3,161 research outputs found
More Than Yes and No: Predicting the Magnitude of Non-Invariance Between Countries from Systematic Features
Measurement Invariance has long been the cornerstone of cross-cultural comparisons. Nevertheless, over time a research tradition has developed in which invariance tests are applied with the stated end goal of finding invariance between measures and an implicit view that non-invariance is a barrier to cross-cultural research. In the current paper we aim to challenge this view and urge researchers to consider non-invariance critically not as barrier, but as opportunity for cross-cultural research. Specifically, we show how invariance effect sizes of items can be used to understand psychometric distances between countries and formulate novel hypotheses on cultural differences. Using a previously published dataset on the cross-cultural comparability of subjective happiness from 59 countries, we show how invariance effect sizes can be used to detect problematic items and variables which shape the psychometric similarity of countries. Focusing on item differences, we showed that negatively worded items are performing markedly worse in cross-cultural comparisons and that this effect is exacerbated if countries are linguistically distant. Additionally, we showed that country level variables such as GDP or environmental factors such as temperature can be used to cluster similarities in psychometric functioning, creating novel possibilities to systematize sources of non-invariance on a granular level
Reversible magnetomechanical collapse: virtual touching and detachment of rigid inclusions in a soft elastic matrix
Soft elastic composite materials containing particulate rigid inclusions in a
soft elastic matrix are candidates for developing soft actuators or tunable
damping devices. The possibility to reversibly drive the rigid inclusions
within such a composite together to a close-to-touching state by an external
stimulus would offer important benefits. Then, a significant tuning of the
mechanical properties could be achieved due to the resulting mechanical
hardening. For a long time, it has been argued whether a virtual touching of
the embedded magnetic particles with subsequent detachment can actually be
observed in real materials, and if so, whether the process is reversible. Here,
we present experimental results that demonstrate this phenomenon in reality.
Our system consists of two paramagnetic nickel particles embedded at finite
initial distance in a soft elastic polymeric gel matrix. Magnetization in an
external magnetic field tunes the magnetic attraction between the particles and
drives the process. We quantify the scenario by different theoretical tools,
i.e., explicit analytical calculations in the framework of linear elasticity
theory, a projection onto simplified dipole-spring models, as well as detailed
finite-element simulations. From these different approaches, we conclude that
in our case the cycle of virtual touching and detachment shows hysteretic
behavior due to the mutual magnetization between the paramagnetic particles.
Our results are important for the design and construction of reversibly tunable
mechanical damping devices. Moreover, our projection on dipole-spring models
allows the formal connection of our description to various related systems,
e.g., magnetosome filaments in magnetotactic bacteria.Comment: 14 pages, 7 figure
Normative Multiculturalism in Socio-Political Context
Normative multiculturalism refers to individuals’ perceptions about the extent to which interactions between culturally diverse groups, multicultural policies and practices, and diversity-valuing ideologies are common or normative in one’s society. In this paper, we explore these dimensions of normative multiculturalism as predictors of social connectedness (trust) and psychological well-being (flourishing) in two socio-political contexts: The United States and the United Kingdom. Two hundred and eighty-four residents (143 Hispanics and 141 non-Hispanic Whites) in the United States and 375 (125 British Indians and 250 British Whites) participated in the research. The results revealed that normative Multicultural Ideology predicted greater trust and normative Multicultural Contact predicted greater flourishing in both countries; however, minority-majority group status moderated the effects in different ways in the two contexts. The positive effects of normative multicultural ideology were confined to Hispanics in the United States, while in the United Kingdom it held for both groups with the effects being stronger for Whites. In addition, the positive effects of normative multicultural contact on flourishing was stronger for Indians than for Whites in the United Kingdom. The findings are discussed in relation to socio-political context and group characteristics along with limitations of the research
HAMPAO-SPECT of the brain and ocular microangiopathic syndrome in patients infected with the human immunodeficiency virus type 1
Explosive Disintegration of a Massive Young Stellar System in Orion
Young massive stars in the center of crowded star clusters are expected to
undergo close dynamical encounters that could lead to energetic, explosive
events. However, there has so far never been clear observational evidence of
such a remarkable phenomenon. We here report new interferometric observations
made with the Submillimeter Array (SMA) that indicate the well known enigmatic
wide-angle outflow located in the Orion BN/KL star-forming region to have been
produced by such a violent explosion during the disruption of a massive young
stellar system, and that this was caused by a close dynamical interaction about
500 years ago. This outflow thus belongs to a totally different family of
molecular flows which is not related to the classical bipolar flows that are
generated by stars during their formation process. Our molecular data allow us
to create a 3D view of the debris flow and to link this directly to the well
known Orion H "fingers" farther outComment: Accepted by ApJ Letters The 3D movie can be found in:
ftp://ftp.mpifr-bonn.mpg.de/outgoing/lzapata/movie.gi
PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR). Inhibitors of mTOR complex 1 (mTORC1) reduced atherosclerosis in preclinical studies, but side effects including insulin resistance and dyslipidemia limit their clinical use in this context. Therefore, we investigated PRAS40, a cell type-specific endogenous modulator of mTORC1, as alternative target. Indeed, we previously found PRAS40 gene therapy to improve metabolic profile; however, its function in endothelial cells and its role in atherosclerosis remain unknown. Here we show that PRAS40 negatively regulates endothelial mTORC1 and pro-inflammatory signaling. Knockdown of PRAS40 in endothelial cells promoted TNFα-induced mTORC1 signaling, proliferation, upregulation of inflammatory markers and monocyte recruitment. In contrast, PRAS40-overexpression blocked mTORC1 and all measures of pro-inflammatory signaling. These effects were mimicked by pharmacological mTORC1-inhibition with torin1. In an in vivo model of atherogenic remodeling, mice with induced endothelium-specific PRAS40 deficiency showed enhanced endothelial pro-inflammatory activation as well as increased neointimal hyperplasia and atherosclerotic lesion formation. These data indicate that PRAS40 suppresses atherosclerosis via inhibition of endothelial mTORC1-mediated pro-inflammatory signaling. In conjunction with its favourable effects on metabolic homeostasis, this renders PRAS40 a potential target for the treatment of atherosclerosis
CO(1-0) in z ≳ 4 Quasar Host Galaxies: No Evidence for Extended Molecular Gas Reservoirs
We present ^(12)CO(J = 1 → 0) observations of the high-redshift quasi-stellar objects (QSOs) BR 1202-0725 (z = 4.69), PSS J2322+1944 (z = 4.12), and APM 08279+5255 (z = 3.91) using the NRAO Green Bank Telescope (GBT) and the MPIfR Effelsberg 100 m telescope. We detect, for the first time, the CO ground-level transition in BR 1202-0725. For PSS J2322+1944 and APM 08279+5255, our observations result in line fluxes that are consistent with previous NRAO Very Large Array (VLA) observations, but they reveal the full line profiles. We report a typical lensing-corrected velocity-integrated intrinsic ^(12)CO(J = 1 → 0) line luminosity of L'_(CO) = 5 × 10^(10) K km s^(-1) pc^2 and a typical total H_2 mass of M(H_2) = 4 × 10^(10) M_☉ for the sources in our sample. The CO/FIR luminosity ratios of these high-z sources follow the same trend as seen for low-z galaxies, leading to a combined solution of log L_(FIR) = (1.39 ± 0.05) log L_(CO) - 1.76. It has previously been suggested that the molecular gas reservoirs in some quasar host galaxies may exhibit luminous, extended ^(12)CO(J = 1 → 0) components that are not observed in the higher J CO transitions. Using the line profiles and the total intensities of our observations and large velocity gradient (LVG) models based on previous results for higher J CO transitions, we derive that emission from all CO transitions is described well by a single gas component in which all molecular gas is concentrated in a compact nuclear region. Thus, our observations and models show no indication of a luminous extended, low surface brightness molecular gas component in any of the high-redshift QSOs in our sample. If such extended components exist, their contribution to the overall luminosity is limited to at most 30%
Real Time Full-Color Imaging in a Meta-Optical Fiber Endoscope
Endoscopes are an important component for the development of minimally
invasive surgeries. Their size is one of the most critical aspects, because
smaller and less rigid endoscopes enable higher agility, facilitate larger
accessibility, and induce less stress on the surrounding tissue. In all
existing endoscopes, the size of the optics poses a major limitation in
miniaturization of the imaging system. Not only is making small optics
difficult, but their performance also degrades with downscaling. Meta-optics
have recently emerged as a promising candidate to drastically miniaturize
optics while achieving similar functionalities with significantly reduced size.
Herein, we report an inverse-designed meta-optic, which combined with a
coherent fiber bundle enables a 33% reduction in the rigid tip length over
traditional gradient-index (GRIN) lenses. We use the meta-optic fiber endoscope
(MOFIE) to demonstrate real-time video capture in full visible color, the
spatial resolution of which is primarily limited by the fiber itself. Our work
shows the potential of meta-optics for integration and miniaturization of
biomedical devices towards minimally invasive surgery
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