Visualization of the non-steady state oblique detonation wave phenomena around hypersonic spherical projectile

We studied experimentally the shock waves and combustion waves generated by a hypersonic spherical projectile in an explosive mixture. An acetylene/oxygen mixture diluted with argon (2C2H2 + 5O2 + 7Ar) was used with various initial pressures (detonation cell sizes) to observe optically with a shadowgraph imaging system a shock-induced combustion (SIC), a stable oblique detonation wave (ODW), and a wave called a Straw Hat type consisting of a strong SIC and ODW. The criticality of stabilizing an ODW around a projectile is expressed by the ratio of the projectile diameter, d, to the cell size, λ, as d/λ = 3.63–4.84. Although the Straw Hat type wave in the vicinity of criticality is an unstable phenomena, it has been mainly observed by a single frame picture to date, so that it is difficult to discuss the time history of its wave structure. In this study, it was remarkable to directly carry out continuous optical observations using a high speed video camera which can continuously film 100 pictures with a 1 μs frame speed so as to allow an investigation of the sustaining mechanism of the unstable wave structure. Our results allowed the identification of an increase in unsteadiness in the relative distance between the projectile fronts and the transition points to an ODW as the time increased. They also showed local explosions in the SIC region near transition point transformed the ODW front upstream

Thrust Measurement of a Multicycle Partially Filled Pulse Detonation Rocket Engine

In the present research, we experimentally verified the partial-fill effect in a multicycle pulse detonation rocketengine. The intermittent thrust of a pulse detonation rocket engine was measured by using a spring-dampermechanism that smoothed this intermittent thrust in the time direction. The intermittent mass flow rates wereassessed by gas cylinder pressure or mass difference measurement. The maximum specific impulse was 305 9 s atan ethylene and oxygen propellant fill fraction of 0:130 0:004. When the fill fraction was greater than 0.130, thespecific impulse was increased as the partial-fill fraction was decreased. When the fill fraction was less than 0.130, thespecific impulse was sharply decreased as the partial-fill fraction was decreased. This decrease was due to diffusionbetween propellant and purge gases and the short length of the transition from deflagration to detonation. Themulticycle pulse detonation rocket engine had a partial-fill effect that may have been mainly due to the suctioned airand was consistent with the single-cycle partial-fill model of Endo et al

Propulsive Performance and Heating Environment of Rotating Detonation Engine with Various Nozzles

Geometric throats are commonly applied to rocket combustors to increase pressure and specific impulse. This paper presents the results from thrust measurements of an ethylene/gas-oxygen rotating detonation engine with various throat geometries in a vacuum chamber to simulate varied backpressure conditions in a range of 1.1–104 kPa. For the throatless case, the detonation channel area was regarded to be equivalent the throat area, and three throat-contraction ratios were tested: 1, 2.5, and 8. Results revealed that combustor pressure was approximately proportional to equivalent throat mass flux for all test cases. Specific impulse was measured for a wide range of pressure ratios, defined as the ratio of the combustor pressure to the backpressure in the vacuum chamber. The rotating detonation engine could achieve almost the same level of optimum specific impulse for each backpressure, whether or not flow was squeezed by a geometric throat. In addition, heat-flux measurements using heat-resistant material are summarized. Temporally and spatially averaged heat flux in the engine were roughly proportional to channel mass flux. Heat-resistant material wall compatibility with two injector shapes of doublet and triplet injection is also discussed

LDL-C/HDL-C Ratio Predicts Carotid Intima-Media Thickness Progression Better Than HDL-C or LDL-C Alone

High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are strong predictors of atherosclerosis. Statin-induced changes in the ratio of LDL-C to HDL-C (LDL-C/HDL-C) predicted atherosclerosis progression better than LDL-C or HDL-C alone. However, the best predictor of subclinical atherosclerosis remains unknown. Our objective was to investigate this issue by measuring changes in carotid intima-media thickness (IMT). A total of 1,920 subjects received health examinations in 1999, and were followed up in 2007. Changes in IMT (follow-up IMT/baseline IMT × 100) were measured by ultrasonography. Our results showed that changes in IMT after eight years were significantly related to HDL-C (inversely, P < 0.05) and to LDL-C/HDL-C ratio (P < 0.05). When the LDL-C/HDL-C ratios were divided into quartiles, analysis of covariance showed that increases in the ratio were related to IMT progression (P < 0.05). This prospective study demonstrated the LDL-C/HDL-C ratio is a better predictor of IMT progression than HDL-C or LDL-C alone

Giant Pulsations Excited by a Steep Earthward Gradient of Proton Phase Space Density: Arase Observation

