6 research outputs found
Comparative Analysis of Teleost Genome Sequences Reveals an Ancient Intron Size Expansion in the Zebrafish Lineage
- Author
- Adams
- Aparicio
- Benson
- Benton
- Bergman
- Bosco
- Boulesteix
- Burnette
- Castillo-Davis
- Chamary
- Coghlan
- David H. Lunt
- Deutsch
- Domino A. Joyce
- Flicek
- Frischmeyer
- Gaffney
- Gazave
- Haffter
- Hankeln
- Hatton
- Hawkins
- Hughes
- Iwamoto
- Jaillon
- Jeffares
- Jurka
- Katherine J. Tindall
- Kim
- Kimura
- Lander
- Li
- Lin
- Lynch
- López-Bigas
- Majewski
- Marais
- Mills
- Mironov
- Morgulis
- Neafsey
- Roest Crollius
- Rogers
- Roy
- Schwartz
- Sela
- Sharp
- Sharpton
- Shepard
- Smit
- Smit
- Stabenau
- Stajich
- Stajich
- Stein
- Stephen P. Moss
- Stuart Humphries
- Venter
- Wagner
- Yandell
- Zhu
- Zhuang
- Publication venue
- Oxford University Press
- Publication date
- 01/01/2011
- Field of study
We have developed a bioinformatics pipeline for the comparative evolutionary analysis of Ensembl genomes and have used it to analyze the introns of the five available teleost fish genomes. We show our pipeline to be a powerful tool for revealing variation between genomes that may otherwise be overlooked with simple summary statistics. We identify that the zebrafish, Danio rerio, has an unusual distribution of intron sizes, with a greater number of larger introns in general and a notable peak in the frequency of introns of approximately 500 to 2,000 bp compared with the monotonically decreasing frequency distributions of the other fish. We determine that 47% of D. rerio introns are composed of repetitive sequences, although the remainder, over 331 Mb, is not. Because repetitive elements may be the origin of the majority of all noncoding DNA, it is likely that the remaining D. rerio intronic sequence has an ancient repetitive origin and has since accumulated so many mutations that it can no longer be recognized as such. To study such an ancient expansion of repeats in the Danio, lineage will require further comparative analysis of fish genomes incorporating a broader distribution of teleost lineages
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Featherstone Carolyn J
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
- Hamdy F C
- Hamdy Freddie
- Hamilton C
- Hammonds John
- Hampson S J
- Hanbury Damien C
- Hardman P D John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
- Harris Sarah
- Harrison G S M
- Harriss D R
- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Spiers Alexander
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Symons Stephanie J
- Syndikus Isabel
- Taari Kimmo
- Tahir Saad
- Tammela Teuvo L
- Tammela Teuvo L J
- Tanquay J
- Taylor J W
- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tidball Sarah
- Tillmans Lori
- Tilsley Owen
- Tindall Stuart F
- Tipples K
- Tong [Unknown]
- Toussi Hamid
- Toy Elizabeth W
- Travis Ruth C
- Trembath Richard C
- Tulloch David N
- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
The problem of behaviour change: From social norms to an ingroup focus
- Publication venue
- 'Wiley'
- Publication date
- 24/02/2016
- Field of study
Social norms are of increasing interest to public policy experts and those conducting behaviour change interventions (e.g. safe driving, recycling). While there is agreement that social norms play a central role in explaining behaviour, such consensus i
Multiple loci on 8q24 associated with prostate cancer susceptibility
- Author
- Abrams Paul H
- Adamson Andrew
- Adeyoju A
- Afzal N
- Ahiaku Ernest K. N
- Ahmed Munir
- Al Olama Ali Amin
- Al-Samerraie
- Alcock Christopher
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Apakama Ike
- Aparcia F
- Archbold J. A. A
- Ardern-Jones Audrey T
- Ash D
- Ashford Richard F. U
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M. J
- Ball Andrew J
- Bancroft E
- Banerjee G
- Barber Jim
- Barber N
- Baria
- Barnes Douglas G
- Barwell Julian
- Basu Pradip
