Institutionalism in Labor Economics

Labor economics is the science which analyzes labor market, labor resources and employment, long-term analysis of labor relations, explores the revenue of workers and labor costs, investigates the problems of labor productivity and efficiency, develops the methods of explanation the number of employees, as well as explains the concept of human capital. Also, labor economics studies the processes of reproduction of labor power and interaction of employees, means and objects of labor

PERSPECTIVE DIRECTIONS OF PATRIOTIC EDUCATION

Introduction. Nowadays, patriotic education is a strategic reference point of the Russian education system. However, in the modern sociocultural situation, characterised by diversity, discrepancy, multi-vector nature of development of society and polystylicity of culture, it is necessary to revise the forms of patriotic education in order to adjust them in accordance with the  requirements and mental features of new young generation – so-called generation Z, which is considerably different from the previous generation of peers. The aims of the research were the following: to identify promising areas and vectors of patriotic education, to demonstrate its resources and to highlight the most relevant means and possibilities, which are appropriate to present-day realities. Methodology and research methods. The work was based on the method of discursive analysis, which allows the dependence of patriotic education practices on modern realities and socio-psychological characteristics of adolescents and youth to be revealed. In the course of the research, the methods of comparative analysis, systematisation and classification were employed. Results and scientific novelty. The conceptual and category-based framework of patriotic education and its structure are specified. Patriotism is considered as the most important component of the value-normative system of a personality. Patriotism is based on a positive cultural identity. Patriotism is distinguished by an active character-readiness and ability of a person to transform his or her  feelings towards homeland into deeds and acts, which are necessary for the good of the country. The analysis of practices of patriotic education in different countries allowed the authors to allocate two basic directions – civil-patriotic and military-patriotic education, which act as the complementary components of integral system. Civil-patriotic education is a purposeful, consciously carried out pedagogical process of organisation and management of learners’ activities for mastering socio-cultural, socio-political, economic, moral and ethical experience of democratic relations through media education and participation in socially approved projects, civil-law campaigns and charitable events, which foster tolerance for various categories of fellow citizens. Military-patriotic education implies the formation of necessary qualities and skills for performance of a military duty in ranks of the Russian Federation’s Armed Forces and, furthermore, for understanding and awareness of the personal role and place in service to the Fatherland. This direction involves education towards military traditions, museum pedagogics, participation in historical reconstructions and specially designed computer games related to military-patriotic issues. The list of educational practices, outlined in the present publication, does not purport to be complete and exhaustive. The task of authors consisted in the search for and choice of those, which, on the one hand, fill an ideological construct “patriotism” with live contents, attract teenagers and youth, and, on the other hand, answer the requests of society for education of a socially responsible personality with sustainable value system. Practical significance of the research is determined by the appropriateness and efficiency of applying the described forms and methods of educational work into teaching practice.Введение. Воспитание, в том числе патриотическое, является стратегическим ориентиром российского образования. Однако в современной социокультурной ситуации, характеризующейся разноплановостью, противоречивостью, многовекторностью развития общества и полистилистичностью культуры, необходим пересмотр его форм, с тем чтобы привести их в максимальное соответствие с потребностями и ментальными особенностями нового юного поколения – так называемого поколения Z, заметно  отличающегося от предшествующих генераций сверстников. Цели работы – обозначить перспективы и векторы патриотического воспитания, продемонстрировать его ресурсы и выявить наиболее актуальные, адекватные сегодняшним реалиям способы и возможности его реализации. Методология и методы. В качестве ведущего метода работы применялся дискурсивный анализ, позволяющий установить зависимость использующихся форм и видов воспитания патриотизма от быстро меняющихся условий жизнедеятельности и социально-психологических качеств современных подростков и молодежи. Кроме того, при выполнении исследования были задействованы методы сравнительно-сопоставительного анализа, систематизации и классификации. Результаты и научная новизна. Уточнены понятийно-категориальный аппарат патриотического воспитания и его структура. Рассмотрена сущность патриотизма как важнейшего компонента ценностно-нормативной системы личности, в основе которого лежит положительная культурная идентичность. Подчеркивается деятельный характер патриотизма, выражающийся в готовности и способности преобразовывать чувства, испытываемые человеком к Родине, в дела и поступки ради ее блага. С учетом результатов анализа и обобщения практик и содержания патриотического воспитания в разных странах выделены два его основополагающих направления – гражданско-патриотическое и военно-патриотическое, которые выступают взаимодополняющими составляющими целостной системы. Гражданско-патриотическое направление трактуется как целенаправленный, сознательно осуществляемый педагогический процесс организации и управления деятельностью обучающихся по овладению социально-культурным, социально-политическим, экономическим, морально-этическим опытом демократических отношений посредством участия в социально одобряемых проектах, гражданско-правовых акциях, благотворительных мероприятиях, укрепляющих толерантность к разным категориям сограждан, и через получение медиаобразования. Военно-патриотический аспект  воспитания подразумевает прежде всего формирование качеств и навыков, которые нужны для выполнения воинского долга в рядах Вооруженных сил Российской Федерации; а также осмысление и осознание молодыми людьми своей роли и места в служении Отечеству. Данное направление включает воспитание на воинских традициях, музейную педагогику, участие в исторических реконструкциях и специальных компьютерных играх военно-патриотической тематики. Перечень воспитательных практик, о которых идет речь в публикации, не претендует на полноту и исчерпанность. Задача авторов состояла в поиске и выборе тех практик, которые, с одной стороны, наполняют идеологический конструкт «патриотизм» живым содержанием, привлекательны для подростков и молодежи, а с другой стороны, отвечают запросам общества на воспитание социально ответственной личности с устойчивой ценностной системой.Практическая значимость исследования определяется целесообразностью внедрения в педагогическую практику и эффективностью описанных авторами форм и методов воспитательной работы