AbstractWe present observational evidence of drift resonance between westward propagating odd mode standing ultralow frequency waves and energetic protons. Compressional ∼13 mHz (Pc4 band) waves and proton flux oscillations at >50 keV were detected at ∼03 hr magnetic local time by the Arase satellite on 15 April 2017. The azimuthal wave number (m number) is estimated to be ∼−50 from ground observations, while the theory of drift resonance gives m ∼− 49 for odd mode waves and ∼110‐keV protons, providing evidence that the drift resonance indeed took place in this event. We also found a steep earthward gradient of proton phase space density, which can quantitatively explain the wave excitation. The observed waves show typical features of giant pulsations (Pgs), regarding local time, m number, and flux oscillations. This study, therefore, has great implications to the field line mode structure and excitation mechanism of Pgs

Protocol for a Randomized, Crossover Trial : ISCHIA study

Objective: Intermittent-scanning continuous glucose monitoring (isCGM) is widely used in type 1 diabetes (T1D) patients; however, the education required to prevent hypoglycemia by using isCGM is not established. This study examines the combined effect of isCGM device usage and the education to reduce the time in hypoglycemia in comparison to conventional self-monitoring of blood glucose (SMBG). Methods: The Effect of Intermittent-Scanning Continuous Glucose Monitoring to Glycemic Control Including Hypoglycemia and Quality of Life of Patients with Type 1 Diabetes Mellitus Study (ISCHIA Study), a randomized, crossover trial, enrolls 104 T1D patients (age, 20-74 years) with T1D. Participants are randomized to use isCGM combined with structured education (Intervention period) or SMBG (Control period) for 84 days, followed by the other for a further 84 days. During the Intervention period, participants have access to the sensor glucose levels and trend arrow of the device. During the Control period, participants conduct SMBG at least three times a day, and retrospective CGM is used to record the blinded sensor glucose levels. The primary endpoint is the decrease of time in hypoglycemia ( < 70 mg/dL) per day (hour/day) during the Intervention period compared with the Control period. The secondary endpoints include other indices of glycemic control, glycoalbumin, accuracy of isCGM, diabetes-related quality of life (QOL), adherence, and cost-effectiveness. The study protocol has received Certified Review Board (CRB) approval from National Hospital Organization Osaka National Hospital (N2018002, February 14, 2019). This study is carried out in accordance with the Declaration of Helsinki and the Clinical Trials Act. The findings will be published in peer-reviewed journals. Conclusion: The ISCHIA study will contribute to the standardization of patient education regarding the prevention of hypoglycemia by using isCGM

A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production

The Psmb11-encoded β5t subunit of the thymoproteasome, which is specifically expressed in cortical thymic epithelial cells (cTECs), is essential for the optimal positive selection of functionally competent CD8+ T cells in mice. Here, we report that a human genomic PSMB11 variation, which is detectable at an appreciable allele frequency in human populations, alters the β5t amino acid sequence that affects the processing of catalytically active β5t proteins. The introduction of this variation in the mouse genome revealed that the heterozygotes showed reduced β5t expression in cTECs and the homozygotes further exhibited reduction in the cellularity of CD8+ T cells. No severe health problems were noticed in many heterozygous and 5 homozygous human individuals. Long-term analysis of health status, particularly in the homozygotes, is expected to improve our understanding of the role of the thymoproteasome-dependent positive selection of CD8+ T cells in humans

Prevention of hypoglycemia by intermittent-scanning continuous glucose monitoring device combined with structured education in patients with type 1 diabetes mellitus : A randomized, crossover trial

Aims: We conducted a randomized, crossover trial to compare intermittent-scanning continuous glucose monitoring (isCGM) device with structured education (Intervention) to self-monitoring of blood glucose (SMBG) (Control) in the reduction of time below range. Methods: This crossover trial involved 104 adults with type 1 diabetes mellitus (T1DM) using multiple daily injections. Participants were randomly allocated to either sequence Intervention/Control or sequence Control/Intervention. During the Intervention period which lasted 84 days, participants used the first-generation FreeStyle Libre (Abbott Diabetes Care, Alameda, CA, USA) and received structured education on how to prevent hypoglycemia based on the trend arrow and by frequent sensor scanning (≥10 times a day). Confirmatory SMBG was conducted before dosing insulin. The Control period lasted 84 days. The primary endpoint was the decrease in the time below range (TBR; <70 mg/dL). Results: The time below range was significantly reduced in the Intervention arm compared to the Control arm (2.42 ± 1.68 h/day [10.1 %±7.0 %] vs 3.10 ± 2.28 h/day [12.9 %±9.5 %], P = 0.012). The ratio of high-risk participants with low blood glucose index >5 was significantly reduced (8.6 % vs 23.7 %, P < 0.001). Conclusions: The use of isCGM combined with structured education significantly reduced the time below range in patients with T1DM