- Bates Christopher A
- Bax N. A
- Baxter-Smith D
- Beacock Christopher
- Beaney Ronald P
- Beard Ralph
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bellringer James
- Benson Richard
- Bhatt R. I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C. Shekhar
- Blacklock A. R. E
- Blades Rosemary
- Bloomfield David J
- Bollina Prasad
- Bonnington Sue
- Booth C. M
- Bose Pradeep
- Bottomley David
- Boucher Nigel R
- Bower Mark
- Bowsher W. G
- Boyd P. J. R
- Bramble F. James
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Brough Richard
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Butterworth Paul C
- Cahill D
- Callaghan P. S
- Calman Frances
- Campbell Alister
- Carnell Dawn M
- Carr T. W
- Carter Adam
- Carter Charles J. M
- Carter Simon
- Castle Bruce M
- Chadwick David
- Chakraborti P
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh Francis I
- Chong Irene
- Chow Wai-Man
- Christmas Timothy J
- Churn Mark J
- Clarke Noel W
- Coe M
- Cohen N. P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Cooke Peter
- Coombs L
- Cooper Colin
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P. A
- Corolis
- Corr John
- Costello C. B
- Cowan Richard
- Cox Robert
- Coyle C
- Crisp John C
- Cruger Dorthe
- Crundwell Malcolm
- Cummings
- Dahar Nazeer
- Daruwala Pallon
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David P
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dinneen Michael
- Dixit Sanjay
- Dobbs H. Jane
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Douglas S. Fiona
- Drake
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W. D
- Durkan Garrett
- Easton Douglas F
- Eccles Diana
- Eden C. D
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Ellis B. W
- Ellis R
- Elves Andrew W. S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- English Dallas R
- Errington R. D
- Evans D. Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Frim Olivera
- Gallegos Christopher
- Gelister James S
- George Anne
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E. M
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R. L
- Gurun Riza Murat
- Guy Michelle
- Guy Peter J
- Hall Amanda L
- Hamdy F. C
- Hamilton C
- Hammonds John
- Hampson S. J
- Hanbury Damien C
- Hardman P. D. John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harrison G. S. M
- Harriss D. R
- Harvey-Hills N
- Hawkyard Simon
- Heath Catherine M
- Hehir Michael
- Hendry David
- Henley Mike
- Herbert Pippa
- Hickish Tamas
- Hindmarsh John R
- Ho Edwin T. S
- Hodgson Shirley
- Holden David
- Holding Peter
- Hollins Graham W
- Holmes Simon A. V
- Hopper John L
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Izatt Louise
- Izegbu Victor
- James Michael J
- James Michael J
- James R. Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joss Shelagh
- Kaisary Amir
- Karim O
- Karp Stephen J
- Keeley F. X
- Kelkar Anand R
- Kelleher J. P
- Kenwrick Sue
- Khan F
- Khoo Vincent
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Kockelbergh Roger
- Koreich O
- Kote-Jarai Zsofia
- Kourah Mohamed
- Kulkarni Ravi
- Kumar M
- Kunkler Ian H
- Kynaston Howard
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Langley Stephen E. M
- Laniado Marc
- Larner T. R
- Lau Maurice W
- Lawrence W. T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J. O
- Lee L
- Lemburger R. John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel A
- Lester Jason
- Leung Hing
- Lewis D. Christopher
- Lewis J
- Liston Thomas
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lucas Malcolm G
- Luscombe C. J
- Lydon Anna
- Lynch Michael
- Lyons Norma
- MacDermott James P. A
- Macdonagh Ruaraidh P
- Maher E. R
- Mahmood Rana
- Mair Graeme H. M
- Malone Peter R
- Mark I
- Marsden Gemma
- Mason M. D
- Mason Robert
- Matenhelia Shyam
- Matthews Philip N
- McBride Donna
- McFarlane Jonathan
- McGrath John
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McMenemin Rhona
