48 research outputs found
Crafting sustainability in iconic skyscrapers: a system of building professions in transition?
This paper focuses on coordination, fragmentation, and the potential for transition in the system of building professions in the American construction industry. The paper relies mainly on local press coverage of three iconic New York skyscrapersâthe Empire State Building (completed in 1931), the U.N. Secretariat (completed in 1952) and One World Trade Center (completed in 2014)â to compare how the roles of different building professionals are seen by and portrayed to the public eye over time. The historic cases show how different professional groupsâbuilders in the 1930s, architects in the 1950s, and engineers in the 2010sâimbued each project with âsustainableâ qualities appropriate for its time. Using a system of professions (Abbott 1988[r]) approach, the paper describes and discusses the implications of changes in societal interest from doing to designing in American skyscrapers. The paper concludes by arguing that greater coordination between doers and designers in the construction industry, of the kind exhibited in the early days of skyscrapers, would enable the social production of sustainable buildings. For this to happen, however, society would need to place a higher value on tangible outcomes compared to lofty goals..
Pursuing a net-zero carbon future for all: Challenges for commercial real estate
The commercial real-estate industry faces both opportunities and challenges in reaching net-zero carbon goals. Successful low-carbon strategies rely on organizational decision-making, including cooperation between diverse groups of stakeholders. Not all landlords and tenants are equal, so a key challenge will be activating change across the industry as a whole
Beyond feedback: introducing the 'engagement gap' in organizational energy management
This paper discusses socio-technical relationships between people, organizations and energy in workplaces. Inspired by Sherry Arnsteinâs ladder of citizen participation, it explores widening energy management beyond energy managers to other employees, introducing the idea of an âengagement gapâ to support a move beyond unidirectional forms of engagement (e.g. feedback and nudging) to more socially interactive processes. Results are drawn from two projects researching energy practices in public authorities and retail organizations. The first project, âGoodDeedsâ, collaboratively created an information and communication technology tool and explored participatory processes within a municipality. The second project, Working with Infrastructure, Creation of Knowledge, and Energy strategy Development (WICKED), explored energy management in retail companies. The paper uses a â4Csâ framework to articulate the influences of concerns, capacities and technical conditions within organizational communities. The results concur with previous research that energy management sits against a backdrop of competing organizational, institutional and political concerns. New data reveal discrepancies across organizations with regard to energy management capacities and technical metering conditions. The authors suggest employee engagement can be broadened by treating energy as a communal subject for discussion, negotiation and partnership. This objective moves beyond the âinformation-deficitâ approach intrinsic in the existing focus on analytics, dashboards and feedback
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal
The canonical Wnt/ÎČ-catenin signaling pathway governs diverse developmental, homeostatic and pathologic processes. Palmitoylated Wnt ligands engage cell surface Frizzled (Fzd) receptors and Lrp5/6 co-receptors enabling ÎČ-catenin nuclear translocation and Tcf/Lef-dependent gene transactivation1â3. Mutations in Wnt downstream signaling components have revealed diverse functions presumptively attributed to Wnt ligands themselves, although direct attribution remains elusive, as complicated by redundancy between 19 mammalian Wnts and 10 Fzds1 and Wnt hydrophobicity2,3. For example, individual Wnt ligand mutations have not revealed homeostatic phenotypes in the intestinal epithelium4, an archetypal canonical Wnt pathway-dependent rapidly self-renewing tissue whose regeneration is fueled by proliferative crypt Lgr5+ intestinal stem cells (ISCs)5â9. R-spondin ligands (Rspo1â4) engage distinct Lgr4-6 and Rnf43/Znrf3 receptor classes10â13, markedly potentiate canonical Wnt/ÎČ-catenin signaling and induce intestinal organoid growth in vitro and Lgr5+ ISCs in vivo8,14â17. However, the interchangeability, functional cooperation and relative contributions of Wnt versus Rspo ligands to in vivo canonical Wnt signaling and ISC biology remain unknown. Here, we deconstructed functional roles of Wnt versus Rspo ligands in the intestinal crypt stem cell niche. We demonstrate that the default fate of Lgr5+ ISCs is lineage commitment, escape from which requires both Rspo and Wnt ligands. However, gain-of-function studies using Rspo versus a novel non-lipidated Wnt analog reveal qualitatively distinct, non-interchangeable roles for these ligands in ISCs. Wnts are insufficient to induce Lgr5+ ISC self-renewal, but rather confer a basal competency by maintaining Rspo receptor expression that enables Rspo to actively drive and specify the extent of stem cell expansion. This functionally non-equivalent yet cooperative interplay between Wnt and Rspo ligands establishes a molecular precedent for regulation of mammalian stem cells by distinct priming and self-renewal factors, with broad implications for precision control of tissue regeneration
sodC-Based Real-Time PCR for Detection of Neisseria meningitidis
Real-time PCR (rt-PCR) is a widely used molecular method for detection of
Neisseria meningitidis (Nm). Several rt-PCR assays for Nm
target the capsule transport gene, ctrA. However, over
16% of meningococcal carriage isolates lack ctrA,
rendering this target gene ineffective at identification of this sub-population
of meningococcal isolates. The Cu-Zn superoxide dismutase gene,
sodC, is found in Nm but not in other
Neisseria species. To better identify Nm, regardless of
capsule genotype or expression status, a sodC-based TaqMan
rt-PCR assay was developed and validated. Standard curves revealed an average
lower limit of detection of 73 genomes per reaction at cycle threshold
(Ct) value of 35, with 100% average reaction efficiency
and an average R2 of 0.9925. 99.7% (624/626) of Nm isolates
tested were sodC-positive, with a range of average
Ct values from 13.0 to 29.5. The mean sodC
Ct value of these Nm isolates was 17.6±2.2 (±SD).
