Probing Dark Matter

Recent novel observations have probed the baryonic fraction of the galactic dark matter that has eluded astronomers for decades. Late in 1993, the MACHO and EROS collaborations announced in this journal the detection of transient and achromatic brightenings of a handful of stars in the Large Magellanic Cloud that are best interpreted as gravitational microlensing by low-mass foreground objects (MACHOS). This tantalized astronomers, for it implied that the population of cool, compact objects these lenses represent could be the elusive dark matter of our galactic halo. A year later in 1994, Sackett et al. reported the discovery of a red halo in the galaxy NGC 5907 that seems to follow the inferred radial distribution of its dark matter. This suggested that dwarf stars could constitute its missing component. Since NGC 5907 is similar to the Milky Way in type and radius, some surmised that the solution of the galactic dark matter problem was an abundance of ordinary low-mass stars. Now Bahcall et al., using the Wide-Field Camera of the recently repaired Hubble Space Telescope, have dashed this hope.Comment: 3 pages, Plain TeX, no figures, published as a News and Views in Nature 373, 191 (1995

Patient-generated data in the management of HIV: a scoping review

Objectives Patient-generated data (PGData) are an emergent research area and may improve HIV care. The objectives of this scoping review were to synthesise, evaluate and make recommendations based on the available literature regarding PGData use in HIV care. Design Scoping review. Data sources Embase, Medline, CINAHL Plus, Web of Science, Scopus, PsycINFO and Emcare databases. Eligibility criteria Studies involving PGData use within HIV care for people living with HIV and/or healthcare professionals (HCPs) published before February 2021. Data extraction and synthesis Data were extracted using a table and the Mixed Methods Appraisal Tool was used to assess empirical rigour. We used thematic analysis to evaluate content. Results 11 articles met the eligibility criteria. Studies were observational, predominantly concerned hypothetical or novel digital platforms, mainly conducted in high-income settings, and had small sample sizes (range=10–160). There were multiple definitions of PGData. In the majority of studies (n=9), participants were people living with HIV, with a few studies including HCPs, informatics specialists or mixed participant groups. Participants living with HIV were aged 23–78 years, mostly men, of diverse ethnicities, and had low educational, health literacy and income levels. We identified four key themes: (1) Perceptions of PGData and associated digital platforms; (2) Opportunities; (3) Anticipated barriers and (4) Potential impact on patient–HCP relationships. Conclusions Use of PGData within HIV care warrants further study, especially with regard to digital inequalities, data privacy and security. There is a need for longitudinal data on use within HIV in a variety of settings with a broad range of users, including impact on clinical outcomes. This will allow greater understanding of the role of PGData use in improving the health and well-being of people living with HIV, which is increasingly pertinent as digital healthcare becomes more widespread as a result of COVID-19

Early identification of wound infection: understanding wound odour

Malodorous wounds can be distressing for patients and their families, negatively impacting on quality-of-life outcomes. For health professionals malodorous wounds can also cause distress manifesting in feelings of disgust when faced with a wound emitting an unpleasant or repulsive odour. There has been investigation into the management of controlling odour particularly in relation to fungating wounds. However, there is limited research that explores techniques for early identification and recognition of wound odours that may be indicative of infection. Electronic nose technology has received some attention, but to date has not been integrated into either diagnostics of infection in wounds or education of health professionals to prepare them for the realities of clinical practice

How primary care can contribute to good mental health in adults.

The need for support for good mental health is enormous. General support for good mental health is needed for 100% of the population, and at all stages of life, from early childhood to end of life. Focused support is needed for the 17.6% of adults who have a mental disorder at any time, including those who also have a mental health problem amongst the 30% who report having a long-term condition of some kind. All sectors of society and all parts of the NHS need to play their part. Primary care cannot do this on its own. This paper describes how primary care practitioners can help stimulate such a grand alliance for health, by operating at four different levels - as individual practitioners, as organisations, as geographic clusters of organisations and as policy-makers

Analysis and Prediction of the Metabolic Stability of Proteins Based on Their Sequential Features, Subcellular Locations and Interaction Networks

The metabolic stability is a very important idiosyncracy of proteins that is related to their global flexibility, intramolecular fluctuations, various internal dynamic processes, as well as many marvelous biological functions. Determination of protein's metabolic stability would provide us with useful information for in-depth understanding of the dynamic action mechanisms of proteins. Although several experimental methods have been developed to measure protein's metabolic stability, they are time-consuming and more expensive. Reported in this paper is a computational method, which is featured by (1) integrating various properties of proteins, such as biochemical and physicochemical properties, subcellular locations, network properties and protein complex property, (2) using the mRMR (Maximum Relevance & Minimum Redundancy) principle and the IFS (Incremental Feature Selection) procedure to optimize the prediction engine, and (3) being able to identify proteins among the four types: “short”, “medium”, “long”, and “extra-long” half-life spans. It was revealed through our analysis that the following seven characters played major roles in determining the stability of proteins: (1) KEGG enrichment scores of the protein and its neighbors in network, (2) subcellular locations, (3) polarity, (4) amino acids composition, (5) hydrophobicity, (6) secondary structure propensity, and (7) the number of protein complexes the protein involved. It was observed that there was an intriguing correlation between the predicted metabolic stability of some proteins and the real half-life of the drugs designed to target them. These findings might provide useful insights for designing protein-stability-relevant drugs. The computational method can also be used as a large-scale tool for annotating the metabolic stability for the avalanche of protein sequences generated in the post-genomic age

