Daily fluctuations of progesterone and testosterone are associated with fibromyalgia pain severity

The purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for fibromyalgia provided venous blood samples and reported their fibromyalgia pain severity over 25 consecutive days. All women exhibited normal menstrual cycles and were not taking oral contraceptives. Corti- sol, and the sex hormones estradiol, progesterone, and testosterone, were assayed from serum. A linear mixed model was used to determine if fluctuations of sex hormones were associated with changes in pain severity. In the entire sample, day to day changes in progesterone (P = .002) as well as tes- tosterone (P = .015) were significantly and inversely correlated with pain severity. There was no relationship between estradiol and pain (P = .551) or cortisol and pain (P = .633). These results suggest that progesterone and testosterone play a protective role in fibromyalgia pain severity. Sex and other hormones may serve to increase as well as decrease fibromyalgia pain severity.Publisher PDFPeer reviewe

Daily fluctuations of progesterone and testosterone are associated with fibromyalgia pain severity

The purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for fibromyalgia provided venous blood samples and reported their fibromyalgia pain severity over 25 consecutive days. All women exhibited normal menstrual cycles and were not taking oral contraceptives. Corti- sol, and the sex hormones estradiol, progesterone, and testosterone, were assayed from serum. A linear mixed model was used to determine if fluctuations of sex hormones were associated with changes in pain severity. In the entire sample, day to day changes in progesterone (P = .002) as well as tes- tosterone (P = .015) were significantly and inversely correlated with pain severity. There was no relationship between estradiol and pain (P = .551) or cortisol and pain (P = .633). These results suggest that progesterone and testosterone play a protective role in fibromyalgia pain severity. Sex and other hormones may serve to increase as well as decrease fibromyalgia pain severity

SOFIA/HAWC+ observations of the Crab Nebula: dust properties from polarized emission

International audienceSupernova remnants (SNRs) are well-recognized dust producers, but their net dust production rate remains elusive due to uncertainties in grain properties that propagate into observed dust mass uncertainties, and determine how efficiently these grains are processed by reverse shocks. In this paper, we present a detection of polarized dust emission in the Crab pulsar wind nebula, the second SNR with confirmed polarized dust emission after Cassiopeia A. We constrain the bulk composition of the dust with new SOFIA/HAWC+ polarimetric data in band C 89 μm and band D 154 μm. After correcting for synchrotron polarization, we report dust polarization fractions ranging between 3.7–9.6 per cent and 2.7–7.6 per cent in three individual dusty filaments at 89 and 154 μm, respectively. The detected polarized signal suggests the presence of large (≳0.05–0.1 μm) grains in the Crab Nebula. With the observed polarization, and polarized and total fluxes, we constrain the temperatures and masses of carbonaceous and silicate grains. We find that the carbon-rich grain mass fraction varies between 12 and 70 per cent, demonstrating that carbonaceous and silicate grains co-exist in this SNR. Temperatures range from ∼40 to ∼70 K and from ∼30 to ∼50 K for carbonaceous and silicate grains, respectively. Dust masses range from ∼10^−4 to ∼10^−2 M_⊙ for carbonaceous grains and to ∼10^−1 M_⊙ for silicate grains, in three individual regions

Comparison of diagnoses of early-onset sepsis associated with use of Sepsis Risk Calculator versus NICE CG149: a prospective, population-wide cohort study in London, UK, 2020–2021

Objective We sought to compare the incidence of early-onset sepsis (EOS) in infants ≥34 weeks’ gestation identified >24 hours after birth, in hospitals using the Kaiser Permanente Sepsis Risk Calculator (SRC) with hospitals using the National Institute for Health and Care Excellence (NICE) guidance.Design and setting Prospective observational population-wide cohort study involving all 26 hospitals with neonatal units colocated with maternity services across London (10 using SRC, 16 using NICE).Participants All live births ≥34 weeks’ gestation between September 2020 and August 2021.Outcome measures EOS was defined as isolation of a bacterial pathogen in the blood or cerebrospinal fluid (CSF) culture from birth to 7 days of age. We evaluated the incidence of EOS identified by culture obtained >24 hours to 7 days after birth. We also evaluated the rate empiric antibiotics were commenced >24 hours to 7 days after birth, for a duration of ≥5 days, with negative blood or CSF cultures.Results Of 99 683 live births, 42 952 (43%) were born in SRC hospitals and 56 731 (57%) in NICE hospitals. The overall incidence of EOS (<72 hours) was 0.64/1000 live births. The incidence of EOS identified >24 hours was 2.3/100 000 (n=1) for SRC vs 7.1/100 000 (n=4) for NICE (OR 0.5, 95% CI (0.1 to 2.7)). This corresponded to (1/20) 5% (SRC) vs (4/45) 8.9% (NICE) of EOS cases (χ=0.3, p=0.59). Empiric antibiotics were commenced >24 hours to 7 days after birth in 4.4/1000 (n=187) for SRC vs 2.9/1000 (n=158) for NICE (OR 1.5, 95% CI (1.2 to 1.9)). 3111 (7%) infants received antibiotics in the first 24 hours in SRC hospitals vs 8428 (15%) in NICE hospitals.Conclusion There was no significant difference in the incidence of EOS identified >24 hours after birth between SRC and NICE hospitals. SRC use was associated with 50% fewer infants receiving antibiotics in the first 24 hours of life