3,089 research outputs found
Investigating five key predictive text entry with combined distance and keystroke modelling
This paper investigates text entry on mobile devices using only five-keys. Primarily to support text entry on smaller devices than mobile phones, this method can also be used to maximise screen space on mobile phones. Reported combined Fitt's law and keystroke modelling predicts similar performance with bigram prediction using a five-key keypad as is currently achieved on standard mobile phones using unigram prediction. User studies reported here show similar user performance on five-key pads as found elsewhere for novice nine-key pad users
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Complementary Metagenomic Approaches Improve Reconstruction of Microbial Diversity in a Forest Soil.
Soil ecosystems harbor diverse microorganisms and yet remain only partially characterized as neither single-cell sequencing nor whole-community sequencing offers a complete picture of these complex communities. Thus, the genetic and metabolic potential of this "uncultivated majority" remains underexplored. To address these challenges, we applied a pooled-cell-sorting-based mini-metagenomics approach and compared the results to bulk metagenomics. Informatic binning of these data produced 200 mini-metagenome assembled genomes (sorted-MAGs) and 29 bulk metagenome assembled genomes (MAGs). The sorted and bulk MAGs increased the known phylogenetic diversity of soil taxa by 7.2% with respect to the Joint Genome Institute IMG/M database and showed clade-specific sequence recruitment patterns across diverse terrestrial soil metagenomes. Additionally, sorted-MAGs expanded the rare biosphere not captured through MAGs from bulk sequences, exemplified through phylogenetic and functional analyses of members of the phylum Bacteroidetes Analysis of 67 Bacteroidetes sorted-MAGs showed conserved patterns of carbon metabolism across four clades. These results indicate that mini-metagenomics enables genome-resolved investigation of predicted metabolism and demonstrates the utility of combining metagenomics methods to tap into the diversity of heterogeneous microbial assemblages.IMPORTANCE Microbial ecologists have historically used cultivation-based approaches as well as amplicon sequencing and shotgun metagenomics to characterize microbial diversity in soil. However, challenges persist in the study of microbial diversity, including the recalcitrance of the majority of microorganisms to laboratory cultivation and limited sequence assembly from highly complex samples. The uncultivated majority thus remains a reservoir of untapped genetic diversity. To address some of the challenges associated with bulk metagenomics as well as low throughput of single-cell genomics, we applied flow cytometry-enabled mini-metagenomics to capture expanded microbial diversity from forest soil and compare it to soil bulk metagenomics. Our resulting data from this pooled-cell sorting approach combined with bulk metagenomics revealed increased phylogenetic diversity through novel soil taxa and rare biosphere members. In-depth analysis of genomes within the highly represented Bacteroidetes phylum provided insights into conserved and clade-specific patterns of carbon metabolism
The order of the quantum chromodynamics transition predicted by the standard model of particle physics
We determine the nature of the QCD transition using lattice calculations for
physical quark masses. Susceptibilities are extrapolated to vanishing lattice
spacing for three physical volumes, the smallest and largest of which differ by
a factor of five. This ensures that a true transition should result in a
dramatic increase of the susceptibilities.No such behaviour is observed: our
finite-size scaling analysis shows that the finite-temperature QCD transition
in the hot early Universe was not a real phase transition, but an analytic
crossover (involving a rapid change, as opposed to a jump, as the temperature
varied). As such, it will be difficult to find experimental evidence of this
transition from astronomical observations.Comment: 7 pages, 4 figure
Fluctuations of conserved charges at finite temperature from lattice QCD
We present the full results of the Wuppertal-Budapest lattice QCD
collaboration on flavor diagonal and non-diagonal quark number susceptibilities
with 2+1 staggered quark flavors, in a temperature range between 125 and 400
MeV. The light and strange quark masses are set to their physical values.
