A new surgical approach for O-C2 fusion, solving the problem of dysphagia.

The fusion of the second cervical vertebrae to the occipital bone (O-C2 fusion) for head stabilization can result in postoperative dysphagia and dyspnea, negatively impacting the patient’s quality of life. Currently, the O-C2 angle is used for head placement, which may not place the head neutrally. We hypothesize that aligning the external auditory meatus with midline of the C2 will reduce oropharyngeal stenosis, reducing dysphagia. One male patient with poor swallow quality of life who required a revision of a previous O-C2 surgery was evaluated via videofluoroscopy and completed the standard swallow quality of life questionnaire (SWAL-QOL) before and after revision. The diameter and area of the oropharyngeal space were measured. Data shows increased oropharyngeal area and diameter after surgery, and an improved SWAL-QOL score. This is early evidence of an improved surgical approach for O-C2 fusion which could eliminate the complication of dysphagia

Peripheral Vision: Mimesis and Materiality along the James River, Virginia, 1619-1660

Applying the concepts of mimesis and third space to Virginia\u27s early colonial settlements, this study presents a comparative examination of documentary, pictorial, cartographic, and material evidence surrounding City Point\u27s Site 44PG102 and contemporary James River plantations. By considering archaeological site data that are possibly contemporaneous, but previously have been segregated by archaeologists into prehistoric (Native Virginian) and historic (European) categories, I investigate the evidence for interethnic interactions as well as the social conventions surrounding 17th-century object and landscape use. This thesis argues that people of European, West Central African, West African, and Algonquian-speaking Native Virginian backgrounds endowed shared objects, buildings, and places with different values and social functions, impairing the ability of colonial material culture to convey clear and consistent messages of status and intention across ethnic boundaries. I propose that mimetic landscapes and material culture with precolonial histories of use as signals of prestige became central to socially competent interethnic communication in colonial contexts

Inside the history of Italian coloring industries. An investigation of ACNA dyes through a novel analytical protocol for synthetic dye extraction and characterization

The introduction of synthetic dyes completely changed the industrial production and use of colorants for art materials. From the synthesis of the first synthetic dye, mauveine, in 1856 until today, artists have enjoyed a wider range of colors and selection of chemical properties than was ever available before. However, the introduction of synthetic dyes introduced a wider variety and increased the complexity of the chemical structures of marketed dyes. This work looks towards the analysis of synthetically dyed objects in heritage collections, applying an extraction protocol based on the use of ammonia, which is considered favorable for natural anthraquinone dyes but has never before been applied to acid synthetic dyes. This work also presents an innovative cleanup step based on the use of an ion pair dispersive liquid–liquid microextraction for the purification and preconcentration of historical synthetic dyes before analysis. This approach was adapted from food science analysis and is applied to synthetic dyes in heritage science for the first time in this paper. The results showed adequate recovery of analytes and allowed for the ammonia-based extraction method to be applied successfully to 15 samples of suspected azo dyes from the Azienda Coloranti Nazionali e Affini (ACNA) synthetic dye collection, identified through untargeted HPLC-HRMS analyses

The Ursinus Weekly, May 23, 1960

Dr. Paisley completes 50 years as Board President • Alumni Day to be held June 4 • Library has comedy of errors display • Sigma Rho Lambda sponsors annual dinner dance on May 20 • Brownback-Anders pre-medical society elects new officers • Phi Psi and Tau Sig hold picnic in college woods • Baccalaureate speaker will be Dr. D. Horton • Officers selected for new UC group • Pete Wise is re-elected as president of the Newman Club • John Innes wins two outstanding chemistry awards • Awards presented at WAA banquet • Robert Linker is elected new president of student PSEA • Senator Scott to speak at June 6th graduation • Senior banquet is tonight at 7 • Men elect soph rulers; Feldstein is head • WSGA passes revised rules drawn up by the senate • Mike Mehrer is selected new Debating Club head • Language clubs select officers for next year • Editorial: Examinations • Letters to the editor • Requisition: 1960 • International events • Reviews: New and blue; New Lantern • Lacrosse team ends undefeated • Diamondmen eke win over Wilkes • Wenhold given top Varsity Club award • Track team ends with 5-5 season • Stroudsburg girls shade softballershttps://digitalcommons.ursinus.edu/weekly/1365/thumbnail.jp

Measuring Mass Loss Rates from Galactic Satellites

We present the results of a study that uses numerical simulations to interpret observations of tidally disturbed satellites around the Milky Way. When analysing the simulations from the viewpoint of an observer, we find a break in the slope of the star count and velocity dispersion profiles in our models at the location where unbound stars dominate. We conclude that `extra-tidal' stars and enhanced velocity dispersions observed in the outskirts of Galactic satellites are due to contamination by stellar debris from the tidal interaction with the Milky Way. However, a significant bound population can exist beyond the break radius and we argue that it should not be identified with the tidal radius of the satellite. We also develop and test a method for determining the mass loss rate from a Galactic satellite using its extra-tidal population. We apply this method to observations of globular clusters and dwarf spheroidal satellites of the Milky Way, and conclude that a significant fraction of both satellite systems are likely be destroyed within the next Hubble time. Finally, we demonstrate that this mass loss estimate allows us to place some limits on the initial mass function (IMF) of stars in a cluster from the radial dependence of its present day mass function (PDMF).Comment: 18 pages including 22 figures. Submitted to MNRA

