Research on the structure of home-based nursing care provided by family caregivers responsible for dialysis patients requiring nursing care

取得学位 : 博士（保健学）, 学位授与番号 : 医博甲第1987号 , 学位授与年月日 : 平成20年9月26日, 学位授与大学 : 金沢大学, 審査結果の報告日 : 平成20年8月25日, 主査 :稲垣 美智子 , 副査 :長谷川 雅美, 塚崎 恵

Functional ultrasound reveals effects of MRI acoustic noise on brain function

Loud acoustic noise from the scanner during functional magnetic resonance imaging (fMRI) can affect functional connectivity (FC) observed in the resting state, but the exact effect of the MRI acoustic noise on resting state FC is not well understood. Functional ultrasound (fUS) is a neuroimaging method that visualizes brain activity based on relative cerebral blood volume (rCBV), a similar neurovascular coupling response to that measured by fMRI, but without the audible acoustic noise. In this study, we investigated the effects of different acoustic noise levels (silent, 80 dB, and 110 dB) on FC by measuring resting state fUS (rsfUS) in awake mice in an environment similar to fMRI measurement. Then, we compared the results to those of resting state fMRI (rsfMRI) conducted using an 11.7 Tesla scanner. RsfUS experiments revealed a significant reduction in FC between the retrosplenial dysgranular and auditory cortexes (0.56 ± 0.07 at silence vs 0.05 ± 0.05 at 110 dB, p=.01) and a significant increase in FC anticorrelation between the infralimbic and motor cortexes (−0.21 ± 0.08 at silence vs −0.47 ± 0.04 at 110 dB, p=.017) as acoustic noise increased from silence to 80 dB and 110 dB, with increased consistency of FC patterns between rsfUS and rsfMRI being found with the louder noise conditions. Event-related auditory stimulation experiments using fUS showed strong positive rCBV changes (16.5% ± 2.9% at 110 dB) in the auditory cortex, and negative rCBV changes (−6.7% ± 0.8% at 110 dB) in the motor cortex, both being constituents of the brain network that was altered by the presence of acoustic noise in the resting state experiments. Anticorrelation between constituent brain regions of the default mode network (such as the infralimbic cortex) and those of task-positive sensorimotor networks (such as the motor cortex) is known to be an important feature of brain network antagonism, and has been studied as a biological marker of brain disfunction and disease. This study suggests that attention should be paid to the acoustic noise level when using rsfMRI to evaluate the anticorrelation between the default mode network and task-positive sensorimotor network.journal articl

Proposal for Global Standard Maneuvering Orders for Tugboats

The use of “Standard Maneuvering Orders” for tugboats, vocabulary and phrases mutually pre-agreed between ships and tugboats, is essential for the former to provide clear direction for the latter when berthing or un-berthing safely. Tugboats will need time to change their posture before they take actions in response to orders from persons responsible for ships’ maneuvering. Therefore, when giving directions to change tugboats’ posture, persons who handle their ships are required to send out tug orders, with regard to “delay time,” a gap be-tween the orders from ships and the actions taken by tugboats. “Tug Orders” standardized and used in Japan are composed of the following three factors concerning towage work: tugboat’s motion, direction and engine power, but the author’s research shows that there are “Non-standard” special maneuvering orders other than those “standardized,” which causes such problems as a gap in perception between pilots and tugboat’s opera-tors, etc. The purpose of this paper is to research the delay time between orders for and actions by tugboats and consider the appropriate and safe timing of providing instructions to them, and then to propose globally-authorized “Standard Maneuvering Orders for tugboats”, discussing a problem involved in the use of the special orders used in Japan, and the way in which tug orders are used in other countries

Retrorectal epidermoid cyst with unusually elevated serum SCC level, initially diagnosed as an ovarian tumor

Retrorectal epidermoid cyst is one of the developmental cysts which arise from remnants of embryonic tissues. We report a rare case of retrorectal epidermoid cyst, initially diagnosed as an ovarian tumor. Serum SCC value as tumor marker was elevated to the high level. Laparoscopy revealed ovaries, uterus and other pelvic organs were all normal. This tumor existed in the retroperitoneal cavity and compressed the rectum. Later, complete tumor resection was performed by laparotomy. Histological study revealed the epithelium of this tumor consisted of only squamous cells without atypia, and the diagnosis of this tumor was retrorectal epidermoid cyst. Retrorectal epidermoid cyst is very rare, and difficult to diagnose before surgery. However, if we have-knowledge of developmental cysts, and by careful digital examination and image diagnosis, a differential diagnosis can be made