- McNicholas T. A
- Meddings Robert N
- Mee A. David
- Memon
- Menzes Pravin
- Mills Robert
- Mitchell S
- Mithal Natasha
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E. F
- Mokete Moeketsi
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Morley Roland
- Morris Sean B
- Morrison Jonathan
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth R
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki Jan
- Neal David E
- Neilson Donald
- Nethersell A
- Newman Hugh
- Newton R
- O'Boyle P. J
- O'Brien J
- O'Brien Tim S
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J. S
- O'Sullivan Joe
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Osborn David
- Ostler Peter
- O’Brien Lynne T
- Palfrey Edward
- Panades Miguel
- Pancharatnam M
- Pantelides Michalakis L
- Parikh Omi
- Parker Chris
- Parker Christopher C
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Patel Anup
- Patterson Helen
- Payne Heather
- Peake David
- Pedley I
- Pengelly A
- Peracha A. M
- Perry Matthew
- Persad Raj
- Philp N. H
- Philp T
- Pigott Katharine
- Plail R
- Plowman P. Nicholas
- Pocock Richard D
- Pope A. J
- Popert Rick
- Porter Tim
- Powell Christopher
- Powell Philip
- Prasad Krishna
- Prejbisz J. W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Ragavan Narasimhan
- Rankin Julia
- Rao Y
- Ravi Ramachandran
- Read Graham
- Reddy Paul J
- Rimington Peter R
- Roberts J. Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rogers P. B
- Rowbotham Carl
- Rowe Edward
- Rowley Kathryn
- Rundle John
- Russell John M
- Ryan P. G
- Saggar Anand K
- Samanci Ali
- Saunders Ed
- Sawyer Emma
- Saxby M. F
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shah Nihil
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum L
- Simcock R
- Singh Pravin
- Siva M
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Sreenivasan Thiagarajan
- Srihari Narayana N
- Srinivasan
- Sriram Rajagopalan
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M. J
- Strachan John R
- Subramonian K
- Sugden Elaine
- Sundar Santhanam
- Sundaram S. K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Syndikus Isabel
- Tahir Saad
- Taylor John W
- Terry T
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tilsley Owen
- Tindall Stuart F
- Tong
- Trembath Richard C
- Tulloch David N
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C. J
- Urwin Graeme H
- Van As Nicholas
- Vesey Sean
- Violet John
- Virdi Jaspal
- Waite Katherine
- Walker E. M
- Walker Roger
- Wallace David M. A
- Watkin Nicholas A
- Watson M. E
- Waxman J. H
- Waymont Brian
- Weaver Andrew
- Webb Ralph, J
- Wedderburn Andrew
- Wells Paula
- Wemyss-Holden G. D
- Weston P. M. T
- Wheatley Duncan
- Whelan P
- Whillis D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary A
- Williams John H
- Williams Simon
- Willis Michael
- Wilson J. R
- Wilson Richard
- Wise Marcus
- Woodhams Simon
- Woodhouse C
- Woolfenden K. A
- Worlding Jane
- Wright Mark
- Wylie James P
- Wynne Chris
- Zang Angelika
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
- Author
- Abrams Paul H
- Adamson Andrew
- Adeyoju A
- Afzal N
- Ahiaku Ernest K. N
- Ahmed Munir
- Aitken Joanne
- Al Olama Ali Amin
- Al-Samerraie Dr
- Alcock Christopher
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Apakama Ike
- Aparcia F
- Archbold J. A. A
- Ardern-Jones Audrey T
- Arrand John
- Ash D
- Ashford Richard F. U
- Auvinen Anssi
- Badenoch David
- Bagnato Melisa
- Bahl Amit
- Bailey Karen
- Bailey M. J
- Ball Andrew J
- Bancroft E
- Banerjee G
- Banks Annette
- Barber Jim
- Barber N
- Baria Dr
- Barnes Douglas G
- Barrett Sandra
- Barwell Julian
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N. A
- Baxter-Smith D
- Beacock Christopher
- Beaney Ronald P
- Beard Ralph
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Belcheva Olga
- Bellringer James
- Benson Richard
- Bhatt R. I
- Biedermann Cédric
- Bieri Sabine
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C. Shekhar
