The Impact of Ethics on Job criminalization

The criminalization of some jobs can be traced in the law system of all countries. The criteria for this criminalization vary according to the legal system of each country. In Iran, job criminalization is based on the approach of Imami jurisprudence, which is a text-oriented and sometimes intellect-oriented paradigm. Therefore, jurisprudence determines whether a job is criminal or not. Along with theology and ethics, the science of jurisprudence constitutes the three scientific pillars of Islam. The relationship between these three is one of the fundamental discussions that have great impacts on the attitude of scholars of jurisprudence in dealing with issues. Among these, the relationship between ethics and jurisprudence is very important because these two are formed on the basis of instructions and warnings and it has caused a disagreement among Islamic scholars about their relationship. Some deny their relationship, some believe that ethics requires jurisprudence, and some consider jurisprudence to require ethical supervision. These variations have led to differences in their perceptions of issues. Of course, looking at the meaning of ethics and jurisprudence, it is clear that the two are in close contact with each other, and since human behavior must be accepted by God in order to lead to human happiness, ethics acts as an observer of jurisprudence. This effect is sometimes based on the imaginary and affirmative principles of jurisprudence, and sometimes on the methods of jurisprudence. These effects can be observed in the difference between a job criminalization, which is mentioned in this article

Biocompatibility of Portland Cement Modified with Titanium Oxide and Calcium Chloride in a Rat Model

Introduction: The aim of the present study was to evaluate the biocompatibility of two modified formulations of Portland cement (PC) mixed with either titanium oxide or both titanium oxide and calcium chloride. Methods and Materials: Polyethylene tubes were filled with modified PCs or Angelus MTA as the control; the tubes were then implanted in 28 Wistar rats subcutaneously. One tube was left empty as a negative control in each rat. Histologic samples were taken after 7, 15, 30 and 60 days. Sections were assessed histologically for inflammatory responses and presence of fibrous capsule and granulation tissue formation. Data were analyzed using the Fisher’s exact and Kruskal-Wallis tests. Result: PC mixed with titanium oxide showed the highest mean scores of inflammation compared with others. There was no statistically significant difference in the mean inflammatory grades between all groups in each of the understudy time intervals. Conclusion: The results showed favorable biocompatibility of these modified PC mixed with calcium chloride and titanium oxide.Keywords: Biocompatibility; Mineral Trioxide Aggregate; Portland Cemen

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation

The Impact of Ethics on Job criminalization

The criminalization of some jobs can be traced in the law system of all countries. The criteria for this criminalization vary according to the legal system of each country. In Iran, job criminalization is based on the approach of Imami jurisprudence, which is a text-oriented and sometimes intellect-oriented paradigm. Therefore, jurisprudence determines whether a job is criminal or not. Along with theology and ethics, the science of jurisprudence constitutes the three scientific pillars of Islam. The relationship between these three is one of the fundamental discussions that have great impacts on the attitude of scholars of jurisprudence in dealing with issues. Among these, the relationship between ethics and jurisprudence is very important because these two are formed on the basis of instructions and warnings and it has caused a disagreement among Islamic scholars about their relationship. Some deny their relationship, some believe that ethics requires jurisprudence, and some consider jurisprudence to require ethical supervision. These variations have led to differences in their perceptions of issues. Of course, looking at the meaning of ethics and jurisprudence, it is clear that the two are in close contact with each other, and since human behavior must be accepted by God in order to lead to human happiness, ethics acts as an observer of jurisprudence. This effect is sometimes based on the imaginary and affirmative principles of jurisprudence, and sometimes on the methods of jurisprudence. These effects can be observed in the difference between a job criminalization, which is mentioned in this article.La criminalización de algunos trabajos se puede rastrear en el sistema legal de todos los países. Los criterios para esta criminalización varían según el sistema legal de cada país. En Irán, la criminalización del trabajo se basa en el enfoque de la jurisprudencia Imami, que es un paradigma orientado al texto y, a veces, al intelecto. Por tanto, la jurisprudencia determina si un trabajo es criminal o no. Junto con la teología y la ética, la ciencia de la jurisprudencia constituye los tres pilares científicos del Islam. La relación entre estos tres es una de las discusiones fundamentales que tienen un gran impacto en la actitud de los estudiosos de la jurisprudencia al abordar los temas. Entre estos, la relación entre ética y jurisprudencia es muy importante porque estos dos se forman sobre la base de instrucciones y advertencias y ha causado un desacuerdo entre los eruditos islámicos sobre su relación. Algunos niegan su relación, algunos creen que la ética requiere jurisprudencia y algunos consideran que la jurisprudencia requiere supervisión ética. Estas variaciones han dado lugar a diferencias en sus percepciones de los problemas. Por supuesto, al observar el significado de la ética y la jurisprudencia, queda claro que las dos están en estrecho contacto entre sí, y dado que el comportamiento humano debe ser aceptado por Dios para conducir a la felicidad humana, la ética actúa como observadora de la jurisprudencia. . Este efecto a veces se basa en los principios imaginarios y afirmativos de la jurisprudencia y, a veces, en los métodos de la jurisprudencia. Estos efectos se pueden observar en la diferencia entre una criminalización laboral, que se menciona en este artículo

