837 research outputs found
Industrial applications of multiaxial warp knit composites
Over the past few years, multiaxial warp knit (MWK) fabrics have made significant inroads into the industrial composites arena. This paper examines the use of MWK fabrics in industrial composite applications. Although the focus is on current applications of MWK fabrics in composites, this paper also discusses the physical properties, advantages and disadvantages of MWK fabrics. The author also offers possibilities for the future of MWK fabrics in the industrial composites arena
Integrating Renewable Energy Requirements Into Building Energy Codes
This report evaluates how and when to best integrate renewable energy requirements into building energy codes. The basic goals were to: (1) provide a rough guide of where we’re going and how to get there; (2) identify key issues that need to be considered, including a discussion of various options with pros and cons, to help inform code deliberations; and (3) to help foster alignment among energy code-development organizations. The authors researched current approaches nationally and internationally, conducted a survey of key stakeholders to solicit input on various approaches, and evaluated the key issues related to integration of renewable energy requirements and various options to address those issues. The report concludes with recommendations and a plan to engage stakeholders. This report does not evaluate whether the use of renewable energy should be required on buildings; that question involves a political decision that is beyond the scope of this report
Orbiting Circum-galactic Gas as a Signature of Cosmological Accretion
We use cosmological SPH simulations to study the kinematic signatures of cool
gas accretion onto a pair of well-resolved galaxy halos. Cold-flow streams and
gas-rich mergers produce a circum-galactic component of cool gas that generally
orbits with high angular momentum about the galaxy halo before falling in to
build the disk. This signature of cosmological accretion should be observable
using background-object absorption line studies as features that are offset
from the galaxy's systemic velocity by ~100 km/s. Accreted gas typically
co-rotates with the central disk in the form of a warped, extended cold flow
disk, such that the observed velocity offset is in the same direction as galaxy
rotation, appearing in sight lines that avoid the galactic poles. This
prediction provides a means to observationally distinguish accreted gas from
outflow gas: the accreted gas will show large one-sided velocity offsets in
absorption line studies while radial/bi-conical outflows will not (except
possibly in special polar projections). This rotation signature has already
been seen in studies of intermediate redshift galaxy-absorber pairs; we suggest
that these observations may be among the first to provide indirect
observational evidence for cold accretion onto galactic halos. Cold mode halo
gas typically has ~3-5 times more specific angular momentum than the dark
matter. The associated cold mode disk configurations are likely related to
extended HI/XUV disks seen around galaxies in the local universe. The fraction
of galaxies with extended cold flow disks and associated offset absorption-line
gas should decrease around bright galaxies at low redshift, as cold mode
accretion dies out.Comment: 15 pages, 9 figures, edited to match published version. Includes
expanded discussion, with primary results unchange
Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials
Objectives. To investigate the safety and immunogenicity of boosting BCG with modified vaccinia Ankara expressing antigen
85A (MVA85A), shortly after BCG vaccination, and to compare this first with the immunogenicity of BCG vaccination alone and
second with a previous clinical trial where MVA85A was administered more than 10 years after BCG vaccination. Design. There
are two clinical trials reported here: a Phase I observational trial with MVA85A; and a Phase IV observational trial with BCG.
These clinical trials were all conducted in the UK in healthy, HIV negative, BCG naı¨ve adults. Subjects were vaccinated with BCG
alone; or BCG and then subsequently boosted with MVA85A four weeks later (short interval). The outcome measures, safety
and immunogenicity, were monitored for six months. The immunogenicity results from this short interval BCG prime–MVA85A
boost trial were compared first with the BCG alone trial and second with a previous clinical trial where MVA85A vaccination
was administered many years after vaccination with BCG. Results. MVA85A was safe and highly immunogenic when
administered to subjects who had recently received BCG vaccination. When the short interval trial data presented here were
compared with the previous long interval trial data, there were no significant differences in the magnitude of immune
responses generated when MVA85A was administered shortly after, or many years after BCG vaccination. Conclusions. The
clinical trial data presented here provides further evidence of the ability of MVA85A to boost BCG primed immune responses.
This boosting potential is not influenced by the time interval between prior BCG vaccination and boosting with MVA85A. These
findings have important implications for the design of efficacy trials with MVA85A. Boosting BCG induced anti-mycobacterial
immunity in either infancy or adolescence are both potential applications for this vaccine, given the immunological data
presented here. Trial Registration. ClinicalTrials.Oxford University was the sponsor for all the clinical trials reported here
The Relationship Between Radiative Forcing and Temperature: What Do Statistical Analyses of the Instrumental Temperature Record Measure?