- Blacklock A. R. E
- Blades Rosemary
- Blizzard Leigh
- Bloomfield David J
- Bollina Prasad
- Bonnington Sue
- Booth C. M
- Bose Pradeep
- Bottomley David
- Boucher Nigel R
- Bower Mark
- Bowsher W. G
- Boyd P. J. R
- Bradley Sita Ann
- Bramble F. James
- Bremer Michael
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Brough Richard
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Brugger Margot
- Butorac Kate
- Butterworth Paul C
- Cahill D
- Callaghan P. S
- Calman Frances
- Campbell Alister
- Cannon-Albright Lisa
- Cao Guangwen
- Carnell Dawn M
- Carr T. W
- Carter Adam C
- Carter Charles J. M
- Carter Simon
- Castle Bruce M
- Chadwick David
- Chakraborti P
- Challis David
- Chambers Suzanne
- Chang Wen-Jun
- Chappuis Pierre O
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F. I
- Chong Irene
- Chow Wai-Man
- Christmas Tim
- Christova Svetlana
- Churn Mark J
- Clarke Noel W
- Clements Judith
- Coe M
- Cohen N. P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Cooke Peter
- Coombs L
- Coomes Margerie
- Cooney Kathleen A
- Cooper Colin S
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P. A
- Corolis Mr
- Corr John
- Corral Roman
- Costello C. B
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crisp John C
- Cruger Dorthe
- Crundwell Malcolm
- Cummings Mr
- Cunningham Julie
- Dahar Nazeer
- Daruwala Pallon
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David P
- Defabiani Nicolas
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickinson Joanne L
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H. Jane
- Doble Andrew
- Dodds David
- Dodova Rumjana
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dork Thilo
- Douglas S. Fiona
- Drake Mr
- Dubrowinskaja Natalia
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W. D
- Durkan Garrett
- Easton Douglas F
- Eccles Diana
- Eden C. D
- Edwards Stephen M
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Ellis B. W
- Ellis R
- Elves Andrew W. S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- English Dallas R
- Errington R. D
- Evans D. Gareth
- Falconer Alison
- Farnham Jim
- Fawcett Derek
- Featherston C
- Feggetter Jeremy
- Ferguson C
- Ferguson Megan
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel M
- Flanagan Louise
- Fletcher Matthew
- Folkes A
- Foote Simon
- Ford Trevor F
- Foulkes William D
- Frim Olivera
- Gallagher Stephen
- Gallegos Christopher
- Gardiner R. A. (Frank)
- Gelister James S
- George Anne
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Girardet Christophe
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E. M
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R. L
- Gurun Riza Murat
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Hall Amanda L
- Hamdy Freddie C
- Hamel Nancy
- Hamilton C
- Hammonds John
- Hampson S. J
- Hanbury Damien C
- Hardman P. D. John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harrison G. S. M
- Harriss D. R
- Harvey-Hills N
- Hawkyard Simon
- Heath Catherine M
- Hehir Michael
- Henderson Brian E
- Hendry David
- Henley Mike
- Herbert Pippa
- Herkommer Kathleen
- Hickish Tamas
- Hillemanns Peter
- Hindmarsh John R
- Hinze Kimberly
- Ho Edwin T. S
- Hodgson Shirley
- Holden David
- Holding Peter
- Hollins Graham W
- Holmes Simon A. V
- Hopper John L
- Horwich Alan
- Hoskin Peter
- Hou Jian-Guo
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert A
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Hutter Pierre
- Iacovou John W
- Ibrahim A
- Ingles Sue A
- Inglis John A
- Irving Stuart
- Irwin C
- Isotalo Jarkko
- Izatt Louise
- Izegbu Victor
- James Michael J
- James N
- James R. Lester
- Jameson Charles
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- John Esther M
- Johnson Emilie K
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joshi Amit D
- Joss Shelagh
- Kachakova Darina
- Kaisary Amir
- Kaneva Radka
- Karim O
- Karp Stephen J
- Karstens Johann H
