despite their classical chaoticity, these systems exhibit a ``nonintegrable analog'' of the Einstein-Brillouin-Keller quantization formula which provides their spectra explicitly, state by state, by means of convergent periodic orbit expansions.Comment: 32 pages, 10 figure

Separability of Black Holes in String Theory

We analyze the origin of separability for rotating black holes in string theory, considering both massless and massive geodesic equations as well as the corresponding wave equations. We construct a conformal Killing-Stackel tensor for a general class of black holes with four independent charges, then identify two-charge configurations where enhancement to an exact Killing-Stackel tensor is possible. We show that further enhancement to a conserved Killing-Yano tensor is possible only for the special case of Kerr-Newman black holes. We construct natural null congruences for all these black holes and use the results to show that only the Kerr-Newman black holes are algebraically special in the sense of Petrov. Modifying the asymptotic behavior by the subtraction procedure that induces an exact SL(2)^2 also preserves only the conformal Killing-Stackel tensor. Similarly, we find that a rotating Kaluza-Klein black hole possesses a conformal Killing-Stackel tensor but has no further enhancements.Comment: 27 page

Noncritical M-Theory in 2+1 Dimensions as a Nonrelativistic Fermi Liquid

We claim that the dynamics of noncritical string theories in two dimensions is related to an underlying noncritical version of M-theory, which we define in terms of a double-scaled nonrelativistic Fermi liquid in 2+1 dimensions. After reproducing Type 0A and 0B string theories as solutions, we study the natural M-theory vacuum. The vacuum energy of this solution can be evaluated exactly, its form suggesting a duality to the Debye model of phonons in a melting solid, and a possible topological nature of the theory. The physical spacetime is emergent in this theory, only for states that admit a hydrodynamic description. Among the solutions of the hydrodynamic equations of motion for the Fermi surface, we find families describing the decay of one two-dimensional string theory into another via an intermediate M-theory phase.Comment: 47 pages, 1 figure; v2: typos corrected, references adde