Multi-scale assessment of human-induced changes to Amazonian instream habitats
Context Land use change and forest degradation have myriad effects on tropical ecosystems. Yet their consequences for low-order streams remain very poorly understood, including in the world´s largest freshwater basin, the Amazon. Objectives Determine the degree to which physical and chemical characteristics of the instream habitat of low-order Amazonian streams change in response to past local- and catchment-level anthropogenic disturbances. Methods To do so, we collected field instream habitat (i.e., physical habitat and water quality) and landscape data from 99 stream sites in two eastern Brazilian Amazon regions. We used random forest regression trees to assess the relative importance of different predictor variables in determining changes in instream habitat response variables. Results Multiple drivers, operating at multiple spatial scales, were important in determining changes in the physical habitat and water quality of the sites. Although we found few similarities in modelled relationships between the two regions, we observed non-linear responses of specific instream characteristics to landscape change; for example 20 % of catchment deforestation resulted in consistently warmer streams. Conclusions Our results highlight the importance of local riparian and catchment-scale forest cover in shaping instream physical environments, but also underscore the importance of other land use changes and activities, such as road crossings and upstream agriculture intensification. In contrast to the property-scale focus of the Brazilian Forest code, which governs environmental regulations on private land, our results reinforce the importance of catchment-wide management strategies to protect stream ecosystem integrity
Merger Histories of Galaxy Halos and Implications for Disk Survival
We study the merger histories of galaxy dark matter halos using a high
resolution LCDM N-body simulation. Our merger trees follow ~17,000 halos with
masses M_0 = (10^11--10^13) Msun at z=0 and track accretion events involving
objects as small as m = 10^10 Msun. We find that mass assembly is remarkably
self-similar in m/M_0, and dominated by mergers that are ~10% of the final halo
mass. While very large mergers, m > 0.4 M_0, are quite rare, sizeable accretion
events, m ~ 0.1 M_0, are common. Over the last 10 Gyr, an overwhelming majority
(~95%) of Milky Way-sized halos with M_0 = 10^12 Msun have accreted at least
one object with greater total mass than the Milky Way disk (m > 5x10^10 Msun),
and approximately 70% have accreted an object with more than twice that mass (m
> 10^11 Msun). Our results raise serious concerns about the survival of
thin-disk dominated galaxies within the current paradigm for galaxy formation
in a CDM universe. In order to achieve a ~70% disk-dominated fraction in Milky
Way-sized CDM halos, mergers involving m ~ 2x10^11 Msun objects must not
destroy disks. Considering that most thick disks and bulges contain old stellar
populations, the situation is even more restrictive: these mergers must not
heat disks or drive gas into their centers to create young bulges.Comment: 14 pages, 10 figures. This version accepted for publication in ApJ.
v2 and v3 fixed typos and mislabels, v4 restructured and expanded the
discussion section, added fitting functions to appendix, and other minor
changes. Results and primary conclusions remain unchange
RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities
With rising rates of drug-resistant infections, there is a need for diagnostic methods that rapidly can detect the presence of pathogens and reveal their susceptibility to antibiotics. Here we propose an approach to diagnosing the presence and drug-susceptibility of infectious diseases based on direct detection of RNA from clinical samples. We demonstrate that species-specific RNA signatures can be used to identify a broad spectrum of infectious agents, including bacteria, viruses, yeast, and parasites. Moreover, we show that the behavior of a small set of bacterial transcripts after a brief antibiotic pulse can rapidly differentiate drug-susceptible and -resistant organisms and that these measurements can be made directly from clinical materials. Thus, transcriptional signatures could form the basis of a uniform diagnostic platform applicable across a broad range of infectious agents
Secondary somatic mutations restoring RAD51C and RAD51D associated with acquired resistance to the PARP inhibitor rucaparib in high-grade ovarian carcinoma
High-grade epithelial ovarian carcinomas (OC) containing mutated BRCA1 or BRCA2 (BRCA1/2) homologous recombination (HR) genes are sensitive to platinum-based chemotherapy and poly(ADP-ribose) polymerase inhibitors (PARPi), while restoration of HR function due to secondary mutations in BRCA1/2 has been recognized as an important resistance mechanism. We sequenced core HR pathway genes in 12 pairs of pre-treatment and post-progression tumor biopsy samples collected from patients in ARIEL2 Part 1, a phase 2 study of the PARPi rucaparib as treatment for platinum-sensitive, relapsed OC. In six of 12 pre-treatment biopsies, a truncation mutation in BRCA1, RAD51C or RAD51D was identified. In five of six paired post-progression biopsies, one or more secondary mutations restored the open reading frame. Four distinct secondary mutations and spatial heterogeneity were observed for RAD51C. In vitro complementation assays and a patient-derived xenograft (PDX), as well as predictive molecular modeling, confirmed that resistance to rucaparib was associated with secondary mutations
Clinical risk factors and atherosclerotic plaque extent to define risk for major events in patients without obstructive coronary artery disease: the long-term coronary computed tomography angiography CONFIRM registry.
AimsIn patients without obstructive coronary artery disease (CAD), we examined the prognostic value of risk factors and atherosclerotic extent.Methods and resultsPatients from the long-term CONFIRM registry without prior CAD and without obstructive (≥50%) stenosis were included. Within the groups of normal coronary computed tomography angiography (CCTA) (N = 1849) and non-obstructive CAD (N = 1698), the prognostic value of traditional clinical risk factors and atherosclerotic extent (segment involvement score, SIS) was assessed with Cox models. Major adverse cardiac events (MACE) were defined as all-cause mortality, non-fatal myocardial infarction, or late revascularization. In total, 3547 patients were included (age 57.9 ± 12.1 years, 57.8% male), experiencing 460 MACE during 5.4 years of follow-up. Age, body mass index, hypertension, and diabetes were the clinical variables associated with increased MACE risk, but the magnitude of risk was higher for CCTA defined atherosclerotic extent; adjusted hazard ratio (HR) for SIS >5 was 3.4 (95% confidence interval [CI] 2.3-4.9) while HR for diabetes and hypertension were 1.7 (95% CI 1.3-2.2) and 1.4 (95% CI 1.1-1.7), respectively. Exclusion of revascularization as endpoint did not modify the results. In normal CCTA, presence of ≥1 traditional risk factors did not worsen prognosis (log-rank P = 0.248), while it did in non-obstructive CAD (log-rank P = 0.025). Adjusted for SIS, hypertension and diabetes predicted MACE risk in non-obstructive CAD, while diabetes did not increase risk in absence of CAD (P-interaction = 0.004).ConclusionAmong patients without obstructive CAD, the extent of CAD provides more prognostic information for MACE than traditional cardiovascular risk factors. An interaction was observed between risk factors and CAD burden, suggesting synergistic effects of both
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