- Karyadi Danielle M
- Kedda Mary Anne
- Keeley F. X
- Kelham Penelope
- Kelkar Anand R
- Kelleher J. P
- Kenwrick Sue
- Khan F
- Khan Humera
- Khoo Vincent S
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Kockelbergh Roger
- Kolonel Laurence N
- Konzelmann Isabelle
- Koopmeiners Joseph S
- Koreich O
- Kotar Kimberley
- Kote-Jarai Zsofia
- Kourah Mohamed
- Kuczyk Markus
- Kuefer Rainer
- Kulkarni Ravi
- Kumar M
- Kunkler Ian H
- Kwon Erika M
- Kynaston Howard
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lange Ethan M
- Langley Stephen E. M
- Laniado Marc
- Larner T. R
- Lau Maurice W
- Lawrence W. T
- Lawson Anne
- Le Marchand Loic
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J. O
- Lee L
- Lemburger R .John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel A
- Lester Jason
- Leung Hing
- Lewis D. Christopher
- Lewis J
- Lewis Sarah J
- Liston Thomas
- Liu Jo-Fen
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lose Felicity
- Lu Yong-Jie
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C. J
- Lydon Anna
- Lynch Michael
- Lyons Norma
- MacDermott James P. A
- Macdonagh Ruaraidh P
- Machtens Stefan
- Maher E. R
- Mahmood Rana
- Maier Christiane
- Mair Graeme H. M
- Malone Peter R
- Mark I
- Marsden Gemma
- Mason M. D
- Mason Robert
- Matenhelia Shyam
- Matikainen Mika
- Matthews Philip N
- Mattila Henna
- McArdle John
- McBride Donna
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath John
- McInerney Paul
- McIntosh Gregor
- McKay James
- McKinna F
- McLaren Duncan
- McMenemin Rhona
- McNicholas T. A
- McWhirter Rebekah
- Meddings Robert N
- Mee A. David
- Meier Marie-Mathilde
- Memon Mr
- Menzes Pravin
- Meyer Andreas
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E. F
- Mokete Moeketsi
- Money-Kyrle Julian
- Montgomery Bruce
- Montie James E
- Moody Hilary
- Morley Roland
- Morris Sean B
- Morrison Jonathan
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki Jan
- Neal David E
- Neilson Donald
- Nelson Colleen
- Nethersell A
- Newman Beth
- Newman Hugh
- Newton R
- Nicol David
- Nikolov Momchil
- O'Boyle P. J
- O'Brien J
- O'Brien Lynne T
- O'Brien Tim S
- O'Donoghue E
- O'Donoghue Neil
- O'Mara Tracy
- O'Reilly P
- O'Rourke J. S
- O'Sullivan Joe
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Osborn David
- Ostler Peter
- Ostrander Elaine A
- Page Elizabeth C
- Paiss Thomas
- Pakkanen Sanna
- Palfrey Edward
- Panades Miguel
- Pancharatnam M
- Pantelides Michalakis L
- Parikh Omi
- Park Hyun Y
- Park Jong Y
- Parker Christopher C
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Patel Anup
- Patterson Briony
- Patterson Helen
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha A. M
- Perry Matthew
- Persad Raj
- Peter Hans-Ulrich
- Philp N. H
- Philp T
- Pigott Katharine
- Plail R
- Plowman P. Nicholas
- Pocock Richard D
- Polanowski Andrea
- Pope A. J
- Popert Rick
- Popov Elenko
- Porter Tim
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Prasad Krishna
- Prejbisz J. W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Radein Selina
- Ragavan Narasimhan
- Rankin Julia
- Rao Y
- Ravi Ramachandran
- Ray Anna M
- Read Graham
- Rebbeck Timothy R
- Reddy Paul J
- Rimington Peter R
- Rincon Maria
- Roberts J. Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rogers P. B
- Rowbotham Carl
- Rowe Edward
- Rowley Kathryn
- Rundle John
- Russell John M
- Ryan P. G
- Saggar Anand K
- Samanci Ali
- Saunders Edward J
- Sawyer Emma J
- Saxby M. F
- Schaid Daniel
- Schleutker Johanna
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Sellers Thomas A
- Sells Henry
- Serth Jürgen
- Sethia Krishna K
- Severi Gianluca
- Shah Nihil
- Shahabi Ahva
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum L
- Siltanen Sanna
- Simcock R
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smark Heidi
- Smith Charmaine
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Spangler Elaine
- Speakman Mark J