The Effects of Hypoxia on U937 Cell Line in Mesenchymal Stem Cells Co-Culture System

Purpose: Mesenchymal Stem Cells (MSCs) are the most important members of Bone Marrow (BM) milieu. MSCs affect different kinds of cells, particularly malignant cells of hematologic malignancies, but the effects of MSCs are unclear exactly. Here we analyzed the effects of derived Umbilical Cord Blood-MSCs on proliferation, cell death and some surface markers of U937 cell line in a Co-culture system with MSCs. Methods: Here we designed Co-culture systems as a model of BM milieu. We cultured U937 cells on UCB-MSCs and MSCs Conditioned Medium (C.M) driven and then treated U937 cells with optimum concentration of chloride cobalt (CoCl2) as a hypoxia-mimetic agent. In addition, we applied suitable concentrations of H2O2 to induce cell death. Proliferation rate, cell death rate and some surface markers of hypoxic U937 cells were analyzed by MTT assay, flow cytometry and Real Time-PCR were flown respectively. Results: UCB-MSCs showed supportive effects on U937 proliferation rate in normoxia and hypoxia. Lethal effect of H2O2 suppressed in the presence of UCB-MSCs in hypoxia and normoxia. Among CD11a, CD14, CD49d, CD54 and CD116 markers, CD49d was down regulated in presence of UCB-MSCs and CD116 was up regulated in hypoxia. Other markers didn’t show any significant changes. Conclusion: This work provides evidences that MSCs play critical roles in U937 cells biology. These observations shed new light on MSCs roles and demonstrated that MSCs should be regarded as an important member of BM milieu in several clinical applications such as BM transplantation prognosis and treatment of hematologic malignancies

Electrochemical Performance Improvement of the Catalyst of the Methanol Microfuel Cell Using Carbon Nanotubes

In this research, the electrocatalytic activity of platinum-ruthenium nanoparticles on carbon nanotubes and carbon black in methanol oxidation reaction has been investigated. Moreover, the electrochemical performance of a single passive direct methanol fuel cell run by these two different electrocatalysts has been reported. Physical characterization and electrochemical tests reveal the superiority of PtRu on carbon nanotubes. Based on the voltammetry outcomes, it was found that methanol oxidation reaction kinetics has been improved on the nanotube-supported catalyst. The current density of oxidation reaction has increased up to 62% in nanotube sample compared to carbon black-supported one. The electrochemical test results have shown that the carbon nanotubes increase the performance of the microfuel cell by 37% at maximum power density, compared to the carbon black. Moreover, the resistance of the samples supported by carbon nanotubes to poisonous intermediate species has been found 3% more than carbon black-supported one. According to the chronoamperometry test results, it was concluded that the performance and sustainability of the carbon nanotube electrocatalyst show a remarkable improvement compared to carbon black electrocatalyst in the long term

Knowledge, attitude and practice of nursing students Dezful university of medical sciences towards evidence-based nursing in the second semester of the academic year 2017-2018

Introduction: Nowadays The health care systems around the world face many challenges and in many cases, health care is accompanied by many question Therefore, evidence-based practice, as an essential factor for improving health care is more emphasis.  This study aimed to investigate the knowledge and attitude of nursing students of Dezful university of medical sciences toward evidence-based nursing. Method: This descriptive-analytical study was conducted in the second semester of the academic year of 2017-2018 at the Faculty of Nursing and Midwifery of Dezful university of medical sciences. The data collection tool was a standard questionnaire "Knowledge, attitude and practice of undergraduate nursing students about evidence-based practice". Data were analyzed using descriptive and analytical statistics in SPSS software. Results: The results showed that knowledge and attitude toward evidence-based practice with access to medical evidence from the Internet (p = 0/001, r = 0/273) and journal clubs (p = 0/000, r = 0 / 306) and the use of reference books and referring to them (p = 0/000, r = 0/401), there is a statistically significant relationship (p=0/01, r=0/277). This means that the mean scores of knowledge and attitudes among students most in search of scientific evidence in various ways (internet and journal clubs and reference books), as well as easier access to evidence, were significantly higher than other students. Conclusion: Evidence-based nursing is a process that is Emphasis on the latest findings will take the best decisions in order to raise the quality of care. Therefore, it is better for students to become fully acquainted with this concept and learn it. although The students' attitudes toward evidence-based practice was moderate; But with proper planning educational reforms in the education of nursing students, can be an important step in the development and promotion of evidence-based practice picked up. &nbsp