Lattices with Nt=6, 8, 10, 12, 16 are used. We perform a continuum
extrapolation of all observables under study. A Symanzik improved gauge and a
stout-link improved staggered fermion action is utilized. All results are
compared to the Hadron Resonance Gas model predictions: good agreement is found
in the temperature region below the transition.Comment: 13 pages, 8 figures in Jhep styl
Cosmological vacuum selection and metastable susy breaking
We study gauge mediation in a wide class of O'Raifeartaigh type models where
supersymmetry breaking metastable vacuum is created by gravity and/or quantum
corrections. We examine their thermal evolution in the early universe and the
conditions under which the susy breaking vacuum can be selected. It is
demonstrated that thermalization typically makes the metastable supersymmetry
breaking cosmologically disfavoured but this is not always the case. Initial
conditions with the spurion displaced from the symmetric thermal minimum and a
small coupling to the messenger sector can result in the realization of the
susy breaking vacuum even if the reheating temperature is high. We show that
this can be achieved without jeopardizing the low energy phenomenology. In
addition, we have found that deforming the models by a supersymmetric mass term
for messengers in such a way that the susy breaking minimum and the susy
preserving minima are all far away from the origin does not change the
conclusions. The basic observations are expected to hold also in the case of
models with an anomalous U(1) group.Comment: 28 pages, 4 figures, plain Latex, journal versio
Towards Logical Specification of Statistical Machine Learning
We introduce a logical approach to formalizing statistical properties of
machine learning. Specifically, we propose a formal model for statistical
classification based on a Kripke model, and formalize various notions of
classification performance, robustness, and fairness of classifiers by using
epistemic logic. Then we show some relationships among properties of
classifiers and those between classification performance and robustness, which
suggests robustness-related properties that have not been formalized in the
literature as far as we know. To formalize fairness properties, we define a
notion of counterfactual knowledge and show techniques to formalize conditional
indistinguishability by using counterfactual epistemic operators. As far as we
know, this is the first work that uses logical formulas to express statistical
properties of machine learning, and that provides epistemic (resp.
counterfactually epistemic) views on robustness (resp. fairness) of
classifiers.Comment: SEFM'19 conference paper (full version with errors corrected
Dynamical completions of generalized O'Raifeartaigh models
We present gauge theory completions of Wess-Zumino models admitting
supersymmetry breaking vacua with spontaneously broken R-symmetry. Our models
are simple deformations of generalized ITIY models, a supersymmetric theory
with gauge group Sp(N), N+1 flavors plus singlets, with a modified tree level
superpotential which explicitly breaks (part of) the global symmetry. Depending
on the nature of the deformation, we obtain effective O'Raifeartaigh-like
models whose pseudomoduli space is locally stable in a neighborhood of the
origin of field space, or in a region not including it. Hence, once embedded in
direct gauge mediation scenarios, our models can give low energy spectra with
either suppressed or unsuppressed gaugino mass.Comment: 21 pages, 1 figure; v3: reference adde
A patient on RIPE therapy presenting with recurrent isoniazid-associated pleural effusions: a case report
<p>Abstract</p> <p>Introduction</p> <p>The clinical scenario of a new or worsening pleural effusion following the initiation of antituberculous therapy has been classically referred to as a 'paradoxical' pleural response, presumably explained by an immunological rebound phenomenon. Emerging evidence suggests that there also may be a role for a lupus-related reaction in the pathophysiology of this disorder.</p> <p>Case presentation</p> <p>An 84-year-old Asian man treated with isoniazid, along with rifampin, pyrazinamide and ethambutol for suspected extrapulmonary tuberculosis, presented with a recurrent pleural effusion, his third episode since the initiation of this therapy. The first effusion occurred one month after the start of treatment, without any prior evidence of pulmonary tuberculosis involvement. Follow-up testing, including thoracoscopic pleural biopsies, never confirmed tuberculosis infection. Further evaluation yielded serological evidence suggesting drug-induced lupus. No effusions recurred following the discontinuation of isoniazid, although other antituberculosis medications were continued.</p> <p>Conclusion</p> <p>The immunological rebound construct is inconsistent with the evolution of this case, which indicates rather that drug-induced lupus may explain at least some cases of new pleural effusions following the initiation of isoniazid.</p
A genetically encoded reporter of synaptic activity in vivo
To image synaptic activity within neural circuits, we tethered the genetically encoded calcium indicator (GECI) GCaMP2 to synaptic vesicles by fusion to synaptophysin. The resulting reporter, SyGCaMP2, detected the electrical activity of neurons with two advantages over existing cytoplasmic GECIs: it identified the locations of synapses and had a linear response over a wider range of spike frequencies. Simulations and experimental measurements indicated that linearity arises because SyGCaMP2 samples the brief calcium transient passing through the presynaptic compartment close to voltage-sensitive calcium channels rather than changes in bulk calcium concentration. In vivo imaging in zebrafish demonstrated that SyGCaMP2 can assess electrical activity in conventional synapses of spiking neurons in the optic tectum and graded voltage signals transmitted by ribbon synapses of retinal bipolar cells. Localizing a GECI to synaptic terminals provides a strategy for monitoring activity across large groups of neurons at the level of individual synapses
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