Of the 626 Nm tested, 178 were nongroupable (NG) ctrA-negative
Nm isolates, and 98.9% (176/178) of these were detected by
sodC rt-PCR. The assay was 100% specific, with all
244 non-Nm isolates testing negative. Of 157 clinical specimens tested,
sodC detected 25/157 Nm or 4 additional specimens compared
to ctrA and 24 more than culture. Among 582 carriage specimens,
sodC detected Nm in 1 more than ctrA and
in 4 more than culture. This sodC rt-PCR assay is a highly
sensitive and specific method for detection of Nm, especially in carriage
studies where many meningococcal isolates lack capsule genes
Abstracts of presentations on plant protection issues at the fifth international Mango Symposium Abstracts of presentations on plant protection issues at the Xth international congress of Virology: September 1-6, 1996 Dan Panorama Hotel, Tel Aviv, Israel August 11-16, 1996 Binyanei haoma, Jerusalem, Israel
Telling tales: using stories to remake energy policy
To benefit and protect the populace, government policies often promise aspirational changes to current practice. Different kinds of narratives are important in the framing, explanation, motivation, and understanding of policies and strategies. For example, the UK government's 2008 Climate Change Act proclaimed that all new homes will be zero carbon by 2016. This âhero storyâ, where society is âsavedâ by clever technologies, is inspiring, positive and familiar. An alternative is the âlearning storyâ, where things are not quite as simple as they first seemed. In a learning story, protagonists are normal people who need to overcome a challenge. In energy policy, the learning story could address the gap between the technical potential and what is achieved in practice. Three real-world examples from retrofit and new-build projects are used to show how implicit narratives can create conflict when the tellers (e.g. researchers) have to tell one kind of story but have data for the other. Recommendations are provided for a balanced approach to the deployment of different kinds of tales by policy-makers, researchers, implementers and users. Harnessing the learning story and developing a âcaring storyâ could motivate policy-makers and the public to invest effort in building performance
Working with Infrastructure Creation of Knowledge and Energy strategy Development (WICKED) data
There are qualitative and quantitative data associated with this project; this data will be deposited, and a Digital Object Identifier issued, once it is finalised
Using Stories, Narratives, and Storytelling in Energy and Climate Change Research
Energy and climate change research has been dominated by particular methods and approaches to defining and addressing problems, accomplished by gathering and analysing the corresponding forms of evidence. This special issue starts from the broad concepts of stories, narratives, and storytelling to go beyond these analytic conventions, approaching the intersection of nature, humanity, and technology in multiple ways, using lenses from social sciences, humanities, and practitionersâ perspectives. The contributors use stories as data objects to gather, analyse, and critique; stories as an approach to research an inquiry; narrative analysis as a way of crystallising arguments and assumptions; and storytelling as a way of understanding, communicating, and influencing others. In using these forms of evidence and communication, and applying methods, analytical stances, and interpretations that these invite, something new and different results. This essay is a brief introduction to how, in our view, stories and their kin fit in energy and climate change research. We outline the diversity of data, approaches, and goals represented in the contributions to the special issue. And we reflect on some of the challenges of, and possibilities for, continuing to develop âstoriesâ as data sources, as modes of inquiry, and as creative paths toward social engagement