Tratamento de matrizes de cravo (Dianthus caryophyllus L., Caryophyllaceae) com nitrogênio e calogênese in vitro

Indução de calogênese eficiente e multiplicação celular rápida são pré-requisitos fundamentais em biotecnologia de plantas. Sucesso na calogênese é dependente dos componentes do meio de cultura e da qualidade dos explantes. Neste trabalho é relatada a influência do tratamento de matrizes de Dianthus caryophyllus L. com nitrogênio na indução de calogênese in vitro. Mudas de cravo cultivadas em vasos contendo areia foram tratadas com soluções nutritivas contendo 5 níveis de nitrogênio. Explantes folha, entrenós e nó foram coletados aos 30, 45 e 60 dias após início dos tratamentos e inoculados em meio de cultura contendo os sais básicos e vitaminas de Murashige & Skoog (1962), suplementado com 1 g L-1 de caseína hidrolizada, 2 mimol L-1 de cinetina e 3 mimol L-1 de 2,4-D para indução da calogênese. Ao longo dos 60 dias de tratamento com as soluções nutritivas, as matrizes de cravo não apresentaram sintomas visíveis de deficiência ou de excesso do nutriente nitrogênio. O tratamento com nitrogênio afetou a calogênese avaliada em massa de matéria fresca e seca. A produção da massa de matéria fresca de calos foi proporcional ao tratamento com nitrogênio até concentração de 267 mg L-1 para explantes folha por durante 30 dias. Tratamentos mais prolongados (45 e 60 dias) afetaram negativamente a calogênese e foram inversamente proporcionais a concentração de nitrogênio na solução nutritiva.Efficient calogenesis induction and rapid cell multiplication are fundamental requirements in plant biotechnology. The success of calogenesis is dependent on the growth medium components and the quality of explants. This work is referred to the influence of Dianthus caryophyllus L. nitrogen treatment on calogenesis induction in vitro. Carnation cuts rooted in sand pots were treated with nutrient solutions containing 5 nitrogen levels. Leaves, internodes and node explants were collected and inoculated on callus induction culture media containing Murashige & Skoog (1962) salts and vitamins, supplemented with 1 g L-1 hidrolysed casein, 2 mumol L-1 kinetin and 3 mumol L-1 2,4-D. No plant deficiency and toxicity symptoms were apparent on the treated plants during the 60 day treatment. The nitrogen treatment affected calogenesis in relation to calli fresh and dry weights. Callus fresh weigth yield was proportional to nitrogen concentration up to 267 mg L-1 for leaf explant during 30 days. Longer treatments (45 and 60 days) affected calogenesis negatively which were inversely proportional to the nitrogen concentration of the nutrient solution

Pexophagy suppresses ROS-induced damage in leaf cells under high-intensity light

Although light is essential for photosynthesis, it has the potential to elevate intracellular levels of reactive oxygen species (ROS). Since high ROS levels are cytotoxic, plants must alleviate such damage. However, the cellular mechanism underlying ROS-induced leaf damage alleviation in peroxisomes was not fully explored. Here, we show that autophagy plays a pivotal role in the selective removal of ROS-generating peroxisomes, which protects plants from oxidative damage during photosynthesis. We present evidence that autophagy-deficient mutants show light intensity-dependent leaf damage and excess aggregation of ROS-accumulating peroxisomes. The peroxisome aggregates are specifically engulfed by pre-autophagosomal structures and vacuolar membranes in both leaf cells and isolated vacuoles, but they are not degraded in mutants. ATG18a-GFP and GFP-2×FYVE, which bind to phosphatidylinositol 3-phosphate, preferentially target the peroxisomal membranes and pre-autophagosomal structures near peroxisomes in ROS-accumulating cells under high-intensity light. Our findings provide deeper insights into the plant stress response caused by light irradiation

SUAC トショカン ノ ショウライ ノ カノウセイ ニ ムケテ ノ テイゲン

SUACの図書館は毎年の受入れ状況から換算するとあと数年で書架が飽和状態となることが予想される。一方で、全国の大学図書館に目を転じた場合、サービス面や空間的なデザインの側面からさまざまな工夫をこらし、学生の学習環境の向上を果たすことによって、ひいては大学独自の魅力として受験生や地域社会へのPR効果をもたらしている事例がみられる。そこで本研究では、本学図書館の蔵書スペースの問題や大学図書館としての特色のあり方について考察し、その可能性を提言する。Possible solutions are sought on the issues the library of SUAC is faced with. One is how to deal with the problem of increasing books every year. The other is what kind of features can be added to distinguish the SUAC\u27s library from other libraries