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan Mr
- Sriram Rajagopalan
- Stalder Michèle
- Stanford Janet L
- Stankovich James
- Stefflova Klara
- Stenman Ulf-Håkan
- Stern Mariana C
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M. J
- Strachan John R
- Subramonian K
- Sugden Elaine
- Sundar Santhanam
- Sundaram S. K
- Suresh Gokarakonda
- Surowy Harald
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Syndikus Isabel
- Tahir Saad
- Tammela Teuvo L
- Taylor John W
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thomson Russell
- Thurston A
- Tilsley Owen
- Tindall Stuart F
- Tong Dr
- Trembath Richard C
- Tulloch David N
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C. J
- Urwin Graeme H
- Van As Nicholas
- VandenBergh Patrica
- Vesey Sean
- Violet John
- Virdi Jaspal
- Vlahova Aleksandrina
- Vogel Walther
- von Klot Christoph
- Wahlfors Tiina
- Waite Katherine
- Walker Amy
- Walker E. M
- Walker Roger
- Wallace David M. A
- Wang Liang
- Watkin Nicholas A
- Watson M. E
- Waxman J. H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Weber Bärbel
- Wedderburn Andrew
- Wells Paula
- Wemyss-Holden G. D
- Weston P. M. T
- Wheatley Duncan
- Whelan P
- Whillis D
- Wiest Irina
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary A
- Williams John H
- Williams Simon
- Willis Michael
- Wilson J. R
- Wilson Richard
- Wise Marcus
- Woodhams Simon
- Woodhouse Christopher J
- Woolfenden K. A
- Worlding Jane
- Wright Mark
- Wylie James P
- Wynne Chris
- Xu Dan-Feng
- Xu Xing-Xing
- Yaxley John
- Zachariah Babu
- Zakariah Babu
- Zang Angelika
- Zeegers Maurice
- Zeigler-Johnson Charnita
- Zhang Hong-Wei
- Zuhlke Kimberly A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. To identify common PrCa susceptibility alleles, we have previously conducted a genome-wide association study in which 541, 129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and 1,894 controls. We have now evaluated promising associations in a second stage, in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls, and a third stage, involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to previously identified loci, we identified a further seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11, and 22 (P=1.6×10−8 to P=2.7×10−33)
Empagliflozin in Patients with Chronic Kidney Disease
- Author
- Aamir Navivala
- Abdulwahab Arbi
- Abegail Hernandez Pena
- Abraham Hanburry
- Adedolapo Adeleke
- Adeera Levin
- Adil Hazara
- Adline Ghazi
- Agnes Masengu
- Ahmad Tuffaha
- Ahmed Awad
- Ahmed Ghanem
- Ai Fukasawa
- Aik Kheng Lee
- Aiko Terakawa
- Aiko Tomita
- Aiko Yamada
- Ailsa Geddes
- Airi Sato
- Akane Katanosaka
- Akane Yamamoto
- Akihiro Fujimoto
- Akihiro Katayama
- Akihito Tanaka
- Akiko Fujita
- Akiko Hashimoto
- Akiko Ishiguro
- Akiko Omata
- Akimasa Asai
- Akinwande Akinfolarin
- Akio Kanazawa
- Akiyo Nishiyama
- Akiyo Tanabe
- Alastair Rankin
- Alastair Woodman
- Albert Hing
- Albert Power
- Alberto Rosati
- Aldo P Maggioni
- Aldo Peixoto
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- Qiuhong Gong
- Qur Khai
- Quresh Khairullah
- Rach AitSadi
- Rachel Craik
- Rachel Epp
- Rachel Phillips
- Rachel Raff
- Rachel Sellars
- Rachele Grifa
- Radica Alicic
- Rafizanur Ramli
- Rahimah Ismail
- Rahul Pandey
- Rainer Paul
- Rajan Patel
- Rajat Deo
- Rajesh Pradhan
- Ralph Wendt
- Rashid Almasarwah
- Rashmi Easow
- Ravi Varma
- Rebecca Flora
- Rebecca Frazier
- Rebecca Goldfaden
- Rebecca Sardell
- Rebecca Suckling
- Reem Mustafa
- Reiki Kobayashi
- Reina Umeno
- Rejive Dayanandan
- Remi Nagano
- Remi Rabasa-Lhoret
- Renata Dayrell
- Rene Almaraz
- Rene van Erp
- Renee Hogan
- Ria Rabara
- Ricarda Wolfling
- Ricardo Pulido
- Ricardo Silva
- Ricardo Viera
- Richard Baker
- Richard Bodington
- Richard Brown
- Richard Fish
- Richard Haynes
- Richard Hull
- Richard Sachson
- Richard Smith
- Rieko Mizumachi
- Rijo Kurien
- Rika Kumuji
- Rikako Nakamura
- Rina Kasagi
- Riny Paul
