Observation of "remote knock-on", a new permeation-enhancement mechanism in ion channels

We report observation of a novel ‘‘remote knock-on’’ mechanism for enhancement of permeation in Brownian dynamics simulations of a simple model ion channel. Unlike conventional knock-on, which requires a second ion of the same species to enter the channel in order to knock forward and replace an ion already in the channel, the new mechanism does not require the instigating ion to enter the channel, nor that it be of the same species

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine

Erratum: Corrigendum: Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

International Chicken Genome Sequencing Consortium. The Original Article was published on 09 December 2004. Nature432, 695–716 (2004). In Table 5 of this Article, the last four values listed in the ‘Copy number’ column were incorrect. These should be: LTR elements, 30,000; DNA transposons, 20,000; simple repeats, 140,000; and satellites, 4,000. These errors do not affect any of the conclusions in our paper. Additional information. The online version of the original article can be found at 10.1038/nature0315

Poems

Ginsberg (for Allen) Letter to the Chronicle Fragment from Public Secret The Ancient Rain Bird with Painted Wings Alien Winds A Buddhist Experience The Trip, Dharma Trip, Sangha Trip To My Son Parker, Asleep in the Next Room The American Sun Abomunist ManifestoNotes Dis- and Re-Garding AbomunismFurther Notes$$Abomunus Craxioms$$Excerpts from The Lexicon AbomunonAbomunist Election ManifestoStill Further Notes Dis- & Re-Garding AbomunismBomsAbomunist Rational AnthemAbomunist DocumentsAbomnewscast. . . On the Hour . . . War Memoir Bagel Shop Jaz

Advancing Technology in Swine Production: A Simulation Model of Swine Performance

This article details the impacts that computers and microcomputers can have in farm contexts. Recent advances in computer technology have paved the way for the development of simulation models for biological systems. Mathematical models have taken on a powerful new dimension. The implication is that the computer model, with environmental inputs (such as air temperature and air velocity at the animal level), can be used to predict and control the environment that best meets the needs of the animal and utilizes dietary and supplemental energy resources most efficiently

Cafe Society : Photographs and Poetry from San Franscisco's North Beach

In this album juxtaposing poetry with portraits of San Franciscan poets, Cherkovski presents what constitutes the joy of living in that part of America. Biographical notes on contributors

Clearing the Path: The Perils of Positing Civil Society in Conflict and Transition

Can there be a general theoretical perspective on civil society\u27s involvement in transitional justice? This article considers this question in its application to the Israeli-Palestinian conflict. Within the study of transitional justice and conflict resolution, civil society - a notoriously plastic concept - can be understood narrowly as rights-oriented groups working “for” peace, but the term is equally available to describe a broader array of communities that can either promote or prevent peace and justice. It is, in fact, quite difficult to sustain a theoretical distinction between them, because transitional justice does not escape the dictates of politics - of differing human desires expressed through power. Efforts to memorialise imply conflict over the particular memories to be privileged; claims for reparations are not only demands for justice, but for material redistribution that in turn may promote conflict. A narrow view of civil society problematically assumes we even know - let alone agree on - what constitutes positive change. In the context of the Israeli-Palestinian conflict, that is a fraught proposition. Both an accurate definition of civil society and the valence of justice work slip beyond the narrow confines of the received model\u27s assumptions: both Jewish and Palestinian groups mobilise a spectrum of resources from political engagement, to overseas support, to violent self-help. On both sides, civil society groups are instrumentalised to advance not an agenda of peace or justice in some abstract sense but a parochial claim that, seen from the other side, is, in fact, an obstacle to resolution. Indeed, there may be no peace or justice initiatives that can be analytically separated from efforts the purpose and effect of which is the very opposite of our conventional understanding of the field. The range from vocal activism to violent action, the spectrum of activation, commitment and radicalism, must be understood as fraught but connected and unbroken - as, at most, a kind of punctuated continuum. The real work performed by civil society in promoting agendas of peace and justice cannot properly be understood without locating it in a defensible theoretical and empirical framework. Imagining a narrow civil society risks skewing our analysis ofwhat civil society can do and actually does in relation to conflict. Civil society can clear the path to peace, or can provide the principal obstacles to it - it can simultaneously do both. In this it very much shares the ambiguous, multivalent profile of its classic counterpart: politics in the public sphere