A Low Concentration of Ethanol Impairs Learning but Not Motor and Sensory Behavior in Drosophila Larvae

Drosophila melanogaster has proven to be a useful model system for the genetic analysis of ethanol-associated behaviors. However, past studies have focused on the response of the adult fly to large, and often sedating, doses of ethanol. The pharmacological effects of low and moderate quantities of ethanol have remained understudied. In this study, we tested the acute effects of low doses of ethanol (∼7 mM internal concentration) on Drosophila larvae. While ethanol did not affect locomotion or the response to an odorant, we observed that ethanol impaired associative olfactory learning when the heat shock unconditioned stimulus (US) intensity was low but not when the heat shock US intensity was high. We determined that the reduction in learning at low US intensity was not a result of ethanol anesthesia since ethanol-treated larvae responded to the heat shock in the same manner as untreated animals. Instead, low doses of ethanol likely impair the neuronal plasticity that underlies olfactory associative learning. This impairment in learning was reversible indicating that exposure to low doses of ethanol does not leave any long lasting behavioral or physiological effects

Factors affecting turnaround time of SARS-CoV-2 sequencing for inpatient infection prevention and control decision making: Analysis of data from the COG-UK HOCI study

Background Barriers to rapid return of sequencing results can affect the utility of sequence data for infection prevention and control decisions. Aim To undertake a mixed-methods analysis to identify challenges sites faced in achieving a rapid turnaround time (TAT) in the COG-UK Hospital-Onset COVID-19 Infection (COG-UK HOCI) study. Methods For the quantitative analysis, timepoints relating to different stages of the sequencing process were extracted from both the COG-UK HOCI dataset and surveys of study sites. Qualitative data relating to the barriers and facilitators to achieving rapid TAT were included from thematic analysis. Findings The overall TAT, from sample collection to receipt of sequence report by infection control teams, varied between sites (median 5.1 days, range 3.0 – 29.0 days). Most variation was seen between reporting of a positive COVID-19 PCR result to sequence report generation (median 4.0 days, range 2.3 – 27.0 days). On deeper analysis, most of this variability was accounted for by differences in the delay between the COVID-19 PCR result and arrival of the sample at the sequencing laboratory (median 20.8 hours, 16.0 – 88.7 hours). Qualitative analyses suggest closer proximity of sequencing labs to diagnostic labs, increased staff flexibility and regular transport times facilitated a shorter TAT. Conclusion Integration of pathogen sequencing into diagnostic laboratories may help improve sequencing TAT to allow sequence data to be of tangible value to infection control practice. Adding a quality control step upstream to increase capacity further down the workflow may also optimise TAT if lower quality samples are removed earlier on

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

Percutaneous revascularization for ischemic left ventricular dysfunction: Cost-effectiveness analysis of the REVIVED-BCIS2 trial

BACKGROUND: Percutaneous coronary intervention (PCI) is frequently undertaken in patients with ischemic left ventricular systolic dysfunction. The REVIVED (Revascularization for Ischemic Ventricular Dysfunction)-BCIS2 (British Cardiovascular Society-2) trial concluded that PCI did not reduce the incidence of all-cause death or heart failure hospitalization; however, patients assigned to PCI reported better initial health-related quality of life than those assigned to optimal medical therapy (OMT) alone. The aim of this study was to assess the cost-effectiveness of PCI+OMT compared with OMT alone. METHODS: REVIVED-BCIS2 was a prospective, multicenter UK trial, which randomized patients with severe ischemic left ventricular systolic dysfunction to either PCI+OMT or OMT alone. Health care resource use (including planned and unplanned revascularizations, medication, device implantation, and heart failure hospitalizations) and health outcomes data (EuroQol 5-dimension 5-level questionnaire) on each patient were collected at baseline and up to 8 years post-randomization. Resource use was costed using publicly available national unit costs. Within the trial, mean total costs and quality-adjusted life-years (QALYs) were estimated from the perspective of the UK health system. Cost-effectiveness was evaluated using estimated mean costs and QALYs in both groups. Regression analysis was used to adjust for clinically relevant predictors. RESULTS: Between 2013 and 2020, 700 patients were recruited (mean age: PCI+OMT=70 years, OMT=68 years; male (%): PCI+OMT=87, OMT=88); median follow-up was 3.4 years. Over all follow-ups, patients undergoing PCI yielded similar health benefits at higher costs compared with OMT alone (PCI+OMT: 4.14 QALYs, £22 352; OMT alone: 4.16 QALYs, £15 569; difference: −0.015, £6782). For both groups, most health resource consumption occurred in the first 2 years post-randomization. Probabilistic results showed that the probability of PCI being cost-effective was 0. CONCLUSIONS: A minimal difference in total QALYs was identified between arms, and PCI+OMT was not cost-effective compared with OMT, given its additional cost. A strategy of routine PCI to treat ischemic left ventricular systolic dysfunction does not seem to be a justifiable use of health care resources in the United Kingdom