- Rita Quartagno
- Rita Sheridan
- Ritva Ellison
- Rizna Abdul Cader
- Robert Clarke
- Robert Dykas
- Robert Miller
- Roberta Zani
- Roberto Mangiacapra
- Roberto Minutolo
- Roberto Pontremoli
- Rocco Baccaro
- Rodel Gloria
- Rodolfo Rivera
- Roger DeRaad
- Roland Veelken
- Ronald Goldenberg
- Rosalyn Wheatley
- Rosario Machicado
- Rosemarie Henschel
- Rossello Xavier
- Rossenizal Abd Rahman
- Rotimi Oluyombo
- Rowan McDougall
- Rowan Moys
- Roxana Rodriquez
- Rozita Mohd
- Rudolf Bilous
- Rui Imamine
- Ruka Suzuki
- Rupal Mehta
- Rushab Choksi
- Ruslinda Mustafar
- Ruth Adewuyi-Dalton
- Ruth Oremus
- Ryan Barrios
- Ryan Campbell
- Ryan Lustig
- Ryonfa Lee
- Ryota Tamura
- Ryotaro Bouchi
- Ryoya Tsunoda
- Saad Tufail
- Sabariah Ibrahim
- Sabrina Burnette
- Sadanah Aqashiah Mazlan
- Sadiq Ahmed
- Saeko Asano
- Sajad Hamal
- Saki Kanegae
- Saki Okamoto
- Sally Ham
- Sally Ruse
- Salmi Ramli
- Sam Tholl
- Samantha Armstrong
- Samantha Hagan
- Samantha Hope
- Samee Syed
- Sameh Fikry
- Samira Bell
- Samiul Mostafa
- Sammons Emily
- Sana Akram
- Sandra Gaiser
- Sandra Pickworth
- Saori Akimoto
- Sapna Shah
- Sara Kelley
- Sarah Acheampong
- Sarah Benyon
- Sarah Clark
- Sarah Lerario
- Sarah Morlok
- Sarah Tipper
- Sarah Y A Ng
- Sarah Y A Ng
- Sarasa Ramasamy
- Sarojini Sivanandam
- Sasha Dorestin
- Satoko Horikawa
- Satoshi Mano
- Satoshi Masumoto
- Satoshi Miyamoto
- Savannah Rucker
- Sawako Kato
- Sawako Maeno
- Sayaka Kawashima
- Sayaka Yamamoto
- Scarlett Forest
- Scott Lyle
- Scott Satko
- Sebastian Butler
- Sebastian Gabel
- Seiji Itano
- Seiji Ueda
- Sendogan Aker
- Sergio Rovner
- Serine Alfaress
- Severin Schricker
- Shahbaz Ahmed
- Shahin Mozaffari
- Shameem Beigh
- Shamila Wanninayake
- Shan Darbeau
- Shana Camp
- Shaopeng Yao
- Sharang Ghavampour
- Shariff Sanguila
- Sharirose Abat
- Shayani Raguwaran
- Sheila Carr
- Shenglang Zhu
- Sherald Barnes
- Sherry Brown
- Sherry Gasko
- Shi Zhao
- Shiho Iwagaitsu
- Shin Tsunekawa
- Shingo Iwasaki
- Shinichi Araki
- Shinichi Nishi
- Shinji Kitamura
- Shinji Kume
- Shinjiro Kodama
- Shintaro Nunokawa
- Shintaro Yano
- Shinya Goto
- Shinya Yoshida
- Shiva Ugni
- Shivinder Jolly
- Shizuka Higashi
- Shogo Banno
- Shogo Kimura
- Shoichi Maruyama
- Shoji Saito
- Shoko Hayashi
- Shoko Otomo
- Shona Murray
- Shota Hashimoto
- Shraddha Shah
- Shuai Tang
- Shuang Xia
- Shuhan Zhou
- Shunichiro Asahara
- Shunsuke Goto
- Shweta Bansal
- Sian Griffin
- Sibylle J Hauske
- Silke Markau
- Simona Barberi
- Simona Bianco
- Simone Boedecker
- Simone Hagge
- Simone Streitenberger
- Simone Vettoretti
- Sina Rolfsmeier
- Sion Roy
- Siti Munirah Jaafar
- Siti Nabilah Mohamad Zaini
- Smeeta Sinha
- Smita Gunda
- Sodai Kubota
- Sofia Dayi
- Sonja Grotjahn
- Sonoka Yamamoto
- Soo Kun Lim
- Soon Yi Sor
- Sorcha Mulligan
- Sri Yarlagadda
- Sridhar Ramanaidu
- Srinivasan Beddhu
- Stacey-Ann Villaruel
- Stacie Hitchcock
- Stacy Gillham
- Staplin Natalie
- Stefan Degenhardt
- Stefan Haack
- Stefan Hantel
- Stefanie Jones
- Stefanie Kuhn
- Stephan Matthias
- Stephanie Bolton
- Stephanie Estcourt
- Stephanie Evans
- Stephanie Martinez
- Stephanie Rosenberg
- Stephanie Watson
- Stephanie Whittaker
- Stephany Topping
- Stephen Aronoff
- Steubl Dominik
- Steven Nagelberg
- Stevens Will
- Stewart Moffat
- Subash Somalanka
- Subha Clarke
- Subrata Debnath
- Sucharit Joshi
- Sue Ann Lee
- Sue Hewins
- SueAnn Squyres
- Sui Phin Kon
- Sunil Bhandari
- Sunita Bavanandan
- Suresh Ramadoss
- Suria Junus
- Susan Haskett
- Susan Hurley
- Susan McLaughlin
- Susannah Pajak
- Susanne Bodine
- Susanne Brenner
- Susumu Nakatani
- Suzannah Dorey
- Sybille Merscher
- Tabbatha Duck
- Tabinda Dugal
- Tadahiro Tomita
- Taeko Uchida
- Tai Meng Chen
- Takahiro Ishikawa
- Takahiro Kato
- Takahiro Matsunaga
- Takahiro Yamano
- Takako Kuramae
- Takako Ozawa
- Takanori Hyo
- Takashi Funayama
- Takashi Kadowaki
- Takashi Kobayashi
- Takashi Udagawa
- Takatoshi Otani
- Takayuki Katsuno