EDITORIAL EXPERIENCE ON A HISTORICAL MANUSCRIPT (ON THE BASIS OF THE WORK “RUSSIAN MINING HISTORY” BY A.S. YARTSOV)

Раскрываются особенности подготовки к публикации рукописного труда начала XIX в., перечисляются сложности его корректной расшифровки. Проводится попытка воссоздания образа личности автора на основе имеющихся текстовых характеристик источника.The features of preparation for publication of the manuscript of the early 19th century are revealed, the difficulties of its correct decoding are listed. An attempt to reconstruct the image of the author’s personality on the basis of the available textual characteristics of the source is made

Methods composition of physical therapy in disorder of substances exchange in young girls.

В роботі наведено основні складові методів фізичної терапії при порушенні обміну речовин у молоді. Встановлена ефективність розробленої комплексної програми фізичної терапії при надмірній вазі, яку застосовували, протягом 4 місяців в групі у молоді 17-20 років. Доведено, що після експерименту індекс маси тіла у студенток контрольної групи зменшився на 5,7% (р> 0,05), а в експериментальної групи зменшився на 17,4% (р< 0,05), різниця між групами була статистично значима (р<0,05). Запропонована програма фізичної терапії може бути використана з метою профілактики ожиріння та нормалізації обміну речовин у молоді

PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse

Introduction: Circulating monocytes are main source for tumor-associated macrophages (TAMs) that control tumor growth, angiogenesis, metastasis and therapy resistance. We raised the questions how monocyte programming is affected by growing tumors localized in colon and rectal sections, and how treatment onsets affect monocyte programming in the circulation. Methods: Patients with rectal cancer and colon cancer were enrolled in the study. Peripheral blood monocytes were characterized by phenotypic analysis using flow cytometry, by transcriptomic analysis using RNA sequencing and by gene expression analysis using real-time RT-PCR. Phenotypic analysis was performed with IF/confocal microscopy. Spatial transcriptomic analysis was applied using GeoMX DSP-NGS. Results: In patients with rectal cancer, increased amount of CCR2+ monocytes was indicative for the absence of both lymphatic and hematogenous metastasis. In contrast, in patients with colon cancer CD163+ monocytes were indicative for LN metastasis. NGS analysis identified tumor-specific transcriptional programming of monocytes in all CRC patients compared to healthy individuals. The key transcriptional difference between monocytes of patients with colon and rectal cancer was increased expression of PFKFB3, activator of glycolysis that is currently considered as therapy target for major solid cancers. PFKFB3-expressing monocyte-derived macrophages massively infiltrated tumor in colon. Nanostring technology identified correlation of PFKFB3 with amount and tumor-promoting properties of TAMs in colon but not in rectal cancer. PFKFB3 was indicative for tumor relapse specifically in colon cancer. Discussion: Our findings provide essential argument towards CRC definition to cover two clinically distinct cancers – colon cancer and rectal cancer, that differentially interact with innate immunity

Generating and transferring grassroots innovations in a multi-actor participatory process

Peer reviewe

Supramolecular systems based on amidoammonium and amidoaminocalix[4]resorcinarenes and polyacrylic acid

© 2015 Elsevier B.V. In the solutions of polyacrylic acid (PAA) the amphiphilic calix[4]resorcinarenes 1-. 10 and their complexes with Methyl Orange (MO) form binary (. 1-. 10)-PAA and tertiary (. 2-. 10). -MO-PAA supramolecular complexes which are water-soluble in the case of amidoammonium (. 1-. 5) and water-insoluble in the case of amidoamino (. 6, 7) or amido(dimethylamino) (. 8-. 10) calixresorcinarenes. Almost 90% of removal of MO from the aqueous solution is achieved by the formation of the water-insoluble systems (. 6-. 10)-m{cyrillic}O{cyrillic}-PAA. In aqueous solution the particles of the (. 1-. 5)-PAA systems have average hydrodynamic diameters which values vary depending on the length of the alkyl substituents of macrocycles

Peroral endoscopic myotomy after operative interventions on the gastroesophageal junction

A.S. Loginov Moscow Clinical Scientific Center, Moscow, Russia, Al XIII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” și al III-lea Congres al Societății de Endoscopie, Chirurgie miniminvazivă și Ultrasonografie ”V.M.Guțu” din Republica MoldovaIntroduction: Per oral endoscopic myotomy (POEM) may be a challenge in patients with previous interventions on the esophagealgastric junction. The degree of fibrosis in submucosal space plays a key role in the feasibility and safety of tunnel technique. Aim: To evaluate the safety of per oral endoscopic myotomy in patients previously operated on the esophageal-gastric junction. Material and methods: Between July 2014 and May 2018, 123 patients underwent POEM in the Moscow Clinical Scientific Center, including 46 (37%) patients previously operated on the esophageal-gastric junction. The group of operated patients involved 41 (89%) patients after pneumatic balloon dilation, 3 (6.5%) patients after Heller myotomy, 1 (2%) patient after previous esophagogastroplication, 1 (2%) after POEM. Results: The POEM procedure was successfully completed all patients. The mean operative was comparable in both groups: 106 min (55-195 min) in previously operated patients and 103 min (45-180 min) in naïve patients. F0 degree was detected in 14 (30%) cases, F1 in 29 (63%), maximal fibrosis (F2) in 3 (6.5%) patients who had previously undergone pneumatic balloon dilation. In patients after Heller's myotomy and esophagogastroplication, the degree of fibrosis reached F1, despite the expected more pronounced fibrosis. In the group of primary patients F0, the degree was detected in 27 (35%) observations, F1 - 46 (60%), severe fibrosis (F2) was detected in 4 (5%). There were no intraoperative complications affecting the tactics of surgical intervention in one observation. There were no major bleeding episodes requiring blood transfusion in either group. In one case in the group of previously operated patients, a mucosal defect was detected after the formation of the tunnel. The lesion was clipped. The technical success of the surgical intervention was up to 100%. There were no intraoperative complications. X-ray examination on the 1st day after intervention with a water-soluble contrast showed appropriate evacuation and no leakage. Patients were discharged the 2nd day after surgery. Conclusions: The history of failed previous surgical interventions is not a contraindication to the POEM procedure and does not significantly affect the course of surgical intervention

Solubility, acid-base and complexation properties of calix[4]resorcinarene in aqueous solutions of nonionic surfactants

Solubility and acid-base properties of calix[4]resorcinarene (H8L) in aqueous solutions of nonionic surfactants Triton X-100, Triton X-405, and Brij-35, as well as isopropanol were studied by pH-potentiometry. The dependence of the amount of a nonionic surfactant necessary to dissolve H8L on the length of ethylene oxide chain was found. The dissociation constants of macrocycle for the first four steps are low sensitive to the medium nature (micellar or water-alcohol solutions). Complexation ability of the [H8-nL]n- anions with respect to tetramethyl- and tetraethylammonium, N-methylpyridinium, and [Co(En)2(C2O4)]+ cations was studied by pH-potentiometry. A noticeable increase in the selectivity of guest-host binding was found on going from aqueous or water-alcohol to micellar solutions

One-step synthesis of gold colloids using amidoaminocalix[4]resorcinarenes as reducing and stabilizing agents. Investigation of naproxen binding

© 2017 Elsevier B.V.Amido(dimethylamino) calix[4]resorcinarenes with different substituents on the lower rim (-CH3 (С1), −C5H11 (C5), −C11H23 (C11)) both as reducing and stabilizing agent in an aqueous solution were used for the fabrication of stable gold colloids. Gold colloids are characterized by spectrophotometry, FTIR − spectroscopy, transmission electron microscopy, dynamic light scattering. It is found that increase of the macrocycle's concentration towards HAuCl4 concentration during the synthesis leads to the decrease in the size of formed particles. It is shown that the size of gold nanoparticles (AuNPs) decreases with the increase of the hydrophobicity of the substituents on the macrocycles lower rim (C1@Au − 4–14 nm, C5@Au - 10–11 nm, C11@Au − 7–8 nm). The monolayer packing of the macrocycle molecules on the surface of the metal particle for C1@Au and bilayer − for C5@Au and C11@Au, providing both the stabilization of AuNPs and their solubility in water, are proposed. Temperature and pH variation during the synthesis showed that the optimal synthesis conditions for all kinds of particles C1@Au, C5@Au, C11@Au are spontaneous installed during the synthesis pH (for C1@Au − pH 8.10, C5@Au − pH 8.56, C11@Au − pH 8.63) and the synthesis temperature of the 25 °C. High binding fraction of drug substrate naproxen on the surface of AuNPs modified by C5 and C11 macrocyclic aggregates due to the ordering of the macrocycles on the particle surface and enhancing their receptor ability towards naproxen is defined by fluorescence method