Exposure assessment to support on-farm risk characterisation for pesticides

C. D. Brown, K. Lewis, and A. Hart, ‘Exposure assessment to support on-farm risk characterisation for pesticides’ paper presented at the European Meeting of the Society of Environmental Toxicology and Chemistry (SETAC), 26 -29 August 20001, Copenhagen, Denmark.Peer reviewe

A comparative study of social competence and antisocial behavior between regular education and learning disabled children

This study tested the hypothesis that learning disabled children, when compared to regular education children at an equivalent age level, would score significantly lower on a test of social competence and significantly higher on a test of antisocial behavior according to a teacher rated behavior Scale. Sixty 5th and 6th grade students, 34 males and 26 females, were assigned to one of three conditions according to their educational classification: regular education (N=26), learning disabled resource (N=16), or learning disabled self-contained (N=18). Four teachers served as judges and rated a selected number of subjects on the constructs social competence and antisocial behavior using the School Social Behavior Scale, a teacher rating scale. During an observation period, each subject received a rating on a five point scale describing behaviors that never, sometimes, or frequently occur. A one-way analysis of variance was used to test the differences between the three groups of subjects. For all variables, Tukey post hoc tests showed that the two groups of learning disabled subjects did differ significantly from the regular education subjects on both the test for social competence and antisocial behavior. Significant differences were not found however between the two groups of learning disabled subjects on either scale. Results supported the hypothesis that learning disabled subjects exhibit significantly lower levels of social competence and significantly higher levels of antisocial behavior than the regular education subjects

A retrospective comparison of intrathecal morphine and epidural hydromorphone for analgesia following posterior spinal fusion in adolescents with idiopathic scoliosis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135580/1/pan13037.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135580/2/pan13037_am.pd

Cyanobacterial ribosomal RNA genes with multiple, endonuclease-encoding group I introns

<p>Abstract</p> <p>Background</p> <p>Group I introns are one of the four major classes of introns as defined by their distinct splicing mechanisms. Because they catalyze their own removal from precursor transcripts, group I introns are referred to as autocatalytic introns. Group I introns are common in fungal and protist nuclear ribosomal RNA genes and in organellar genomes. In contrast, they are rare in all other organisms and genomes, including bacteria.</p> <p>Results</p> <p>Here we report five group I introns, each containing a LAGLIDADG homing endonuclease gene (HEG), in large subunit (LSU) rRNA genes of cyanobacteria. Three of the introns are located in the LSU gene of <it>Synechococcus </it>sp. C9, and the other two are in the LSU gene of <it>Synechococcus lividus </it>strain C1. Phylogenetic analyses show that these introns and their HEGs are closely related to introns and HEGs located at homologous insertion sites in organellar and bacterial rDNA genes. We also present a compilation of group I introns with homing endonuclease genes in bacteria.</p> <p>Conclusion</p> <p>We have discovered multiple HEG-containing group I introns in a single bacterial gene. To our knowledge, these are the first cases of multiple group I introns in the same <it>bacterial </it>gene (multiple group I introns have been reported in at least one phage gene and one prophage gene). The HEGs each contain one copy of the LAGLIDADG motif and presumably function as homodimers. Phylogenetic analysis, in conjunction with their patchy taxonomic distribution, suggests that these intron-HEG elements have been transferred horizontally among organelles and bacteria. However, the mode of transfer and the nature of the biological connections among the intron-containing organisms are unknown.</p

A Combined Measure of Vascular Risk for White Matter Lesions

This is the author's accepted manuscript.Background Though hypertension is a commonly studied risk factor for white matter lesions (WMLs), measures of blood pressure may fluctuate depending on external conditions resulting in measurement error. Indicators of arterial stiffening and reduced elasticity may be more sensitive indicators of risk for WMLs in aging; however the interdependent nature of vascular indicators creates statistical complications. Objective The purpose of the study was to determine whether a factor score comprised of multiple vascular indicators would be a stronger predictor of WMLs than traditional measures of blood pressure. Methods In a sample of well-characterized nondemented older adults, we used a factor analytic approach to account for variance common across multiple vascular measures while reducing measurement error. The result was a single factor score reflecting arterial stiffness and reduced elasticity. We used this factor score to predict white matter lesion volumes acquired via fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging. Results The combined vascular factor score was a stronger predictor of deep WML (β = 0.42, p < 0.001) and periventricular WML volumes (β = 0.49, p < 0.001). After accounting for the vascular factor, systolic and diastolic blood pressure measurements were not significant predictors. Conclusions This suggests that a combined measure of arterial elasticity and stiffening may be a stronger predictor of WMLs than systolic and diastolic blood pressure accounting for the multicollinearity associated with a variety of interrelated vascular measures