Management of Root Knot Nematode on Tomato Through Grafting Root Stock of Solanum Sisymbriifolium

The root-knot nematodes (Meloidogyne spp) are difficult to manage once established in the field because of their wide host range, and soil-borne nature. Thus, the aim of the present study was to examine the use of resistant root stock of wild brinjal (Solanum sisymbriifolium) to reduce the loss caused by the nematodes on tomato. For the management of root-knot nematodes, grafted plant with resistant root stock of the wild brinjal was tested under farmers\u27 field conditions at Hemza of Kaski district. Grafted and non-grafted plants were produced in root-knot nematode-free soil. Around three week-old grafted and non-grafted tomato plants were transplanted in four different plastic tunnels where root-knot nematodes had been reported previously. The plants were planted in diagonal position to each other as a pair plot in 80 × 60 cm2 spacing in an average of 20 × 7 m2 plastic tunnels. Galling Index (GI) was recorded three times in five randomly selected plants in each plot at 60 days intervals. The first observation was recorded two months after transplanting. Total fruit yield was recorded from same plants. In the grafted plants, the root system was totally free from gall whereas in an average of 7.5 GI in 0-10 scale was recorded in the non-grafted plants. Fruits were harvested from time to time and cumulated after final harvest to calculate the total fruit yield. It was estimated that on an average tomato fruit yield was significantly (P>0.05) increased by 37 percent in the grafted plants compared with the non-grafted plants. Grafting technology could be used effectively for cultivation of commonly grown varieties, which are susceptible to root-knot nematodes in disease prone areas. This can be used as an alternative technology for reducing the use of hazardous pesticides for enhancing commercial organic tomato production.Journal of Nepal Agricultural Research Council Vol.3 2017: 27-3

Most vital segment barriers

We study continuous analogues of "vitality" for discrete network flows/paths, and consider problems related to placing segment barriers that have highest impact on a flow/path in a polygonal domain. This extends the graph-theoretic notion of "most vital arcs" for flows/paths to geometric environments. We give hardness results and efficient algorithms for various versions of the problem, (almost) completely separating hard and polynomially-solvable cases

On differential rotation and overshooting in solar-like stars

This is the author accepted manuscript. The final version is available from American Astronomical Society via the DOI in this record.We seek to characterize how the change of global rotation rate influences the overall dynamics and large scale flows arising in the convective envelopes of stars covering stellar spectral types from early G to late K. We do so through numerical simulations with the ASH code, where we consider stellar convective envelopes coupled to a radiative interior with various global properties. As solar-like stars spin down over the course of their main sequence evolution, such change must have a direct impact on their dynamics and rotation state. We indeed find that three main states of rotation may exist for a given star: anti-solar-like (fast poles, slow equator), solar-like (fast equator, slow poles), or a cylindrical rotation profile. Under increasingly strict rotational constraints, the latter profile can further evolve into a Jupiter-like profile, with alternating prograde and retrograde zonal jets. We have further assessed how far the convection and meridional flows overshoot into the radiative zone and investigated the morphology of the established tachocline. Using simple mixing length arguments, we are able to construct a scaling of the fluid Rossby number $R_{of} = \tilde{\omega}/2\Omega_* \sim \tilde{v}/2\Omega_* R_*$, which we calibrate based on our 3-D ASH simulations. We can use this scaling to map the behavior of differential rotation versus the global parameters of stellar mass and rotation rate. Finally, we isolate a region on this map ($R_{of} \gtrsim 1.5-2$) where we posit that stars with an anti-solar differential rotation may exist in order to encourage observers to hunt for such targets.We acknowledge funding by ERC STARS2 207430 grant, ANR Blanc Toupies SIMI5-6 020 01, INSU/PNST, CNES SolarOrbiter, PLATO and GOLF grants, FP7 SpaceInn 312844 grant, and NASA grants NNX11AJ36G, NNX13AG18G and NNX16AC92G. K. C. Augustson is funded through the ERC SPIRE 647383 grant. A. Strugarek acknowledges support from the Canadian Institute of Theoretical Astrophysics (National Fellow), from Canadas Natural Sciences and Engineering Research Council and from CNES postdoctoral fellowship