- Takehiko Wada
- Takehiro Sugiyama
- Takeshi Kurose
- Takeshi Miyatsuka
- Takeshi Ogihara
- Takuji Ishimoto
- Takuma Kojo
- Takuya Haraguchi
- Takuya Yokoyama
- Tamaki Sasaki
- Tamara Isakova
- Tammi Glider
- Tammy Ross
- Tanaji Dasgupta
- Taneera Ghate
- Taniya Nimbkar
- Tanvi Talsania
- Tara Johnson
- Tasuku Nagasawa
- Tatsuhito Himeno
- Tatyana Chavagnon
- Tejas Patel
- Teresa Kozlowski
- Teresa McKinley
- Terri Chant
- Tetsuya Hosooka
- Tetsuya Shigehara
- Thahir Abdul-Samad
- The EMPA-KIDNEY Collaborative Group: Colin Baigent
- Theresa McCarthy
- Thiemo Pfab
- Thisun Saram
- Thomas Arnold
- Thomas Jones
- Thomas Phillips
- Thomas Pickett
- Thomas Sitter
- Thomas Walters
- Thomas Weinreich
- Tim Doulton
- Tim Williams
- Timothy Ellam
- Tina Harding
- Tina Ramsey
- Ting Meng
- Tingting Kan
- Tobias Bergler
- Toluleyi Sobande
- Tomoe Sato
- Tomohide Hayami
- Tomohito Gohda
- Tomohito Izumi
- Tomoka Nakamura
- Tomoki Kosugi
- Tomoko Hisatake
- Tomoko Morisaki
- Tomoko Takahashi
- Tomoko Takai
- Tomonori Hasegawa
- Tomoya Mita
- Torsten Schramm
- Toru Ikeda
- Toshiki Kano
- Toshimasa Yamauchi
- Toshiya Yamamoto
- Toshiyuki Komiya
- Toyoyoshi Uchida
- Tracey Cummins
- Tracy Fuller
- Tracy Spinola
- Trevor Greene
- Tricia Young
- Tristan Daniels
- Tsukasa Iwakura
- Tuttle Katherine R
- Tze Jian Ng
- Ulla Ludwig
- Ulrike Giebeln-Hudnell
- Ulrike Schmidt
- Urs Benck
- Ursula Hohenstatt
- Usah Lilavivat
- Vahid Mahabadi
- Vanessa Rivers
- Verlaine Stewart-Ray
- Veronica Poma
- Veronica Yousif
- Vesta Lai
- Vicki Adell
- Vicki Brindle
- Vicki Dodds
- Vicki Donley
- Vickie Jones
- Victoria Carnall
- Victoria Gonce
- Vimal Derebail
- Vinay Varad
- Vittorio Ortalda
- Vivian Yiu
- Vladimir Cejka
- Volker Schettler
- Volker Vielhauer
- Wael Eid
- Wagdy Basily
- Wakako Isari
- Wallendszus Karl
- Waltraud Kmietschak
- Wan Ahmad Faizal Alaidin Razali
- Wan Hazlina Wan Mohamad
- Wanner Christoph
- Waqar Ayub
- Waseem Karsan
- Wasim Deeb
- Wasim Hanif
- Wataru Ogawa
- Wei Wang
- Wei Wei
- Weijing Bian
- Weiping Hou
- Weixin Kong
- Wen Jiun Liu
- Wen Liu
- Wendy Arriaga
- Wiebke Kaluza-Schilling
- Will Stevens
- William Durham
- William G Herrington
- William G Herrington
- William Hodge
- William Petchey
- Wolf-Adam Seeger
- Wolfgang Seeger
- Wuhanbilige Hundei
- Xavier Rossello
- Xia Song
- Xiangcheng Xiao
- Xiaojing Jiao
- Xiaojue Li
- Xiaoliang Wang
- Xinzhou Zhang
- Xiumei Hu
- Xuejiao Liu
- Xueying Wang
- Yan Li
- Yanmei Xu
- Yanping Wang
- YanRu Qiao
- Yanwu Yu
- Yanyun Xie
- Yao Weng
- Yao Yao
- Yasemin Kavak
- Yasuhiko Furukawa
- Yasuhiko Ito
- Yasuhiko Kanaguchi
- Yasuhiro Suzuki
- Yasushi Iwaita
- Ye Mun Low
- Yee Yan Lee
- Yew Fong Liew
- Yi Loon Tye
- Yik Hong Wong
- Yik Shen Lim
- Ying Hu
- Ying Jiang
- Ying Kuan
- Ying Lu
- Yinghua Chen
- Yohei Ejima
- Yoko Inukai
- Yolanda Miller
- Yong Chieh Chan
- Yonghong Bu
- Yoshiaki Morishita
- Yoshie Shibata
- Yoshifumi Tamura
- Yoshihiko Yamasaki
- Yoshihisa Wada
- Yoshikazu Tamori
- Yoshiki Suzuki
- Yoshimitsu Yamasaki
- Yoshinari Yasuda
- Yoshinori Osaki
- Yoshiro Kato
- Yoshiyuki Hamamoto
- Yosuke Hirakawa
- Yosuke Nakagawa
- Youcef Mostefai
- Young Lee-Barkey
- Yu An
- Yu Chen
- Yu Chen Ong
- Yu Yamanouchi
- Yuana Mohd Yusoff
- Yuichiro Munakata
- Yuji Oe
- Yuka Sato
- Yuka Ueda
- Yukari Miura
- Yuki Fujita
- Yuki Fukao
- Yuki Omori
- Yukihiro Shimizu
- Yukihiro Yamaji
- Yukiko Nakayama
- Yukiko Toyonaga
- Yukiko Wakita
- Yuko Katsuda
- Yuko Makita
- Yuko Okada
- Yuko Orimo
- Yumi Osawa
- Yushi Hirota
- Yusuke Suzuki
- Yutaka Kamimura
- Yuya Nishida
- Yvette Webley
- Yvonne Ehrl
- Yvonne Jackson
- Zabrina Lozon
- Zaid Azhari
- Zaiha Harun
- Zainab Sheriff
- Zanaida Cooper
- Zay Htet
- Zhang Duan Tham
- Zhi-Hong Liu
- Zhirui Zhao
- Zhu Doreen
- Zhuo Tang
- Zohreh Forghani
- Zuber Patel
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2023
- Field of study
Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo